2019Disorders2023TherapeuticsGLOBE NEWSWIREROCKVILLEPatientsMarylandVaccinesViral vectorsOutcomesMutationsDiagnosisDiseasesAcuteCoronavirusGene and cell therapyGeneticsFacility2016Clinical trials2018DiseaseBiotechImmunologyCellularDisorderResearchPredispositionInhibitorsProteinsTherapeuticTreatmentPhysicalDevelopmentMechanismsAssessmentTreatVirusesLatestSupportCancerFound
20192
- As of July 2019, the FDA has approved 17 cellular and gene therapy products, some of which treat different cancers or genetic disorders ( list of FDA approvals ). (americangene.com)
- The 2019 IEEE Quantum Meeting in Gaithersburg showcased the latest advancements in quantum technologies, including the development of more powerful quantum computers and the use of quantum communication to transmit information securely. (al-islami.com)
Disorders7
- Vigene is at the forefront of developing products for gene and cellular therapy for people around the world battling cancer and other life-threatening disorders, and we are very excited that they are continuing to do that important work right here in Maryland," said Maryland Commerce Secretary Kelly M. Schulz. (areadevelopment.com)
- Founded in 2012, Vigene Biosciences' mission is to make gene therapy affordable for patients with cancer and serious genetic disorders. (areadevelopment.com)
- It develops and markets therapies for genetic disorders. (valuewalk.com)
- CRISPR has the potential to revolutionize experimental therapies for genetic disorders such as sickle cell disease and blindness. (al-islami.com)
- Myeloid neoplasms are clonal hematopoietic stem cell disorders driven by the sequential acquisition of recurrent genetic lesions. (nature.com)
- Chronic myeloid neoplasms are malignant clonal hematopoietic stem cell disorders driven by recurrent genetic events, with an inherent risk of transformation to acute myeloid leukemia (AML) 1 , 2 . (nature.com)
- Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)
20232
- In 2016, during the Annual BioHealth Capital Region Forum at MedImmune/AstraZeneca in Gaithersburg, Maryland, an ambitious goal was set: to make the BioHealth Capital Region (BHCR) a Top 3 BioHealth cluster in the United States by 2023. (biohealthinnovation.org)
- GAITHERSBURG, Md. , Feb. 13, 2023 /PRNewswire/ -- Novavax, Inc. (Nasdaq: NVAX), a biotechnology company dedicated to developing and commercializing next-generation vaccines for serious infectious diseases, today announced a modification to its existing agreement with the U.S. Department of Health and Human Services (HHS), in collaboration with the Department of Defense, to deliver up to 1.5 million doses of the Novavax COVID-19 Vaccine, Adjuvanted (NVX-CoV2373). (yahoo.com)
Therapeutics2
- LSE: MXCT), a leading, cell-engineering focused company providing enabling platform technologies to advance the discovery, development and commercialization of next-generation cell-based therapeutics and to support innovative, cell-based research, today announced the signing of a strategic partnership with Prime Medicine, Inc. , a biotechnology company committed to delivering a new class of differentiated one-time curative genetic therapies. (biohealthinnovation.org)
- A biopharmaceutical company focusing on the discovery, development, and commercialization of RNAi therapeutics for treating rare genetic, cardio-metabolic, hepatic infectious, and central nervous system (CNS) diseases. (golden.com)
GLOBE NEWSWIRE1
- GAITHERSBURG, Md., June 22, 2020 (GLOBE NEWSWIRE) - Altimmune, Inc. (Nasdaq: ALT), a clinical-stage biopharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application to conduct a Phase 2 trial of HepTcell, a peptide-based immunotherapeutic for the treatment of chronic hepatitis B. The Company is also filing clinical trial applications in Canada, Spain, Germany and the United Kingdom. (biohealthcapital.com)
ROCKVILLE2
- Armed with the latest tools from the companies that innovated, refined, and reduced the cost of sequencing in the industry, the Human Genome Project created an explosion of genetic research and development that radiated out from the Rockville Maryland epicenter. (americangene.com)
- ROCKVILLE, Md. - The U.S. Department of Commerce's National Institute of Standards and Technology (NIST), the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) and United States Pharmacopeia (USP) have announced a research collaboration to assess analytical methods and develop standards for adeno-associated virus (AAV), an important mechanism for delivering gene therapies. (nist.gov)
Patients8
- XP is a severe genetic disease carrying a very high predisposition to skin cancers caused by severe burns when patients are exposed to UV light. (bioworld.com)
- Recent studies suggest that the most effective treatments for hereditary and acquired CP may differ, but the indications for genetic studies in CP patients and their role in defining therapy remain uncertain. (nih.gov)
- CAR-T therapies like Yescarta are uniquely time-sensitive medicines, requiring the extraction, genetic engineering and subsequent reinfusion of immune cells into cancer patients within a short window of time. (biopharmadive.com)
- The FDA has approved delayed-release cysteamine bitartrate (Procysbi) for the management of nephropathic cystinosis, the most severe form of the rare genetic disorder cystinosis, in patients ages 6 years and older. (medscape.com)
- Background Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) is a promising immunotherapeutic approach for patients with advanced solid tumors. (bmj.com)
- The HBV peptides were designed to drive T cell responses against all HBV genotypes in patients of diverse genetic background. (biohealthcapital.com)
- In the Phase 1 clinical study conducted in the United Kingdom and South Korea, three monthly injections at two dose levels of HepTcell peptides were given with and without IC31® adjuvant as add-on therapy to entecavir or tenofovir in patients with Hepatitis B e-antigen (HBeAg)-negative chronic infections. (biohealthcapital.com)
- Scipher Medicine is a precision immunology company that aims to match patients with their most effective therapy. (golden.com)
Maryland6
- The Maryland Stem Cell Research Fund's 2018 Annual Report announced that Maryland was "at the forefront of the cell therapy market and [has] all the right assets to take the lead in this emerging industry, in particular, to fill the critical need of manufacturing. (americangene.com)
- Many gene therapy product successes are staged to happen in Maryland. (americangene.com)
- The NIDDK will authorize an external meeting planning group, The Scientific Consulting Group, Inc. (SCG) of Gaithersburg, Maryland, to assist with the meeting logistics. (nih.gov)
- Vigene Biosciences, a global leader in gene therapy development, plans to expand into a new facility in Montgomery County, Maryland . (areadevelopment.com)
- The Gaithersburg, Maryland-based biopharma company is developing a coronavirus vaccine. (valuewalk.com)
- In a May 15 statement , Gilead also disclosed that it has leased 26,000 square feet in Gaithersburg, Maryland, to support a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute. (biopharmadive.com)
Vaccines2
- Altimmune is a clinical stage biopharmaceutical company focused on developing treatments for liver disease, immune modulating therapies and intranasal vaccines. (biohealthcapital.com)
- Nanomedicine company developing vaccines and therapies with cell-specific targeting. (golden.com)
Viral vectors3
- E1-deleted (including E1a-deleted) adenoviruses are replication defective and are commonly used as viral vectors to carry therapeutic genes for gene therapy. (hindawi.com)
- Genetic research that followed the Human Genome Project helped advance viral vectors and other gene-editing techniques that underlie a vibrant gene and cell therapy industry that continues to grow in the State. (americangene.com)
- By addressing the quality attributes assessment of viral vectors, the field of gene therapies as a whole will benefit from access to high quality components to enable the development of a variety of products. (nist.gov)
Outcomes2
- The outcomes of the Human Genome Project reinvigorated the gene therapy industry. (americangene.com)
- Predicated on our outcomes from the in vitro research, we claim that inhibition of HDAC10 might potentiate the response to platinum-based therapy in ovarian cancer. (thetechnoant.info)
Mutations3
- CMML shares the typical repertoire of genetic driver lesions with other myeloid neoplasms and is particularly enriched in truncating mutations involving ASXL1 (prevalence ~40%) 3 . (nature.com)
- Panels A through D show examples of different patterns of clearance of leukemia-associated mutations after induction therapy in 4 acute myeloid leukemia cases. (jamanetwork.com)
- Duchenne muscular dystrophy is an x-linked recessive genetic disease that is also caused by mutations in the DMD gene. (ericpedersen.org)
Diagnosis2
- The delayed diagnosis complicates effective therapy, and both forms of chronic pancreatitis (CP) result in severe disability, lifelong metabolic disease, and a high risk of pancreatic cancer. (nih.gov)
- The proper determination of variations in facial types is important for orthodontic diagnosis and treatment since certain procedures performed during orthodontic therapy may attenuate or enhance facial features. (bvsalud.org)
Diseases3
- AAV-based therapies are currently used to treat a type of inherited retinal dystrophy that causes blindness and spinal muscular atrophy in children, and treatments for many more diseases are currently being developed. (nist.gov)
- A company developing gene therapies for the treatment of genetic diseases and cancer. (golden.com)
- Gene and cell therapy group focused on developing life changing treatments for serious diseases. (golden.com)
Acute1
- The build-out should also help Gilead stand toe-to-toe with rival Novartis, which markets its competing CAR-T therapy Kymriah (tisagenlecleucel) for both acute lymphoblastic leukemia and non-Hodgkin lymphoma. (biopharmadive.com)
Coronavirus1
- This protein is part of the genetic sequence that is unique to the novel coronavirus. (umaryland.edu)
Gene and cell therapy1
- AAV is important because these are critical components to manufacture a variety of gene and cell therapy products," explained Kelvin Lee, NIIMBL institute director. (nist.gov)
Genetics1
- Contact us at Gaithersburg Animal Hospital or request an appointment online to test your dog's genetics. (gburganimalhospital.com)
Facility1
- The Swiss pharma manufactures Kymriah at a site in Morris Plains, New Jersey, but also has set up its CAR-T manufacturing process at the Fraunhofer-Institut for cell therapy and immunology facility in Leipzig, Germany. (biopharmadive.com)
20162
- In 2016, Vigene acquired Omnia Biologics with its significant clinical manufacturing experience to respond to growing product demand as gene therapy candidates progressed to clinical trials. (areadevelopment.com)
- Inhibitors of DNA glycosylases as potential therapeutic drugs in cancer," International Cancer Study & Therapy Conference (Cancer-2016), Baltimore, MD, April 4, 2016. (nist.gov)
Clinical trials2
- The 6th World Conference on Targeting Phage Therapy will keep you updated about the results of the latest phage clinical trials. (phagetherapy-site.com)
- He provides advice to the leadership team to help design and implement clinical trials of radiation therapy and radiation response modifying drugs. (shuttlepharma.com)
20181
- Genetic and Environmental Toxicology Association of Northern California (GETA) 2018 Spring Symposium on DNA Damage, Repair and Replication, Sacramento, CA, April 23, 2018. (nist.gov)
Disease1
- AAVs are particularly useful for gene therapies because they are not known to cause human disease and cannot replicate on their own. (nist.gov)
Biotech1
- By setting up operations next to the Amsterdam airport, the biotech will be able to more easily receive patient cells and ship finished cell therapy product across Europe. (biopharmadive.com)
Immunology1
- Our Scientific Advisory Board is comprised accomplished scientific leaders who are experts in the fields of oncology, radiation therapy, immunology and drug discovery and development. (shuttlepharma.com)
Cellular3
- Although virus-based gene therapy is a promising strategy to combat advanced prostate cancer, its current effectiveness is limited partially due to inefficient cellular transduction in vivo . (hindawi.com)
- It was just a year ago that we cut the ribbon at Vigene's new custom-built headquarters and already the growing demand for its gene and cellular therapy products requires additional physical expansion," said Benjamin H. Wu, president and CEO of Montgomery County Economic Development Corporation. (areadevelopment.com)
- Others may be part of a genetic program involved in cellular and synaptic plasticity. (jneurosci.org)
Disorder1
- Alkaptonuria is a genetic disorder in which the urine of the patient turns black once exposed to air. (hxbenefit.com)
Research2
- The CRADA will focus on research into cell therapies targeting patient-specific tumor neoantigens, Gilead said. (biopharmadive.com)
- Put together, Gilead appears to be laying a foundation for a greater research and commercial footprint in cell therapy - something that aligns with the goal of company leadership to transform the technology into a "cornerstone" of cancer therapy . (biopharmadive.com)
Predisposition1
- Understand genetic markers that could signal a predisposition to certain health conditions. (gburganimalhospital.com)
Inhibitors1
- Small molecule inhibitors of DNA glycosylases as potential drugs in cancer therapy," 2nd International Conference on Molecular Biology, Nucleic Acids & Molecular Medicine (Keynote Speaker), Philadelphia, PA, September 1, 2017. (nist.gov)
Proteins1
- Other proteins that stimulate the DSB repair pathway may also contribute to tumorigenesis when mutated and may provide targets for therapy. (thetechnoant.info)
Therapeutic1
- Given the paucity of effective therapies for CMML, delineating the molecular mechanisms of ASXL1 -mutant CMML (ASXL1 MT ) is of particular interest from a therapeutic standpoint. (nature.com)
Treatment1
- The role of genetic testing, the evaluation and treatment of pain syndromes, and the possible value of separate treatment algorithms all provide new evidence for improved management of CP. (nih.gov)
Physical1
- Physical therapy may help preserve movement as long as possible. (myriad.com)
Development1
- And it will support the development of promising new gene therapies that will greatly improve peoples' lives. (nist.gov)
Mechanisms1
- The work package focusing on molecular studies generated new evidence about the changes effected by antibiotic therapy on commensal organisms or opportunistic pathogens in the oropharyngeal, nasal and gastro-intestinal flora and study AMR mechanisms and the dissemination of successful clones of fluoroquinolone-resistant, carbapenem-resistant or extended-spectrum beta-lactamase harboring Gram-negative bacteria, MRSA and fluoroquinolone-resistant viridans streptococci. (europa.eu)
Assessment1
- by 2025, we predict that the FDA will be approving 10 to 20 cell and gene therapy products a year based on an assessment of the current pipeline and the clinical success rates of these products" ( BioSpace ). (americangene.com)
Treat1
- If a cure cannot be obtained, palliative therapy is given to treat pain and discomfort. (cdc.gov)
Viruses1
- Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. (cdc.gov)
Latest1
- That vision has been realized in the latest Genetic Engineering & Biotechnology News " Top 10 U.S. Biopharma Clusters " rankings, marking a significant milestone in the region's relentless pursuit of excellence, collaboration, and innovation in the BioHealth field. (biohealthinnovation.org)
Support1
- Gilead said Tuesday it has leased a nearly 120,000-square-foot site in the Netherlands to support manufacture of its cancer cell therapy Yescarta, which is currently awaiting a decision on approval by EU regulators. (biopharmadive.com)
Cancer2
Found1
- Rocco's owner found the results of the canine genetic health testing to be highly informative. (gburganimalhospital.com)