Gadolinium. Medical search. Frequent questions

Late gadolinium enhancement (LGE) is frequently found in patients with dilated cardiomyopathy (DCM), there is little information about its frequency and distribution pattern according to underlying genetic substrate. (nih.gov)
Jensen CJ, Zadeh B, Wambach JM, Lambers M, Nassenstein K, Bruder O. Association of QRS-T angle and Late Gadolinium Enhancement in patients with a Clinical Suspicion of Myocarditis. (medsci.org)
To investigate the association of a wide QRS-T angle on the surface ECG and late gadolinium enhancement on contrast-enhanced cardiovascular magnetic (CMR) imaging in patients with clinically suspected myocarditis. (medsci.org)
Late gadolinium enhancement (LGE) visualizes myocardial necrosis and fibrosis in patients with biopsy-proven myocarditis. (medsci.org)
A wide QRS-T angle of 90 degrees or more is linked to myocardial fibrosis or necrosis (late gadolinium enhancement) in patients with suspected myocarditis. (medsci.org)
Late gadolinium enhancement (LGE) on contrast-enhanced cardiac magnetic resonance (CMR) imaging depicts myocardial necrosis and later replacement fibrosis (scar) in patients with myocarditis with high spatial resolution. (medsci.org)
4 We present a case of sCAD with early progression and marked gadolinium enhancement suggestive of acute inflammation. (neurology.org)
Cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) revealed a substantial variation in the extent of myocardial scarring, a pathological hallmark of hypertrophic cardiomyopathy (HCM). (go.jp)
Assessment of late gadolinium enhancement in hypertrophic cardiomyopathy improves risk stratification based on current guidelines. (bvsalud.org)
The aim of this study was to externally validate the 2022 European Society of Cardiology (ESC) model and other guideline -based ICD class of recommendation (ICD-COR) models and explore the utility of late gadolinium enhancement (LGE) in further risk stratification. (bvsalud.org)

January 2, 2007 - The US Food and Drug Administration (FDA) warned healthcare professionals last week about additional reports of nephrogenic systemic fibrosis/nephrogenic fibrosing dermopathy (NSF/NFD) in patients with renal failure exposed to gadolinium-based contrast agents. (medscape.com)

Evidence of in vivo gadolinium deposition in bone tissue in patients with normal renal function is well-established, but recent literature showing that gadolinium might also deposit in the brain in patients with intact blood-brain barriers caught many individuals in the imaging community by surprise. (ajnr.org)
The purpose of this review was to summarize the literature on gadolinium-based contrast agents, tying together information on agent stability and animal and human studies, and to emphasize that low-stability agents are the ones most often associated with brain deposition. (ajnr.org)
The effects of this deposition are not known, but radiologists are working proactively to optimise patient safety while preserving the important information that gadolinium-enhanced MRI scans provide. (europeanpharmaceuticalreview.com)
Gadolinium is toxic and to avoid its deposition in tissues, it must be chemically bonded with nonmetal ions to facilitate its excretion by the kidneys. (snmjournals.org)
The median SUV max in the DN and GP was 16% and 27% lower, respectively, in patients who received GBCAs than in those who had not received GBCAs, possibly related to gadolinium deposition in these areas. (snmjournals.org)
High purity cerium gadolinium evaporation materials play a huge role in deposition processes to ensure high quality deposited film. (sputtertargets.net)

It is used as the additive of gadolinium iron garnet, yttrium aluminum garnet, medical equipment industry as the sensitizing fluorescence material, and can also be used as the additive of the optical prism. (riad-on-time.com)

The findings validate previous ones that show macrocyclic gadolinium chelates are safer than those having a linear structure with excess chelate. (diagnosticimaging.com)
There are two types of gadolinium-based contrast agents - linear agents and macrocyclic agents. (tga.gov.au)
Published studies have found that linear gadolinium-based contrast agents appear to result in greater gadolinium retention in the brain than macrocyclic agents (see below for references ).The TGA will continue to monitor this issue and take further action if necessary. (tga.gov.au)

CUSTOMER ADVISORY: American Elements does not supply gadolinium for use in ANY form of GBCA ("Gadolinium-Based Contrast Agents") or for ANY medical, pharmaceutical or nutritional use whatsoever or for the manufacture, testing, or development of ANY such products. (americanelements.com)
High signal intensity in the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted MR images has been both morphologically and pathologically linked to gadolinium-based contrast agent (GBCA) retention in the brain. (snmjournals.org)

In addition, researchers have identified gadolinium in skin biopsies of patients with the condition. (medscape.com)
The gadolinium found in skin biopsies, we don't know if it is in a free or a bound state. (diagnosticimaging.com)

The causal relationship between gadolinium-based contrast agents and nephrogenic systemic fibrosis in patients with renal insufficiency resulted in new policies regarding the administration of these agents. (ajnr.org)
Previously, these sclerotic bodies were thought to be pathognomonic for nephrogenic systemic fibrosis (NSF) in the setting of chronic renal disease with associated gadolinium exposure. (qxmd.com)
Nephrogenic systemic fibrosis is widely attributed to gadolinium ions dissociating from their chelating agents and depositing in tissues ( 3 ). (snmjournals.org)

Because of its paramagnetic properties, solutions of chelated organic gadolinium complexes are used as intravenously administered gadolinium-based MRI contrast agents in medical magnetic resonance imaging. (wikipedia.org)
The paramagnetic properties of Gadolinium have been used in clever design of 'contrasting agents' for recording MRI of human organs. (cam.ac.uk)

Gadolinium was discovered in 1880 by Jean Charles de Marignac, who detected its oxide by using spectroscopy. (wikipedia.org)
However, it tarnishes quickly in moist air, forming a loosely-adhering gadolinium(III) oxide (Gd2O3): 4 Gd + 3 O2 → 2 Gd2O3, which spalls off, exposing more surface to oxidation. (wikipedia.org)
Hydrophobic gadolinium embedded iron oxide (GdIO) nanocrystals are self-assembled into nanoclusters in the water phase with the help of stearic acid modified low molecular weight polyethylenimine (stPEI). (rsc.org)
This new gadolinium embedded iron oxide nanocluster provides an important platform for safe and efficient gene delivery with non-invasive T 1 - T 2 dual-modal MRI monitoring capability. (rsc.org)

Consumers and health professionals are advised that the TGA has reviewed recent information relating to the potential for small amounts of gadolinium to be retained in the brain, following use of gadolinium-based contrast agents during magnetic resonance imaging (MRI) scans. (tga.gov.au)
This research is related to the preparation and initial characterization of gadolinium nanoparticles as a Magnetic Resonance Imaging (MRI) contrast agent. (duke.edu)
The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. (preprints.org)
On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast enhanced magnetic resonance imaging. (preprints.org)

Gadolinium is a chemical element with the symbol Gd and atomic number 64. (wikipedia.org)
Gadolinium Metal chemical element: Gd ( granular ) Ultra pure quantities of the element Gadolinium (atomic number 64), ideal for element collectors or those conducting experiments/producing alloys with pure Gadolinium metal. (unitednuclear.com)
Ultra pure quantities of the element Gadolinium (atomic number 64 ), ideal for element collectors or those conducting experiments/producing alloys with pure Gadolinium metal. (unitednuclear.com)

The FDA is currently gathering additional information about NSF/NFD and is actively investigating whether gadolinium exposure is linked to the condition and whether other populations besides those with renal failure may be at risk. (medscape.com)
2016) Pediatric Brain: Repeated Exposure to Linear Gadolinium-based Contrast Material Is Associated with Increased Signal Intensity at Unenhanced T1-weighted MR Imaging. (tga.gov.au)
A radiation conversion and radiation transport model applicable to gadolinium-exposure neutron imaging is formulated. (dtic.mil)
The distinct conversion-electron contributions thus identified confirm the supposition about the dominant mode of image formation in gadolinium-exposure neutron imaging. (dtic.mil)
In June 2006, the FDA issued its first warning about the risk of NSF as a result of gadolinium exposure. (gacovinolake.com)
Sclerotic bodies have been reported only in association with gadolinium exposure (eg, gadodiamide) either in the sclerotic skin in NSF or in GAP. (qxmd.com)

H. Tokumitsu, J. Hiratsuka, Y. Sakurai, T. Kobayashi, H. Ichikawa, Y. Fukumori, "Gadolinium neutron-capture therapy using novel gadopentetic acid-chitosan complex nanoparticles: in vivo growth suppression of experimental melanoma solid tumor", Cancer Letters, Vol. 150, pp. 177-182. (scirp.org)
H. Tokumitsu, H. Ichikawa, Y. Fukumori, "Chitosan-gadopentetic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: preparation of novel emulsion-droplet coalescence technique and characterization", Pharmaceutical Research, Vol. 16, 1999, pp. 1830-1835. (scirp.org)
Gadolinium nanoparticles were synthesized using polyol method with stabilizer and chemical reaction process at high temperature. (duke.edu)
for 4 hours to obtain gadolinium nanoparticles with uniform size and shape. (duke.edu)
The results of hydrodynamic and visual measurements using DLS and HRTEM instruments on the gadolinium nanoparticles produced were 50 nm and 18 nm, respectively. (duke.edu)
Setiawan H, Triyatna F, Nurmanjaya A, Subechi M, Sarwono DA, Billah AA, Rindiyantono F. Synthesis and characterization of gadolinium nanoparticles using polyol method as a candidate for MRI Contrast Agent . (duke.edu)

Gadolinium as a metal or a salt absorbs neutrons and is, therefore, used sometimes for shielding in neutron radiography and in nuclear reactors. (wikipedia.org)
The isotope gadolinium-157 has the highest thermal-neutron capture cross-section among any stable nuclide: about 259,000 barns. (wikipedia.org)
Positive result obtained at destruction of CHO cells allows one to state that the advantages of this biomaterial are a simple manipulation with it, a possibility to adjust its gadolinium content, long-term stability of its physico-chemical properties, as well as a reduced cost of neutron-capture experiment. (scirp.org)
T. K Saha, K. Jono, H. Ichikawa, Y. Fukumori, "Preparation and evaluation of glutaraldehyde cross-linked chitosan microspheres as a gadolinium reservoir for neutron-capture therapy", Chemical & Pharmaceutical Bulletin, Vol. 46, 1988, pp. 537-539. (scirp.org)
Gadolinium compounds have very high neutron absorption capability and can be used as shields in nuclear reactors. (cam.ac.uk)

No harmful effects of gadolinium retention in the brain have been identified at this time, but the TGA is working with sponsors of these products to update their Product Information (PI) documents to reflect the new information. (tga.gov.au)
While no harmful effects of gadolinium retention in the brain have been identified at this time, the TGA is working with sponsors to update the PI documents and is recommending judicious use of gadolinium-based contrast agents, particularly linear agents ( Table 1 ). (tga.gov.au)
Nanomaterial-based contrast agents aim to improve clearer imaging, longer examination retention times with lower toxicity than gadolinium ion-based contrast agents, and evaluate the potential use of MRI contrast agents for early detection of cancer. (duke.edu)
however, recent studies have shown that high signal intensity in the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted MR images have been linked to gadolinium retention in the brain ( 4 ). (snmjournals.org)

Gadolinium metal is used as an emergency shut-down measure in some types of nuclear reactors. (unitednuclear.com)

In current practice, gadolinium-based contrast agents have been considered safe when used at clinically recommended doses in patients without severe renal insufficiency. (ajnr.org)
The patient who did not have renal disease received high doses of gadolinium. (qxmd.com)

Thus, to study whether valence state is important in CeO2 toxicity, CeO2 nanoparticle s were doped with gadolinium (Gd) to adjust Ce toward a +3 state. (cdc.gov)
Thus, to study whether valence state and oxygen vacancy concentration are important in CeO2 toxicity, CeO2 nanoparticle s were doped with gadolinium to adjust the cation (Ce, Gd) and anion (O) defect states. (cdc.gov)

Like most of the rare earths, gadolinium forms trivalent ions with fluorescent properties, and salts of gadolinium(III) are used as phosphors in various applications. (wikipedia.org)
Gadolinium(III) ions in water-soluble salts are highly toxic to mammals. (wikipedia.org)
Gadolinium metal is attacked readily by dilute sulfuric acid to form solutions containing the colorless Gd(III) ions, which exist as [Gd(H2O)9]3+ complexes: 2 Gd + 3 H2SO4 + 18 H2O → 2 [Gd(H2O)9]3+ + 3 SO2− 4 + 3 H2. (wikipedia.org)

Although the utility of this measure for preventing or treating NSF/NSD in patients with impaired renal function has not been established, average excretory rates of gadolinium during consecutive hemodialysis sessions are 78%, 96%, and 99%, respectively. (medscape.com)
In a separate study reported at the ECR, radiologist Dr. Gertraud Heinz-Peer and colleagues at the Medical University of Vienna reviewed the records of 552 patients with chronic renal failure undergoing peritoneal dialysis and hemodialysis who were scanned with gadolinium-enhanced MR between 1997 and 2007. (diagnosticimaging.com)

Gadolinium is a silvery-white metal when oxidation is removed. (wikipedia.org)

Electron microscopy studies have identified gadolinium deposits in fibrosed skin taken from patients, Dr. Christoph Herborn, a radiologist at the University Medical Centre in Hamburg, Germany, told delegates attending a satellite symposium organized by GE Healthcare. (diagnosticimaging.com)
There is concrete evidence that gadolinium deposits in the brain and body," said study lead author Dr Enhao Gong , researcher at Stanford University in Stanford, Calif. "While the implications of this are unclear, mitigating potential patient risks while maximising the clinical value of the MRI exams is imperative. (europeanpharmaceuticalreview.com)
however, recent studies have shown that gadolinium deposits in the brain of patients who have normal renal function and intact blood-brain barriers after multiple contrast administrations ( 2 ). (snmjournals.org)

However, chelated gadolinium(III) compounds prevent the gadolinium(III) from being exposed to the organism and the majority is excreted by healthy kidneys before it can deposit in tissues. (wikipedia.org)
Gadolinium compounds are often introduced to the body as 'contrasting agents' while recording MRI. (cam.ac.uk)
Gadolinium(III) forms beautiful fluorescent compounds (known as phosphors) and these have been used in projection (TV) technology! (cam.ac.uk)
Fluorescence of Gadolinium(III) compounds is used in developing phosphors. (cam.ac.uk)

Use of Gadolinium in MRI and MRA Linked to NSF/NFD in Patients With Renal Failure - Medscape - Jan 02, 2007. (medscape.com)
Dr. Vincent Launay-Vacher and colleagues at the Pitié-Salpêtrière Hospital in Paris retrospectively reviewed data from 308 patients with renal insufficiency who underwent MRI with and without gadolinium from July 2005 to July 2006 at nine sites across France. (diagnosticimaging.com)
We also do not know whether it is retained there after the development of the disease or deposited there beforehand," Herborn said.The incidence of NSF in patients with end-stage renal disease who receive gadolinium-based contrast is approximately 2% at present. (diagnosticimaging.com)

The GE product is a gadolinium-based contrast dye used in MRIs and other imaging scans. (gacovinolake.com)
T1-weighted transaxial gadolinium-enhanced MRIs of the same patient as in the previous image show a well-defined hypervascular enhancing mass. (medscape.com)

The FDA notes that none of the 5 currently approved gadolinium products ( Omniscan , OptiMARK , Magnevist , ProHance [made by Bracco Diagnostics, Inc], and MultiHance [made by Bracco Diagnostics, Inc]) are approved for use in MRA. (medscape.com)

Nearly four-fifths of the patients were given gadolinium-containing agents, with 57% receiving gadoterate meglumine and 2.3% receiving gadodiamide. (diagnosticimaging.com)
Linear agents, such as gadodiamide, seem more likely to release free gadolinium into the body, Launay-Vacher said. (diagnosticimaging.com)
It is related to a particular type of gadolinium (gadodiamide) used for contrast-enhanced radiologic studies. (qxmd.com)

Gadolinium reacts with atmospheric oxygen or moisture slowly to form a black coating. (wikipedia.org)

Individual gadolinium atoms can be isolated by encapsulating them into fullerene molecules, where they can be visualized with a transmission electron microscope. (wikipedia.org)
Structure of Gadolinium Zirconate, with the Gadolinium atoms shown in light green. (cam.ac.uk)
These Gadolinium based pyrochlore structures can incorporate actinide atoms in their lattice and thus can be used for nuclear waste management! (cam.ac.uk)

This scleroderma-like disorder has been linked to the administration of gadolinium-containing contrast media. (diagnosticimaging.com)

PI documents for gadolinium-based contrast agents have previously stated that gadolinium 'does not cross the intact blood brain barrier' and in some instances that gadolinium does not accumulate in normal brain tissue. (tga.gov.au)

Gadolinium is a toxic element. (bmj.com)

CNS accumulation of gadolinium-based contrast agents has been reported in nearly all patients included in a screening program for VHL disease. (medscape.com)

Gadolinium is quite electropositive and reacts slowly with cold water and quite quickly with hot water to form gadolinium(III) hydroxide (Gd(OH)3): 2 Gd + 6 H2O → 2 Gd(OH)3 + 3 H2. (wikipedia.org)

Stanford Advanced Materials (SAM) is a leading manufacturer and supplier of high purity cerium gadolinium evaporating materials and a wide variety of evaporation pellets. (sputtertargets.net)

Drug makers GE Healthcare, Bayer and Covidien have face hundreds of lawsuits claiming injuries from gadolinium-based contrast agent products. (gacovinolake.com)

Gadolinium possesses unusual metallurgical properties, to the extent that as little as 1% of gadolinium can significantly improve the workability and resistance to oxidation at high temperatures of iron, chromium, and related metals. (wikipedia.org)

Gadolinium below its Curie point of 20 °C (68 °F) is ferromagnetic, with an attraction to a magnetic field higher than that of nickel. (wikipedia.org)
Gadolinium is believed to be ferromagnetic at temperatures below 20 °C (68 °F) and is strongly paramagnetic above this temperature. (wikipedia.org)
There is evidence that gadolinium is a helical antiferromagnetic, rather than a ferromagnetic, below 20 °C (68 °F). Gadolinium demonstrates a magnetocaloric effect whereby its temperature increases when it enters a magnetic field and decreases when it leaves the magnetic field. (wikipedia.org)
Gadolinium becomes superconductive below a critical temperature of 1.083 K. It is strongly magnetic at room temperature, and exhibits ferromagnetic properties below room temperature. (unitednuclear.com)

Stanford Advanced Materials (SAM) specializes in producing high purity cerium gadolinium evaporation materials using quality assurance processes to guarantee product reliability. (sputtertargets.net)

The presence or absence of late gadolinium enhancements in these patients is prognostically meaningful. (medsci.org)

This study was designed to evaluate the safety, MR imaging characteristics, and clinical response to intrathecal gadopentetate dimeglumine (gadolinium) administration in human patients. (nih.gov)
Gadolinium-associated plaques: a new, distinctive clinical entity. (qxmd.com)

Most of these patients had previously undergone imaging with a gadolinium-based agent on one or more occasions.Findings released in Vienna suggest that evidence is not sufficient to indict all gadolinium-based agents under the same suspicion. (diagnosticimaging.com)
Recent studies have found that trace amounts of the metal remain in the bodies of people who have undergone exams with certain types of gadolinium. (europeanpharmaceuticalreview.com)

This pilot study shows the relative safety and feasibility of low-dose intrathecal gadolinium administration. (nih.gov)

Gadolinium-based contrast agents are injected into a patient's vein to enhance the quality of MRI scans of internal organs, blood vessels and tissues. (tga.gov.au)

The formation and physico-chemical properties of biomaterial, based on double-stranded (ds) DNA molecules and bearing high concentration of gadolinium, is described. (scirp.org)
High magnetic field properties of gadolinium, terbium, and holmium. (nps.edu)

Use of Gadolinium in MRI and MRA Linked to NSF/NFD in Patients With. (medscape.com)
However, 100% of NSF/NFD cases reviewed thus far (75 of approximately 215 cases worldwide) have occurred in patients who had received a gadolinium-based contrast agent for MRI or MRA. (medscape.com)
In addition, at least two patients developed NSF who have never been injected with gadolinium, Herborn said. (diagnosticimaging.com)
But for now, in situations where gadolinium-enhanced MRI is indicated, radiologists can reduce the risk to patients by keeping the dose as low as possible, Herborn said. (diagnosticimaging.com)
A federal jury in Ohio has awarded $5 million in the first case to go to trial in the multidistrict litigation (MDL) involving patients who were injured from the body scan contrast agent "gadolinium. (gacovinolake.com)
A new condition, gadolinium-associated plaques (GAP), is reported in 2 patients. (qxmd.com)

Gadolinium-based contrast agents (GBCAs) are widely used in imaging today. (bmj.com)
A major component of MRI is the use of gadolinium-based contrast agents (GBCAs). (snmjournals.org)

Please be advised that this issue only relates to gadolinium-based contrast agents used in MRI scans and not to other types of scanning agents used for other imaging procedures. (tga.gov.au)

These properties show that we are dealing with a novel type of biomaterial strongly enriched by gadolinium. (scirp.org)

We propose to develop and commercialize a new class of extreme ultraviolet (EUV) multilayer coatings containing the rare-earth element gadolinium (Gd), designed as efficient narrow-band reflective mirror coatings operating near normal incidence in the 60-65 nm wavelength range. (nasa.gov)

Do Gadolinium-Based Contrast Agents Affect 18F-FDG PET/CT Uptake in the Dentate Nucleus and the Globus Pallidus? (snmjournals.org)
Do Gadolinium-Based Contrast Agents Affect 18 F-FDG PET/CT Uptake in the Dentate Nucleus and the Globus Pallidus? (snmjournals.org)
New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. (preprints.org)
CIEDs and gadolinium-based contrast agents pas passer ce type d'examen pour des raisons de s ecurit e. (bvsalud.org)

Anatomy6

Diseases9

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes6

Information Science2

Health Care3

Enhancement10

Exposed to gadolinium-based contrast1

Deposition6

Yttrium alumin1

Macrocyclic3

GBCA2

Skin biopsies2

Nephrogenic Systemic3

Paramagnetic properties2

Oxide4

Magnetic resonance4

Atomic3

Exposure6

Nanoparticles6

Neutron5

Retention4

Nuclear reactors1

Doses2

Toxicity2

Ions3

Hemodialysis2

Silvery1

Deposits3

Compounds4

Renal3

MRIs2

Omniscan1

Gadodiamide3

Atmospheric oxygen1

Atoms3

Contrast media1

Brain1

Toxic element1

Accumulation1

Reacts1

Pellets1

Lawsuits1

Chromium1

Ferromagnetic4

Quality Assurance1

Late1

Clinical2

Undergone2

Feasibility1

Tissues1

High2

Patients6

GBCAs2

Imaging1

Properties1

Coatings1

Agents4