Despite treatment with 60 ml of glycyrrhizin, 1 g of gabexate mesylate, and 500 mg of methylprednisolone, she died on April 23. (scirp.org)
Gabexate Mesylate is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation. (absource.de)
Mesilate4
Gabexate is a serine protease inhibitor which is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis. (wikipedia.org)
Therefore, ulinastatin and gabexate mesilate, of T cells in a T-cell-receptor V-selective manner (1,2). (cdc.gov)
Furthermore, protease inhibition by gabexate mesilate did not prevent autophagosome formation indicating that trypsinogen activation is not a prerequisite for vacuole formation. (uni-greifswald.de)
Protease inhibitor1
The effects of the cholecystokinin (CCK)-receptor antagonist proglumide, the protease inhibitor gabexate, and the hormones secretin and cholecystokinin-octapeptide (CCK-8) were studied in a model of acute hemorrhagic pancreatitis induced by feeding mice a choline-deficient, ethionine-supplemented (CDE) diet. (duke.edu)
Endoscopic1
Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. (wikipedia.org)
Pancreatitis4
Injections of gabexate and proglumide from initiation of CDE diet (before induction of pancreatitis) increased survival from 37% (diet alone) to 85 and 75%, respectively, and also ameliorated histological alterations and increases in serum amylase concentration and pancreatic activated trypsin. (duke.edu)
When proglumide or gabexate were given after induction of pancreatitis, proglumide still increased survival to 75%, whereas gabexate no longer did. (duke.edu)
Injection of nontoxic doses of CCK-8 before proglumide or gabexate injections completely abolished all beneficial effects and also increased the severity of pancreatitis due to CDE diet alone. (duke.edu)
Gabexate in the prevention of post-ERCP pancreatitis:Should we be inhibited by the cost? (gastro-update.hu)
Serine protease1
Gabexate is a serine protease inhibitor which is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis. (wikipedia.org)
Mesilate inhibits1
17. Gabexate mesilate inhibits colon cancer growth, invasion, and metastasis by reducing matrix metalloproteinases and angiogenesis. (nih.gov)
Nafamostat mesilate2
2. All of these reactions to ioxaglate were reversed by the pretreatment with gabexate mesilate (10 and 50 mg kg -1 , 5 min prior to injection) or nafamostat mesilate (3 and 10 mg kg -1 ), in which the inhibition was complete after injection of nafamostat mesilate (10 mg ks -1 ). (elsevierpure.com)
3. Both gabexate mesilate and nafamostat mesilate inhibited the activity of purified human lung tryptase, although the latter compound was far more potent than the former. (elsevierpure.com)
Ulinastatin3
Additional research was found to be required to justify confirmatory RCTs for topical epinephrine, aggressive intravenous fluids, gabexate, ulinastatin, secretin, and antibiotics. (medscape.com)
Therefore, ulinastatin and gabexate mesilate, of T cells in a T-cell-receptor V-selective manner (1,2). (cdc.gov)
Therefore, ulinastatin and gabexate mesilate, which possess both antifibrinolytic and anticoagulative effects, were administered ( 8 , 9 ). (cdc.gov)