InterneuronsNeuronsSynapsesNeuronNeurotransmissionGlutamatergicModulationInhibitionPlasticitySynaptic transmissionInhibitoryDopaminergicSubtype-specificPathwaysSignalingAlterationsElectrophysiologicalCellsHippocampusSynapseCircuitsPhysiologyNeuralMarkersNeurological DiseasesFunctionTargetsActivityEffectsSystemBrain
Interneurons19
- This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. (nih.gov)
- Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. (nih.gov)
- The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons. (alzforum.org)
- GABAergic interneurons have relevance for cognitive impairments and brain disorders, such as Alzheimer's and Parkinson's diseases, epilepsy, schizophrenia and autism spectrum disorders. (lu.se)
- They confirmed that injecting somatostatin peptides into the specific type of GABAergic interneurons also completely restored the GABAergic synaptic deficits and increased frequency of seizures caused by IQSEC3 deficiency. (cureepilepsy.org)
- We generated light-sensitive human embryonic stem cell (hESC)-derived GABAergic interneurons (hdIN) and tested their functionality. (lu.se)
- Recently, we reported that restoring spinal cord GABAergic signaling by intraspinal transplantation of cortical precursors of GABAergic interneurons from the embryonic medial ganglionic eminence (MGE) can reverse the mechanical hypersensitivity (allodynia) that characterizes a neuropathic pain model in the mouse. (escholarship.org)
- Andreas Bruzelius defended his Ph.D. thesis 'Generating GABAergic interneurons through reprogramming and differentiation strategies' on Friday, 20 October 2023. (lu.se)
- During my time as a Ph.D. student, my research has focused on GABAergic interneurons. (lu.se)
- The focus has been on GABAergic interneurons and making them from different starting cells. (lu.se)
- Collectively this thesis provides a variety of ways to produce neurons with a special focus on GABAergic interneurons. (lu.se)
- The first part of the thesis (Paper I and II) explores reprogramming of adult human fibroblasts and human glial progenitor cells into GABAergic interneurons in 2D cultures. (lu.se)
- We provide evidence that the two cell sources can successfully convert into subtype-specific GABAergic interneurons. (lu.se)
- The functions of the cerebral cortex rely upon highly interconnected and dynamic microcircuits composed of two types of neurons: glutamatergic excitatory neurons that propagate signals through the various stages of processing, and GABAergic interneurons that regulate this information flow and sculpt cortical circuit dynamics. (grantome.com)
- While the PV and SST interneuron populations have been well studied, this Program Project is focused on the 5HT3aR family of GABAergic interneurons whose prevalence, breadth and contributions to cortical function have been previously underestimated. (grantome.com)
- GABAergic interneurons (INs) are critical for the normal function of the brain and have been implicated in human disease. (grantome.com)
- Unitary GABAergic volume transmission from individual interneurons to astrocytes in the cerebral cortex by: Rózsa Márton, et al. (u-szeged.hu)
- In Dlx1/2 −/− double mutant mice, the tangential migration of GABAergic interneurons into pallial structures is nearly extinguished and neuronal precursors accumulate in the SVZ of the MGE and CGE (Anderson et al. (biomedcentral.com)
- The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
Neurons23
- The suppression involved the ability of male flies to detect females by contact chemosensation through the pheromone-sensing ion channel ppk29 and was mediated by male-specific GABAergic neurons acting on the GABAA receptor RDL in target cells. (nih.gov)
- In this paper, we used an optimized protocol for adult skin fibroblast reprogramming based on RE1 Silencing Transcription Factor (REST) inhibitn together with a combination of GABAergic fate determinants to convert human adult skin fibroblasts into GABAergic neurons. (lu.se)
- Moreover, we identified specific gene combinations that converted fibroblasts into neurons of a GABAergic intraneuronal fate. (lu.se)
- The ELEMF exposure selectively promoted the proliferation of a particular population of neurons, evidenced by the increased proportion of GABAergic neurons. (frontiersin.org)
- This poster highlights how human induced pluripotent stem cells (hiPSCs) can be precision reprogrammed to generate a highly pure population of GABAergic neurons for a more accurate model of neuronal circuits. (technologynetworks.com)
- The GABAergic (γ-aminobutyric acid-producing) neurons in the suprachiasmatic nucleus (SCN) (SCN GABA neurons) were reported to control the diurnal rhythm of insulin-mediated suppression of hepatic glucose production in mice in earlier work 1 . (diabetesjournals.org)
- REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity. (diabetesjournals.org)
- Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons. (bvsalud.org)
- After differentiating human induced pluripotent stem cells into electrophysiologically active striatal-like GABAergic neurons , we found that HD-derived neurons displayed reduced density of inhibitory synapse markers and GABA receptor -mediated ionotropic signaling. (bvsalud.org)
- Treatment with EVs secreted by control (CTR) fibroblasts reversed the deficits in GABAergic synaptic transmission and increased the density of inhibitory synapses in HD-derived neuron cultures , while EVs from HD-derived fibroblasts had the opposite effects on CTR-derived neurons . (bvsalud.org)
- The EV-mediated reversal of the abnormal GABAergic phenotype in HD-derived neurons reinforces the potential role of EV- miRNAs on synapse regulation . (bvsalud.org)
- Furthermore, Smad proteins, transcriptional effectors of TGF-β signaling, are co-expressed and physically interact in the basal ganglia with Dlx homeodomain transcription factors, which are critical regulators of the differentiation, migration and survival of telencephalic GABAergic neurons. (biomedcentral.com)
- However, little is known about the identity and function of these GABAergic inhibitory neurons and what determines their activity. (gwu.edu)
- In this study we have identified a population of GABAergic neurons in the ventrolateral medulla that receive increased excitatory post-synaptic potentials during inspiration, but also have spontaneous firing in the absence of synaptic input. (gwu.edu)
- Using transgenic mice that express GFP under the control of the Gad1 (GAD67) gene promoter, we determined that this population of GABAergic neurons is in close apposition to cardioinhibitory parasympathetic cardiac neurons in the nucleus ambiguus (NA). (gwu.edu)
- Although they receive excitatory glutamatergic synaptic inputs during inspiration, this excitatory neurotransmission was not altered by blocking nicotinic receptors, and many of these GABAergic neurons continue to fire after synaptic blockade. (gwu.edu)
- The spontaneous firing in these GABAergic neurons was not altered by the voltage-gated calcium channel blocker cadmium chloride that blocks both neurotransmission to these neurons and voltage-gated Ca2+ currents, but spontaneous firing was diminished by riluzole, demonstrating a role of persistent sodium channels in the spontaneous firing in these cardiorespiratory GABAergic neurons that possess a pacemaker phenotype. (gwu.edu)
- The spontaneously firing GABAergic neurons identified in this study that increase their activity during inspiration would support respiratory rhythm generation if they acted primarily to inhibit post-inspiratory neurons and thereby release inspiration neurons to increase their activity. (gwu.edu)
- This population of inspiratory-modulated GABAergic neurons could also play a role in inhibiting neurons that are most active during expiration and provide a framework for respiratory sinus arrhythmia as there is an increase in heart rate during inspiration that occurs via inhibition of premotor parasympathetic cardioinhibitory neurons in the NA during inspiration. (gwu.edu)
- The involvement of specific subsets of GABAergic neurons in hippocampal opiate effects provide evidence that endogenous opioids can indirectly modulate the activity of principal cells and play a crucial role in the normal and pathological activity of the hippocampal formation. (huveta.hu)
- In this study, they focused on the analysis of neuronal positioning of GABAergic neurons in the forebrain. (elsevierpure.com)
- p39 −/− mice in which forebrain GABAergic neurons have lost their Cdk5 kinase activity. (elsevierpure.com)
- Here, we undertook a cross-sectional analysis of GABAergic function in deep layer pyramidal neurons of the medial PFC of wild-type and haploinsufficient heterozygous reeler mice. (frontiersin.org)
Synapses6
- Modulation of GABA receptors and of GABAergic synapses by the natural alkaloid gelsemine. (iasp-pain.org)
- Professor Um said, "We found a key clue that somatostatin, which is a key for regulation of synaptic transmission between nerve cells, directly mediates the development of GABAergic synapses. (cureepilepsy.org)
- This can be used as a novel treatment strategy for epilepsy and various refractory brain diseases caused by a breakdown of the excitatory-GABAergic balance at synapses and neural circuits. (cureepilepsy.org)
- These results suggest that spines are able to limit short-term ionic plasticity [4] at dendritic GABAergic synapses. (uni-frankfurt.de)
- Altogether these results let us propose that, during a key developmental period, postsynaptic A2ARs act as sensors of the activity of GABAergic presynaptic terminals to stabilize active nascent GABAergic synapses. (sorbonne-universite.fr)
- Nous avons mis en évidence (i) une sécrétion activité-dépendante accrue d'adénosine et d'ATP pendant la période de synaptogenèse, (ii) un pic d'expression de l'enzyme limitant la formation de l'adénosine à partir de l'ATP extracellulaire, l'ecto-5'-nucleotidase, aux synapses pendant cette période critique, et (iii) un pic d'expression péri/post- synaptique du A2AR concomitant de la période de synaptogenèse. (sorbonne-universite.fr)
Neuron2
- For example, a synapse is GABAergic if it uses GABA as its neurotransmitter, and a GABAergic neuron produces GABA. (wikipedia.org)
- Together, these results suggest that TGF-β superfamily signaling plays a role in telencephalic GABAergic neuron development through functional interactions with Dlx transcription factors. (biomedcentral.com)
Neurotransmission3
- A substance is GABAergic if it produces its effects via interactions with the GABA system, such as by stimulating or blocking neurotransmission. (wikipedia.org)
- The results demonstrate, for the first time, that EO can improve GABAergic neurotransmission via interactions with GABA A receptor and modulation of GABA uptake. (hindawi.com)
- To determine this, the research team produced a knockdown virus which eliminates IQSEC3 and injected it into the hippocampal dentate gyrus of mice, which showed a decrease in GABAergic synapse numbers and neurotransmission with severe seizures. (cureepilepsy.org)
Glutamatergic3
- Mammalian neocortex is important for conscious processing of sensory information with balanced glutamatergic and GABAergic signaling fundamental to this function. (gla.ac.uk)
- Differential Nicotinic Modulation of Glutamatergic and GABAergic VTA Microcircuits. (wakehealth.edu)
- We have recently shown that reelin plays a key role in the maturation of glutamatergic functions in the postnatal PFC, but no data are available regarding the GABAergic circuits. (frontiersin.org)
Modulation4
- Considering that PTZ blocks the chloride channel coupled to the GABA A receptor complex, the present study aimed to analyze the possible modulation of GABAergic homeostasis within synaptic clefts in vitro . (hindawi.com)
- Recent studies show that essential oils are emerging as a promising source for modulation of the GABAergic system and sodium ion channels. (mdpi.com)
- We determined in addition that gelsemine diminished the frequency of GABAergic synaptic events, likely through a presynaptic modulation. (iasp-pain.org)
- GABAergic modulation of memory. (bvsalud.org)
Inhibition5
- We propose that the GABAergic inhibition represents a critical cellular mechanism that enables prior experience to modulate aggression. (nih.gov)
- Spatiotemporal changes of intracellular Cl− concentration alter the concentration gradient for Cl− across the neuronal membrane and thus affect the current flow through GABAARs and the efficacy of GABAergic inhibition. (uni-frankfurt.de)
- Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity. (escholarship.org)
- Decreased spinal cord GABAergic inhibition is a major contributor to the persistent neuropathic pain that can follow peripheral nerve injury. (escholarship.org)
- GABAergic inhibition takes two forms: phasic and tonic. (en-journal.org)
Plasticity1
- the role of reelin in the maturation and plasticity of GABAergic connectivity has not been investigated. (frontiersin.org)
Synaptic transmission2
- As neuronal development progresses, GABAergic synaptic transmission undergoes a defined program of reconfiguration. (dundee.ac.uk)
- Using electrophysiological approaches, we showed that decreased reelin levels impair the maturation of GABAergic synaptic transmission without affecting the inhibitory nature of GABA. (frontiersin.org)
Inhibitory1
- Taken together, these results demonstrate the therapeutic potential of GABAergic precursor cell transplantation in diverse neuropathic pain models and support our contention that restoration of inhibitory controls through release of GABA from the transplants is their mode of action. (escholarship.org)
Dopaminergic1
- A simple model of basal ganglia function states that dopaminergic and GABAergic impulses from the substantia nigra and motor cortex, respectively, are funneled through the pallidum into the motor thalamus and motor cortex. (medscape.com)
Subtype-specific1
- Baruchin, L. J. , Ghezzi, F. , Kohl, M. M. and Butt, S. J.B. (2022) Contribution of interneuron subtype-specific GABAergic signalling to emergent sensory processing in mouse somatosensory whisker barrel cortex. (gla.ac.uk)
Pathways2
- GABAergic pathways in the brainstem play an essential role in respiratory rhythmogenesis and interactions between the respiratory and cardiovascular neuronal control networks. (gwu.edu)
- Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways. (cdc.gov)
Signaling1
- Accordingly, the time is ripe for investigating alterations in GABAergic signaling that may play a role in changes in neuronal activity observed in the major brain disorders that occur during various stages of life. (en-journal.org)
Alterations1
- Here, we assessed the contribution of EVs to GABAergic synaptic alterations using a human HD model and studied the miRNA content of isolated EVs. (bvsalud.org)
Electrophysiological1
- MicrocircuitDB: An electrophysiological model of GABAergic double bouquet cells (Chrysanthidis et al. (yale.edu)
Cells2
- Porcine fetal neural gabaergic cells and/or precursors aseptically prepared for intracerebral implantation for Huntington's disease. (checkorphan.org)
- GABAergic Neurogliaform Cells. (u-szeged.hu)
Hippocampus2
- This injection method resulted in reliable memory impairment in a behavioral test, decreased GABAergic activity in the frontal cortex affecting spatial memory, and no change in the hippocampus. (atsbio.com)
- During my PhD, I addressed the role of A2AR-mediated signalling in GABAergic synaptogenesis in the hippocampus. (sorbonne-universite.fr)
Synapse1
- Professor Um's research team had been steadily discovering and researching key molecules that mediate the development of GABAergic synapse associated with brain diseases and discovered IQSEC3, a GABAergic synapse-specific protein, for the first time in 2016. (cureepilepsy.org)
Circuits2
- Yet little is known about how this interaction arises despite increasing insight into early GABAergic interneuron (IN) circuits. (gla.ac.uk)
- These data indicate that reelin is necessary for the correct maturation and refinement of GABAergic synaptic circuits in the postnatal PFC and therefore provide a mechanism for altered E/I balance of prefrontal circuits associated with psychiatric disorders. (frontiersin.org)
Physiology1
- In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter gamma-aminobutyric acid (GABA). (wikipedia.org)
Neural2
- In this research, her research team uncovered a new molecular mechanism that mediates the GABAergic synaptic development by regulating neural circuit activity in the hippocampal dentate gyrus, in which IQSEC3 mediates higher brain functions such as memory and learning. (cureepilepsy.org)
- Porcine fetal neural gabaergic. (checkorphan.org)
Markers2
- Decrease of GABAergic Markers and Arc Protein Expression in the Frontal Cortex by Intraventricular 192 IgG-Saporin. (atsbio.com)
- Jeong DU, Chang WS, Hwang YS, Lee D, Chang JW (2011) Decrease of GABAergic Markers and Arc Protein Expression in the Frontal Cortex by Intraventricular 192 IgG-Saporin. (atsbio.com)
Neurological Diseases1
- Abnormal GABAergic function is associated with a variety of neurological diseases. (technologynetworks.com)
Function2
- Our findings establish gelsemine as a negative modulator of GABARs and of GABAergic synaptic function. (iasp-pain.org)
- This revealed that IQSEC3 protein was a key factor in mediating the GABAergic synaptic structure and function. (cureepilepsy.org)
Targets1
- This study investigated the effects of EO on the main GABAergic targets for anticonvulsant drugs, analyzing the effect on the GABA receptor's benzodiazepine and picrotoxinin binding sites and the GABA uptake. (hindawi.com)
Activity1
- These results indicate that Cdk5 is required for the formation of the ventral striatum in a cell-autonomous manner, and loss of the kinase activity of Cdk5 causes GABAergic neuronal death in the developing mouse forebrain. (elsevierpure.com)
Effects1
- A GABAergic or GABAnergic agent is any chemical that modifies the effects of GABA in the body or brain. (wikipedia.org)
System1
- De Vuyst, Geert (20 November 2022) Aromas Influencing the GABAergic System. (geertdevuyst.be)
Brain1
- DGIST announced on February 12 that the joint research team of Professor Jaewon Ko and Professor Ji Won Um in the Department of Brain and Cognitive Sciences found a new candidate target to treat epilepsy by regulating GABAergic synaptic functions. (cureepilepsy.org)