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  • agonist
  • Clinical studies show that the use of baclofen (GABA(B) receptor agonist), while effective in modulating spasticity is associated with major side effects such as general sedation and progressive tolerance development. (jove.com)
  • PROTEINS
  • Compounds that suppress or block the plasma membrane transport of GAMMA-AMINOBUTYRIC ACID by GABA PLASMA MEMBRANE TRANSPORT PROTEINS. (ctdbase.org)
  • this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity). (genecards.org)
  • inhibits
  • Parawixin2, a compound isolated from Parawixia bistriata spider venom, inhibits both GABA and glycine uptake and has an anticonvulsant effect against a wide range of chemoconvulsants. (mdpi.com)
  • therapeutic
  • These results show that systemic administration of the GAT-1 inhibitor NO-711 has preventative and therapeutic activity against paclitaxel-induced thermal hyperalgesia and cold allodynia. (peerj.com)
  • subunits
  • It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. (genecards.org)
  • treatment
  • at 4 °C) of female BALB/c mice was recorded before and after intraperitoneal treatment with paclitaxel, its vehicle, and/or a selective GAT-1 inhibitor NO-711. (peerj.com)
  • Previous meta-analyses suggest that individuals treated with serotonin-specific reuptake inhibitors (SSRIs) in randomised controlled trials (RCTs) are less likely to discontinue treatment than those on tricyclic antidepressants. (ebscohost.com)
  • 152. Yogeeswari P , Sravan Kumar Patel, Ingala Vikram Reddy, Arvind Semwal, Monika Sharma, Gangadhar M, Siddarth Sai M, Sriram D. GABA derivatives for the treatment of epilepsy and neuropathic pain: A synthetic integeration of GABA into 1,2,4-Triazol-2H-one nucleus. (google.com)
  • development
  • The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. (whsmith.co.uk)