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  • AMPA
  • These results suggest that the activation of postsynaptic AMPA receptors is necessary to produce TTX-resistant synchronized discharges. (jneurosci.org)
  • Excitatory
  • A change in chloride ion concentration on either side of cell membranes would reverse the direction of ion flow through the GABA receptor and ultimately encourage that neuron to chat (excitatory), and this could result in anxious behavior. (biologists.org)
  • synaptic plasticity
  • During blockade of either D1R or MOR, low-frequency (0.2 or 3 Hz) stimulation (LFS) to the sciatic nerve induced long-term potentiation (LTP) of C-fiber-evoked potentials, revealing a constituent role of both receptors in repressing afferent-induced synaptic plasticity. (jneurosci.org)
  • selective
  • SNL led to increased immunoreactivity for met-enkephalin in dorsal horn homogenates, which was dose-dependently attenuated by selective D1LR antagonist SCH 23390. (jneurosci.org)
  • regulate
  • GABA and malate appear to interact with ALMTs in a complex manner to regulate each other's transport, suggestive of a role for ALMTs in communicating metabolic status. (plantcell.org)
  • acid
  • 2007), with effects of a known GABAc receptor antagonist, 1, 2, 5, 6-tetrahydropyridine -4-yl-methylphosphinic acid (TPMPA), in vivo . (arvojournals.org)
  • In the present study, the neuroprotective effects of PNE were systematically studied via investigation of the regulation by PNE of the gastrointestinal microbial community and γ aminobutyric acid (GABA) receptors. (aspetjournals.org)
  • We investigated the involvement of γ-aminobutyric acid A (GABA A ) receptors in the neuroprotective effect of γ-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. (go.jp)
  • Neuron
  • So, if a rockfish changes its ion distribution across neuron membranes to accommodate ocean acidification, it is more anxious because opening the GABA receptor excites the neuron that should be inhibited, as chloride ions flow out instead of in. (biologists.org)
  • vivo
  • Effect of intracerebroventricular injection of GABA receptors antagonists on morphine-induced changes in GABA and GLU transmission within the mPFC: an in vivo microdialysis study', Iranian Journal of Basic Medical Sciences , 22(3), pp. 246-250. (ac.ir)
  • Hence, we investigated the role of this receptor on morphine- induced GABA/ glutamate (GLU) changes in the mPFC following morphine administration using in vivo microdialysis. (ac.ir)
  • Effects of a newly developed GABAc antagonist 2-AEMP and a known antagonist TPMPA are similar in vivo , causing b-wave attenuation and enhancement of OPs of the dark-adapted mouse ERG. (arvojournals.org)
  • The actions of GABA on arteriolar diameter were examined using ex vivo retinal whole-mount preparations and isolated vessel segments. (arvojournals.org)
  • activation
  • Maximal activation and GABA release occurs in the CF direction, while minimal activation occurs in the CP direction. (elifesciences.org)
  • These actions appear largely dependent upon the activation of GABA B receptors in the retinal neuropile, possibly those located on perivascular Müller cells. (arvojournals.org)
  • We show that TaALMT1 activation reduces [GABA] i because TaALMT1 facilitates GABA efflux but GABA does not complex Al 3+ . (plantcell.org)
  • blocks
  • Chiken and Nambu (2013) suggest that DBS of the GPi blocks cortical and basal ganglia signals by increasing GABA release from afferent fibers to the GPi, thereby suppressing GPi activity. (jneurosci.org)
  • nervous system
  • His lab has identified that classical molecules ascribed to the immune system, IL-4 receptor alpha and JAK1, are also functional in the nervous system and critically mediate itch. (washington.edu)
  • spinal
  • SIGNIFICANCE STATEMENT The current study shows that dopamine D1-like receptors (D1LRs) and μ-opioid receptors (MOR) in the spinal dorsal horn constitutively repress the expression of synaptic long-term potentiation (LTP) of C-fiber-evoked potentials. (jneurosci.org)
  • occurs
  • Since null-direction motion for a DSGC corresponds to centrifugal motion for its presynaptic SAC dendrites, maximal GABA release from SACs to DSGCs occurs during motion in the null direction ( Figure 1B ). (elifesciences.org)