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  • meiosis
  • Learn about the stages of meiosis, details about the events that occur in each of the different phases of cell division. (cherisha.net)
  • Before meiosis begins, during S phase of the cell cycle, the DNA of each chromosome is replicated so that it consists of two identical sister chromatids, which remain held together through sister chromatid cohesion. (wikipedia.org)
  • Wee1
  • Though Wee1 is a fairly conserved negative regulator of mitotic entry, no general mechanism of cell size control in G2 has yet been elucidated. (wikipedia.org)
  • maintains
  • In this study, we use this same system to show that G2 phase chromatin lacks determinants of replication timing but maintains the overall spatial organization of chromatin domains, and we confirm this finding by genome-wide analysis of rereplication in vivo. (rupress.org)
  • In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. (wikipedia.org)
  • spatial
  • In this study, we have distinguished between these two possibilities, demonstrating that G2 phase chromatin lacks the determinants of a normal replication timing program upon rereplication in Xenopus egg extracts despite retaining the normal chromatin spatial organization established at the TDP. (rupress.org)
  • kinases
  • The M-phase kinases Polo-like kinase (Plk1) and Cdc2 phosphorylate two serine residues in Wee1A which are recognized by SCFβ-TrCP1/2. (wikipedia.org)
  • therefore
  • Therefore, YSY01A represents a potential therapeutic for breast cancer MCF-7 by inducing G2 phase arrest via ERα and PI3K/Akt pathways. (jcancer.org)
  • Although G1 is a genuinely monitored negative controller of mitotic passage, no extensive system of cell size control in G2 has yet illustrated, and therefore it becomes difficult to monitor the experimentation. (differencebtw.com)
  • nucleus
  • Using a Xenopus laevis egg extract replication system, we previously demonstrated that replication timing is established during early G1 phase of the cell cycle (timing decision point [TDP]), which is coincident with the repositioning and anchorage of chromatin in the newly formed nucleus. (rupress.org)