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  • transition
  • Stem cells are believed to actively and reversibly transition between these phases to respond to injury stimuli and seem to gain enhanced tissue regenerative function in GAlert. (wikipedia.org)
  • In muscle stem cells, mTORC1 activity has been identified to control the transition from G0 into GAlert along with signaling through the HGF receptor cMet. (wikipedia.org)
  • In the absence of pRb, E2F1 (along with its binding partner DP1) mediates the trans-activation of E2F1 target genes that facilitate the G1/S transition and S-phase. (wikipedia.org)
  • Thus
  • Thus it was thought of as a resting phase. (wikipedia.org)
  • This is important because a doublet of two G0/G1 cells has the same total content of DNA and thus the same fluorescence intensity as a single G2/M cell. (wikipedia.org)
  • However
  • However, the incorporation of 5-ethynyl-2'-deoxyuridine (EdU), the precursor whose detection offers certain advantages over BrdU, has now become the preferred methodology do detect DNA replicating (S-phase) cells. (wikipedia.org)
  • early
  • In vivo footprinting experiments obtained on Cdc2 and B-myb promoters demonstrated E2F DNA binding site occupation during G0 and early G1, when E2F is in transcriptional repressive complexes with the pocket proteins. (wikipedia.org)
  • time
  • More importantly, G0/G1 is the time the cells sense and respond to the extracellular environment. (madsci.org)
  • results
  • Results from the phase II trial in patients with breast cancer and leptomeningeal carcinomatosis, a fatal form of brain metastasis, were presented at ASCO in 2016. (wikipedia.org)