AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and Processes
Granulocyte Colony-Stimulating FactorReceptors, Granulocyte Colony-Stimulating FactorGranulocytesNeutropeniaVision, EntopticRecombinant ProteinsColony-Stimulating FactorsLeukocyte CountHematopoietic Stem CellsHematopoietic Stem Cell MobilizationBone Marrow CellsGranulocyte-Macrophage Colony-Stimulating FactorHematopoiesisNeutrophilsColony-Forming Units AssayBone MarrowInjections, SubcutaneousLeukocytesInterleukin-3Cell DifferentiationCell DivisionCells, CulturedInterleukin-6Cerebrospinal FluidAgranulocytosisColony Count, MicrobialColony CollapseMonocytesPhagocytosisCulture MediaAntigens, CD34Macrophage Colony-Stimulating FactorMacrophagesClone CellsAntsLeukemia, MyeloidTime FactorsLeukocytosisCerebrospinal Fluid ProteinsAgarStem Cell FactorGrowth SubstancesMice, Inbred C57BLHematopoietic Cell Growth FactorsCell SeparationCell LineEosinophilsRespiratory BurstAntigens, CDLeukocyte Transfusion
Macrophage colonyNeutrophilsCSF3RMacrophagesDifferentiationCytokine receptorGCSFRProliferationProteinBoneMonocytesThrombopoietin receptorEndothelialInducesProgenitorCD114NeutropeniaFilgrastimErythropoietinPattern recognitiAntigenIsoformNucleotide-binding oligomeRecombinant humanChemokineHigh-affinityTumorBindsSignal transductionTyrosine kinasesApoptosisSolublePathwaysInterleukinCellsMutationsTransmembraneInterferonCellMolecularHumanHematopoiesisTissuePeripheral bloodMembraneExpressionPegfilgrastimClinical
Macrophage colony2
  • Decreased specific binding of 125l-G-CSF by human neutrophils was consistently observed in the presence of excess unlabeled human granulocyte-macrophage colony-stimulating factor (GM-CSF), suggesting competition or down modulation by GM-CSF of the G- CSF receptor. (ashpublications.org)
  • Maturation depends on different stimulating factors including the granulocyte-macrophage-colony stimulating factor (GM-CSF) and the granulocyte-colony stimulating factor (G-CSF), two of the most relevant growth factors that control such maturation process. (biomedcentral.com)
Neutrophils12
  • G-CSF R is expressed in mature neutrophils, neutrophilic precursors, myeloid leukemia cells, and placenta. (rndsystems.com)
  • G-CSF stimulates production and mobilization of neutrophils and regulates survival, proliferation, and differentiation of various cells of the neutrophil lineage. (q2labsolutions.com)
  • It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf & Nicola). (stemcell.com)
  • The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. (stemcell.com)
  • G-CSF also modulates multiple differentiated functions of human neutrophils, including enhanced oxidative metabolism in response to f- Met-Leu-Phe (f-MLP), increased antibody-dependent cell-mediated cytotoxicity (ADCC), and augmented arachidonic acid release in response to ionophore and chemotactic agents. (ashpublications.org)
  • These effects are all maximal at a concentration of 100 to 500 pmol/L. Using 125I-labeled recombinant human G-CSF, high affinity binding sites were identified on human neutrophils, the myeloid leukemia cell lines KG-1 and HL-60, and the small cell carcinoma cell lines, H128 and H69. (ashpublications.org)
  • G-CSF stimulates your bone marrow to produce a type of white blood cell, called neutrophils. (drugs.com)
  • Examples for such strategies include inhibition of CXCR1 and CXCR2 to decrease migration of neutrophils to tumoral areas or the inhibition of granulocyte colony stimulating factor to decrease the amount of neutrophils which has shown efficacy in preclinical models. (biomedcentral.com)
  • Neutrophilic granulocytes (neutrophils) account for 50-70% of all leukocytes and depend on a sequential process of maturation in the bone marrow that provokes the conversion of myeloblasts to segmented neutrophils [ 7 ]. (biomedcentral.com)
  • The association of exogenous granulocyte colony-stimulating factors (G-CSF) with the development of Sweet syndrome also supports the importance of neutrophils and related endogenous cytokines in the underlying process. (medscape.com)
  • G-CSF suppresses apoptosis and prolongs the survival of neutrophils in vivo in a CD34 + cell population. (medscape.com)
  • The functional properties of neutrophils, rather than the absolute number, is thought to be significant because patients with Sweet syndrome due to G-CSF develop lesions as the neutrophil count rapidly increases, despite the absolute neutrophil count being low. (medscape.com)
CSF3R2
  • The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. (wikipedia.org)
  • CD114 is a ~150 kDa type I transmembrane glycoprotein that is encoded by CSF3R (colony stimulating factor 3 receptor) and belongs to the class 1 cytokine receptor family. (bdbiosciences.com)
Macrophages6
Differentiation9
  • The class IV isoform defective for both internalization and differentiation signaling, and colony-stimulating. (wikipedia.org)
  • CD114 serves as the receptor for granulocyte colony stimulating factor (G-CSF) which plays a role in myeloid cell proliferation and differentiation. (bdbiosciences.com)
  • Granulocyte Colony Stimulating Factor (G-CSF) is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. (rndsystems.com)
  • LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. (hindawi.com)
  • Binds to cell surface receptors on hematopoietic cells and stimulates proliferation, differentiation, and some end-cell functional activation. (hemonc.org)
  • Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. (stemcell.com)
  • Neupogen (filgrastim) is a recombinant analog of granulocyte colony-stimulating factor (G-CSF) isoform B, which binds and activates G-CSF receptors modulating neutrophilic granulocyte progenitor activity, production, and differentiation (NCI Drug Dictionary). (jax.org)
  • EGF is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. (dvcstem.com)
  • Notch proteins are a family of receptors that play a key role in cell communication, influencing cell proliferation, differentiation, and apoptosis. (dvcstem.com)
Cytokine receptor1
  • Cell activation by G-CSF is mediated by a type I membrane protein belonging to the cytokine receptor superfamily. (rndsystems.com)
GCSFR1
  • The GCSFR-2 form, which lacks the transmembrane domain, may represent a soluble form of the receptor. (lu.se)
Proliferation4
  • A) The biological activity of Human Recombinant G-CSF, ACF was tested by its ability to promote the proliferation of mouse NFS-60 cells. (stemcell.com)
  • IL-6 is a cytokine that plays an essential role in the immune response and can stimulate hematopoietic stem cell proliferation. (dvcstem.com)
  • While these factors don't directly activate stem cells, they can create an environment conducive to stem cell health and proliferation. (dvcstem.com)
  • Quizartinib and its active metabolite (AC886) inhibit FLT3 kinase activity, preventing autophosphorylation of the receptor, thereby inhibiting downstream FLT3 receptor signaling and blocking FLT3-ITD-dependent cell proliferation. (medscape.com)
Protein12
  • Signal transduction from pathways that involve Janus tyrosine kinases/signal transducer and activator of transcription proteins (Jak1, Jak2, and Tyk2/STAT3, STAT3, and STATG), src-related protein tyrosine kinases (Lyn and Syk), Ras/MAP kinase, and phosphatidylinositol have been reported to be activated upon G-CSF stimulation (1). (rndsystems.com)
  • Release of pathogen-associated molecular patterns due to the viral infection and activation of transcription factors such as nuclear factor kappa B, NOD-like receptor protein 3 inflammasome via pattern recognition receptors and ongoing production of cytokines at the entry sites. (racgp.org.au)
  • LPA activates at least six G-coupled protein receptors (LPA 1-6 ) stimulating different signaling pathways through heterotrimeric G proteins such as G i/0 , G 12/13 , G q/11 , and G s . (hindawi.com)
  • Pembrolizumab is an antibody-drug that targets the cell surface receptor programmed cell death protein 1 (PD-1) found on T cells. (transcriptionfactor.org)
  • Moreover, we found that the upregulation of AQP9 by G-CSF depends on the transcription factor CCAAT enhancer binding protein beta (CEBPB). (biomedcentral.com)
  • ATO can target and degrade the promyelocytic leukemia-retinoic acid receptor-α (PML/RARα) protein, which is the abnormal protein product generated by APL-specific t(15;17) chromosomal translocation and is essential for the leukemogenesis of APL [ 4 , 5 ]. (biomedcentral.com)
  • In one aspect, there is provided an antigen-binding protein, or an antigen-binding fragment thereof that competes with the antigen binding protein as defined herein for binding to AXL receptor tyrosine kinase. (justia.com)
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. (wikidoc.org)
  • Through its death domain , this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. (wikidoc.org)
  • [2] The DR6 is an alpha-helical integral membrane receptor protein that shows evidence that it has something to do with the inhibition of blood vessels forming on tumors which would allow them to grow larger. (wikidoc.org)
  • Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
  • It is a bispecific humanized monoclonal antibody against CD3, a T-cell surface antigen, and GPRC5D (human G-protein coupled receptor family C group 5 member D), a tumor-associated antigen with potential antineoplastic activity. (medscape.com)
Bone7
  • These mutations typically led to a truncation in the cytoplasmic domain of the G-CSF R leading to maturation arrest of neutrophil precursors in the bone marrow and neutropenia in peripheral blood (2). (rndsystems.com)
  • These primary myelofibrosis progeny cells stimulate bone marrow fibroblasts (which are not part of the neoplastic transformation) to secrete excessive collagen. (msdmanuals.com)
  • Importantly, G-CSF can also mobilize CD34+ stem cells from bone marrow to peripheral blood. (q2labsolutions.com)
  • In this report, we show that biosynthetic (recombinant) human G-CSF enhances colony formation by normal human bone marrow and the human myeloid leukemic cell lines, HL-60 and KG-1, as well as nonhematopoietic small cell lung cancer lines, H128 and H69. (ashpublications.org)
  • Specifically, TNF-α is a potent inhibitor of the clonal growth of primitive and committed murine and human bone marrow progenitors in combination with multiple cytokines, including granulocyte colony-stimulating factor (G-CSF), CSF-1, erythropoietin (Epo), stem cell factor (SCF), and flt3 ligand (FL). (ox.ac.uk)
  • In contrast, TNF-α at low concentrations can synergistically and directly enhance the clonal growth of primitive and more mature human CD34+ bone marrow progenitors when combined with GM-CSF or interleukin (IL)-3. (ox.ac.uk)
  • G-CSF is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. (dvcstem.com)
Monocytes1
Thrombopoietin receptor3
  • Using in vivo high-resolution single HSC divisional tracking, we directly demonstrate that clinically applied thrombopoietin receptor but not granulocyte colony-stimulating factor (G-CSF) receptor agonists drive HSCs into self-renewing divisions leading to quantitative expansion of functional HSC as defined by their in vivo serial multilineage and long-term repopulating potential. (uzh.ch)
  • These results suggest that thrombopoietin mimetics might be applicable to expand HSCs in vivo and to sensitize thrombopoietin receptor-expressing HSCs to cell cycle-dependent cytotoxic agents. (uzh.ch)
  • Mutations of the thrombopoietin receptor gene ( MPL ) or the calreticulin ( CALR ) gene also may be the cause of primary myelofibrosis. (msdmanuals.com)
Endothelial7
  • Endothelial activation and endotheliitis due to direct viral activity and also via downregulated receptors (ACE2 and other receptors). (racgp.org.au)
  • The G-CSF receptor (G-CSFR) is expressed on myeloid progenitors and endothelial cells. (q2labsolutions.com)
  • Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
  • Ranibizumab is a recombinant humanized IgG1 monoclonal antibody fragment that targets human vascular endothelial growth factor A (VEGF-A). The antibody lacks an Fc-region and is smaller than the full-sized antibody, thus allowing efficient penetration. (transcriptionfactor.org)
  • Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. (transcriptionfactor.org)
  • In addition to hematopoietic cells, G-CSF is also expressed in cardiomyocytes, neuronal cells, mesothelial cells, and endothelial cells. (stemcell.com)
  • In particular, inhibition of angiogenesis by blocking Vascular Endothelial Growth Factor (VEGF) using the monoclonal antibody bevacizumab led to further improvement in the outcome of patients with mCRC. (biomedcentral.com)
Induces3
  • Binding of G-CSF to its receptor induces dimerization or oligomerization of the receptor activating cytoplasmic tyrosine kinases. (rndsystems.com)
  • COVID-19 is caused by SARS-CoV-2, which primarily targets angiotensin converting enzyme-2 (ACE2) receptors on cells of the respiratory system and induces an immediate immunological cascade of cytokine responses that affect the individual cells and vascular system. (racgp.org.au)
  • Release of tissue factor, Von Willebrand factor, that in turn induces hypercoagulation and prothrombotic state. (racgp.org.au)
Progenitor2
  • Human granulocyte colony-stimulating factor (G-CSF) is a regulatory glycoprotein that stimulates the production of neutrophilic granulocytes from committed hematopoietic progenitor cells both in vitro and in vivo. (ashpublications.org)
  • Thus, a critical determinant of whether TNF-α elicits a stimulatory or inhibitory effect on the in vitro growth of hematopoietic progenitors appears to be the specific growth factors with which it interacts, rather than the maturity of the targeted progenitor. (ox.ac.uk)
CD1142
  • The LMM741 monoclonal antibody specifically recognizes CD114 which is also known as the Granulocyte-Colony Stimulating Factor Receptor (G-CSFR). (bdbiosciences.com)
  • Detects human G-CSF R/CD114 in ELISAs and Western blots. (rndsystems.com)
Neutropenia5
  • FYLNETRA is a leukocyte growth factor indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia. (nih.gov)
  • Recombinant human G-CSF has been approved for the amelioration of chemotherapy induced neutropenia as well as for severe chronic neutropenia following marrow transplant. (rndsystems.com)
  • Mutations have been found in the gene encoding G-CSF R in some patients with severe congenital neutropenia. (rndsystems.com)
  • Such sensitive G-CSF detection is useful for clinical studies in neutropenia, cancer chemotherapy, neurologic, cardiovascular, and autoimmune diseases. (q2labsolutions.com)
  • Recombinant G-CSF is used to treat neutropenia and chemotherapy-associated neutropenia. (q2labsolutions.com)
Filgrastim1
Erythropoietin1
Pattern recogniti1
  • Phagocytosis can involve the recognition of pathogen- and damage-associated molecular patterns (PAMPs and DAMPs, respectively) through pattern recognition receptors (PRRs) on the macrophage surface ( 5 , 6 ). (frontiersin.org)
Antigen5
  • Among these markers the two most promising ones are soluble urokinase plasminogen activator receptor (suPAR) and the CD64 antigen expression. (biomedcentral.com)
  • The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to a glycan on the AXL receptor tyrosine kinase. (justia.com)
  • The present invention also relates to antigen-binding proteins, or antigen-binding fragment conjugated to a radioisotope or cytotoxin, and wherein said antigen-binding proteins, or antigen-binding fragment is internalised into a cell upon binding to AXL receptor tyrosine kinase. (justia.com)
  • Such therapy functions through mediating alterations in antigen or receptor function, modulating the immune system or delivering a specific drug that is conjugated to an antibody that targets a specific antigen. (justia.com)
  • Suitability of an antigen for therapy is dependent on various factors including but not limited to the nature of the antigen (e.g. accessibility, abundance, location of expression on cancerous cells etc.), therapeutic approach, antibody affinity and other pharmacokinetic properties. (justia.com)
Isoform1
  • In clinical medicine, there is a suggestion that use of GCSF should be avoided, at least in children and adolescents and perhaps adults, when G-CSFR isoform IV is overexpressed. (wikipedia.org)
Nucleotide-binding oligome1
  • Intracellular pathogens are also detected via nucleotide-binding oligomerization domain-like receptors (NLRs), a class of PRRs that reside in the cytosol ( 28 ). (frontiersin.org)
Recombinant human2
Chemokine1
  • Motixafortide is an inhibitor of C-X-C motif chemokine receptor 4 (CXCR4) and blocks binding of its cognate ligand, stromal-derived factor-1α (SDF-1α)/C-X-C motif chemokine ligand 12 (CXCL12). (medscape.com)
High-affinity1
  • Omalizumab inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and. (transcriptionfactor.org)
Tumor5
  • Although tumor-promoting functions have been attributed to other granulocytes, like eosinophils ( 17 ), basophils ( 18 ) and mast cells ( 19 ), further research is required to fully elucidate their role in cancer, as antitumoral roles have also been described ( 20 , 21 ). (frontiersin.org)
  • The clinical application of tumor necrosis factor-α (TNF-α) has so far been limited due to the severe adverse effects associated with its systemic use. (ox.ac.uk)
  • We also demonstrated that the combination of G-CSF and ATO significantly inhibited tumor growth in the xenograft mouse model. (biomedcentral.com)
  • Death receptor 6 ( DR6 ), also known as tumor necrosis factor receptor superfamily member 21 ( TNFRSF21 ), is a cell surface receptor of the tumor necrosis factor receptor superfamily which activates the JNK and NF-κB pathways. (wikidoc.org)
  • In addition, some studies have suggested a role for tumor necrosis factor, and others have suggested an imbalance of type 1 helper T cells. (medscape.com)
Binds1
  • SCF is a cytokine that binds to the c-Kit receptor and is important for hematopoietic stem cells, which give rise to all the other blood cells through the process of haematopoiesis. (dvcstem.com)
Signal transduction3
  • The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. (wikipedia.org)
  • GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. (wikipedia.org)
  • Binding of G-CSF to its receptor leads to activation of the JAK/STAT, MAPK, PI3K, and AKT signal transduction pathways. (stemcell.com)
Tyrosine kinases1
  • AXL receptor tyrosine kinase belongs to the TAM subfamily of receptor tyrosine kinases (RTKs) and overexpression has been detected in various cancers. (justia.com)
Apoptosis3
  • Compared with using ATO alone, the combination of G-CSF with ATO induced the cell apoptosis more dramatically. (biomedcentral.com)
  • This receptor has been shown to activate NF-κB and MAPK8 / JNK , and induce cell apoptosis . (wikidoc.org)
  • Death receptor 6 gets a chemical message and starts a signaling pathway that causes apoptosis, also known as cell death, to occur. (wikidoc.org)
Soluble1
  • however the existence of soluble G-CSF R in human serum has not been reported (1). (rndsystems.com)
Pathways1
  • TLR2, a membrane-bound receptor for bacterial lipoproteins, signals activation of inflammatory pathways, much like TLR4, the receptor for endotoxin (LPS). (campaignfornonviolentschools.org)
Interleukin1
  • Tocilizumab is a recombinant, humanized, anti-human interleukin 6 (IL-6) receptor monoclonal antibody. (transcriptionfactor.org)
Cells7
  • Herein, we demonstrate that myostatin propeptide expands primitive CML and normal BM cells, as shown by increased colony-forming capacity. (haematologica.org)
  • In addition, the number and the migratory activity of these cells are inversely correlated with risk factors such as hypertension, hypercholesterolemia, diabetes, and metabolic syndrome. (intechopen.com)
  • Pegfilgrastim is a leukocyte growth factor that works by binding to a receptor on immature cells called hematopoietic cells, which can develop into any type of blood cell. (drugs.com)
  • We hypothesized that the pretreatment with G-CSF may enhance the antitumor effect of ATO in non-APL AML cells. (biomedcentral.com)
  • G-CSF upregulated the expression of AQP9 and enhanced the intracellular concentrations of ATO in AML cells. (biomedcentral.com)
  • Stem cell activators are agents that stimulate the body's own stem cells to enhance tissue regeneration and repair. (dvcstem.com)
  • Stem cell activators are compounds that stimulate the body's own stem cells, encouraging them to proliferate and differentiate into various cell types. (dvcstem.com)
Mutations1
  • Mutations in the intracellular part of this receptor are also associated with certain types of leukemia. (wikipedia.org)
Transmembrane1
  • Human G-CSF R is 863 amino acids (aa) in length, with a 604 aa extracellular domain, a 26 aa transmembrane domain, and a 183 aa cytoplasmic domain that include a 23 amino acid signal sequence. (rndsystems.com)
Interferon2
  • Interferon gamma receptor 1 has been shown to interact with Interferon-gamma . (wikidoc.org)
  • The human interferon-gamma receptor. (wikidoc.org)
Cell9
  • G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). (wikipedia.org)
  • SDF, stromal cell-derived factors. (cdc.gov)
  • Multidrug resistance parameters, tissue infiltration parameters, receptors for colony-stimulating factors (CSFr) and cell cycle parameters were analyzed using flow cytometry in 145, 109 initial and 36 relapsed or refractory, acute nonlymphoblastic leukemia (ANLL) patients to find out clinically more reliable functional parameters. (karger.com)
  • Bruton tyrosine kinase (BTK) inhibitors have demonstrated a high degree of efficacy in the treatment of B cell malignancies characterized by constitutive B cell receptor activation, including chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). (biomedcentral.com)
  • G-CSF receptor numbers ranged between 138 and 285 sites per cell with a kd of 77 to 140 pmol/L, consistent with the concentrations of G-CSF that elicit biologic responses in vitro. (ashpublications.org)
  • Non-APL AML cell lines including THP-1 and HL-60 were pretreated with or without G-CSF (100 ng/ml) for 24 h, followed by the treatment with ATO (2 μM) for 48 h. (biomedcentral.com)
  • FGF is a family of growth factors involved in a wide variety of processes, including the regulation of cell growth, wound healing, and embryonic development. (dvcstem.com)
  • Stem cell activation can be influenced by various lifestyle factors. (dvcstem.com)
  • The free serum levels of this DR6 are heightened with anti-cell death factors in patients that have later stage ovarian cancer. (wikidoc.org)
Molecular1
  • Recently, two distinct TNF receptors with molecular weights of 55 kDa (TNFR55) and 75 kDa (TNFR75) have been cloned and characterized. (ox.ac.uk)
Human3
  • Rules-Based Medicine's (RBM) internally developed and manufactured ultrasensitive immunoassay to granulocyte-colony stimulating factor (G-CSF) based on the Simoa® bead technology can accurately quantitate sub-pg/mL levels of G-CSF in human serum and plasma. (q2labsolutions.com)
  • Secukinumab is a human IgG1 monoclonal antibody that targets IL-17α and prevents its association with the receptor IL-17R. (transcriptionfactor.org)
  • The development of the human blood-CSF-brain barrier. (cdc.gov)
Hematopoiesis1
  • G-CSF plays an important role in defense against infection, in inflammation and repair, and in the maintenance of steady state hematopoiesis. (rndsystems.com)
Tissue1
  • Under normal physiological conditions, circulating levels of G-CSF are low in contrast to infection, tissue injury, inflammation, or other stress and pathological conditions. (q2labsolutions.com)
Peripheral blood1
  • G-CSF levels in peripheral blood are increased in patients with active Sweet syndrome, suggesting that high levels of G-CSF may one day be a useful indicator of activity level of the disease. (medscape.com)
Membrane1
  • In this case, ubiquitinated substrates (such as bacterial components or damaged membrane) are recognized by autophagy receptors, including p62 and NDP52, which direct formation of the autophagic membrane around the targeted pathogen ( 18 - 20 ). (frontiersin.org)
Expression5
  • The percentage of the granulocyte-macrophage-CSFr expression was high in M4 and M5, and granulocyte-CSFr-positive ANLL showed less extramedullary infiltration (p = 0.007) and more PGP expression. (karger.com)
  • G-CSF causes a range of effects including a transient reduction of SDF-1 expression (Petit et al. (stemcell.com)
  • Recently, we found that granulocyte colony stimulating factor (G-CSF) can upregulate the expression of AQP9. (biomedcentral.com)
  • In addition, we aimed to elucidate the underlying mechanisms by which G-CSF upregulates the expression of AQP9. (biomedcentral.com)
  • We hypothesized that GR1SN contains factors secreted by probiotic Rabbit Polyclonal to NBPF1/9/10/12/14/15/16/20 which inhibit pro-inflammatory cytokine expression in the myometrium. (campaignfornonviolentschools.org)
Pegfilgrastim2
  • Pegfilgrastim ( Neulasta , Fulphila, Fylnetra, Nyvepria, Stimufend, Udenyca, Ziextenzo) is a man-made version of granulocyte colony-stimulating factor (G-CSF), which is a growth factor produced by your body. (drugs.com)
  • Pegfilgrastim is a pegylated or long-acting form of recombinant G-CSF, which means that it stays in your body for longer and doesn't need to be administered as often. (drugs.com)
Clinical1
  • Identification of individuals with risk factors for the development of severe alcoholic hepatitis may provide insight to the diverse clinical spectrum and prognosis of the disease. (wjgnet.com)