• Granulocyte/macrophage - Colony-stimulating factor (GM-CSF) is a hematopoietic factor that is produced by activated T-cells, B-cells, mast cells, macrophages, fibroblasts, and endothelial cells. (neobiotechnologies.com)
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. (stemcell.com)
  • To address this issue, human granulocyte-macrophage colony-stimulating factor (hGM-CSF) receptor (hGMR)-transgenic mice and heterozygous EPOR mutant mice were crossed by in vitro fertilization. (elsevierpure.com)
  • The OptEIA™ Set for mouse granulocyte macrophage colony stimulating factor (GM-CSF) contains the components necessary to develop enzyme-linked immunosorbent assays (ELISA) for natural or recombinant mouse GM-CSF in serum, plasma, and cell culture supernatants. (bdbiosciences.com)
  • The G-CSF receptor (G-CSFR) is expressed on myeloid progenitors and endothelial cells. (q2labsolutions.com)
  • Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils and basophils) and monocytic lineages in vivo. (stemcell.com)
  • FYLNETRA is a leukocyte growth factor indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia. (nih.gov)
  • The biological effects of GM-CSF are mediated through its binding to cell surface receptors, which appear to be widely expressed by thermatopoietic cells and also by some non-thermatopoietic cells, such as endothelial cells. (biovendor.com)
  • JAK2 is a member of the class I type tyrosine kinase family of enzymes and is involved in signal transduction for erythropoietin , thrombopoietin, and granulocyte colony-stimulating factor (G-CSF) receptors among other entities. (msdmanuals.com)
  • Recombinant G-CSF is used to treat neutropenia and chemotherapy-associated neutropenia. (q2labsolutions.com)
  • A) The biological activity of Human Recombinant GM-CSF was tested by its ability to promote the proliferation of TF-1 cells. (stemcell.com)
  • Standardization: This immunoassay is calibrated against purified Baculovirus-expressed recombinant mouse GM-CSF. (bdbiosciences.com)
  • G-CSF stimulates production and mobilization of neutrophils and regulates survival, proliferation, and differentiation of various cells of the neutrophil lineage. (q2labsolutions.com)
  • All together, the results of the present study demonstrated that hGM-CSF can stimulate the proliferation and differentiation of primitive and definitive erythroid cells independently of EPOR signal if they express hGMR, and the activity is comparable to that of EPO in definitive, but not primitive, erythropoiesis. (elsevierpure.com)
  • GM-CSF is a small glycoprotein growth factor which stimulates the production and function of neutrophils, eosinophils and monocytes. (biovendor.com)
  • Although tumor-promoting functions have been attributed to other granulocytes, like eosinophils ( 17 ), basophils ( 18 ) and mast cells ( 19 ), further research is required to fully elucidate their role in cancer, as antitumoral roles have also been described ( 20 , 21 ). (frontiersin.org)
  • In addition to supporting colony formation of granulocyte/macrophage progenitors, GM-CSF is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. (neobiotechnologies.com)
  • In methylcellulose clonal culture of fetal liver (FL) cells of generated hGMR-expressing EPOR -/- embryos at embryonic day (E) 12.5 of gestation, hGM-CSF stimulated erythroid colony formation under serum-containing and serum-free conditions. (elsevierpure.com)
  • and induced increase of GATA-1 expression and decrease of erythroid Kruppel-like factor and cMyb expression in the FL cells. (elsevierpure.com)
  • On the other hand, in E8.0 yolk sac erythropoiesis, both substances had a similar effect on erythroid colony formation, but hGM-CSF induced an increase of β-major globin expression, while EPO did not. (elsevierpure.com)
  • Granulocyte colony-stimulating factor (GCSF) is currently used to treat neutropenia due to chemotherapy and has been successfully used for patients who require bone marrow transplants. (sciencedaily.com)
  • GCSF enhances blood cellular development and is currently used to treat neutropenia (low white blood cells) caused by chemotherapy and has successfully been used with very few side effects for patients who require bone marrow transplants to stimulate blood cell formation. (sciencedaily.com)
  • GCSF improved long-term behavioral outcomes while also stimulating a neural progenitor recovery response in a mouse model. (sciencedaily.com)
  • Results showed that GCSF improved neurological deficits that occur in the first few days following cerebral ischemia and improved long-term behavioral outcomes while also stimulating a neural progenitor recovery response. (sciencedaily.com)
  • Rules-Based Medicine's (RBM) internally developed and manufactured ultrasensitive immunoassay to granulocyte-colony stimulating factor (G-CSF) based on the Simoa® bead technology can accurately quantitate sub-pg/mL levels of G-CSF in human serum and plasma. (q2labsolutions.com)
  • For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)
  • These primary myelofibrosis progeny cells stimulate bone marrow fibroblasts (which are not part of the neoplastic transformation) to secrete excessive collagen. (msdmanuals.com)
  • Patients with a history of serious allergic reaction to human granulocyte colony-stimulating factors such as pegfilgrastim products or filgrastim products. (drugs.com)
  • The development of the human blood-CSF-brain barrier. (cdc.gov)
  • GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz et al. (stemcell.com)
  • In recent years, many studies including ours have shown that as an endogenous growth factor and immune system modulator factor, GCSF is beneficial in models of neurological disorders such as stroke and traumatic brain injury," said Jang-Yen (John) Wu, Ph.D., corresponding author, distinguished professor of biomedical science in FAU's Schmidt College of Medicine, and a member of the FAU Brain Institute (I-BRAIN). (sciencedaily.com)
  • Growth factors and cytokines involved in their migration, development and survival could be absent in this tissue and need further investigations. (bvsalud.org)
  • Analysis of globin expression in individual erythrocyte-containing colonies formed from E12.5 FL cells showed that hGM-CSF supports primitive and definitive erythropoiesis even in EPOR -/- embryos. (elsevierpure.com)
  • Factors that could hinder the growth of the rituximab biosimilar market in the future include stringent regulations related to biosimilar approvals, and prolonged production and approval time. (thebusinessresearchcompany.com)
  • Glicoproteínas que se encuentran en una subfracción del plasma y orina normales de los mamíferos. (bvsalud.org)
  • Under normal physiological conditions, circulating levels of G-CSF are low in contrast to infection, tissue injury, inflammation, or other stress and pathological conditions. (q2labsolutions.com)
  • The parametric variability associated with the Oncotype results was the main uncertainty factor in the decision. (isciii.es)
  • Synergism of glucocorticoids with granulocyte macrophage colony stimulating factor (GM-CSF) but not interferon gamma (IFN-gamma) or interleukin-4 (IL-4) on induction of HLA class II expression on human monocytes. (ox.ac.uk)
  • Peripheral blood monocytes from up to 13 normal donors were stimulated with the cytokines interferon gamma (IFN-gamma), interleukin 4 (IL-4) and granulocyte macrophage-colony stimulating factor (GM-CSF) in the presence or absence of dexamethasone (Dex), and the effects on HLA class II (HLA-DR, DP and DQ) expression studied. (ox.ac.uk)
  • Granulocyte-macrophage colony-stimulating factor ( GM-CSF ), as its name suggests, sends cells down the path leading to both those cell types. (biology-pages.info)
  • Stimulated by macrophage colony-stimulating factor ( M-CSF ) the granulocyte/macrophage progenitor cells differentiate into monocytes, macrophages , and dendritic cells (DCs). (biology-pages.info)
  • Other treatments used to stimulate the immune system in a general way and used in combination with monoclonal antibodies, vaccines or chemotherapy are substances called cytokines - hormones produced by the body that help the immune system function. (lls.org)
  • Multiparameter flow cytometric analysis of GM-CSF expressed in stimulated human peripheral blood mononuclear cells. (bdbiosciences.com)
  • The fluorochrome-labeled MP1-22E9 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify GM-CSF -producing cells within mixed cell populations. (biolegend.com)
  • We identified a unique cytokine response, with higher plasma GM-CSF and CXCL10 in COVID-19 patients that were independently associated with the longer duration of mechanical ventilation. (biomedcentral.com)
  • The cells were then stained with either BD Horizon™ BV421 Rat IgG2a, κ Isotype Control (Cat No. 562602, Left Panel) or BD Horizon™ BV421 Rat Anti-Human GM-CSF antibody (Cat No. 562930, Right Panel) by using BD Biosciences Intracellular Cytokine Staining protocol. (bdbiosciences.com)
  • For example, Interleukin-7 ( IL-7 ) is the major cytokine in stimulating bone marrow stem cells to start down the " lymphoid " path leading to the various lymphocytes (mostly B cells and T cells ). (biology-pages.info)
  • Monoclonal antibody therapy is sometimes referred to as passive immunotherapy because it doesn't directly stimulate your immune system to respond to a disease. (lls.org)
  • Upon re-exposure, an antigen-antibody complex is formed and activate inflammatory cells to secrete several factors responsible for allergic immune responses [ 2 ]. (hindawi.com)
  • Anti-Human G-CSF-specific antibody was purified from cell culture by Protein A affinity chromatography. (prosci-inc.com)
  • To detect Human G-CSF by Western Blot analysis, this antibody can be used at a concentration of 0.20-0.40 μg/ml. (prosci-inc.com)
  • Two-color flow cytometric dot plots showing the expressed levels of GM-CSF (or Ig isotype control staining) versus cellular autofluorescence were derived from gated events with the forward and side light-scatter characteristics of intact lymphocytes. (bdbiosciences.com)
  • PMA+ Ionomycin-stimulated Th2-polarized C57BL/6 splenocytes were surface stained with CD3 FITC and intracellularly stained with GM-CSF (clone MP1-22E9) PerCP/Cyanine5.5 (top) or rat IgG2a, κ PerCP/Cyanine5.5 isotype control (bottom). (biolegend.com)
  • Concentrations of cutaneous T-cell attracting chemokine, eotaxin, hepatocyte growth factor, interleukin 6 (IL-6), IL-16, and stem cell factor are significantly higher in COPD patients compared with in control patients. (dovepress.com)
  • Thrombopoietin ( TPO ), assisted by Interleukin-11 ( IL-11 ), stimulates the production of megakaryocytes . (biology-pages.info)
  • Virus RNA and inflammatory factors were measured in nasal lavage fluids (NLF) serially after LAIV inoculation. (nih.gov)
  • An early example was the recognition of the central importance of tumour necrosis factor-α (TNF-α) in granuloma maintenance, and hence protection against reactivation of latent tuberculosis. (bmj.com)
  • Particularly striking were the effects on HLA-DQ expression, since stimulation with a combination of Dex and GM-CSF induced markedly higher levels of HLA-DQ antigen than stimulation with IFN-gamma. (ox.ac.uk)
  • Northern blot analysis of samples treated for 40 hours with Dex and GM-CSF indicated that levels of DR alpha, DP alpha and DQ alpha mRNA were also increased. (ox.ac.uk)
  • Multivariate regression analysis confirmed that GM-CSF, CXCL10 and IL-10 levels were independently associated with the duration of mechanical ventilation. (biomedcentral.com)
  • Multiple regression analysis predicts that cutaneous T-cell-attracting chemokine, eotaxin, IL-6, and stem cell factor are inversely associated with forced expiratory volume in 1 second and peak oxygen uptake change, whereas smoking is related to eotaxin and hepatocyte growth factor changes. (dovepress.com)
  • The development of the human blood-CSF-brain barrier. (cdc.gov)
  • Dex markedly augmented HLA-DR, DP and DQ levels induced by GM-CSF, in all samples tested. (ox.ac.uk)