In this population-based, retrospective cohort study, the researchers reclassified 318 of 725 follicular variant papillary thyroid cancer (FVPTC) cases as potential NIFTP (NIFTPs were previously identified as a subset of FVPTC). (cancernetwork.com)
Materials and methods: Thyroid resections during an 11-year period, with histologic diagnosis of follicular variant of papillary thyroid carcinoma (FVPTC), were retrospectively reviewed to identify NIFTP. (elsevierpure.com)
Objective: To examine genotypic and clinical differences between encapsulated, nonencapsulated, and diffuse follicular variant of papillary thyroid carcinoma (EFVPTC, NFVPTC, and diffuse FVPTC, respectively), to characterize the entities and identify predictors of their behavior. (johnshopkins.edu)
Subtypes include the invasive encapsulated follicular variant of PTC (Ienc-fvPTC) and infiltrative fvPTC (inf-fvPTC), with tumors lacking invasive features classified as noninvasive follicular thyroid neoplasms with papillary-like features (NIFTPs). (chop.edu)
NIFTP6
Of note, the results of this study defy earlier research in 2016, the results of which originally supported changing the nomenclature of a subset of FVPTC to NIFTP. (cancernetwork.com)
It's quite possible that some of the cases that were called NIFTP would be classified as FVPTC on review of the histological tissue sections, and if so, they presumably would be the 'NIFTP cases' most likely to recur," Umbricht noted. (cancernetwork.com)
Results: Of 244 cases of FVPTC identified, 74 (30%) cases were reclassified as NIFTP. (elsevierpure.com)
Conclusions: A significant percentage of tumors previously diagnosed as FVPTC were reclassified as NIFTP. (elsevierpure.com)
Clinical and histopathologic parameters were described for NIFTP, Ienc-fvPTC, and inf-fvPTC subtypes, with specific comparison of Ienc-fvPTC and inf-fvPTC cases. (chop.edu)
The case cohort included 42 pediatric patients, with 6 (14%), 25 (60%), and 11 (26%) patients meeting criteria for NIFTP, Ienc-fvPTC, and inf-fvPTC, respectively. (chop.edu)
Subtypes3
Conclusions: FVPTC consists of several distinct subtypes. (johnshopkins.edu)
Understanding the different subtypes of FVPTC will help guide appropriate treatment strategies. (johnshopkins.edu)
This study aimed to report the clinical and histological features of pediatric cases meeting criteria for these histological subtypes, with specific focus on Ienc-fvPTC and inf-fvPTC. (chop.edu)
Tumors1
Ienc-fvPTC tumors demonstrated clearly demarcated tumor capsules and capsular/vascular invasion, while inf-fvPTC tumors displayed infiltrative growth lacking a capsule. (chop.edu)
Lymph node1
Forty-five patients with FVPTC and in whom at least 1 central compartment lymph node was removed were included. (johnshopkins.edu)
NIFTPs1
All cases were rereviewed, and 5 patients originally diagnosed with Ienc-fvPTC before 2017 were reappraised as having NIFTPs. (chop.edu)
Papillary thyroid c3
16. Follicular variant of papillary thyroid carcinoma (FVPTC): histological features, BRAF V600E mutation, and lymph node status. (nih.gov)
The follicular variant of papillary thyroid carcinoma (FVPTC) presents a type of papillary thyroid cancer that has created continuous diagnosis and treatment controversies among clinicians and pathologists. (edu.au)
The literature suggests that FVPTC behaves in a way similar, clinically, to conventional papillary thyroid carcinoma. (edu.au)
Follicular1
ETV6- NTRK3 was exclusively found in the follicular variant of PTC (FVPTC), leading to a prevalence of 16% (6/45) in this variant. (unifesp.br)
Features1
This research has described the nomenclature, the clinical features, diagnostic problems and the molecular biology of FVPTC. (edu.au)