Fusions genes bacterial. Medical search. Frequent questions

The detecting methods to inventory gene fusion events on a large biological scale can provide insights about the multi modular architecture of proteins. (wikipedia.org)
Bacterial proteases are important enzymes used in several technical applications where controlled cleavage of proteins is needed. (lu.se)
The eukaryotic model organism Saccharomyces cerevisiae is potentially a good expression host as it tolerates several stress conditions and is known to better express insoluble proteins compared to bacterial systems. (lu.se)
For example, MVs from E. coli under envelope stress contain multiple misfolded proteins, whose release enhances bacterial survival [ 9 ]. (nature.com)
First, chloramphenicol treatment allows the selection of bacteria expressing antigen-CAT fusion proteins in frame, which greatly reduces the number of colonies to be screened. (nih.gov)
Third, the uniformly high expression level of antigen-CAT fusion proteins permits the establishment of large and representative pool sizes. (nih.gov)
Detection of fusion proteins containing 3xFLAG ® is enhanced up to 200 times more than any other system. (sigmaaldrich.com)
Our selection of CMV vectors provides options for transient or stable expression of 3xFLAG ® fusion proteins. (sigmaaldrich.com)
Vectors containing the preprotrypsin leader (PPT) sequence direct secretion of FLAG fusion proteins into the culture medium for purification using ANTI-FLAG antibodies, resins, and plates. (sigmaaldrich.com)
The preparation of valuable recombinant (genetically engineered) polypeptides, for example pharmaceutical proteins, relies frequently on techniques which involve the production of these polypeptides as fusion or hybrid proteins. (justia.com)
Despite the additional steps which are required to produce a protein of interest as a fusion protein, rather than directly in its active form, the production of hybrid proteins has been found to overcome a number of problems. (justia.com)
Enzymes known to the prior art as "proteolytic enzymes" have been found to be particularly well suited for the cleavage of fusion proteins. (justia.com)
To deliver the candidate antigen on the surface, we fused the mpt64 gene to the sequence encoding the PE domain of the PE_PGRS33 protein of M. tuberculosis (to create strain (H)PE-ΔMPT64-BCG), which we have previously shown to transport proteins to the bacterial surface. (unicatt.it)
Then, we selected 48 genes that may encode uncharacterised effectors (e. g. no detectable amino acid identity to other proteins or with a particular putative biochemical activity) from the genome of C. trachomatis strain L2/434/Bu. (europa.eu)
T3S assays performed with T3S-competent Y. enterocolitica or with an isogenic T3S-deficient strain individually expressing the TEM-1 fusions revealed a statistically significant higher level of secretion of 22 fusion proteins relative to RplJ20-TEM-1. (europa.eu)
2013). A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation. (addgene.org)
To illuminate these opportunities, we made fusions between your Cas9(D10A) nickase and RecA or bacteriophage T4-produced single-stranded binding proteins (SSB). (mycareerpeer.com)

Fusion genes can contribute to tumor formation because fusion genes can produce much more active abnormal protein than non-fusion genes. (wikipedia.org)
If it happens in coding sequences, gene fusion cause the assembly of a new gene, then it allows the appearance of new functions by adding peptide modules into a multi-domain protein. (wikipedia.org)
The protocol provided may be adopted for other bacterial proteases through minor modifications of the fused protein. (lu.se)
Each protein fusion tag was cloned separately on the C terminal of GST. (sigmaaldrich.com)
The ParB protein forms DNA bridging interactions around parS to condense DNA and earmark the bacterial chromosome for segregation. (elifesciences.org)
When you transpose an alien gene (in this case from a soil habiting bacterium, Bacillus thurengiensis, known popularly as Bt) into a plant cell, targeting a specific pest, in this case the dreaded American Bollworm (the most devastating cotton pest), it is expected that the protein configuration which acts as a "poison" when in the gut of the sucking insect (boll worm), stays stable. (vijayvaani.com)
Main function of each fusion partner protein. (uth.edu)
To speed-up the discovery process, we have developed a computational approach that can consider a vast array of data sets, including data on mutant-based phenotypes, gene expressions, protein interactions, gene functional annotations, literature, drugs, and effects of drug treatments. (uni-lj.si)
The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. (justia.com)
The pro-peptide-polypeptide fusion protein can be cleaved and the recombinant polypeptide released under the appropriate conditions. (justia.com)
Fusion partners known to the prior art include maltose binding protein (Di Guan et al. (justia.com)
The cleavage reaction is performed by contacting the fusion protein with a proteolytic enzyme under appropriate conditions. (justia.com)
No. 4,743,679 which discloses a process for the production of human epidermal growth factor comprising cleavage of a fusion protein by Staphylococcus aureus V8 protease. (justia.com)
IglA is a 21 kDa protein encoded by a gene that is part of an iglABCD operon located on the Francisella pathogenicity island (FPI). (biomedcentral.com)
We also have solved the crystal structure of TTHA0988, a Thermus thermophilus protein of unknown function that is homologous to a KipI-KipA fusion. (rcsb.org)
Recombinant Fusion Protein Joining E Protein Domain III of Tick-Borne " by Vasily Golotin, Nina M. Sanina et al. (usf.edu)
To enhance the immunogenicity of this protein, which has a low molecular weight, the aim of the present work was to express, isolate, and characterize a chimeric protein based on the fusion of the bacterial chaperone HSP70 of Yersinia pseudotuberculosis and EIII (DIII + stem) as a prospective antigen for an adjuvanted delivery system, the tubular immunostimulating complex (TI-complex). (usf.edu)
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
For this, we constructed translational fusions comprising the first 20 amino acids of the IncA or IncC effectors and a reporter protein (the mature form of TEM-1 beta-lactamase), expressed under the control of the Y. enterocolitica yopE effector gene promoter (PyopE). (europa.eu)
As negative control, we used a fusion between the first 20 amino acids of a C. trachomatis ribosomal protein and TEM-1 (RplJ20-TEM-1). (europa.eu)
This gene codes a fusion protein with high tyrosine kinase activity, resulting in growth factor-independent proliferation. (medscape.com)
Two IDV lineages, D/swine/Oklahoma/1334/2011 and D/bovine/Oklahoma/660/2013 (D/660), have been identified in swine and cattle in Europe on the basis of the hemagglutinin-esterase fusion protein (HEF). (cdc.gov)

It is the body's first-line defense against many bacterial pathogens. (medscape.com)
Over the last decade, research on antimicrobials has shifted towards an alternative approach to combat pathogens using anti-infective drugs that selectively interrupt virulence pathways to help prevent or cure bacterial infections. (nature.com)
Anti-infective drugs that do not perturb survival or viability of bacterial pathogens should be less likely to promote resistance than conventional antibiotics 1 , 2 . (nature.com)
Chlamydia trachomatis are obligate intracellular bacterial pathogens that cause ocular and genital infections, which are a significant public health concern worldwide. (europa.eu)

A major distinctive feature of the purine biosynthetic pathways in Bacteria is the prevalence of gene fusions where two or more purine biosynthetic enzymes are encoded by a single gene. (wikipedia.org)
Merging both the fusion order and evolutionary origin, organisms end up having fused UMPS where one of its catalytic domains comes from bacteria and the other from eukaryotes. (wikipedia.org)
MVs are released from the outer membrane of bacterial cells, such as outer membrane vesicles (OMVs) from Gram-negative bacteria, and from the cytoplasmic membrane of cells, such as MVs from Gram-positive bacteria. (nature.com)
Type IV pili are ubiquitous surface appendages in Gram-negative bacteria that promote diverse activities including attachment, virulence, biofilm formation, horizontal gene transfer, and twitching motility [ 1 - 5 ]. (biorxiv.org)
The increased prevalence of antibiotic-resistant bacteria urges us to explore alternative strategies to treat bacterial infections. (uni-lj.si)
Nature abounds with species that are highly resistant to pathogenic bacteria, including the popular model organism Dictyostelium, which is a bacterial predator. (uni-lj.si)

However, none of the prognostic models incorporates parameters reflecting the status of chromosomal rearrangements and transcriptional disorganization in a patient sample, even though gene fusions are known to drive PCa development and progression [ 8 ]. (biomedcentral.com)
Furthermore, monitoring QS signaling gene expression revealed that AHL synthases LasI/RhlI and QS transcriptional regulators LasR/RhlR genes were inhibited and antagonized, respectively, by cerPAC. (nature.com)
Apart from performing the routine differential expression analysis using two different suite of tools, this hands-on training will help participants learn advanced RNA-Seq analysis techniques and tools for detecting snps, fusion genes, allele specific expressions, circular RNAs,viral/bacterial sequence identification, alternative polyadenylation and transcriptional regulatory network analysis. (biostars.org)
op), a transcriptional fusion gene, was used to form lysogens in the wild-type, rpoH or/and rpoS mutants. (openmicrobiologyjournal.com)

Gene fusions are chimeric genes that combine at least two parental genes. (biomedcentral.com)
The chimeric construction was obtained using pET-40b(+) vector by ligating the respective genes. (usf.edu)
In CML, a balanced (9;22) chromosomal translocation results in a chimeric BCR-ABL fusion gene. (medscape.com)

Bacterial communities that are attached to a surface, so-called biofilms, and their inherent resistance to antimicrobial agents are a cause of many persistent and chronic bacterial infections. (biomedcentral.com)
Formation of these sessile communities and their inherent resistance to antimicrobial agents are at the root of many persistent and chronic bacterial infections. (biomedcentral.com)
Recent advances in our understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections. (biomedcentral.com)
Morbidity results from patients succumbing to frequent bacterial infections or to an accelerated-phase lymphoproliferation into the major organs of the body. (medscape.com)

In the case of TMPRSS2-ERG, by disrupting androgen receptor (AR) signaling and inhibiting AR expression by oncogenic ETS transcription factor, the fusion product regulates the prostate cancer. (wikipedia.org)
When gene fusion happens in non-coding sequence region, it can lead to the misregulation of the expression of a gene now under the control of the cis-regulatory sequence of another gene. (wikipedia.org)
To reduce potentially toxic effect on the host cell, the growth and production phases were separated by using the inducible promoter GAL1p to control recombinant gene expression. (lu.se)
The datasets included transcriptome-wide expression and matched clinical follow-up data to detect and characterize gene fusions in PCa. (biomedcentral.com)
DEAF-1 activates the expression of Mtk and Drs promoter-luciferase fusion genes in S2 cells. (sdbonline.org)
DEAF-1 recognizes several TTCG motifs within the portion of the Dfd autoregulatory region termed 'module E.' In addition, DEAF-1 binds several similar motifs within a Dfd response element ( DRE ) from the 1.28 gene that enhances maxillary gene expression during embryogenesis (Pederson, 2000). (sdbonline.org)
Production of the fusion polypeptide involves the introduction of the hybrid gene into a biological host cell system, for example yeast cells, which permits the expression and accumulation of the fusion polypeptide. (justia.com)
Regulation of gene expression. (cnr.it)
Additionally, gene expression of AtVPS34 was increased upon infection by Pst DC3000 ( avrRpt2 ), and SA upregulated AtVPS34 gene expression in this process. (frontiersin.org)
Furthermore, overexpression of AtVPS34 enhanced PR gene expression after syringe infiltration with Pst DC3000 ( avrRpt2 ), while PI3K inhibitors inhibited that. (frontiersin.org)
The production of hydrogen peroxide and the expression of gene encoding antioxidant enzyme were both enhanced in AtVPS34 overexpressing lines after spray inoculation or syringe infiltration with Pst DC3000 ( avrRpt2 ). (frontiersin.org)
Collectively, these results unraveled a novel and broad role of PI3K in plant immunity which promoted stomatal closure and PR gene expression possibly via regulating ROS production. (frontiersin.org)
The availability of complete bacterial genome sequences, together with the development of microarrays with which the expression of the entire genome of an organism grown under two conditions can be assayed, has launched the post-genomic era of biofilm research and generated a wealth of new information. (biomedcentral.com)
But a comparison of the differentially expressed gene sets identified in several recent DNA microarray studies [ 7 - 10 ] reveals that no common expression pattern for biofilms has yet emerged. (biomedcentral.com)
One explanation for these apparent discrepancies is that DNA microarrays provide a sensitive but transient snapshot of gene expression and that gene expression does not necessarily directly correlate with phenotype. (biomedcentral.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
BACKGROUND: High expression of the Cytokine Receptor-Like Factor 2 (CRLF2) gene has been observed in patients with acute lymphoblastic leukemia BCR-ABL1-like subtype. (bvsalud.org)
We conclude that RpoH itself regulates clpQ + Y + gene expression. (openmicrobiologyjournal.com)
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)

Uncovering its bacterial resistance pathways could improve our understanding of core resistance mechanisms and lead us to drugs that target such pathways in humans. (uni-lj.si)
Gene technology, combined with a solid knowledge of catabolic pathways and microbial physiology, enables the experimental evolution of new or improved catabolic activities for such pollutants. (igem.org)
This cause of mutation is unexpected, because the fusion of two such replication forks is a fundamental process when DNA is copied, and we have identified a number of pathways that can prevent the harmful consequences of fork fusions. (ukri.org)

We recently described a Francisella pathogenicity island (FPI) harboring several genes necessary for intracellular growth. (biomedcentral.com)

Both OPRTase and ODCase have passed through lateral gene transfer, resulting in eukaryotes' having enzymes from bacterial and eukaryotic origin. (wikipedia.org)
Other rearrangements are also possible, since Fungi have bacterial OPRTase and eukaryotic ODCase, whereas kinetoplastids have the inverse combination. (wikipedia.org)
P.1604 left column 2nd paragraph: 'Timing of the appearance of eubacterial genes in eukaryotic genomes is another way to attempt to distinguish between different hypotheses about the origin of the pro-eukaryotic genome. (harvard.edu)
Thus, for the accurate completion of genome duplication the fusion of two converging forks must be carefully controlled, a theme also emerging for the hundreds of fork fusion events in eukaryotic cells. (ukri.org)
Our data will form an important foundation for the understanding of how the hundreds of fork fusions in eukaryotic cells are achieved and how their processing contributes towards maintaining genomic stability. (ukri.org)

That significant fractions of the bacterial genome could be involved in, or affected during, biofilm formation was shown in Escherichia coli in a genome-wide screen using random chromosomal insertions of a lacZ reporter gene fusion construct [ 5 ]. (biomedcentral.com)
Currently we are using the bacterium Escherichia coli to gain a better insight into the mechanics of such fork fusion events. (ukri.org)
We have demonstrated in Escherichia coli that fork fusion events, if not processed correctly, result in surprisingly severe consequences, such as persistent over-replication of the chromosome, increased recombination and chromosome segregation defects. (ukri.org)

While we have identified some of the pathologies that arise if fork fusions are not processed correctly, our understanding of the molecular mechanics of fork fusion is still limited. (ukri.org)

Since chromosomal translocations play such a significant role in neoplasia, a specialized database of chromosomal aberrations and gene fusions in cancer has been created. (wikipedia.org)
Presence of certain chromosomal aberrations and their resulting fusion genes is commonly used within cancer diagnostics in order to set a precise diagnosis. (wikipedia.org)

Such gene fusions are almost exclusively between genes that encode enzymes that perform sequential steps in the biosynthetic pathway. (wikipedia.org)
The top category of Deaf1-regulated genes consists of glycolytic enzymes, which are suppressed by Deaf1 and Gsk3 but are upregulated by Deaf1 RNAi. (sdbonline.org)

Finally, we found that the heme carried in MVs is utilized by multiple species, and we further verified that membrane fusion efficiency and species evolutionary distance determine heme delivery. (nature.com)
Author Summary Almost all bacterial species use thin surface appendages called pili to interact with their environments. (biorxiv.org)
Finally, we succeeded in cloning of the genomic deoxyribonucleic acid (DNA) which contains genes encoding melanoma antigen with species specific determinant (M562). (go.jp)
Most, if not all of these transfers seem to be the result of a gene being transferred from the mitochondrial genome of one species to that of another. (biomedcentral.com)
To screen for novel T3S effectors of C. trachomatis, we used Yersinia enterocolitica as a genetically tractable surrogate bacterial species assembling a T3S apparatus, which has been shown to recognise heterologous T3S substrates. (europa.eu)

Most fusion genes are found from hematological cancers, sarcomas, and prostate cancer.BCAM-AKT2 is a fusion gene that is specific and unique to high-grade serous ovarian cancer. (wikipedia.org)

Herein, we demonstrated that rpS3 and Lyn interact with each other, and the phosphorylation of rpS3 by Lyn, causing ribosome heterogeneity, upregulates the translation of p-glycoprotein, which is a gene product of multidrug resistance gene 1. (bmbreports.org)
For bacterial resistance, we have predicted the role for nine new genes. (uni-lj.si)

The diagnosis of many infectious diseases, both viral and bacterial, may include the use of reverse transcriptase-polymerase chain reaction (RT-PCR). (medscape.com)

Following detection, we annotated the gene fusions using published databases for gene fusions in cancer. (biomedcentral.com)
Of 60 blood cultures positive for Gram-positive cocci in clusters, LAMP (via detection of the Fem A and Mec A genes) showed 100% sensitivity and specificity for identification of MRSA/MSSA. (who.int)

Immunity genes are activated in the Drosophila fat body by Rel and GATA transcription factors. (sdbonline.org)

Searches for single virulence genes can now be performed on a genomewide scale by a variety of computer and genetic techniques. (cdc.gov)
Bacterial type IV pili are critical for diverse biological processes including horizontal gene transfer, surface sensing, biofilm formation, adherence, motility, and virulence. (biorxiv.org)

Although several genes gave strongly supported conflicting trees under certain conditions, we are confident of HGT in only a single case beyond the rubisco HGT already reported. (biomedcentral.com)

fusion gene was constructed, with the clpQ + Y + promoter fused to a lacZ reporter gene. (openmicrobiologyjournal.com)

These techniques are based upon the preparation of hybrid genes, i. e. genes comprising genetic material encoding the polypeptide of interest linked to genetic material additional to the gene of interest. (justia.com)

The course presents methods to express genes, which have products that are known, unknown or not well characterized, and to analyze the gene products. (lu.se)

They were infected into ED8767 E. coli, and then transfected into the human melanoma cell line P-36 by protoplast fusion with polyethylene glycol. (go.jp)
In E. coli only one such fusion event occurs, as the entire DNA is copied by only two replication forks. (ukri.org)
The relative simplicity of fork fusions in E. coli will allow us to study these events at very high detail with many different tools. (ukri.org)

Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. (uth.edu)
Instead, in different studies different genes are found up- and down-regulated, in varying numbers ranging from 1% to 38% of the total genome. (biomedcentral.com)

In this study, we analyzed all genes from sequenced plastid genomes to unearth any neglected cases of HGT and to obtain a measure of the overall extent of HGT to the plastid. (biomedcentral.com)

Recent genomic and proteomic studies have identified many of the genes and gene products differentially expressed during biofilm formation, revealing the complexity of this developmental process. (biomedcentral.com)
With so many genes involved, it is perhaps not surprising that biofilm formation is regarded as a developmental process (Figure 1 ), not unlike that observed in the formation of fruiting bodies containing spores by the soil bacterium Myxococcus xanthus and sporulation in Bacillus subtilis [ 6 ]. (biomedcentral.com)
A model of the stages of bacterial biofilm development. (biomedcentral.com)

It has been known for 30 years that the corresponding gene fusion plays an important role in tumorigenesis. (wikipedia.org)

We can observe its effect if gene fusion occurs in coding sequences. (wikipedia.org)
It was suggested that both estimates relate to the same event, fusion between an archaebacterium and a eubacterium, and the shift in the appearance time of bacterial genes to the present day was merely due to involvement in the analysis of mitochondrial and α-proteobacterial sequences. (harvard.edu)
Our search relied primarily on phylogenetic analyses, but also involved scrutiny of each potential case (including generation of new gene sequences from phylogenetically relevant taxa) to rule out artifacts and various types of homoplasy. (biomedcentral.com)

Total DNA was isolated from the transfectants, and the B16 genomic DNA clones were rescued by the in vitro packaging with lysogenic bacterial extracts. (go.jp)

Specifically, this approach provides detailed insight into structural features of the cellular envelope, including the distance of the inner and outer membranes, as well as the scattering length densities of all bacterial compartments. (iucr.org)

The resulting compressed data system is then used to identify genes with high probability of a target phenotype. (uni-lj.si)

ABL1 fusion gene, composed of the 3' part of the ABL1 gene in the breakpoint on chromosome 9 and the 5' part of a gene called BCR in the breakpoint in chromosome 22. (wikipedia.org)
This database is called Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer. (wikipedia.org)
In humans, the gene that codes for this enzyme is located on the long arm of chromosome 3 (3q13). (wikipedia.org)
CRLF2 fusion, some researchers prepare home-grown FISH probes from bacterial artificial chromosome clones flanking the IGH and CRLF2 genes, which is the best alternative to confirm the fusion, however difficult to reproduce in most cytogenetic laboratories. (bvsalud.org)
We will investigate how fork fusion intermediates are processed and what happens when this processing goes awry, and we will determine how termination is choreographed in the context of whole chromosome dynamics, segregation and cell division. (ukri.org)

Alternatively, a proto-oncogene is fused to a strong promoter, and thereby the oncogenic function is set to function by an upregulation caused by the strong promoter of the upstream fusion partner. (wikipedia.org)

Duplication, sequence divergence, and recombination are the major contributors at work in gene evolution. (wikipedia.org)

These effectors manipulate host cell processes to enable e. g. bacterial invasion, acquisition of nutrients, inhibition of apoptosis, or interference with immune signalling. (europa.eu)
Jointly, these data demonstrate that localizing hRad51 to a targeted DNA nick through the RDN fusion boosts nick-mediated HDR performance without inhibition of strand invasion mediated by mobile hRad51. (mycareerpeer.com)
RecA is certainly a bacterial homolog of hRad51 that catalyzes strand invasion between homologous strands of DNA. (mycareerpeer.com)
Used jointly, these observations reveal that neither the fusion orientation of hRad51 in accordance with Cas9(D10A) nor the strand invasion and strand exchange actions of hRad51 are crucial for the power of RDN to mediate HDR. (mycareerpeer.com)

This suggests that gene replacement somehow occurred by recombination at the very ends of rpl36 , without the level and length of similarity normally expected to support recombination. (biomedcentral.com)

It has also been proposed to employ fusion partners as affinity peptides. (justia.com)

Together, it represents a first paradigm for the recruitment of acetylated NrtR to regulate bacterial central NAD + metabolism. (elifesciences.org)

To carry out their function, pili dynamically extend and retract from the bacterial surface. (biorxiv.org)
These approaches commonly use phage display, yeast surface display, or bacterial surface display to screen large libraries of antibodies 11-13 . (jove.com)
At stage 1, the bacterial cells attach reversibly to the surface. (biomedcentral.com)

op or pr) fusion gene was each crossed into lambda phage. (openmicrobiologyjournal.com)

Passananti C, Corbi N, Onori A, Di Certo MG, Mattei E. Transgenic mice expressing an artificial zinc finger regulator targeting an endogenous gene. (cnr.it)

The latter is common in lymphomas, where oncogenes are juxtaposed to the promoters of the immunoglobulin genes. (wikipedia.org)

For example, we will use recently developed microscopy techniques which allow us to directly visualise and track single replication forks inside living cells to study what happens if forks fuse and to identify how these fusion events can cause corruption of the DNA. (ukri.org)
These analyses will provide a detailed view of replication termination and how the incorrect processing of fork fusions can result in pathologies. (ukri.org)

Oncogenic fusion transcripts may also be caused by trans-splicing or read-through events. (wikipedia.org)

To relate the occurrence of gene fusions to Gleason Grading Groups and disease prognosis, we performed survival analyses using the Kaplan-Meier estimator, log-rank test, and Cox regression. (biomedcentral.com)

CRLF2 gene fusion we designed a methodological approach requiring the two commercially available IGH and CRLF2 break-apart probes. (bvsalud.org)

This gene thus plays a role in both cell-cycle and epigenetic regulation. (cancerindex.org)

Our partners at Baylor College of Medicine took five years to discover four bacterial resistant genes. (uni-lj.si)

The first fusion gene was described in cancer cells in the early 1980s. (wikipedia.org)
log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). (uth.edu)
log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). (uth.edu)

A fusion gene is a hybrid gene formed from two previously independent genes. (wikipedia.org)

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