Furthermore mechanism src homology 3 domain. Medical search. Frequent questions

Although genetic evidence strongly suggests that Btk plays a crucial role in B-lymphocyte differentiation and activation, its precise mechanism of action remains unknown, primarily because the proteins that it interacts with have not yet been identified. (caltech.edu)
Upon activation, JAK2 phosphorylates specific tyrosine residues in the intracellular tail of LepRb, which leads to the serial phosphorylation and activation of downstream signaling proteins, such as the signal transducer and activator of transcription 3 (STAT3) 11 . (nature.com)
Cloning of the chicken and quail genes encoding the putative receptor for RSV, subgroup A. Although the sequencing of genes encoding this long-sought receptor is not yet complete, it will undoubtedly offer a new perspective on viral-host interactions, the mechanism of early events in the virus life cycle, and the nature of the presumptively polymorphic avian proteins that recognize the several subgroups of RSV. (nih.gov)
Characterization of src mutants with host-dependent and dominant-negative phenotypes that define important functional domains outside the protein-tyrosine kinase domain of sre proteins (15, 16, 17, 18). (nih.gov)
In conjunction with work in several other labs, these mutants brought the Src-homology (SH) domains 2 and 3 to widespread attention, providing new opportunites for identifying the proteins that are crucial modifiers and targets for Sre-like kinases. (nih.gov)
Signaling through the insulin receptor occurs through an intracellular tyrosine kinase domain and resultant phosphorylation of the receptor, itself, and downstream effector and scaffolding proteins. (nih.gov)
These may include scaffolding proteins such as the Insulin Receptor Substrate (IRS) 1- 4, other proteins containing src-homology domains (SH2/3), protein tyrosine phosphatases such as PTB-1B, and others. (nih.gov)
It is known that the human Ras GTPase activating protein (GAP) p120-GAP can be phosphorylated by different members of the Src kinase family and recently phosphorylation of the GDP/GTP exchange factor (GEF) CDC25Mm/GRF1 by proteins of the Src kinase family has been revealed in vivo [Kiyono, M., Kaziro, Y. & Satoh, T. (2000) J. Biol. (embl.de)
Our results suggest that phosphorylation by p60c-Src and Lck is a selective process that can modulate the activity of p120-GAP and CDC25Mm towards Ras proteins. (embl.de)
This domain is found in many signal-transducing proteins 25 . (pharmacology2000.com)
In addition to active Ras proteins, several interac- tion partners have been identified, including Rab5,7 ABL tyrosine kinases,8 signal-transducing adapter molecule,9 epidermal growth factor receptor (EGFR),10 and 14-3-3 proteins.11 Two downstream RIN1 effector pathways have been described. (malt1inhibitor.com)
The mechanism of apoptosis is evolutionarily conserved and is executed by a family of proteins, called caspases. (hindawi.com)
No significant homology exists between CD19 and other known proteins, making it an ideal biomarker for B-cells. (shu.edu)
Functional protein microarrays normally contain full-length functional proteins or protein domains bound to a solid surface. (gomolecular.pk)
The proposed AOP for food sensitization is based on information on molecular and cellular mechanisms and pathways evidenced to be involved in sensitization by food and food proteins and uses the AOPs for chemical skin sensitization and respiratory sensitization induction as templates. (biomedcentral.com)
Current research goals in the lab relate to the spatio-temporal coordination of FGF2 secretion in living cells, the analysis of the molecular mechanism by which FGF2 physically traverses the plasma membrane and the relevance of this process for other unconventional secretory proteins such as HIV Tat. (db-engine.de)
There are 18332 RasGEF domains in 18317 proteins in SMART's nrdb database. (embl.de)
Taxonomic distribution of proteins containing RasGEF domain. (embl.de)
The complete taxonomic breakdown of all proteins with RasGEF domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing RasGEF domain in the selected taxonomic class. (embl.de)
HN - 2017 MH - ADAM12 Protein UI - D000072199 MN - D8.811.277.656.675.374.102.125 MN - D9.400.430.500.125 MN - D12.776.395.33.125 MS - A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS. (nih.gov)

Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). (nih.gov)
2014). In the present report, we revealed that exposure to As3+ for short time period inhibited tyrosine-705 phosphorylation of signal transducer and activator of transcription 3 (pSTAT3Y705) and induced Src homology region 2 domain-containing phosphatase-1 (SHP-1) in bronchial epithelial cell line, BEAS-2B. (nih.gov)
13. Regulation of the Lck SH2 domain by tyrosine phosphorylation. (nih.gov)
16. Role of the Lck Src homology 2 and 3 domains in protein tyrosine phosphorylation. (nih.gov)
The use of the catalytic domain of p60c-Src showed that its SH3/SH2 domains are not required for the interaction and the phosphorylation of both regulators. (embl.de)
The phosphorylation of p120-GAP by p60c-Src inhibited its ability to stimulate the Ha-Ras-GTPase activity, whereas phosphorylation by Lck did not display any effect. (embl.de)
phosphorylation by Lck increased its capacity to stimulate the GDP/GTP exchange on Ha-Ras, whereas its phosphorylation by p60c-Src was ineffective. (embl.de)
High levels of tyrosine phosphorylation correspond to enhanced proliferative state ( N Engl J Med 353(2) (2005)">3 ). (cancerdiagnosisprognosis.org)
We aimed to study the molecular mechanisms of how the gastric pathogen Helicobacter pylori hijacks cortactin phosphorylation via tyrosine kinase Abl to trigger cancer-related signal transduction events. (mdpi.com)
The binding of the ligand to the receptor triggers the oligomerisation of the receptors and phosphorylation of specific tyrosine residues in the intracytoplasmic kinase domain. (eonco.info)
Following STAT phosphorylation by JAK, the phosphorylated STAT monomers bind to a special structural region, the SH2 domain, located on another STAT monomer. (pharmacology2000.com)
Our goal was to identify the molecular mechanisms responsible for the suppression of PKB/Akt phosphorylation by iAs III and MAs III . (nih.gov)
Subtoxic concentrations of iAs III or MAs III had little or no effect on the activity of phosphatidylinositol 3-kinase (PI-3K), which synthesizes phosphatidylinositol-3,4,5-triphosphate (PIP 3 ), or on phosphorylation of PTEN (phosphatase and tensin homolog deleted on chromosome ten), a PIP 3 phosphatase. (nih.gov)
Neither iAs III nor MAs III interfered with the phosphorylation of 3-phosphoinositide-dependent kinase-1 (PDK-1) located downstream from PI-3K. (nih.gov)
[ 3 ] The activity of MAPKs is regulated through phosphorylation by MAPK kinases (MAPKKs), which in turn are regulated by MAPKK kinases (MAPKKKs). (medscape.com)
Using specific kinase inhibitors, we demonstrate that tyrosine phosphorylation of Tks5 is catalyzed by Src tyrosine kinase. (biomedcentral.com)
In addition, treatment of cells with LY294002, an inhibitor of PI 3-kinase, or mutation of the PX domain reduces tyrosine phosphorylation and membrane translocation of Tks5. (biomedcentral.com)
Tyrosine phosphorylation of RNA polymerase II carboxyl-terminal domain by the Abl-related gene product. (nih.gov)
Tyrosine phosphorylation of mammalian RNA polymerase II carboxyterminal domain. (nih.gov)

One such inhibitor is imatinib mesylate, which occupies the tyrosine kinase domain and inhibits BCR-ABL's influence on the cell cycle. (wikipedia.org)
The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. (nih.gov)
3. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. (nih.gov)
8. The Src tyrosine kinase Lck binds to CD2, CD4-1, and CD4-2 T cell co-receptors in channel catfish, Ictalurus punctatus. (nih.gov)
14. The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development. (nih.gov)
18. Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways. (nih.gov)
In this chapter, we will focus on molecular events leading to GLUT4 translocation, starting with activation of insulin receptors through signaling cascade involving phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB) and finally, the action of their effectors. (intechopen.com)
The phosphatidylinositol 3-kinase (PI3K) pathway is frequently deregulated in human cancer and is an essential regulator of cellular proliferation. (cancerdiagnosisprognosis.org)
This resistance was via activation of the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) axis. (cancerdiagnosisprognosis.org)
The phosphatidylinositol 3-kinase (PI3K) pathway is one of the most activated signaling pathways in human cancer. (cancerdiagnosisprognosis.org)
These compensatory mechanisms include forkhead box O (FOXO) transcription factors along with mitogen-activated protein kinase (MAPK)-dependent pathways ( Cancer Discov 9(4) (2019)">11 , Cancer Cell 21(2) (2012)">12 ). (cancerdiagnosisprognosis.org)
2 All three Trk receptors are structured with an extracellular domain for ligand binding, a transmembrane region and an intracellular domain with a kinase domain. (eonco.info)
The phosphatidylinositol 3‑kinase (PI3K)/RAC‑α serine/threonine‑protein kinase (AKT) signaling pathway was additionally analyzed in hippocampal cells following treatment with nicergoline. (spandidos-publications.com)
In contrast, inhibitors of the non-receptor tyrosine kinases, spleen tyrosine kinase and janus kinase 3, have demonstrated a significant clinical efficacy together with an acceptable safety profile. (medscape.com)
As BCR (B-cell receptor) signaling requires protein tyrosine kinase (PTK) activation, CD19 recruits and amplifies the activation of Src-family protein tyrosine kinases such as Lyn and Fyn. (shu.edu)
Tks5 is a substrate of the tyrosine kinase Src and is required for the organization of podosomes/invadopodia implicated in invasion of tumor cells. (biomedcentral.com)
The AXL protein is characterized by an extracellular structure consisting of two fibronectin type 3-like repeats and two immunoglobulin-like repeats along with its intracellular tyrosine kinase domain. (wikipedia.org)
Ras-mediated activation of DH-PH-Sos did not require activation of mitogen-activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase. (embl.de)

Here, we show that Btk interacts with Src homology 3 domains of Fyn, Lyn, and Hck, protein-tyrosine kinases that get activated upon stimulation of B- and T-cell receptors. (caltech.edu)
In this setup, the ligand interacts with an extracellular domain, the consequence of which is a change in intracellular, cytoplasmic enzyme activity. (pharmacology2000.com)

Upon activation of receptor tyrosine kinases (RTKs), recruitment of PI3K to the cell membrane occurs via coupling the Src homology-2 (SH2) domains of p85 with tyrosine phosphorylated residues of activated receptors ( Nat Rev Drug Discov 8(8) (2009)">4 ). (cancerdiagnosisprognosis.org)
Elucidation of the primary mechanisms of PI3K resistance might be a significant therapeutic approach for tumorigenesis ( Mol Cancer 18(1) (2019)">6 ). (cancerdiagnosisprognosis.org)

15. Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. (nih.gov)
Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm. (embl.de)
Src (sarcoma) is a group of proto-oncogenic tyrosine kinases. (pharmacology2000.com)

Proteolytic cleavage of the AXL extracellular domain by the metalloproteinases ADAM10 and ADAM17 can downregulate this signalling activity. (wikipedia.org)

We identified an interaction of paxillin with the vinexin adaptor protein family member ponsin in nascent costameres during muscle differentiation, which is mediated by an interaction of the second src homology domain 3 (SH3) domain of ponsin with the proline-rich region of paxillin. (ox.ac.uk)
To understand the molecular basis of this interaction, we determined the structure of this SH3 domain at 0.83 A resolution, as well as its complex with the paxillin binding peptide at 1.63 A resolution. (ox.ac.uk)
Contrary to the charged SH3 binding interface, the peptide contains only non-polar residues and for the first time such an interaction was observed structurally in SH3 domains. (ox.ac.uk)
The SH2 domain references 'Src-homology 2' which is described as a common structural feature among signaling molecules which promote protein-protein association through direct phosphotyrosine interaction. (pharmacology2000.com)

Interestingly, although mTid-1 is found tyrosine-phosphorylated in v-src-transformed fibroblast cells, GAP selectively binds to the unphosphorylated form of mTid-1. (embl.de)
This transcriptional factor belongs to the CREB/ATF family and binds to the specific sequence, 5'-TGACGTCA-3' known as CRE [ 31 ]. (biomedcentral.com)
Mature miRNA, along with Agonaute 2, forms an RNA-dependent silencing complex and binds to the 3′-UTRs of the target gene mRNAs with imperfect complementarity to cause their degradation or translational suppression [ 11 , 12 ]. (biomedcentral.com)
These agents contain an Fv domain, which binds to tumor-selective antigens, and a bacterial toxin (Pseudomonas exotoxin), which can kill a cell when only one or a few molecules reach the target cell s cytoplasm. (nih.gov)

A main feature of the catalytic domain is the protrusion of a helical hairpin important for the nucleotide-exchange mechanism. (embl.de)
This entry represents the catalytic domain of the Ras guanine-nucleotide exchange factors. (embl.de)

Our data extend the range of interactions mediated by Src homology 3 domains and provide an indication of a link between Btk and established signaling pathways in B lymphocytes. (caltech.edu)
These results reveal a potential mechanism for coupling of Ras and Rac signaling pathways. (embl.de)

The data indicated that apoptosis‑associated genes, including caspase‑3, BCL2 associated X, BH3 interacting domain death agonist and caspase‑9, were downregulated in hippocampal cells isolated from nicergoline-treated experimental mice. (spandidos-publications.com)
This leads to the activation of caspase 9, which then triggers a cascade of caspases activation (caspases 3 and 7) resulting in the morphological and biochemical changes associated with apoptosis. (hindawi.com)
MicroRNAs (miRNAs) are a class of small (~ 22 nucleotide long), non-coding RNAs in multicellular organisms, which modulate key cellular mechanisms of proliferation, metabolism and apoptosis via post-transcriptional regulation of hundreds of genes [ 10 ]. (biomedcentral.com)

1973) Preparation and properties of Chromatin (III) nucleotide complexes for use in the study of enzyme mechanisms, Biochemistry 12:3714-3724. (nih.gov)

However, the long-term prognosis is still unsatisfactory due, primarily, to the high recurrence and invasion rates even after resec- tion (50%-70% at 5 years).4,5 Unfortunately, little is known about the cellular mechanisms underlying hepatocarcino- genesis. (malt1inhibitor.com)

17. Gene transfer investigations of p56-LCK function in IL-2-dependent T-cell lines: implications for mechanisms of IL-2-signal transduction. (nih.gov)
Gene gun delivered DNA-based immunizations mediate rapid production of murine monoclonal antibodies to the Flt-3 receptor. (southernbiotech.com)
5 In 1999 Indo et al cloned the full-length NTRK1 human gene encoding a 790-residue or 796-residue protein (TrkA receptor) with an intracellular domain containing a juxtamembrane region, a TK domain and a short C terminal tail. (eonco.info)
In 2007, autosomal dominant mutations in signal transducer and activator of transcription-3 (STAT3) gene were identified as the molecular cause of this disease. (medscape.com)
The human CD36 gene is located on chromosome 7 (7q11.2) and consists of 15 exons with a single peptide chain of 472 amino acids and has a predicted molecular mass of 53 kDa [ 3 ]. (e-dmj.org)
Among the different mechanisms, we can distinguish a direct effect on gene expression by regulation of transcription factors or an indirect effect through increases in mRNA stability. (shu.edu)
Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. (cancerindex.org)
The zebrafish embryo is an ideal model system for studying PGC migration due to 1) the transparency of the embryo, allowing in vivo analyses of cell migration and development, 2) the availability of various mutant stocks and the morpholino antisense oligo nucleotide gene knockdown system, and 3) the availability of PGC marker genes, for which localisation and functions are well characterised. (exeter.ac.uk)

ZAP70 has a crucial role in T-cell receptor signaling activation and T-cell development ( Immunity 5(3) (1996)">18 ). (cancerdiagnosisprognosis.org)
Our current CAR constructs also include either a CD28 or 4-1BB costimulatory signaling domain to mimic a "second signal" that amplifies the activation of the CAR T cells, leading to a more robust signal to the T cell to multiply and kill the cancer cell. (shu.edu)
The tandem DH-PH domain of Sos (DH-PH-Sos) was defective in Rac activation but regained Rac stimulating activity when it was coexpressed with activated Ras. (embl.de)

This is the structurally conserved protein domain of the Src oncoprotein. (pharmacology2000.com)

To assess mechanisms underlying this differentiation process, we searched for muscle specific-binding partners of paxillin. (ox.ac.uk)
In addition to initial studies indicating the capability of miRNAs to modulate the magnitude of the innate immune response, participating as integral components of feedback loop regulatory mechanisms, which significantly shape the inflammatory response, recent studies have also established their role in tuning macrophage differentiation and polarization. (frontiersin.org)

Genetic and epigenetic mechanisms initiate the progression of cancer. (medscape.com)

However, we do not currently know the regulating mechanism and physiological role of CD36 on glucolipotoxicity in pancreatic β-cells. (e-dmj.org)

Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase alpha by multiple mechanisms. (nih.gov)
We investigate how protein substrates sample the cavity prior to encapsulation by GroES using paramagnetic relaxation enhancement to detect transient, sparsely populated interactions between apo GroEL, paramagnetically labeled at several sites within the cavity, and three variants of an SH3 protein domain (the fully native wild type, a triple mutant that exchanges between a folded state and an excited folding intermediate, and a stable folding intermediate mimetic). (nih.gov)

In the sections that follow, I summarize our progress towards understanding the retroviral lifecycle (with emphasis upon viral entry, proviral integration, synthesis of reverse transcriptase by ribosomal frameshifting, and virus assembly) and some of the genes (especially src, Wnt-l/int-1, myc, and their relatives) implicated in retrovirus-induced neoplasia. (nih.gov)

and (4) cytoplasmic signaling domain. (shu.edu)

We will present regulatory mechanisms and modulators of insulin-mediated glucose uptake. (intechopen.com)

Binding of acetylcholine to an α-subunit binding domain induces a change in receptor geometry enabling increased ion flow down the central core 27 (see representation below). (pharmacology2000.com)
We previously found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) exerts cytoprotective and pro-angiogenic functions via G-protein coupled receptor 15 (GPR15). (haematologica.org)

2019). The mechanisms of As3+-induced carcinogenesis had been extensively studied, and different mechanisms might be involved in different types of cancer (Wei et al. (nih.gov)

3] Each of these 6 acquired physiologic capabilities occurs during tumor development because of reactivation and changing of existing cellular programs utilized during embryogenesis and development. (medscape.com)

For preserving β-cell function, it is essential to understand the cause and mechanisms about the progression of β-cells failure. (e-dmj.org)

Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer. (microbiologyresearch.org)

Our subsequent studies of this phenomenon in the context of RSV (5), MMTV (6), and HIV (7) produced the first insights into the viral signals that influence frameshifting (a "slippery" heptanucleotide sequence and RNA secondary structure downstream) and attracted attention to a translational mechanism for generating diversity that has now been encountered in £.coli, yeast, and coronaviruses. (nih.gov)

The structure consists of two distinct alpha helical structural domains: the N-terminal domain which seems to have a purely structural role and the C-terminal domain which is sufficient for catalytic activity and contains all residues that interact with Ras. (embl.de)

Our lab investigates unconventional mechanisms of protein secretion from mammalian cells. (db-engine.de)

HN - 2017 (1997) MH - ADAM17 Protein UI - D000072198 MN - D8.811.277.656.675.374.102.375 MN - D9.400.430.500.375 MN - D12.776.395.33.375 MN - D23.50.301.264.35.57 MN - D23.101.100.110.57 MS - A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. (nih.gov)

Other mechanisms, including hypothalamic inflammation and endoplasmic reticulum (ER) stress, are known to be involved in obesity-associated leptin resistance 16 . (nature.com)
In this review, we highlight the essential molecular mechanisms underlying the different phases of inflammation that are targeted by microRNAs to inhibit or accelerate restoration to tissue integrity and homeostasis. (frontiersin.org)

However, the precise molecular mechanism of YAP in regulating murine embryonic neural stem cells (NSCs) remains largely unknown. (jneurosci.org)
Finally, the molecular mechanism of FGF2 secretion is used in the lab to develop inhibitors of this process with great potential for the development of drugs for cancer therapy that block the function of FGF2 as a tumor cell survival factor. (db-engine.de)

However, we do not currently know the regulating mechanism and pathophysiological role of CD36 and its upstream and downstream targets on glucolipotoxicity in pancreatic β-cells. (e-dmj.org)

Transfection experiments revealed further characteristics of ponsin functions in muscle cells: All three SH3 domains in the C terminus of ponsin appeared to synergise in targeting the protein to force-transducing structures. (ox.ac.uk)
A first-generation CD19 or HER2 CAR and a PD-L1 CCR containing the CD28 signaling domain were constructed and delivered into Jurkat T cells or primary T cells by a pseudotyped lentivirus. (researchsquare.com)
CAR T-cells have evolved from first generation constructs that contained an extracellular binding domain and intracellular signaling domain, to third generation structures that also include co-stimulatory molecules. (shu.edu)
3 The development of SOS after HSCT is associated with injury to sinusoidal endothelial cells (ECs) and hepatocytes via a variety of factors, including a hepatotoxic conditioning regimen, immunosuppressive treatments with calcineurin inhibitors, and lipopolysaccharide (LPS) released by gram-negative bacteria. (haematologica.org)
In COS-1 cells, the DH domain of Sos stimulated guanine nucleotide exchange on Rac but not Cdc42 in vitro and in vivo. (embl.de)

These receptors elicit a signaling cascade that enhances phagocytic activity and activates the production of pro-inflammatory cytokines, chemokines, reactive oxygen and nitrogen species, and antimicrobial peptides ( 3 ). (frontiersin.org)
3) Cytokine receptors represent another class. (pharmacology2000.com)

As it still remains unclear how these phosphorylations can influence the Ras pathway we have analyzed the ability of p60c-Src and Lck to phosphorylate these two Ras regulators and have compared the activity of the phosphorylated and unphosphorylated forms. (embl.de)

These results suggest that inhibition of the PDK-1/PKB/Akt-mediated transduction step is the key mechanism for the inhibition of ISGU in adipocytes exposed to iAs III or MAs III , and possibly for impaired glucose tolerance associated with human exposures to iAs. (nih.gov)

only cancers of the lung and stomach result in more deaths worldwide.1 Hepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers.2 It devel- ops mostly in cirrhotic livers, and the risk factors include chronic infection by hepatitis B and C viruses and nonvi- ral liver diseases.3 The prognosis of HCC has improved because of significant enhancements in surgical techniques and diagnostic methods in recent years. (malt1inhibitor.com)

The binding domain for JCAR015 is SJ25C1 and the costimulatory domain is CD28, whereas JCAR017 has a binding domain of FMC63 and a costimulatory domain of 4-1BB. (shu.edu)

Two mechanisms, a decrease in leptin transport from the periphery into the brain and the suppression of leptin signaling by an increase in negative regulatory molecules, have been proposed to explain central leptin resistance 16 . (nature.com)
However, the "Achilles heel" of cancer treatment has been failure of current treatments because of the emergence of genetic mechanisms of drug resistance. (medscape.com)

DNA sequence data for the cagA 3′ region of Western isolates differ markedly in their EPIYA motifs from those of East Asian isolates. (microbiologyresearch.org)
The NH2-terminal region of Sos contains a Dbl homology (DH) domain in tandem with a pleckstrin homology (PH) domain. (embl.de)

Identifying mechanisms of neural stem cell (NSC) regulation will have important clinical implications. (jneurosci.org)
We propose that regulation of MT stability and RhoA/ROCK activity is a mechanism to alter T-cell migratory behavior from lamellipodium-based persistent migration to bleb-based migration with frequent turning. (exeter.ac.uk)

These advances have allowed a precise definition of substrates and intermediates in the reaction (3) and stimulated the development of in vitro assays (e.g., for att site binding (29) that use purified components. (nih.gov)

A better understanding of the uncovered molecular mechanisms of the disease allowed the scientific community to develop strategies of potential therapy and helped to create some promising therapeutic approaches for SCA2 treatment. (nih.gov)

Earlier, we observed a PSC-specific downregulation of miR-29a in PDAC pancreas, however, the mechanism of action of the molecule in PSCs is still to be elucidated. (biomedcentral.com)

Glucose uptake is regulated by several mechanisms, where insulin plays the most prominent role. (intechopen.com)

HN - 2017 MH - ADAM10 Protein UI - D000072197 MN - D8.811.277.656.675.374.102.250 MN - D9.400.430.500.250 MN - D12.776.395.33.250 MN - D23.50.301.264.35.48 MN - D23.101.100.110.48 MS - A disintegrin and metalloproteinase domain-containing protein. (nih.gov)

Anatomy22

Organisms11

Diseases1

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes68

Information Science4

Proteins21

Phosphorylation19

Kinase18

Interacts2

PI3K2

Kinases3

Extracellular domain1

Interaction4

Binds4

Catalytic domain2

Signaling pathways2

Apoptosis3

Biochemistry1

Cellular mechanisms1

Gene8

Activation3

Structurally1

Differentiation2

Epigenetic1

Physiological role1

Interactions2

Genes1

Cytoplasmic1

Regulatory mechanisms1

Receptor2

20191

Occurs1

Progression1

Helicobacter1

Diversity1

Residues1

Mammalian1

Membrane1

Inflammation2

Molecular mechanism2

Downstream1

Cells5

Receptors2

Pathway1

Inhibition1

Cancers1

CD281

Resistance2

Region2

Regulation2

Precise1

Therapeutic1

Pancreas1

Role1

20171