In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)
Excessive glutamate release resulting in excessive Ca +2 entry into cells is the excitotoxicity which initiates the brain ischemic damage seen in stroke and cardiac arrest. (benbest.com)
We found no association between outdoor measures of CO, SO2, PM10 and COPD, heart failure and ischemic stroke visits. (turkjemergmed.com)
The idea here is that if the stroke is ischemic (temporary restriction of oxygenated blood) the body naturally and preferentially preserves blood flow to the brain, so cooling the rest of the body will cause the blood to shunt rapidly to the brain. (healthy.net)
A transient ischemic attack (TIA) is a type of stroke that lasts for a short period of time and does not result in long-lasting damage. (belmarrahealth.com)
A transient ischemic attack, or mini-stroke, takes place when a blood clot temporarily blocks the flow of blood to the brain. (belmarrahealth.com)
Hypoxic-Ischemic Encephalopathy5
This equipment is useful in curing Hypoxic-ischemic encephalopathy (when there is a shortage of oxygen in the baby's body). (vngmedical.com)
Hypoxic-ischemic encephalopathy (HIE) is a type of brain disorder resulting from birth asphyxia, this condition occurs when a newborn lacks proper blood flow or oxygen flow to the brain, leading to disrupted circulation. (vngmedical.com)
As we also know, to cure Hypoxic-ischemic encephalopathy, Hypothermia therapy the only successful and proven treatment. (vngmedical.com)
Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of infant death. (kusumatrust.org)
We are currently developing these ASOs as therapeutic approach in hypoxic ischemic encephalopathy (HIE) and other neurodegenerative conditions. (fu-berlin.de)
Cause of ischemic2
The development of atherosclerosis (plaques) in the heart muscles is the main cause of ischemic heart disease that causes the arteries to harden and accumulate cholesterol plaques on their walls. (cacherbal.com)
Since the cause of ischemic colitis isn't always clear, there's no certain way to prevent the disorder. (ahdubai.com)
Bowel disease1
Ischemic colitis can often be confused with other disorders because their symptoms overlap, especially inflammatory bowel disease (IBD). (ahdubai.com)
Time17
this is termed donor warm ischemic time (WIT). (medscape.com)
In addition, several studies have demonstrated the beneficial effects of empagliflozin on myocardial infarction (MI) in diabetic animal models 10 , 11 , prompting us to investigate the real-time ATP change in cardiac energy production in an ischemic-reperfusion model of MI. (nature.com)
Reducing warm ischemic time can optimize islet cell yield in pancreatic islet cell autotransplantation following total pancreatectomy. (sages.org)
Cryonics patients frequently experience ischemic & reperfusion injury between the time when the heart stops and cryostorage begins. (benbest.com)
The RPN group had significantly less warm ischaemic time than the LPN group ( p = 0.0008). (soton.ac.uk)
How can we reduce the ischemic time for forearm replantation? (biomedcentral.com)
Ischemic time is a key factor in satisfactory functional results after forearm replantation. (biomedcentral.com)
In this study, we provide a detailed description of our surgical technique, the temporary screw plate fixation technique, which aims to reduce ischemic time. (biomedcentral.com)
To reduce ischemic time, we need a plan that progressively reduces time at each stage. (biomedcentral.com)
In order to reduce ischemic time during surgery, it is especially important to reduce the time required for debridement, exploration, and bone fixation, which are the steps before artery anastomosis. (biomedcentral.com)
However, in a situation where ischemic time must be reduced, surgery is performed based on each surgeon's experience and usual skills of the surgeon that only they have. (biomedcentral.com)
We suggest several tips for reducing ischemic time based on a conventional surgical technique in this paper and report our results. (biomedcentral.com)
The median pancreas warm ischemic time was 3 minutes. (elsevierpure.com)
The increasing heat-related MI risk over time can be explained by the relatively temperate but warming climate in Augsburg, where residential air conditioning is not widely used, as well as increasing vulnerability due to a rising prevalence of MI risk factors like diabetes and hyperlipidaemia. (evropane.org)
Running-clip renorrhaphy reducing warm ischemic time during laparoscopic partial nephrectomy. (ac.ir)
The second warm ischaemic time in the Simple LLDN group was slightly shorter than the Complex LLDN group (32 versus 36 min P = 0.016). (edu.au)
Inflammation3
Nevertheless, its importance in timely resolution of post-ischemic inflammation remains incompletely understood. (springer.com)
The expression of TLRs and their role in inflammation and ischemic injury in the adult brain is well documented. (biomedcentral.com)
Ischemic colitis that occurs in a young adult may be a sign of a blood-clotting abnormality or inflammation of the blood vessels (vasculitis). (ahdubai.com)
Transplantation2
Damage to organs during transplantation occurs in 2 phases: the warm ischemic phase and the cold ischemic phase. (medscape.com)
During vascular anastomosis* 1 in kidney transplantation procedures, kidneys removed from donors and stored after cooling are exposed to the risk of second warm ischemic injury* 2 due to heating by contact with a surgeon or donor's tissues. (screen.co.jp)
Cardiac1
Empagliflozin also enhanced cardiac robustness by maintaining intracellular ATP levels and the recovery capacity in the infarcted area during ischemic-reperfusion. (nature.com)
Ischemia8
If biological tissues are exposed to body temperature without blood flow (warm ischemia), cellular homeostasis is not maintained due to the lack of oxygen and nutrients, and so disabling substances are released outside the cell. (screen.co.jp)
Objective We hypothesized that cold ischemia during partial orchiectomy Peramivir would lead to higher serum testosterone levels and preservation of testicular architecture than warm ischemia in a prepubescent rat model. (biopaqc.com)
Results Mean serum testosterone levels were 1445 ± 590 pg/mL for the sham group 449 ± 268 pg/mL for the cold ischemia group and 879 ± 631 pg/mL for the warm ischemia group (= 0.12). (biopaqc.com)
Histological evaluation revealed significant difference in tissue injury grading with more injury in the cold ischemia than in the warm ischemia group (= 0.01). (biopaqc.com)
4 rats 8 testicles) Group 2 underwent bilateral partial orchiectomy with 30 min of cord compression and cold ischemia via ice slush (= 7 rats 14 testicles) and Group 3 underwent bilateral partial orchiectomy with 30 min of cord compression and warm ischemia (no ice slush = 7 rats 14 testicles). (biopaqc.com)
Each histologic parameter was compared between the cold ischemia and warm ischemia groups and total mean histology score was compared between the Peramivir two groups [13]. (biopaqc.com)
Laparoscopic2
There was no difference regarding postoperative length of hospital stay ( p = 0.37), complications ( p = 0.86), or positive margins ( p = 0.93).Conclusions: in early experience, RPN appears to be a feasible and safe alternative to its laparoscopic counterpart with decreased warm ischaemia times noted. (soton.ac.uk)
This study aimed to document the surgical and oncologic results of nephron sparing of non-ischemic laparoscopic partial nephrectomy without the step of hilus controlling and even without dissecting to expose the main renal vascularity and directly focusing on mass removal. (ac.ir)
Reducing1
These data suggest that endothelial TRPA1 channels are sensors of hypoxia leading to vasodilation, thereby reducing ischemic damage. (elifesciences.org)
Coronary2
Ischemic heart disease, also known as coronary artery disease, is a condition that affects the blood supply to the heart. (cacherbal.com)
Ischemic heart disease causes early childhood damage or injury to the inner layer of a coronary artery. (cacherbal.com)
Hypoxia2
We hypothesized that TRPA1 channels in endothelial cells are activated by hypoxia-derived reactive oxygen species, leading to cerebral artery dilation and reduced ischemic damage. (elifesciences.org)
At 48 h after the injections, hypoxic-ischemic (HI) injury was induced by unilateral carotid artery ligation followed by hypoxia for 65 min. (biomedcentral.com)
Cerebral2
We hypothesized that TLRs other than TLR-4 may mediate preconditioning against cerebral ischemic injury in the developing brain. (biomedcentral.com)
Thanks to funding from Kusuma, the new unit includes a cerebral function monitor, incubator, cooling and warming devices, two video laryngoscopes, mechanical ventilator and is home to Baby Paul, a state of the art baby simulator which has already been used to train doctors, nurses and midwives in Gibraltar and nearby Spain. (kusumatrust.org)
Injury12
During clinical death, all tissues and organs in the body steadily accumulate a type of injury called ischemic injury. (wikipedia.org)
The brain, however, appears to accumulate ischemic injury faster than any other organ. (wikipedia.org)
Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
I focus my attention on ischemic/reperfusion injury to the brain. (benbest.com)
Of the 155 primary metabolites measured, the pre-perfusion levels (t=0 hours) of 33 of them were found to be significantly correlated with WIT, suggesting that they could be putative biomarkers for ischemic injury. (confex.com)
Poly I:C-induced preconditioning against ischemic injury may be mediated by modulation of TLR-3 signaling pathways. (biomedcentral.com)
This is the first study to show that TLR-3 is expressed in the immature brain and mediates preconditioning against ischemic injury. (biomedcentral.com)
However, the role of TLRs in ischemic injury of the developing brain is yet to be determined. (biomedcentral.com)
After a certain delay, the brain develops tolerance to ischemic injury caused by the injurious stimulus. (biomedcentral.com)
Ischemic preconditioning, therefore, protects against subsequent ischemic injury. (biomedcentral.com)
For starters, always remember to warm up and cool down, or else you are putting yourself at a higher risk for injury. (belmarrahealth.com)
ISP reduces warm ischemic injury which is associated with DCD donation. (maastrichtuniversity.nl)
Diseases1
Since the initial success of cell therapy for ischemic diseases many attempts have been made to increase its efficacy. (biomedcentral.com)
Nephrectomy1
Present un-controlled results pointed that tumor-focusing nephron-sparing non-ischemic partial lap-aroscopic nephrectomy may be preferable for small-sized, low-complex renal masses. (ac.ir)
Occurs2
Ischemic colitis occurs when a part of the colon experiences a decrease in blood flow. (ahdubai.com)
Ischemic colitis occurs when blood flow to part of the large intestine (colon) is temporarily reduced, usually due to constriction of the blood vessels supplying the colon or lower flow of blood through the vessels due to low pressures. (ahdubai.com)
Respiratory1
We observed a J-shaped exposure-response function only for 15-day average temperature and respiratory mortality in the warm period, with 21.3°C as the threshold temperature. (biomedcentral.com)
Infection1
You may need medication to treat ischemic colitis or prevent infection, or you may need surgery if your colon has been damaged. (ahdubai.com)
Tolerance2
It is still an experimental procedure with numerous critical details remaining to be established, including tolerance to warm and cold ischemic insults. (nih.gov)
Ischemic tolerance or preconditioning is a phenomenon by which a sub-injurious stimulus is applied to a tissue such as the brain. (biomedcentral.com)
Rats1
We have shown that preconditioning by lipopolysaccharide (LPS) will result in 90% reduction in ischemic brain damage in P7 rats. (biomedcentral.com)
Cold4
Effects were explored for warm (April to September) and cold periods (October to March) separately. (biomedcentral.com)
Excess winter mortality has been well known (which may have also caused that in recent years, particularly in the light of global warming, there were fewer studies particularly focusing on cold spells or temperature decreases). (biomedcentral.com)
Or, you may take a neutral bath that is neither freezing cold, nor warm. (healthy.net)
These same actions were performed with the contralateral testicle in the cold ischemic group. (biopaqc.com)
Immune1
Vibrio vulnifi cus, a gram-negative bacterium of the fam- tered immune status, and history of ischemic heart disease ily Vibrionaceae , is a worldwide inhabitant of salt wa- were identifi ed as independent risk factors for death, which ter ( 1-3 ). (cdc.gov)
The major risk factors for ischemic heart disease include smoking, diabetes, and high levels of cholesterol in the blood. (cacherbal.com)
Treatment1
Pre-treatment with poly I:C downregulated NF-κB and upregulated IRF3 expression in P5 rat ischemic brains. (biomedcentral.com)
Group1
The warm ischemic group underwent the same procedure without ice slush. (biopaqc.com)
Area1
Then, 3-4 days later inflammatory monocytes are recruited into ischemic area of the heart. (springer.com)
Damage1
For a more quantitative approach less concerned with molecular biology, see Quantifying Ischemic Damage for Cryonics Rescue . (benbest.com)
Asthma1
PM10 were strongly associated with pulmonary embolus and asthma visits during the warm season. (turkjemergmed.com)
Risk1
Conditions that affect the way the blood clots, such as factor V Leiden, may increase the risk of ischemic colitis. (ahdubai.com)
Global3
Under the influence of global warming as well as population growth and ageing, the heat-related impact on health is expected to increase in the upcoming decades. (evropane.org)