Further comprises a nucleic acid. Medical search. Frequent questions

The name of this family corresponds to an amino acid sequence (or motif) that is found, more or less conserved, in all the proteins of this family. (wikipedia.org)
To create tailor-made meganucleases, two main approaches have been adopted: Modifying the specificity of existing meganucleases by introducing a small number of variations to the amino acid sequence and then selecting the functional proteins on variations of the natural recognition site. (wikipedia.org)
Carbon is found in all organic molecules, whereas nitrogen is an important component of nucleic acids and proteins . (wikipedia.org)
Proven, performance-leading magnetic particle technology enables purification of high-quality nucleic acids that are free of proteins, nucleases, and other impurities. (qiagen.com)
Conventional vaccine design strategies mainly focus on live-attenuated vaccines, inactivated microorganisms, and subunits thereof comprising purified components or recombinantly expressed proteins, mostly formulated with adjuvants. (nih.gov)
It is thought that proteins in the human cell can tell if a sequence of nucleic acids is from an invading organism. (sciencedaily.com)
To try to identify these proteins the research team has developed a technique to test which proteins in a cell bind specifically to foreign nucleic acids. (sciencedaily.com)
Biological cells are complex dynamic systems, comprising thousands of interacting nucleic acids, proteins, and metabolites acting in concert to perform coordinated and well regulated tasks. (confex.com)
HIV infection can be diagnosed based on detection of antibodies that are directed against the proteins encoded by the 3 major genes, the detection of the p24 antigen, the viral nucleic acid, and, finally, by means of culturing the virus. (medscape.com)
The structure of the cell, the structure and function of nucleic acids, the structure and function of proteins and membranes, enzyme catalysis, the metabolism of the cell and its regulation, bioinformatics and proteomics, and cell biology related methods. (lu.se)

Detection of viral nucleic acid in tissue sections of cancer- of 161 BAL and tracheal secretion samples were collected ous prostate glands and cloning of the viral integration sites from patients with severe RTI and immunosuppression as a confi rmed XMRV as a bona fi de human infection with a result of solid organ or bone marrow transplantation. (cdc.gov)
A Nucleic Acid Amplification Test, or NAAT, is a type of viral diagnostic test for SARS-CoV-2, the virus that causes COVID-19. (cdc.gov)
The use of PCR and real-time PCR (qPCR)-based methodologies in clinical diagnostic virology demands high sensitivity and specificity for the selected viral nucleic acid target. (nature.com)
Analytical specificity comprises the extent of inclusivity by which all viral phylogenetic variants are captured at the exclusion of its genetic near neighbors. (nature.com)
The QIAsymphony Certal Residual DNA Kit and the QIAsymphony Certal Vaccine NA Kit provide automated solutions for purification of residual host cell DNA and viral nucleic acids from bioprocess purification buffer, cell culture supernatant samples, and vaccine preparations using the QIAsymphony SP . (qiagen.com)
The QIAsymphony Certal Residual DNA Kit enables extraction of residual host cell DNA and viral nucleic acids from biologics (e.g., monoclonal antibodies) purified using chromatography procedures. (qiagen.com)
The QIAsymphony Certal Vaccine NA Kit enables extraction of viral nucleic acids from cell-based vaccine production. (qiagen.com)
Detection of virus or viral ribonucleic acid (RNA) remnants on foods and packaging shows evidence of previous contamination but there is no confirmation of SARS-CoV-2 being transmitted by food or packaging and causing illness in people who touch them. (foodsafetynews.com)
Le VRS demeure un agent étiologique viral important au Maroc, responsable de syndromes de type grippal et d'infections respiratoires aiguës sévères, en particulier chez les nourrissons. (who.int)

We evaluated the effect of time of specimen collection on culture yield following a positive nucleic acid amplification test (NAAT). (bmj.com)
Culture for Neisseria gonorrhoeae in asymptomatic, nucleic acid amplification test (NAAT)-positive extragenital infections usually has a low yield and is not frequently performed. (bmj.com)

Such methods generally comprise providing a cell with one or more precursor nucleic acid sequences that encode two or more RNA molecules. (genomeweb.com)
Such methods employ oligomeric compounds which hybridize with or sterically interfere with nucleic acid molecules comprising or encoding miR-122a," the abstract states. (genomeweb.com)
Specifically, the invention relates to double stranded nucleic acid molecules … capable of mediating RNA interference against 11 beta-hydroxysteroid dehydrogenase-1 gene expression, including cocktails of such small nucleic acid molecules and lipid nanoparticle (LNP) formulations of such small nucleic acid molecules. (genomeweb.com)
MiRNAs (Micro RiboNucleic Acids) are small molecules with chemical building blocks similar to DNA. (news-medical.net)
The invention relates to nucleic acid molecules encoding (poly)peptides having chemotaxis inhibiting (poly)peptides CHIPS activity, to recombinant vectors harboring such molecules, and the host cells carrying the vectors. (patentalert.com)
In another aspect, the invention provides vaccine preparations, comprising the inventive hEbola virus, including recombinant and chimeric forms of the virus, nucleic acid molecules comprised by the virus, or protein subunits of the virus. (naturalnews.com)

This paper proposes a generative adversarial networks (GAN) model to create synthetic nucleic acid sequences of the cat genome tuned to exhibit specific desired properties. (mdpi.com)
NAATs for SARS-CoV-2 specifically identify the RNA (ribonucleic acid) sequences that comprise the genetic material of the virus. (cdc.gov)
GenBank ® is the NIH genetic sequence database, an annotated collection of all publicly available DNA sequences ( Nucleic Acids Research , 2013 Jan;41(D1):D36-42 ). (nih.gov)

A first RNA molecule comprises a double-stranded sequence, which includes a guide strand sequence that is complementary to a portion of an mRNA transcript encoded by the target gene. (genomeweb.com)
Monomeric Cyanine Nucleic Acid stains allow ultrasensitive fluorescence detection of double-stranded nucleic acids. (thermofisher.com)

It is directed to an invention that provides stable nucleic acidlipid particles ("SNALP") that have a non-lamellar structure and "comprise a nucleic acid ․ methods of making the SNALP, and methods of delivering and/or administering the SNALP. (findlaw.com)
Tekmira's LNP technology (formerly referred to as stable nucleic acid-lipid particles, or SNALP) encapsulates siRNAs in uniform lipid nanoparticles that have demonstrated the ability to deliver RNAi therapeutics to disease sites in preclinical models. (genengnews.com)
Tekmira's LNP technology (formerly called stable nucleic acid-lipid particles, or SNALP) encapsulates RNAi triggers with high efficiency in uniform lipid nanoparticles that are effective in delivering therapeutic compounds to disease sites. (genengnews.com)

The '127 patent states that its purpose is to allow for more efficient methods and compositions for introducing nucleic acids into cells and methods of downregulating gene expression. (findlaw.com)
The invention comprises "methods and compositions for the diagnosis, prognosis, and treatment of hepatocellular carcinoma … [as well as] methods of identifying [anti-cancer] agents," the patent's abstract states. (genomeweb.com)
These modified oligomeric compounds are used as single compounds or in compositions, including pharmaceutical compositions, to modulate or mimic the targeted nucleic acid comprising or encoding miR-122a. (genomeweb.com)
This invention relates to compositions comprising a combination of a lipid and a therapeutic agent, particularly to lipid-nucleic acid compositions, for in vivo therapeutic use. (justia.com)
Additionally, the invention provides methods of making the compositions, as well as methods of introducing the nucleic acids into cells using the compositions and treating disease conditions. (justia.com)
In addition, the invention provides therapeutic and diagnostic compositions comprising as the active ingredient the (poly)peptide having CHIPS activity. (patentalert.com)

They are ideally suited for nuclear staining in flow cytometry and fluorescence microscopy applications in fixed cells, along with nucleic acid detection on solid supports and in electrophoresis applications. (thermofisher.com)
The purified nucleic acids are ready for direct use in downstream applications, such as amplification or other detection reactions (e.g. (qiagen.com)
Other typical applications are: inflammation response monitoring (total and subclass IgG, IgE, IgA, IgM, cytokines, etc), assays for immunogenicity detection to your nucleic acid drugs or therapeutic monoclonal antibodies), complement activation monitoring, pathogen pharmacodynamics in antibiotics research (detection by ELISA or Real-Time qPCR), biomarker quantification as surrogate markers in preclinical or clinical drug developmen. (hum-molgen.org)
The nucleic acid-based technique has been widely utilized in many fields including for on-site detection. (frontiersin.org)
In this study, a rapid DNA extraction method (RDEM), recombinase aided amplification (RAA), and chemical heating packet (CHP) are integrated and termed as RRC platform for on-site detection of nucleic acid. (frontiersin.org)
This study provides a novel approach for on-site detection of nucleic acids besides providing valuable insight on related future research. (frontiersin.org)
However, there are some limitations in on-site detection or diagnosis using nucleic acid-based methods. (frontiersin.org)
The nucleic acid-based method generally comprises three steps including nucleic acid extraction, amplification, as well as product detection. (frontiersin.org)
Nucleic acid extraction is the most critical step in the on-site detection of nucleic acid. (frontiersin.org)
As such, it is important to carry out further research on the methods of nucleic acid extraction to facilitate on-site detection of the nucleic acid. (frontiersin.org)

QIAsymphony technology combines the speed and efficiency of silica-based nucleic acid purification with the convenient handling of magnetic particles. (qiagen.com)
According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or Polyamide oligomer-modified lipid is combined with a buffered aqueous solution of a charged therapeutic agent, for example polyanionic nucleic acids, to produce particles in which the therapeutic agent is encapsulated in a lipid vesicle. (justia.com)
The technology relies on the enhanced permeability and retention effect, which occurs because these nucleic acid-containing particles have a long circulation time in the blood. (genengnews.com)

Oligonucleotide therapeutics are nucleic acid polymers generally comprised of a few to several dozen bases (including modified bases) linked together. (shimadzu.com)
We also offer immunology assays to investigate immune response to nucleic acids therapeutics. (hum-molgen.org)
Another recently developed application of Real-Time qPCR uncovers an appealing area of increasing interest: the quantification of nucleic acid therapeutics in preclinical development. (hum-molgen.org)
Privatization of the production of therapeutics with commercial potential, such as vaccines and peptide-based drugs, to suffice healthcare needs is driving the demand for large-scale separation instruments Thus, the nucleic acid isolation and purification industry exhibits lucrative growth potential. (grandviewresearch.com)

Its Smart Consumables segment is engaged in developing and selling scientific materials, such as nucleic acid purification. (morningstar.com)
QIAsymphony Certal Kits, in combination with the QIAsymphony SP, enable fully automated purification of nucleic acids from samples generated during production and purification of cell-culture-based biotechnology-derived products, biopharmaceutical protein drugs (e.g., monoclonal antibodies), or from virus-propagating cell lines for vaccine production. (qiagen.com)
The purification procedure is designed to ensure safe and reproducible handling of potentially infectious samples, and comprises 4 steps: lyse, bind, wash, and elute. (qiagen.com)
The global nucleic acid isolation and purification market size was valued at USD 5.11 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 10.06% from 2023 to 2030. (grandviewresearch.com)
This strategy allowed Zymo to combine its nucleic acid purification technology with Star Array's automation technique to expand its diagnostics portfolio. (grandviewresearch.com)
Rapidly evolving biotechnological applications in various industries, such as food processing, agriculture, recycling & waste management, and energy & environmental, are projected to drive the adoption of nucleic acid isolation and purification. (grandviewresearch.com)
The market comprises of a wide range of DNA and RNA isolation/extraction and purification kits for preparing samples and libraries. (grandviewresearch.com)
Also, the company offers the MagMAX CORE Nucleic Acid Purification Kit, which is utilized for the purification and mechanical lysis of nucleic acids. (grandviewresearch.com)
The demand for kits used in the isolation and purification of nucleic acids is on the rise, driven by the increasing number of research studies focused on comprehending genome-based diseases such as Huntington's disease, polyketonuria, and others. (grandviewresearch.com)

Chlorella Growth Factor (CGF) is a potent phytonutrient comprised of amino acids, beta glucans, nucleic acids, peptides and polysaccharides. (seacoast.com)

Methods for the preparation of a lipid-nucleic acid composition are provided. (justia.com)
LNP formulations comprise several lipid components that can be adjusted to suit the specific application. (genengnews.com)

The yeast cell can also contain a fourth exogenous nucleic acid encoding heme biosynthesis enzymes, which are involved in the production of heme, an important molecule in various biological processes. (just-drinks.com)

NAATs detect genetic material (nucleic acids). (cdc.gov)
Amplifying those nucleic acids enables NAATs to detect very small amounts of SARS-CoV-2 RNA in a specimen, making these tests highly sensitive for diagnosing COVID-19. (cdc.gov)
Our services range from hybridisation assays to Real-Time qPCR to detect your investigational new drug based on nucleic acids chemistry (RNA/DNA). (hum-molgen.org)

The contribution of synthetic biology to vaccine development comprises algorithms for accelerated in silico identification of relevant protein candidates, in silico design of novel immunogens with improved expression, safety and immunogenicity profiles as well as in silico design of (1) nucleic acid based, (2) vectored and (3) live-attenuated vaccines. (nih.gov)
The invention also provides a vaccine formulation comprising a therapeutically or prophylactically effective amount of the inventive hEbola virus described above, and a pharmaceutically acceptable carrier. (naturalnews.com)

Phosphorus is used to make nucleic acids and the phospholipids that comprise biological membranes . (wikipedia.org)

The team has also been developing methods to understand how the human body can recognise invading foreign genetic material - comprising nucleic acids - from bacteria or viruses for example, and distinguish it from its own, innate genetic material. (sciencedaily.com)

The yeast cell contains two exogenous nucleic acids, one encoding a retrograde regulation protein (Rtg) and the other encoding a polypeptide. (just-drinks.com)
Unlike the more famous DNA, miRNAs are typically very short - comprising only around 20 to 25 base units (the building blocks of nucleic acids), and they do not code, in other words they do not specify the production of a protein or peptide. (news-medical.net)
The hepatic urea cycle is the major route for waste nitrogen disposal, which is chiefly generated by protein and amino acid metabolism. (medscape.com)
The drug is intended for patients who cannot be managed by a protein-restricted diet or amino acid supplements alone, and it must be used in conjunction with a protein-restricted diet and, in some cases, dietary supplements. (medscape.com)

At present, numerous nucleic acid-based analytical techniques were developed. (frontiersin.org)

What's more, these compounds comprised up to 50% of the dust that 67P is leaking into space. (ualr.edu)
Compounds that comprise the urea cycle are sequentially numbered, beginning with carbamyl phosphate (1). (medscape.com)

GenBank is part of the International Nucleotide Sequence Database Collaboration , which comprises the DNA DataBank of Japan (DDBJ), the European Nucleotide Archive (ENA), and GenBank at NCBI. (nih.gov)

The invention, the patent's abstract states, comprises "methods for identifying a polynucleotide that can reduce the level of a target mRNA. (genomeweb.com)
The invention comprises "a method of diagnosing, assessing susceptibility, and/or treating schizophrenia involving the identification and/or observation of microRNAs and variant miRNA," according to the patent's abstract. (genomeweb.com)

These high-affinity dyes have low background and bright fluorescence when bound to nucleic acid. (thermofisher.com)
This seemingly trivial observation triggered a critical epiphany for James Watson six years later as he worked out how the two strands of the linear nucleic acids could be bound to one another in DNA. (iucr.org)

Accelerō Bioanalytics offers custom-made quantitative Real-Time RT-qPCR assays for your investigational new nucleic acid drug like siRNA, micro RNA, or RNA aptamers. (hum-molgen.org)

Moreover, increasing collaboration and expansion undertaken by leading market players to bolster their nucleic acid extraction modalities is another factor propelling industry growth. (grandviewresearch.com)
For instance, in April 2020 QIAGEN and Gilson collaborated to make manual nucleic acid extraction more efficient and reproducible. (grandviewresearch.com)
This collaboration integrated QIAGEN's manual nucleic acid extraction kits and TRACKMAN Connected digital bench tool to enhance yield as well as efficiency. (grandviewresearch.com)
These kits are used in the extraction of nucleic acids from tissue, blood, cells, and plants. (grandviewresearch.com)
For instance, Thermo Fisher Scientific offers PrepSEQ 1-2-3 Mycoplasma Nucleic Acid Extraction Kit designed for the extraction of mycoplasma genomic DNA from samples. (grandviewresearch.com)
To date, two methods have been applied in the extraction of nucleic acid. (frontiersin.org)

A ccelerō Bioanalytics is a preferred partner in bioanalytical services for the nucleic acids biotechnology and pharmaceutical industry. (hum-molgen.org)

The yeast cell can have the exogenous nucleic acids stably integrated into its genome or expressed from a replication-competent plasmid. (just-drinks.com)

A particle according to claim 1, further comprising the nucleic acid sequence encoding die protease cleavage signal. (sumobrain.com)

The Diatron segment comprises the business with systems, system components, consumables, and tests in the low throughput hematology and clinical chemistry segment. (morningstar.com)
No clinical assessment currently employs the basic phosphodiester chemistry found in natural nucleic acids, because of these and other known problems. (justia.com)

Building on previous research, representative nucleic acid duplexes were split into logical monomer segments, and atomic coordinates were used to create solid models for 3D printing. (allenpress.com)

In another aspect, the invention provides a method for propagating the hEbola virus in host cells comprising infecting the host cells with the inventive isolated hEbola virus described above, culturing the host cells to allow the virus to multiply, and harvesting the resulting virions. (naturalnews.com)

Advanced biotechnological methods comprising cloning, mutagenesis, PCR technology, synthesis of nucleic acids and DNA sequence determination. (uu.se)

As more research labs and classrooms dive into the field of structural nucleic acid nanotechnology, students and researchers need access to interactive, dynamic, handheld models. (allenpress.com)

To address these challenges, companies are introducing novel isolation kits to facilitate the recovery of nucleic acids. (grandviewresearch.com)

Dynamic and flexible nucleic acid models can provide current and future scientists with physical intuition for the structure of DNA and the ways that DNA and its synthetic mimics can be used to build self-assembling structures and advanced nanomachines. (allenpress.com)

amplifying a paternally inherited nucleic acid from the remaining fluid and subjecting the amplified nucleic acid to a test for the Paternally inherited fetal nucleic acid. (foley.com)
Chinese COVID-19-related restrictions since June 2020 have included exporter statement requirements, suspension of imports from facilities with worker cases of COVID-19, testing, and port-of-entry rejections in the case of positive nucleic acid test results. (foodsafetynews.com)

The patent claim describes a yeast cell comprising exogenous nucleic acids encoding Rtg and a polypeptide, operably linked to promoter elements. (just-drinks.com)
212 ("iPSCs used by Defendants to make at least the iPSC-derived 13 natural kill (NK) cell platforms are made by a process that comprises at least each step of 14 claim 1 of the '856 Patent. (justia.com)

The yeast cells are cultured under conditions suitable for the expression of the exogenous nucleic acids. (just-drinks.com)
Once at the target site, cells take up the LNP through endocytosis and the nucleic acid payload is delivered inside the cell. (genengnews.com)

Nucleic acid sequencing expresses the evolutionary changes among organisms and revolutionizes disease diagnosis in animals. (mdpi.com)

In addition to the Rtg and polypeptide encoding nucleic acids, the yeast cell can also contain a third exogenous nucleic acid encoding a transcriptional activator, such as Mxr1, Mit1, or Trm1. (just-drinks.com)

Preferably, the second guide strand sequence comprises one or more bases that are mismatched with a nucleic acid sequence of the mRNA transcript encoded by the target gene. (genomeweb.com)

A proprietary buffer (buffer CA) is used to equilibrate matrix effects caused by chromatography reagents, thereby improving the recovery of the nucleic acids from bioprocess samples. (qiagen.com)

The SpectraMax ® QuickDrop ™ Spectrophotometer is a versatile ultraviolet-visible (UV-Vis) micro-volume spectrophotometer exceptional at analyzing nucleic acid samples. (moleculardevices.com)
In this application note, we demonstrate how the QuickDrop spectrophotometer can both quantitatively (concentration) and qualitatively (sample purity) analyze nucleic acid samples with great accuracy and consistency. (moleculardevices.com)
However, the labor-intensive process of extracting nucleic acids from these samples and the potential for nucleic acid damage pose significant obstacles, limiting the use of FFPE samples. (grandviewresearch.com)

China has reportedly found the COVID-19 virus in food imports from India, the United States and Canada following nucleic acid tests on imported food and packaging. (foodsafetynews.com)

To identify nucleic acid their permanent residency was unknown. (cdc.gov)

Anatomy5

Organisms13

Diseases3

Chemicals and Drugs119

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes59

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture9

Information Science12

Health Care5

Proteins10

Viral9

Amplification Test2

Molecules6

Sequences3

Double-stranded2

Stable nucleic3

Compositions6

Detection10

Particles3

Therapeutics4

Purification9

Amino acids1

Lipid2

Molecule1

Detect3

Vaccine2

Biological1

Genetic material1

Protein4

Analytical1

Compounds2

Nucleotide1

Abstract2

Bound2

SiRNA1

Extraction6

Biotechnology1

Genome1

Particle1

Chemistry2

Representative1

Invention provides1

Methods1

Structural1

Facilitate1

Synthetic1

Test2

Patent2

Cells2

Diagnosis1

Cell1

Bases1

Recovery1

Samples3

Tests1

Identify1