Fundamental protein stability. Medical search. Frequent questions

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Anatomy14

Cell Line HEK293 Cells Cell Line, Tumor HeLa Cells COS Cells Cells, Cultured Cell Nucleus NIH 3T3 Cells Cytoplasm Cell Membrane Fibroblasts HCT116 Cells Tumor Cells, Cultured Neurons

Organisms10

Escherichia coli Saccharomyces cerevisiae Cercopithecus aethiops Bacteriophage T4 Mice, Knockout Cricetinae Mice, Inbred C57BL Cattle Arabidopsis Bacillus

Diseases1

Genomic Instability

Chemicals and Drugs97

Proteins Proteasome Endopeptidase Complex Ubiquitin Guanidine Ubiquitin-Protein Ligases RNA, Messenger Urea Solvents Recombinant Proteins Muramidase Transcription Factors Mutant Proteins DNA-Binding Proteins Nuclear Proteins Recombinant Fusion Proteins Bacterial Proteins Leupeptins Tumor Suppressor Protein p53 Amino Acids Proto-Oncogene Proteins c-mdm2 Multiprotein Complexes Salts Lysine RNA, Small Interfering Water Carrier Proteins Serine Membrane Proteins DNA Proteasome Inhibitors Solutions F-Box Proteins Cell Cycle Proteins Tumor Suppressor Proteins Protein-Serine-Threonine Kinases DNA Primers Repressor Proteins Cysteine Ribonucleases Complex Mixtures Glycogen Synthase Kinase 3 Disulfides Lactalbumin Proto-Oncogene Proteins c-myc Peptides Peptidylprolyl Isomerase Hypoxia-Inducible Factor 1, alpha Subunit Cullin Proteins Apoproteins Trans-Activators SUMO-1 Protein Saccharomyces cerevisiae Proteins Protein Isoforms Proline Ubiquitins Molecular Chaperones Alanine HSP90 Heat-Shock Proteins Ubiquitin-Specific Proteases Micrococcal Nuclease RNA-Binding Proteins Plant Proteins Protein Subunits Ligands Tryptophan SKP Cullin F-Box Protein Ligases Escherichia coli Proteins Ribonuclease T1 Multienzyme Complexes Histidine Intracellular Signaling Peptides and Proteins Green Fluorescent Proteins Arabidopsis Proteins Cysteine Endopeptidases Peptide Hydrolases Small Ubiquitin-Related Modifier Proteins Drosophila Proteins Proto-Oncogene Proteins Thermolysin Methylamines RNA Protein Synthesis Inhibitors beta-Transducin Repeat-Containing Proteins Adaptor Proteins, Signal Transducing Threonine Cycloheximide Anilino Naphthalenesulfonates Hypoxia-Inducible Factor-Proline Dioxygenases Cyclin-Dependent Kinase Inhibitor p21 Endopeptidases Chymotrypsinogen PTEN Phosphohydrolase Enzymes Fungal Proteins Casein Kinase II Sarcosine Myoglobin

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Enzyme Stability Drug Stability Protein Denaturation Models, Molecular Circular Dichroism Amino Acid Substitution Protein Engineering Mutagenesis, Site-Directed Protein Unfolding Calorimetry, Differential Scanning Models, Biological Models, Chemical Crystallography, X-Ray Sequence Alignment Spectrometry, Fluorescence Transfection Immunoprecipitation Blotting, Western Sequence Analysis, Protein Molecular Dynamics Simulation Calorimetry Two-Hybrid System Techniques Nuclear Magnetic Resonance, Biomolecular Immunoblotting Magnetic Resonance Spectroscopy Reverse Transcriptase Polymerase Chain Reaction Protein Interaction Mapping Microscopy, Fluorescence Spectrophotometry, Ultraviolet Models, Genetic Cloning, Molecular Gene Knockdown Techniques Drug Storage Electrophoresis, Polyacrylamide Gel Precipitin Tests Directed Molecular Evolution Spectrum Analysis

Phenomena and Processes92

Protein Stability Enzyme Stability Protein Denaturation Thermodynamics Protein Folding Mutation RNA Stability Amino Acid Sequence Protein Conformation Protein Structure, Tertiary Protein Binding Ubiquitination Temperature Protein Structure, Secondary Proteolysis Amino Acid Substitution Protein Unfolding Kinetics Hot Temperature Base Sequence Half-Life Protein Processing, Post-Translational Binding Sites Hydrogen Bonding Signal Transduction Phosphorylation Hydrogen-Ion Concentration Structure-Activity Relationship Static Electricity Transcription, Genetic Mutation, Missense Gene Expression Regulation Transition Temperature Amino Acid Motifs Hydrophobic and Hydrophilic Interactions Time Factors Sequence Homology, Amino Acid Transfection Algorithms Protein Structure, Quaternary Point Mutation Protein Transport Protein Multimerization Plasmids Entropy Solubility Dimerization Sumoylation Molecular Dynamics Simulation Phenotype Protein Biosynthesis Cell Cycle Conserved Sequence Down-Regulation Mutagenesis RNA Interference Protein Interaction Domains and Motifs Evolution, Molecular Genomic Instability Molecular Structure Sequence Deletion Cell Proliferation Apoptosis Surface Properties Catalytic Domain Physicochemical Phenomena Promoter Regions, Genetic Gene Expression Transcriptional Activation DNA Damage Substrate Specificity Catalysis Acetylation Molecular Conformation RNA Processing, Post-Transcriptional Glycosylation Fluorescence Biophysical Phenomena Active Transport, Cell Nucleus Genes, Reporter Nucleic Acid Conformation Up-Regulation Osmolar Concentration Gene Deletion Hydrolysis Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Oxidation-Reduction Species Specificity Biomechanical Phenomena Cell Survival Cell Differentiation

Disciplines and Occupations3

Computational Biology Chemistry, Physical Biophysics

Information Science8

Molecular Sequence Data Amino Acid Sequence Base Sequence Computer Simulation Algorithms Molecular Dynamics Simulation Databases, Protein Software

Health Care2

Temperature Hot Temperature

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Disciplines and Occupations Information Science Health Care

Protein Stability Enzyme Stability Drug Stability Protein Denaturation Thermodynamics Protein Folding Models, Molecular Mutation Molecular Sequence Data RNA Stability Proteins Amino Acid Sequence Protein Conformation Protein Structure, Tertiary Protein Binding Ubiquitination Temperature Circular Dichroism Proteasome Endopeptidase Complex Protein Structure, Secondary Proteolysis Ubiquitin Amino Acid Substitution Protein Engineering Guanidine Mutagenesis, Site-Directed Cell Line Protein Unfolding Ubiquitin-Protein Ligases Kinetics Calorimetry, Differential Scanning Models, Biological Hot Temperature Base Sequence Half-Life Protein Processing, Post-Translational RNA, Messenger HEK293 Cells Binding Sites Urea Hydrogen Bonding Computer Simulation Models, Chemical Escherichia coli Signal Transduction Phosphorylation Solvents Recombinant Proteins Hydrogen-Ion Concentration Muramidase Cell Line, Tumor Structure-Activity Relationship Static Electricity Transcription, Genetic Transcription Factors Mutation, Missense Mutant Proteins Gene Expression Regulation DNA-Binding Proteins Transition Temperature Nuclear Proteins Amino Acid Motifs Hydrophobic and Hydrophilic Interactions Recombinant Fusion Proteins Bacterial Proteins Crystallography, X-Ray Sequence Alignment Time Factors Sequence Homology, Amino Acid Spectrometry, Fluorescence Leupeptins HeLa Cells Tumor Suppressor Protein p53 Transfection Algorithms COS Cells Amino Acids Proto-Oncogene Proteins c-mdm2 Protein Structure, Quaternary Multiprotein Complexes Point Mutation Salts Protein Transport Cells, Cultured Protein Multimerization Plasmids Lysine Entropy Saccharomyces cerevisiae RNA, Small Interfering Water Immunoprecipitation Blotting, Western Carrier Proteins Serine Solubility Membrane Proteins Dimerization Sequence Analysis, Protein Sumoylation

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