Functions of mucins. Medical search. Frequent questions

MUC-16 is a member of the mucin family glycoproteins. (wikipedia.org)
The MUC7 gene belongs to a group of genes encoding soluble mucin glycoproteins. (benthamscience.com)
The histological analysis showed that the MPLE dietary supplementation promoted an increase in the number of intestinal goblet cells and modified the composition of mucins' glycoproteins stored in goblet cells, with an increase in the staining intensity of neutral mucins, as well as in mucins rich in carboxylated and weakly sulfated glycoconjugates, particularly those rich in sialic acid residues. (nih.gov)
For example, mucus may function to promote nucleation, whereas bile-specific glycoproteins may function to inhibit nucleation. (medscape.com)
Mucus comprises water, glycoproteins (mucins), and ions. (bmj.com)
Mucins are glycoproteins that are expressed in cells of different types and fulfill multiple functions that determine participation of these proteins in such processes as signal transduction, regulation of gene expression, cell proliferation, embryogenesis, cell differentiation, immunity, apoptosis and cancer development. (benthambooks.com)
BACKGROUND AND AIMS: Trefoil factor family (TFF) peptides and the chromosome 11p15.5 mucin glycoproteins are expressed and secreted in a site specific fashion along the length of the gastrointestinal tract. (embl.de)
Mucin is large group of glycoproteins consisting of a linear polypeptide backbone with alternating naked and densely glycosylated regions. (mit.edu)
The upper layer of the colonic mucus is a niche for a subset of the microbiota which utilise the mucin glycoproteins as a nutrient source and mucin grazing by the microbiota appears to play a key role in maintaining barrier function as well as community stability. (biorxiv.org)
Mammalian mucins, glycoproteins that are major constituents of the glycocalyx that covers mucosal epithelium. (embl.de)
The human genome contains at least 35 genes that encode Golgi sulfotransferases that function in the secretory pathway, where they are involved in decorating glycosaminoglycans, glycolipids, and glycoproteins with sulfate groups. (lu.se)

In particular, the study focused on the effect of these phytogenic compounds on the gut condition by analyzing the transcriptomic profiling (microarray analysis) and histological structure of the intestinal mucosa, as well as the histochemical properties of mucins stored in goblet cells. (nih.gov)
It is involved in the synthesis of mucin, a protein supporting intestinal function and integrity. (sigmaaldrich.com)
A clear understanding of the function of macrophages, as well as their role in pathogens and inflammatory response, will delineate the next steps in the treatment of intestinal inflammatory diseases. (frontiersin.org)
Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. (embl.de)
Here we describe the discovery and characterisation of endo-acting family 16 glycoside hydrolases (GH16s) from prominent mucin degrading gut bacteria that specifically target the oligosaccharide side chains of intestinal mucins from both animals and humans. (biorxiv.org)
The data suggest a new paradigm for mucin breakdown by the microbiota and the endo-mucinases provide a potential tool to explore changes that occur in mucin structure in intestinal disorders such as inflammatory bowel disease and colon cancer. (biorxiv.org)
2 Diagnosis of small cell (neuroendocrine) or mucinous adenocarcinoma of cervical cancer (ie, mucinous NOS, intestinal type, signet ring cell type, invasive stratified mucin producing carcinoma and gastric type) based on 2020 WHO classification of cervical cancer. (who.int)

Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)

The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)

This volume introduces readers to the general properties of mucins, followed by chapters on specific variants of gel-forming and soluble mucins. (benthambooks.com)

Mucin MUC7, Mucins - Potential Regulators of Cell Functions Volume Title: Gel-Forming and Soluble Mucins (2013) 1: 398. (benthamscience.com)

MUC16 is more than twice as long as MUC1 and MUC4 and contains about 22,000 amino acids, making it the largest membrane-associated mucin. (wikipedia.org)
Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
Meanwhile, MUC1, MUC4, and MUC16 are transmembrane (TM) mucins that can facilitate or restrict microbial invasion at the apical surface of the epithelium. (breathinglabs.com)
The study found that during SARS-CoV-2 infection, endogenously expressed TM mucins MUC1 and MUC16 played a protective role. (breathinglabs.com)
However, given the current state of research, it is difficult to conclude whether some specific mucins, such as MUC1, MUC4, or MUC16, or TM mucins in general are protective or contribute to severe disease, within the complexity of the body, during different stages of pathogenesis. (breathinglabs.com)
This disease, previously referred to as MCKD type 1, is due to a mutation in the variable-number tandem repeat region of the MUC1 (Mucin 1) gene. (medscape.com)

Mini Multi Function Formula Snail Mucin Repair Serum. (danglifestyle.co)
The same way snails regenerate their own shell, our snail mucin repair serum will reinforce skin regeneration, reduce acne scars, moisturize dry skin, soothe damaged skin, and give you an instant glow. (danglifestyle.co)
The multi-function snail mucin repair serum takes what nature has given us and turns it into a safe formulation that not only protects your skin but keeps it healthy and glowing. (danglifestyle.co)
What Will the Multi-Function Formula Snail Mucin Repair Serum Do? (danglifestyle.co)
Is the Multi Function Formula Snail Mucin Repair Serum good for me? (danglifestyle.co)
Be the first to review "Mini Multi Function Formula Snail Mucin Repair Serum. (danglifestyle.co)
Snail Mucin: Where Does The Product Fit In Your Skincare Routine? (women.com)
Unconventional ingredients are used as well, including snail mucin, also known as snail slime or snail excretion. (women.com)
Since the Korean brand, Missha, first introduced its Super Aqua Cell Renew Snail Cream , which claims to have 70% snail slime extract, the use of snail mucin has expanded to serums, face masks, and cleansers. (women.com)
Although it is more than 90% water (per The Conversation ), Byrdie lists the following as its components: allantoin, zinc, manganese, copper peptides, glycolic acid, and vitamins A and E. These ingredients help make snail mucin a "mega multi-tasker" that addresses various skin concerns. (women.com)
Dermatologist Dr. Ted Lain told Byrdie that this harvesting process infuses snail mucin with the ingredients that contribute to its skin-repairing and protecting capacity. (women.com)
Plus, just as skeptics point to the lack of long-term studies substantiating its benefits, enthusiasts cite the lack of documented side effects from snail-mucin use. (women.com)
If you're curious to see how it works for your skin, start with a water-based snail mucin essence, as cosmetic chemist Georgia Smith suggested to Everyday Health , before leveling up to serums with their higher concentrations. (women.com)
Dermatologist Dr. Rosemarie Ingleton also advised via Elle to treat snail mucin as an additional step to skin hydration. (women.com)

Mucin-16 (MUC-16) also known as Ovarian cancer-related tumor marker CA125 is a protein that in humans is encoded by the MUC16 gene. (wikipedia.org)
We have now cloned a mouse homolog of the human pS2 cDNA to dispose of an animal model to study the pS2 protein function, which remains unknown at the present time. (xenbase.org)
Both PWN loading and hypoxia enhanced tracheal elasticity and thickened the apical extracellular matrix (aECM) of the tracheal tubes while a notable upregulated expression of a resilin-like mucin protein Muc91C was observed at the aECM layer of PWN-loaded and hypoxic tracheal tubes. (elifesciences.org)
Apart from being an acidic medium containing an assortment of antimicrobial molecules including antibodies (IgA and IgG), mucins, β-defensins, secretory leucocyte protease inhibitor (SLPI), neutrophil gelatinase-associated lipocalin (NGAL), surfactant protein etc. (frontiersin.org)
encodes a protein that belongs to the mucin family of. (mingsheng88.org)
Module IV resembles the CT domain of several extracellular protein including, Von Willebrand's factor and mucins. (neuromics.com)
CD366 also known as TIM-3 (T-cell immunoglobulin and mucin containing protein-3) is a type I transmembrane protein that in humans is encoded by the HAVCR2 gene. (beckman.com)

We tested the hypothesis that individual trefoil peptides are uniquely localised with specific mucins in the UACL and normal gastrointestinal epithelia. (embl.de)
Documenting the function of specific mucins during in vivo infections will be important for future research. (breathinglabs.com)

The goal of the research is to elucidate the functions of transmembrane mucins in health and disease. (uu.nl)
This study analyzed the role played by transmembrane mucins and their terminal glycans in the SARS-CoV-2 entry process in primary airway cultures and a respiratory cell line. (breathinglabs.com)

METHODS: Expression of mucin genes in the UACL from small bowel tissue of patients with Crohn's disease was detected by in situ hybridisation, and localisation of the products by immunohistochemistry. (embl.de)
In support to this hypothesis, the microarray analysis revealed two up-regulated genes, and (Table 2, Physique 3) that play important functions in the host defense against bacterial pathogens. (mingsheng88.org)

1, 2 This review approaches the role of mucin degrading enzymes from the potential interaction of micro-organisms with the cervical mucus barrier, and discusses the contribution that mucin degrading enzymes may make to microbial colonisation of the reproductive tract. (bmj.com)
3 In the female reproductive tract a primary function of the cervical mucus is the defence of the upper reproductive tract from microbial invasion. (bmj.com)
Mucus has an integrated antibacterial function. (bmj.com)

MUC5AC and MUC5B are gel-forming mucins that clear pathogens by mucociliary clearance. (breathinglabs.com)
TM mucins MUC16 and MUC4 and secreted mucin MUC5AC were almost undetectable. (breathinglabs.com)

A recent PLOS Pathogens study analyzed the role played by host mucins and mucin glycans with regard to SARS-CoV-2 entry into the airway epithelial cells. (breathinglabs.com)

StcE, which is the mucin-selective protease, cleaves the glycosylated extracellular portion of the mucins without disturbing the underlying domains. (breathinglabs.com)
Viral infection was enhanced with enzymatic removal of extracellular mucin domains, but not individuals' fucose sugars or sialic acid. (breathinglabs.com)
Based on these observations, a model was proposed in which glycosylated extracellular mucin domains form a protective layer on the ACE2 receptor. (breathinglabs.com)
In sum, this study sheds light on the role of glycosylated extracellular mucin domains as a host defense mechanism during SARS-CoV-2 entry. (breathinglabs.com)

Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
MUC7 provides an opportunity to assess the broader implications of subexonic repeat variation within the context of the functional evolution of the mucin functional group and primate salivary adaptation. (nature.com)
and the role of posttranslational modifications of the MUC7 apomucin in expression of the functions embedded in its polypeptide structure. (benthamscience.com)

Mucin provides a protective barrier toward pathogens and lubricates the epithelial surface. (mit.edu)

Mucinases are enzymes capable of degrading mucins (the complex high molecular weight molecules that are the major non-aqueous components of mucous gels). (bmj.com)
Partial or complete degradation of mucin molecules by microbial enzymes is often a fundamental step in disruption of defensive mucosal barriers, as these constitute direct interfaces between internal and external environments. (bmj.com)
Mucins are represented by two types of molecules: secreted mucins and membrane-bound (receptor) mucins. (benthambooks.com)
As one of the work packages in the SMELLODI, we focus on the computational modeling of mucin-based receptors (synthesized by HUJI) for body odor molecules adsorption process by atomistic simulations. (nano-tud.de)

Mucin hypersecretion by the gallbladder mucosa creates a viscoelastic gel that fosters nucleation. (medscape.com)
The function of the gallbladder is to provide a reservoir for the storage and concentration of bile. (cdc.gov)

Epithelial mucins can be classified into two distinct families: secretory (gel forming) and membrane bound. (bmj.com)
Additionally, there is concomitant production of mucins, immunoglobulins (secretory IgA and IgG), secretory leucocyte protease inhibitor (SLPI), neutrophil gelatinase-associated lipocalin (NGAL), and β-defensins, and other antimicrobial proteins, which all together provide a formidable first line of defense against infection. (frontiersin.org)

T cell immunoglobulin and mucin domain 3 (Tim-3) is a key checkpoint receptor responsible for exhaustion and dysfunction of T cells and plays a critical role in immunosuppression. (medscimonit.com)
A broad antibody response was detected that included immunoglobulin G (IgG) and IgA subtypes with demonstrable Fc-mediated effector function targeting multiple viral antigens. (cdc.gov)

Despite the importance of mucin breakdown for gut health, the mechanisms by which gut bacteria access this complex glycoprotein are not well understood. (biorxiv.org)

namely, MUC3, MUC4, MUC12, MUC13, and the recently described mucin MUC17, which share a C-terminal structural domain that consists of two or three epithelial growth factor (EGF)-like regions, a transmembrane segment, and a short cytoplasmic tail. (bmj.com)

Rationale Mucin homeostasis is fundamental to airway health . (bvsalud.org)

The expression of mucin 16 has been shown to be altered in dry eye, cystic fibrosis, and several types of cancers. (wikipedia.org)
Levels of expression of breast epithelial mucin detected by monoclonal antibody BrE-3 in breast-cancer prognosis. (xenbase.org)
Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
CONCLUSIONS: The UACL has a unique profile of mucin gene expression. (embl.de)
In this study, we examined the expression, regulation, and functions of HPK1 in pancreatic ductal adenocarcinomas (PDA). (aacrjournals.org)
We identified a significant induction of epithelial alarmin (thymic stromal lymphopoietin-TSLP)-dependent interleukin-13 pathway after co-exposure, associated with increased mucin and interferon gene expression. (cdc.gov)

Mucins are highly glycosylated proteins that serve a variety of roles in organisms from lubrication to cell-signaling to defense 7 . (nature.com)
Mucins are a family of high molecular weight O-glycosylated proteins. (breathinglabs.com)
CCN proteins are matricellular proteins which are involved in the regulation of various cellular functions including: proliferation, differentiation, survival, adhesion and migration. (neuromics.com)
It is the leasts conserved one of the four domains at the level of nucleotide sequence, but it appears to be critical for several of the biological functions attributed to the CCN proteins. (neuromics.com)

Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. (embl.de)
Coordinated localisation of trefoil peptides and mucins in UACL and normal gastrointestinal epithelia suggests they may assist each others' functions in protection and repair of gastrointestinal mucosa. (embl.de)

Mast cells, which are found in many body tissues including the skin, are important for the normal protective functions of the immune system. (medlineplus.gov)

Based on specific shifts of microbial species in the PD gut, the researchers speculated that the microbiome could interfere with the production of short chain fatty acids, or the permeability of the mucosal gut barrier-two functions intimately linked with inflammation and potentially with neurodegeneration. (alzforum.org)

Research work in Karin's group explores how commensal and pathogenic bacteria interact with mucins and impact their signaling. (uu.nl)
R torques are mucin degraders that induce an increase in other mucin-using bacteria, which can contribute to gut-barrier compromise. (medscape.com)

Mucin 1 lies on the tubular cell apical surface and has a role in signal transduction pathways. (medscape.com)

The possible contribution of mucin degrading enzymes to the pathogenesis of infection is, therefore, not to be underestimated. (bmj.com)

Biliary disease is caused by abnormalities in bile composition, biliary anatomy, or function. (medscape.com)
Secreted by the liver, bile is composed largely of bile salts, bile pigments and small amounts of organic materials such as cholesterol, lecithin, fatty acid and mucin. (cdc.gov)
Overview of Biliary Function The liver produces about 500 to 600 mL of bile each day. (msdmanuals.com)

The current model for mucin degradation involves exclusively exo-acting glycosidases that sequentially trim monosaccharides from the termini of the glycan chains to eventually allow access to the mucin peptide backbone by proteases. (biorxiv.org)

Dentists are involved with aspects of salivary gland function in several ways, such as diagnosing problems involving the major and minor salivary glands, in the management of oral dryness associated with salivary problems, in the treatment of caries and periodontal disease resulting from decreased salivary flow, and in controlling salivation during restorative procedures. (medscape.com)
It was once thought that salivary function did not change significantly with age. (medscape.com)
More recent research, however, suggests that salivary function in the major glands may diminish with increasing age. (medscape.com)

This E-book series on mucins presents critical reviews on modern data concerning structures and functions of mucins, their roles in cell physiology and pathology as well as molecular aspects of therapy of mucin-associated diseases. (benthambooks.com)
This e-book series represents a unique attempt to describe the molecular nature of mucin multifunctionality in separate volumes. (benthambooks.com)

however, it also plays an active role in the maintenance of absorption, regulation of barrier function, and immune homeostasis [ 1 ]. (hindawi.com)

Hereditary Mucin Deficiency Caused by Biallelic Loss of Function of MUC5B . (bvsalud.org)
Three siblings heterozygous for the familial MUC5B variant were asymptomatic but had a shared pattern of mild lung function impairments. (bvsalud.org)

Structure-function and biological role of betacellulin. (embl.de)
Because of its interesting characteristic and biological behavior, mucin has been used for the monolayer adsorption onto various types of surfaces. (mit.edu)
Here, we are aiming to understand the biological functions of mucin in detail and combine this knowledge with layer-by-layer assembly to build multilayers which retains the same biological features. (mit.edu)
The researchers also inferred potential biological consequences based on the known functions of some microbial species. (alzforum.org)

Cystic fibrosis (CF) is a disease of exocrine gland function that involves multiple organ systems but chiefly results in chronic respiratory infections, pancreatic enzyme insufficiency, and associated complications in untreated patients. (medscape.com)
Co-exposure induced a significantly greater respiratory function decline compared to individual exposure. (cdc.gov)
A synthetic catalase-superoxide dismutase mimetic (EUK-134) significantly blunted lung inflammation and respiratory function decline confirming the role of oxidant imbalance. (cdc.gov)

For the snails themselves, their slime functions both as an adhesive and a form of defense. (women.com)

Members of each family possess common structural characteristics and at least some common functions. (bmj.com)

We performed whole- genome sequencing in an adult proband with unexplained bronchiectasis , impaired pulmonary function, and repeated Staphylococcus aureus infection . (bvsalud.org)
Macrophages play a significant role in many processes, such as the human immune function, parasite infection, and tissue remodeling by secreting cytokines and producing reactive oxygen and nitrogen intermediates. (frontiersin.org)
Overexpression of TM mucins reduced SARS-CoV-2 infection, in comparison to cells with a non-targeting guide (NTG). (breathinglabs.com)
When this apparatus is disrupted by factors such as infection, low-fiber diet, antibiotics, and alcohol, then it cannot function normally to selectively keep out the harmful intraluminal substances. (medscape.com)

Mucins: structure, function, and associations with malignancy. (xenbase.org)

All mucins contain a tandem repeat domain that has repeating amino acid sequences high in serine, threonine and proline. (wikipedia.org)

The CD4+, CD8+, and regulatory T cells in brain-infiltrating lymphocytes were analyzed using flow cytometry, and the effector function of T cells was assessed using ELISA. (medscimonit.com)

This bacterium is therefore thought to improve gut barrier function, which is commonly compromised in people with PD. (alzforum.org)

This review explores the composition, function and adaptive mechanisms of the vaginal microbiome in health and those disease states in which there is a breach in the host-microbial relationship. (frontiersin.org)

Chapters in each volume demonstrate the central role of mucins as connectors and regulators of different signaling pathways and their participation metastatic processes. (benthambooks.com)
Clinical aspects of mucins, such as their role as diagnostic markers as well as possible applications in mucin-based immuno- and gene-therapies are also discussed. (benthambooks.com)
Thus, HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer. (aacrjournals.org)

It consists of calcium bilirubinate (a polymer of bilirubin), cholesterol microcrystals, and mucin. (msdmanuals.com)

Anatomy5

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

Information Science1

Glycoproteins11

Intestinal7

MUC21

Synthesis of mucin1

Properties of mucins1

Potential Regulators1

MUC18

Snail mucin14

Protein7

Specific mucins2

Transmembrane mucins2

Genes2

Mucus3

MUC5AC2

Epithelial cells1

Extracellular4

MUC73

Pathogens1

Molecules4

Gallbladder2

Secretory2

Immunoglobulin2

Glycoprotein1

MUC41

Airway1

Expression7

Proteins4

Mucosa2

Protective1

Permeability1

Bacteria2

Apical surface1

Pathogenesis1

Bile3

Degradation1

Salivary3

Molecular2

Homeostasis1

MUC5B2

Biological4

Respiratory3

Defense1

Family1

Infection4

Structure1

Amino acid1

Effector function1

Barrier1

Explores1

Role3

Cholesterol1