Functional variations. Medical search. Frequent questions

There has been much debate as to the role of rare genetic variation on complex traits ( 2 - 4 ) and how rare variant studies complement GWASs ( 5 ). (frontiersin.org)
However, little is known about the variation in functional traits of bamboo among different functional group. (biodiversity-science.net)
Data of biological characteristics of these bamboo species was collected and organized from Flora of China , including various types of functional group and different functional traits. (biodiversity-science.net)
Analysis of variance and multiple contrasts were performed to explore the variation in the basic morphological traits of bamboo among the different functional groups. (biodiversity-science.net)
Principal component analysis (PCA) was employed to explore the intrinsic correlations among functional traits and analyze functional trait variation in different functional groups of bamboo plants. (biodiversity-science.net)
The results show that: (1) Sympodial, monopodial and mixed bamboos differed significantly in their functional traits. (biodiversity-science.net)
Variation in basic morphological and functional traits of Chinese bamboo[J]. Biodiv Sci, 2019, 27(6): 585-594. (biodiversity-science.net)
Fig. 1 Variations in morphological traits of bamboo plants with different rhizome types. (biodiversity-science.net)
Functional traits of the species studied were also extracted from a public trait dataset. (santafe.edu)
Here, we synthesise current trait‐based approaches and explore how organisms' functional traits (FTs) can be scaled across time and space. (lancs.ac.uk)
However, the functional relevance of the genetic variants, and their impact on disease or traits, is largely unknown. (lu.se)
To address those questions, we applied functional genomics approaches to study genetic variants pertinent to obesity and type 2 diabetes-related traits. (lu.se)

Workshop recommendations highlighted the need for utilizing and developing improved approaches to methodically evaluate the function and phenotypic outcomes of genomic variation. (nih.gov)
Accumulating data have shown broad phenotypic variations, and extracerebral hemorrhages have been linked to these disorders. (nature.com)

August 19, 2020 - Notice of Pre-Application Webinars for the Impact of Genomic Variation on Function (IGVF) Consortium FOAs. (nih.gov)
The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Genomic Variation and Function Data and Administrative Coordinating Center (DACC). (nih.gov)
The DACC will serve as the coordinating center for the Impact of Genomic Variation on Function (IGVF) Consortium and will be responsible for establishing a resource of consortium generated data, metadata, analyses, methods, and tools, and coordination of consortium activities. (nih.gov)
As a member of the IGVF Consortium, the DACC will work closely with all consortium components to accelerate understanding of how genomic variation impacts human health and disease through the coordination of data collection strategies and analyses. (nih.gov)
One of the central problems in biology is understanding how genomic variation affects genome function to influence phenotypes. (nih.gov)
NHGRI considered this problem in part through a workshop entitled "From Genome to Phenotype: Genomic Variation Identification, Association, and Function in Human Health and Disease" as part of its strategic planning efforts . (nih.gov)
By using a 2-stage genomewide association study process, we compared genomic differences between infection and carriage isolates to address genomic variation associated with pathogenicity. (cdc.gov)

We quantified morphological variation for a composite collection of young-of-year paddlefish (N = 55, 61.9-403.7 mm total length) using nine measurements of the rostrum, body, and caudal fin. (researchgate.net)
The presence of shape variations influenced by size (allometry) was confirmed for T. danubialis (C. Pfeiffer, 1828) indicating that allometry could be a component of the morphological variation of this species. (mapress.com)

Structural variation (SV) influences genome organization and contributes to human disease. (biomedcentral.com)

Genome-wide association studies have been designed primarily to capture common variation and so far some 10,000 common genetic variants have been robustly associated with a wide range of complex diseases ( 1 ). (frontiersin.org)
Prediction tools of deleteriousness and in silico evidence of epigenetic modification were used to prioritize variants for functional evaluation. (northwestern.edu)
Furthermore, no functional variants were observed in the 142 phenotyped controls. (northwestern.edu)
The functional variants were significantly associated with PCOS in our cohort of 608 women with PCOS and 142 controls (P = 2.3 3 1025) and very strongly associated with PCOS relative to a larger non-Finnish European (gnomAD) population-based control cohort (P , 1 3 1029). (northwestern.edu)
First, it demonstrates the importance of having a large number of informants if you want to get a reliable picture of the distribution of certain variants or the ongoing development behind syntactic variation. (benjamins.com)
H Heyne, D Baez-Nieto et al, Predicting functional effects of missense variants in voltage-gated sodium and calcium channels, Sci Transl Med;12(556):eaay6848. (lu.se)

Types of functional group included rhizome type (sympodial, monopodial or mixed), shooting season (spring, summer, autumn or winter) and endemism (371 species endemic to China). (biodiversity-science.net)
In her new book, Kuhle brings together findings from comparative ethology with extensive language-typological data and analysis to argue that tool intelligence, which humans share to various degrees with many other species, can not only explain the patterns of cross-linguistic variation and family resemblance, but also, ultimately, shed light on the question of language evolution. (rowman.com)
Here, we show that across 12 plant species in two phylogenetic lineages of the Brassicaceae, variation in realized herbivore communities reveals a phylogenetic signal in the uncertainty of attack on individual plants. (biorxiv.org)
Variation across plant species in the uncertainty of attack may strongly impact the evolution of such plastic defence strategies. (biorxiv.org)
The divergent shifts are hypothesized to arise from both multivariate environmental variations with elevation and corresponding species-specific responses. (santafe.edu)
The contrasting responses could result from the functional dissimilarity among species. (santafe.edu)
Therefore, a detailed understanding of both local environmental variations and species-specific responses can facilitate accurate predictions of species shifts to inform local species conservation. (santafe.edu)
The purpose of this study was to determine the variation of wood and bark water content and stem growth in response to microclimatic variability in three Amazonian species. (scielo.br)
Patterns of within-stem variations in wood specific gravity and water content for five temperate tree species. (scielo.br)

Facilitated by SciLifeLab's Bioinformatics Platform (NBIS) and National Genomics Infrastructure (NGI), researchers from SciLifeLab and Uppsala University shed light on the genetic "tug-of-war" that acts between sexes to maintain variation. (scilifelab.se)

Research over the past decade has shown that quantifying spatial variation in ecosystem properties is an effective approach to investigating the effects of environmental change on ecosystems. (lancs.ac.uk)
We have constrained the spatial variation of the fine structure constant using multi-frequency measurements of the thermal Sunyaev-Zeldovich effect of 618 X-ray selected clusters. (mdpi.com)

However, there is still limited research into spatial and temporal variation patterns of bacterial community assemblages in mangrove soils. (frontiersin.org)
Typically, variation patterns in the data can be decomposed in descending order of eigenvalues with the directions represented by the corresponding eigenvectors or eigenfunctions. (wikipedia.org)

Functional impact of global rare copy number variation in autism spectrum disorders. (ox.ac.uk)
Unlike physical disorders that are functional difficulties in school-aged to children aged 5-17. (cdc.gov)
Differential reinforcement as treatment for behavior disorders: Procedural and functional variations. (bvsalud.org)

Functional connectivity has been studied with different imaging modalities such as electroencephalogram (EEG), magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI). (unm.edu)
Functional connectivity analysis of the human brain in fMRI researches focuses on identifying meaningful brain networks that have coherent activity either during a task or in the resting state. (unm.edu)
Later, we also show that interaction between fMRI networks is not only frequency dependent and temporally dynamic but also may occur cross different frequency spectra which is the first evidennce of cross-frequency depenence between fMRI functional networks. (unm.edu)

We also discovered an enrichment of CNVs disrupting functional gene sets involved in cellular proliferation, projection and motility, and GTPase/Ras signalling. (ox.ac.uk)
In the galactose-utilization (GAL) pathway of Saccharomyces cerevisiae , gene induction is unimodal or bimodal depending on natural genetic variation and pre-induction conditions. (elifesciences.org)
Several common variations (polymorphisms) in the OCA2 gene reduce the amount of functional P protein that is produced. (medlineplus.gov)
Several functional studies have reported that the Ahl gene renders mice more susceptible to noise -induced hearing loss (NIHL) than strains which do not carry this gene [e.g. (cdc.gov)

These differences were not reflected in the ambient water, suggesting that other environmental or host-specific factors may drive the observed geographic variation. (nature.com)
Can brain state be manipulated to emphasize individual differences in functional connectivity? (crossref.org)
To determine whether genetic variation is unevenly enriched in S. pneumoniae infection isolates, we used multiple GWAS analyses to compare genomic differences between infection and carriage isolates. (cdc.gov)
The individual variation in outcomes to repeated strains seen in humans probably results from differences in calcium buffering capacity or bioenergetics. (cdc.gov)

The fixed anatomy of the DVS system and the prevalence of certain anatomic variations are relatively well-understood. (ajnr.org)
Consistent with the definition established by the Americans for Disabilities Act (ADA), the ACS subcommittee determined that, in order to measure prevalence, the concept of disability would be operationalized as functional limitations that would put the individual at a greater risk of participation restrictions. (cdc.gov)
692. In Yarmouk University, most students, demonstrated a marked variation in the nearly 90%, were enrolled in undergraduate prevalence of smoking [ 11 - 21 ]. (who.int)

An increased understanding of the spatial and temporal variation of bacterial communities is critical when assessing delivery of ecosystem services and their role in soil biogeochemical processes. (frontiersin.org)
Yet, current consensus among scientists is that we need a better understanding of short‐ and long‐term (temporal) variation in ecosystem properties to plan effective ecosystem management and predict future ecologies. (lancs.ac.uk)

Genome-wide association studies are therefore, underpowered to detect rare variation. (frontiersin.org)
6 ). In-depth whole-genome sequencing is the most comprehensive approach for measuring rare and common variation in both coding and non-coding regions. (frontiersin.org)

In her new book, Tool Intelligence as an Explanation of Cross-Linguistic Variation and Family Resemblance: An Evolutionary and Typological Investigation , Anneliese Kuhle has rendered the cognitive, linguistics, and evolutionary communities a great service. (rowman.com)

Here, we discuss the organization of human centromeres as well as genomic and functional variation in human centromere location, and current understanding of the genomic and epigenetic mechanisms that underlie centromere flexibility in humans. (duke.edu)

The latter has the advantage of having relatively higher spatial resolution of the underlying functional regions and is our choice for the source of the data in this work. (unm.edu)
Both in principal component analysis (PCA) and in functional principal component analysis (FPCA), modes of variation play an important role in visualizing and describing the variation in the data contributed by each eigencomponent. (wikipedia.org)
In real-world applications, the eigencomponents and associated modes of variation aid to interpret complex data, especially in exploratory data analysis (EDA). (wikipedia.org)
The high-dimensional genomic data can provide unprecedented resolution for identifying subtle genomic variations. (cdc.gov)
Selected estimates are shown for timely data about the characteristics and the educational and health care service use of children with and without basic service use of children with functional actions difficulty. (cdc.gov)
These data show, for the first time, that miRNA-related genetic variations may underlie the etiology of breast cancer in both populations of African and European ancestries. (cdc.gov)
Functional data from each mouse were aligned with the cytocochleogram using the frequency-place map of Ou et al. (cdc.gov)

Functional principal component analysis provides methods for the estimation of μ ( t ) {\displaystyle \mu (t)} and G ( s , t ) {\displaystyle G(s,t)} in detail, often involving point wise estimate and interpolation. (wikipedia.org)
Riesselman A, Ingraham J, Marks D, Deep generative models of genetic variation capture the effects of mutations, Nat Methods;15(10):816-822. (lu.se)

The challenge arises in measuring and statistically analyzing rare variation. (frontiersin.org)
Here, we find that this variation in modality arises from regulation of two features of the pathway response: the fraction of cells that show induction and their level of expression. (elifesciences.org)

The percentage of children several summary measures of functional with difficulty in specific domains varied: 3% had sensory difficulty, 2% difficulties based on NHIS questions movement difficulty, 9% cognitive difficulty, and 10% emotional or behavioral have been proposed (3,5). (cdc.gov)

To test this hypothesis, we sampled soils and leaves to measure elevation variations in soil conditions and determined plant responses using discriminations against heavier isotopes, carbon (13C) and nitrogen (15N). (santafe.edu)

and Denessiouk, Konstantin, "Structural Leitmotif and Functional Variations of the Structural Catalytic Core in (chymo)trypsin-like Serine/cysteine Fold Proteinases" (2021). (usf.edu)

Finally, we show that both natural variation and pre-induction conditions achieve changes in modality by tuning the expression and activity of a single signaling protein in the GAL pathway. (elifesciences.org)

The importance of low frequency and rare variation in complex disease genetics is difficult to estimate in patient populations. (frontiersin.org)
For dense genotyping arrays, imputation is able to predict nearly all missing common variation with high accuracy, but as the variant minor allele frequency (MAF) decreases, so does the accuracy of imputation, depending mainly on the size of the reference panel and the ancestry of the imputed samples, with the best efficiencies in European cohorts, mainly due to the sufficiently large size of the European reference panels ( 7 - 13 ). (frontiersin.org)
1% frequency) copy number variation in ASD using dense genotyping arrays. (ox.ac.uk)

Using this simple framework, we can explain the variation in modality we observed and predict how new perturbations would affect modality. (elifesciences.org)

Synchronous activity related to the functions of the brain is commonly referred to as functional connectivity (FC) and is studied in the form of connectivity states of the brain which measure degree of interactions between distributed parts of the brain. (unm.edu)
Recent studies of functional connectivity have shed light on new aspects of functional connectivity. (unm.edu)
We also discuss that all of these observations would enable us to design novel measures to explain RS-connectivity variation among different group of subjects such as healthy and diseased or males and females which would have clinical diagnosis applications and could possibly serve as new bio-markers to study underlying functions of the brain. (unm.edu)

We identified 98 candidate genes containing rare variation that in aggregate show association with SLE many of which have recognized immunological function, but also function and expression related to relevant tissues such as the joints, skin, blood or central nervous system. (frontiersin.org)
We have previously tested the overall effect of imputed rare variation on particular genes in systemic autoimmunity ( 14 ). (frontiersin.org)
Recently, we have implemented and successfully applied a method based on genotype imputation of rare variation, on a set of genes detected by exome sequencing as possible candidates for association to systemic lupus erythematosus (SLE) by mutation in members of Icelandic SLE-multicase families ( 15 ). (frontiersin.org)
Many of these genes are of fundamental importance for male and female life histories, so this form of genetic conflict between the sexes seems to contribute in a very important way to the maintenance of genetic variation," Arnqvist continues. (scilifelab.se)
Eye color is determined by variations in a person's genes. (medlineplus.gov)

Genomic and functional variation of human centromeres. (duke.edu)
Since variations in human exposure and response, together with the necessity for repeated tissue sampling, make man unsuitable as a research subject, we have developed a rat model of repeated strain injury. (cdc.gov)

Our results reveal many new genetic and functional targets in ASD that may lead to final connected pathways. (ox.ac.uk)

For children, early identification of children with functional difficulties can disability (7). (cdc.gov)

MRI links stem water content to stem diameter variations in transpiring trees. (scielo.br)

This article delves into the fascinating world of Thin Skin Hair Systems, exploring the diverse variations in colors, styles, and hair types, enabling men to make informed choices for their unique hair loss needs. (opensquares.org)
4) The contrasting responses among the three types of shifters agree with their functional dissimilarity, suggested by their separate locations in a multitrait space. (santafe.edu)
A substantially higher percentage of children with basic actions difficulty used measure presented in this report is a health care services, including mental health care, other types of therapy, and broad summary measure of functional prescription medication, than children without basic actions difficulty. (cdc.gov)
Analysis of functional elements as well as a quantitative examination of three established code-switching types was made. (lu.se)

To evaluate the interobserver variation for the AO/OTA fracture classification system: region forty-three-pilon fractures. (lww.com)

These results show that for bamboo plants, the variation in capturing light resources in both horizontal and vertical directions may be the key factors driving the systematic evolution, the endemic distribution and the seasonal difference in bamboo shooting. (biodiversity-science.net)

Functional difficulties in children therapies, and educational services can by the concept of basic actions difficulty have major consequences for children lessen the impact on development (1). (cdc.gov)

This paper discusses some methodological issues in variation studies, drawing mainly on experience gathered in work on syntactic variation in Insular Scandinavian. (benjamins.com)

Taken together, the divergent shifts are associated with the elevation variations in environmental conditions and contrasting plant responses. (santafe.edu)

In statistics, modes of variation are a continuously indexed set of vectors or functions that are centered at a mean and are used to depict the variation in a population or sample. (wikipedia.org)

This work shows that in a typical rainfall year, climatic variability is not large enough to cause significant variation in stem growth, even when rainfall seasonality may cause variation in bark water content. (scielo.br)

We interpret the results as evidence that learning an L2 that lacks variation for a particular feature may lead to reduced sensitivity to that feature as a cue in an analogous L1 structure. (cambridge.org)
While a child's eye color can often be predicted by the eye colors of his or her parents and other relatives, genetic variations sometimes produce unexpected results. (medlineplus.gov)

Modes of variation are a natural extension of PCA and FPCA. (wikipedia.org)

Anatomy1

Organisms3

Diseases1

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes53

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Named Groups3

Health Care21

Geographicals3

Traits12

Phenotypic2

Genomic variation7

Morphological variation2

Structural variation1

Variants6

Species9

Genomics1

Spatial variation2

Patterns2

Disorders3

FMRI3

Gene4

Differences4

Prevalence3

Temporal2

Genome2

Evolutionary1

Organization1

Data7

Methods2

Arises2

Sensory1

Hypothesis1

20211

Pathway1

Frequency3

Perturbations1

Connectivity3

Genes5

Human2

Reveal1

Disability1

Diameter1

Types4

Evaluate1

Show1

Impact1

Studies1

Conditions1

Functions1

Content1

Results2

Natural1