• Sprague-Dawley (SD) rats were subjected to bilateral renal artery clamping for 45 min followed by perfusion restoration for establishing a simulated renal IRI model. (frontiersin.org)
  • A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
  • Rats, subjected to bilateral renal ischemia (45 min) followed by reperfusion (6 h), were administered EUK-134 (0.3 and 3 mg/kg, i.v.) prior to and during reperfusion, after which biochemical and histological indicators of renal dysfunction and injury were measured. (scienceopen.com)
  • Animals underwent bilateral renal ischemia (45 min) 6 weeks later. (jocmr.org)
  • 0.001) and bilateral renal artery involvement (HR 5.053, 95% CI 1.179-21.661, p = 0.029) were significant risk factors for poor outcomes at followup, but performance of revascularization procedure was not (HR 0.663, 95% CI 0.176-2.498, p = 0.543). (jrheum.org)
  • Because multiple other factors can contribute to AKI development in the complex clinical setting of LuTx, we next investigated the role of exogenous CFH administration in a mouse model of mild bilateral renal ischemia reperfusion injury (IRI). (stanford.edu)
  • Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
  • Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)
  • The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)
  • These sequelae of renal ischemia are a result of endothelial dysfunction, which is most probably responsible for the 'no-reflow' phenomenon and further aggravation of tubular ischemia during the early reperfusion period. (scienceopen.com)
  • We then established the rat ischemia-reperfusion injury (IR) model and transplanted the iPSC-derived RPCs into the injured rats in combination with the hydrogel. (biomedcentral.com)
  • We address this question by pharmacologic and genetic blockade of autophagy using mouse models of cisplatin- and ischemia-reperfusion-induced acute kidney injury. (elsevierpure.com)
  • In addition, the knockout mice were more sensitive to renal ischemia-reperfusion injury than their wild-type littermates. (elsevierpure.com)
  • ARA290 Protects Against Renal Ischemia/Reperfusion Injury. (ox.ac.uk)
  • Moreover, preliminary data identified a novel inhibitory effect of PKG on tubular cell necrosis and apoptosis following renal ischemia reperfusion (IR) induced acute kidney injury in young mice and an inhibitory effect of PKG on macrophage migration, suggesting a therapeutic potential of PKG for renal IR injury. (uky.edu)
  • In this proposal, we will test the hypothesis that down-regulation of NO/cGMP/PKG signaling in the kidney contributes to increased susceptibility of older individuals to ischemia reperfusion mediated AKI. (uky.edu)
  • Cell-Free Hemoglobin in Acute Kidney Injury after Lung Transplantation and Experimental Renal Ischemia/Reperfusion. (stanford.edu)
  • Exogenous administration of CFH after reperfusion caused overt AKI with creatinine increase, tubular injury, and enhanced markers of renal inflammation compared with vehicle-treated animals. (stanford.edu)
  • This study was designed to investigate the ability of VPA to mitigate ischemia-reperfusion injury produced by prolonged tourniquet application to an extremity. (bmj.com)
  • Methods The ischemia-reperfusion model in anesthetized rats was established using hemorrhage and a 3-hour tourniquet application. (bmj.com)
  • Ischemia-reperfusion injury was evaluated by investigating pathway signaling, immune modulation of cytokine release, remote organ injury, and skeletal muscle function during convalescence. (bmj.com)
  • Conclusions Our results demonstrate that VPA sustains early prosurvival cell signaling, reduces the inflammatory response, and improves renal function in a hemorrhage with prolonged ischemia and reperfusion model. (bmj.com)
  • The present study was designed to investigate the expression changes of PPAR-alpha, -beta, -gamma and NF-kappa B in the hippocampus of rats with global cerebral ischemia/reperfusion injury (GCIRI) after treatment with agonists or antagonists of PPAR-gamma. (biomedcentral.com)
  • Global cerebral ischemia/reperfusion injury (GCIRI) occurs in patients who are successfully resuscitated from various clinical conditions such as cardiac arrest, asphyxia and shock, which are frequently accompanied by inflammation and can lead to serious neuronal injury, and further to neurodegeneration and learning and memory impairment [ 12 ]. (biomedcentral.com)
  • Proinflammatory cytokines, such as interleukin (IL)-1β, IL-6 and tissue necrosis factor (TNF)-α, have been implicated as important mediators of injury following cerebral ischemia [ 13 ] and contribute to pathogenesis, exacerbating brain tissue damage following ischemia/reperfusion (I/R) injury [ 14 ]. (biomedcentral.com)
  • Since the shortage of donor organs is a major problem, it is imperative to develop methods capable of preserving organs after significant periods of warm and cold ischaemia, and at the same time minimise the reperfusion injury associated with transplantation. (ucl.ac.uk)
  • 2) to investigate the role of HO-1 and its products, CO and bilirubin, in protecting renal tissues during hypothermic storage and subsequent reperfusion. (ucl.ac.uk)
  • The results show that, following induction of HO-1 in renal tissue, the enzymatic activity was maintained during hypothermia, and some beneficial effects on renal function could be observed after storage and reperfusion. (ucl.ac.uk)
  • Other interests include delayed allograft function and effort to limit ischemia-reperfusion injury after transplantation. (lifespan.org)
  • Gong L, He J, Sun X, Li L, Zhang X, Gan H. Activation of sirtuin1 protects against ischemia/reperfusion-induced acute kidney injury. (ac.ir)
  • Feasibility of biology-guided radiotherapy for metastatic renal cell carcinoma driven by PSMA PET imaging. (urotoday.com)
  • Patient-reported outcomes in metastatic renal cell carcinoma trials using combinations versus sunitinib as first-line treatment. (urotoday.com)
  • Immune checkpoint inhibitors combined with tyrosine kinase inhibitors or immunotherapy for treatment-naïve metastatic clear-cell renal cell carcinoma-A network meta-analysis. (urotoday.com)
  • Prevalence of germline mutations in cancer susceptibility genes in Chinese patients with renal cell carcinoma. (urotoday.com)
  • Impact of Overweight and Obesity on U.S. Renal Cell Carcinoma Incidence Trends (1995-2018). (urotoday.com)
  • Cytoreductive partial and radical nephrectomies provide equivalent oncologic outcomes in T1-2M1 renal cell carcinoma. (urotoday.com)
  • Baseline and Dynamic Changes in Hemoglobin Levels Predict Treatment Response and Prognosis in Metastatic Renal Cell Carcinoma: A Multicenter Retrospective Study. (urotoday.com)
  • The Association Between Cytoreductive Nephrectomy and Overall Survival in Metastatic Renal Cell Carcinoma with Primary Tumor Size ≤4 cm. (urotoday.com)
  • B7-H3 expression is associated with high PD-L1 expression in clear cell renal cell carcinoma and predicts poor prognosis. (urotoday.com)
  • Transcriptome mapping of renal clear cell carcinoma revealed by machine learning algorithm based on enhanced CT images. (urotoday.com)
  • Renální karcinom (renal cell carcinoma - RCC) tvoří přibližně 2-3 % všech maligních onemocnění u dospělé populace. (prelekara.sk)
  • Previously, we have identified the profound cystine addiction of renal cell carcinoma (1), breast cancer cells (2, 3), and ovarian cancer cells (4). (duke.edu)
  • It is considered as a major cause of acute renal failure and the main factor in early recovery of renal graft function and long-term survival post renal transplantation. (frontiersin.org)
  • One of the primary causes of ARF is I/R which is a drop in blood flow leading to inadequate supply of oxygen and nutrients to renal tissue which can be caused by, amongst others, surgery, organ transplantation and shock [ 1 ]. (biomedcentral.com)
  • Recent studies have demonstrated that transplantation of functional endothelial cells into ischemic kidney provided a dramatic renoprotective effect. (scienceopen.com)
  • The transplantation of iPSC-derived RPCs decreased the levels of biomarkers indicative of renal injury and attenuated the necrosis and apoptosis of renal tissues, but resulted in the up-regulation of renal tubules formation, cell proliferation, and the expression of pro-renal factors. (biomedcentral.com)
  • In renal transplantation, delayed graft function and primary nonfunction are major sources of graft loss and morbidity. (ucl.ac.uk)
  • Paul Morrissey, MD is interested in outcomes after renal transplantation for organ donors and recipients. (lifespan.org)
  • [ 4 ] This is despite the fact that transplantation is a more cost-effective form of renal replacement therapy and provides better outcomes for patients with end-stage kidney disease. (medscape.com)
  • Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
  • Patients' Perceptions Regarding the Relevance of Items Contained in the Functional Assessment of Cancer Therapy Kidney Symptom Index-19. (urotoday.com)
  • The downstage migration of kidney cancer and the gained expertise in surgical techniquehave contrib-uted to a wider utilization of nephron sparing surgery and an expansion of its indications to include renal cortical tumors of larger size and in difficult anatomical locations. (prelekara.sk)
  • Partial nephrectomy however, is associated with better renal function preservation and lower risk of chronic kidney -disease. (prelekara.sk)
  • Cell-based therapy with mesenchymal stem cells or renal progenitor cells (RPCs) resident in the kidney has appeared to be an effective strategy for the treatment of AKI. (biomedcentral.com)
  • Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney. (biomedcentral.com)
  • Acute kidney injury (AKI) is characterized by acute tubular injury and a rapid decline in renal function [ 1 ]. (biomedcentral.com)
  • In response to acute injury, the adult kidney shows some level of regeneration characterized by the proliferation of the surviving cells and the replacement of the necrotic tubular cells with functional tubular epithelium [ 3 ]. (biomedcentral.com)
  • Compared with wild-type littermates, these knockout mice were markedly more sensitive to cisplatin-induced acute kidney injury as indicated by renal functional loss, tissue damage, and apoptosis. (elsevierpure.com)
  • This age-dependent increase in susceptibility to AKI is linked to a decreased renal functional recovery and even progression to advanced chronic kidney disease, a severe health problem worldwide. (uky.edu)
  • Preliminary studies demonstrated that nitric oxide (NO) and its downstream signaling pathway cGMP and cGMP-dependent protein kinase (PKG) was down-regulated in aging kidney, which was associated with aging-related renal functional changes. (uky.edu)
  • We will determine whether genetically or pharmacologically increased PKG activity reduces the susceptibility of old animals to ischemia mediated acute kidney injury in Aim 1. (uky.edu)
  • Patient summary: Tumor enucleation for kidney cancer involves dissection along the tumor capsule and optimally preserves normal kidney tissue, which may lead to better functional recovery. (elsevierpure.com)
  • Renal fibrosis is the hallmark of chronic kidney disease progression and is characterized by an exaggerated wound-healing process with the production of renal scar tissue. (omicsdi.org)
  • They appear to be the key factors in driving renal fibrosis, independent of the underlying kidney disease. (omicsdi.org)
  • Tubulointerstitial fibrosis is a common end point of chronic kidney diseases, and preventing its progression is key to avoiding renal failure. (omicsdi.org)
  • The present study evaluated LOXL2 expression in human and mouse kidney tissues, as well as in cultured renal cells. (omicsdi.org)
  • The aim of this study is to detect the TFF3 mRNA in kidney and elucidate the relationship between renal TFF3 mRNA and tubulointerstitial fibrosis in IgA nephropathy (IgAN). (omicsdi.org)
  • This is a longitudinal study examining medical, surgical, functional, psychological and cost outcomes associated with living kidney donation across six centers in Massachusetts, Maine, Rhode Island, Florida, Iowa and Arizona. (lifespan.org)
  • Stenting of RAS due to atherosclerosis is followed by stabilization or improvement of Ccr, mainly at the stented kidney, while contralateral renal function showed a decrease. (biomedcentral.com)
  • Instead of the classical surgical approach, percutaneous balloon angioplasty or endovascular stenting have recently become accepted procedures in the attempt to revascularize the stenotic kidney and prevent chronic renal insufficiency. (biomedcentral.com)
  • There is also another type of kidney failure referred to as End State Renal Disease (ESRD) which is the nonfunctioning of the kidneys for more than three months. (standard.gm)
  • Acute kidney failure (or acute kidney infection (AKI) or acute renal failure) as the name suggests, occurs when the kidney(s) suddenly cease(s) to function. (standard.gm)
  • However, these factors can be grouped as prerenal, renal and postrenal (with 'pre' and 'post' meaning before and after respectively and renal meaning the kidney). (standard.gm)
  • Anti-hypertensive drugs such as Enalapril, Captopril, Losartan, Valsartan, Propanolol, Hydralazine, and Nifedipine could also cause acute kidney failure since these drugs impair renal perfusion through the dilation of the efferent arterioles and decrease in intraglomerular pressure. (standard.gm)
  • Renal factors are those that affect the structures in the kidney. (standard.gm)
  • Those that affect the functional unit of the kidney, the Nephron, are caused by ischemia (i.e. low blood flow) to the kidney. (standard.gm)
  • Development of novel therapeutic approaches to bolster kinin activity in the vascular wall and in specific compartments in the kidney might be a highly effective strategy for the treatment of hypertension and its complications, including cardiac hypertrophy and renal failure. (nature.com)
  • Diagnostic and prognostic performance of renal compartment volume and the apparent diffusion coefficient obtained from magnetic resonance imaging in mild, moderate and severe diabetic kidney disease. (charite.de)
  • Monitoring kidney size to interpret MRI -based assessment of renal oxygenation in acute pathophysiological scenarios. (charite.de)
  • Moreover, a kidney explant model was used to demonstrate that only SOX9-positive cells survive the massive injury associated with kidney ischemia and that the surviving SOX9-positive cells spread and repopulate the tubules. (lu.se)
  • These findings shed light on the functional and regulatory aspects of SOX9 activation in the human kidney during injury and regeneration. (lu.se)
  • All adult Medicaid patients in the US Renal Data System who received their first kidney transplant from 1990 to 2011. (medscape.com)
  • At 24 h post-operatively, we assessed the serum levels of creatinine and urea nitrogen, expression levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and NF-κB-related (p-IKK-β and IκB-α) proteins, and mRNA expression levels of the inflammatory cytokines, including TNF-α and MCP-1, in the renal tissue of various study groups. (frontiersin.org)
  • The histopathological evaluation of renal tissue was also conducted. (frontiersin.org)
  • In rat renal tissue, pioglitazone treatment decreased the serum levels of post-renal IRI creatinine and urea nitrogen, as well as necrosis. (frontiersin.org)
  • Pioglitazone also decreased the mRNA expression of TNF-α and MCP-1 in the renal tissue. (frontiersin.org)
  • Chronic inflammation in the vessel wall can lead to stenosis or occlusion, eventually causing tissue ischemia and organ damage. (jrheum.org)
  • The present study demonstrated that LOXL2 is expressed in compartments of renal tissue, where it appears to contribute to the progression of tubulointerstitial fibrosis. (omicsdi.org)
  • This article is a review of exciting, recently generated genetic, biochemical and clinical data from studies that have examined the importance of the tissue kallikrein-kinin system in protection from hypertension, vascular remodeling and renal fibrosis. (nature.com)
  • Nitric oxide production (by iNOS) may play several roles in renal pathophysiology, including induction of tubular damage. (biomedcentral.com)
  • This overview provides information on the pathophysiology of the inducible nitric oxide synthase/nitric oxide (iNOS/NO) system in the injury to cultured renal tubular epithelia, freshly isolated proximal tubules, and the whole organ after hypoxic or ischemic insult. (scienceopen.com)
  • The term cardiorenal syndrome (CRS) is often used to describe this condition and represents an important model for exploring the pathophysiology of cardiac and renal dysfunction. (biomedcentral.com)
  • Animal Models of Renal Pathophysiology and Disease. (charite.de)
  • Takayasu arteritis (TA) involving the renal artery can result in hypertension (HTN), renal dysfunction, and premature death. (jrheum.org)
  • Up to 60% of patients with TA have renal artery involvement, often resulting in refractory hypertension (HTN) and impaired renal function 4 , 5 , 6 . (jrheum.org)
  • Renal artery stenosis (RAS) is a known cause of hypertension and ischemic nephropathy. (biomedcentral.com)
  • Renal artery stenosis due to atherosclerotic changes of the renal arteries has become a serious concern as a cause of hypertension and renal ischemia, resulting frequently in end-stage renal failure [ 1 , 2 ]. (biomedcentral.com)
  • In this case, the lesions involve the main right renal artery and the right accessory renal artery in a 37-year-old man with difficult-to-control hypertension. (medscape.com)
  • The clinical manifestations reflect the arteries involved and most commonly include hypertension caused by renal-artery stenosis (RAS) or strokes from carotid artery disease. (medscape.com)
  • Conventional flush aortogram in a 47-year-old woman with difficult-to-control hypertension shows the characteristic string-of-beads sign of the right renal artery due to medial fibroplasia. (medscape.com)
  • The accumulated data shows sound oncological, functional and morbidity outcomes with these new technologies. (prelekara.sk)
  • The aim of this study was to investigate the longterm outcomes and factors that predict outcomes in patients with TA with renal artery stenosis. (jrheum.org)
  • Renal insufficiency [5/15 (33.3%) vs 3/47 (6.4%), p = 0.016] and bilateral involvement [12/15 (80.0%) vs 23/47 (48.9%), p = 0.041] were significantly more frequent in patients with poor than good outcomes. (jrheum.org)
  • Bilateral lesions and renal functional impairment at presentation, but not implementation of revascularization procedures, were significant factors for outcomes in TA patients with renal artery involvement. (jrheum.org)
  • Further, relatively little is known about longterm clinical outcomes, such as chronic renal insufficiency and death, in TA patients with renal artery stenosis. (jrheum.org)
  • Therefore, outcomes in patients with TA-associated renal artery stenosis have not been evaluated independent of revascularization procedures. (jrheum.org)
  • Therefore, our study analyzed longterm outcomes and clinical variables associated with poor outcomes (e.g., refractory HTN, chronic renal insufficiency, or death) in all patients with TA-associated renal artery involvement, regardless of whether they underwent revascularization procedures. (jrheum.org)
  • No comparisons were possible concerning renal functional outcomes because of non‐homogeneous data reporting. (bjuinternational.com)
  • Our findings demonstrated sustained Akt phosphorylation in skeletal muscle distal to tourniquet application, but this did not translate into improved functional outcomes. (bmj.com)
  • Our study informs the efficacy of histone deacetylase inhibitors for this purpose and demonstrates that Akt signaling may not have utility toward determining functional outcomes. (bmj.com)
  • Objective: To compare functional outcomes for TE and SPN strategies. (elsevierpure.com)
  • In conclusion, the intricate relations between endothelial and epithelial cells, based in part on the relations between endothelial and inducible nitric oxide synthases, are perturbed in renal ischemia primarily as a result of endothelial dysfunction precipitating epithelial injury. (scienceopen.com)
  • In this study, we induced iPSCs differentiation into RPCs using a nephrogenic cocktail of factors combined with the renal epithelial cell growth medium. (biomedcentral.com)
  • We showed that the differentiation efficiency of iPSCs to RPCs increased when cultured with renal epithelial cell growth medium after stimulation with a nephrogenic cocktail of factors. (biomedcentral.com)
  • Immunostaining of the renal specimen of IgAN patients revealed that TFF3 is located in the renal tubular epithelial cells. (omicsdi.org)
  • Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. (biomedcentral.com)
  • Progressive AKI leads to acute renal failure (ARF)[ 1 ]. (biomedcentral.com)
  • Nitric oxide in acute renal failure: NOS versus NOS. (scienceopen.com)
  • Azotemia is common, owing to associated glomerular fibrosis and/or ischemia. (unboundmedicine.com)
  • We investigated the renal mRNA expression of TFF3 by real-time PCR analysis in biopsy specimens from patients with IgAN, other glomerulonephritis (OGN) and minor glomerular abnormalities (MGA). (omicsdi.org)
  • Quantitative assessment of renal perfusion and oxygenation by invasive probes: basic concepts. (charite.de)
  • Tubulointerstitial diseases constitute a diverse group of acute and chronic, hereditary and acquired disorders involving the renal tubules and supporting structures ( Table 146-1 ). (unboundmedicine.com)
  • Renal expression of trefoil factor 3 mRNA in association with tubulointerstitial fibrosis in IgA nephropathy. (omicsdi.org)
  • The renal TFF3 mRNA expression was significantly associated with the urinary TFF3 secretion and the tubulointerstitial fibrosis score in the IgAN group alone. (omicsdi.org)
  • 3) to search for novel "pharmacological preconditioning agents" that are capable of selectively activating the HO-1 gene in renal tissues. (ucl.ac.uk)
  • Thus, pioglitazone ameliorates renal IRI by inhibiting the NF-κB signaling pathway and inflammatory response in rats. (frontiersin.org)
  • The effects of EUK-134 on serum levels of NO in rats subjected to renal I/R or on NO production by PTCs incubated with interferon-γ (IFN-γ, 100 IU/ml) and bacterial lipopolysaccharide (LPS, 10 µg/ml) in combination for 24 h were also measured. (scienceopen.com)
  • However, EUK-134 also reduced nitrosative stress caused by I/R in vivo (reduction of iNOS expression and nitrotyrosine formation), which was reflected by a significant reduction in serum NO levels in rats subjected to renal I/R. Specifically, serum NO levels were reduced from 57 ± 12 (n = 12, I/R only) to 23 ± 3 m M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • Patients were excluded from the analysis if imaging evaluation of renal artery involvement was not available. (jrheum.org)
  • Estimated Direct Costs of Renal Cancer by Stage of Disease at Diagnosis and Phase of Its Management: A Whole-Disease Model. (urotoday.com)
  • The current definition has been expanded into five subtypes whose etymology reflects the primary and secondary pathology, the time frame, as well as cardiac and renal co-dysfunction secondary to systemic disease [ 1 ] (Table 1 ). (biomedcentral.com)
  • harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623061/all/Chapter_146:_Renal_Tubular_Disease. (unboundmedicine.com)
  • The beneficial actions of kinins in renal and cardiovascular disease are largely mediated by nitric oxide and prostaglandins, and extend beyond their recognized role in lowering blood pressure to include cardioprotection and nephroprotection. (nature.com)
  • 18.5 and serious comorbidities such as cancer and heart and renal disease. (who.int)
  • Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. (scienceopen.com)
  • EUK-134 produced a significant reduction in renal dysfunction and injury caused by I/R. Specifically, serum creatinine levels, an indicator of renal dysfunction, were reduced from 227 ± 11 (n = 12, I/R only) to 146 ± 9 µ M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • The findings emphasize the role of concomitant oxidative and nitrosative stress and the role of peroxynitrite in the ensuing renal dysfunction. (scienceopen.com)
  • The functional consequences of tubular dysfunction are outlined in Table 146-2 . (unboundmedicine.com)
  • One may suppose that inadequate stimulation of the humoral/cellular immune response potentially contributes to the higher ischemia susceptibility of the organ in DM. (jocmr.org)
  • Potential for serious and/or life-threatening reactions in patients with renal and/or hepatic impairment (see sections 4.4 and 4.5). (who.int)
  • We also established a renal proximal tubule-specific autophagy-related gene 7-knockout mouse model shown to be defective in both basal and cisplatin-induced autophagy in kidneys. (elsevierpure.com)
  • In this study, we investigated the role of the NF-κB signaling pathway and inflammation in the amelioration of renal IRI using pioglitazone. (frontiersin.org)
  • Background: The healing of foot wounds in patients with diabetes mellitus is frequently complicated by critical limb threatening ischemia (neuro-ischemic diabetic foot syndrome, DFS). (mdpi.com)
  • In collaboration with Fatemah Akhlaghi, PharmD, PhD, of University of Rhode Island College of Pharmacy, Gohh is also investigating the pharmacokinetics of mycophenolate mofetil in diabetic renal transplant recipients. (lifespan.org)
  • Specific tumour features (i.e. size, hilar location, anatomical complexity, nearness to renal sinus and/or urinary collecting system), surgeon's experience, robot‐assisted technology, as well as the aim of reducing warm ischaemia time and the amount of devascularized renal parenchyma preserved represented the key factors driving the evolution of the renorrhaphy techniques during MIPN over the past decade. (bjuinternational.com)
  • We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R. (scienceopen.com)
  • Based on the concept that cystine deprivation triggers the ferroptosis due to the unopposed oxidative stresses, we have performed functional genomic screens to identify many novel genetic determinants of ferroptosis. (duke.edu)
  • The diagnostic and prognostic information available from captopril renography and the increasing availability of magnetic resonance angiography (MRA) have reduced the use of renal arteriography as a diagnostic tool, except in evaluating kidneys with intrarenal branch-artery stenoses and those with complex vascular anatomy, including multiple accessory arteries. (medscape.com)
  • Integrated overview of evidence‐based technical principles for renal reconstruction during minimally invasive partial nephrectomy and suggested standardized reporting of key renorrhaphy features in clinical studies on this topic. (bjuinternational.com)
  • A hypertensive emergency is a sharp rise in blood pressure to a level above 180/120 mmHg that is associated with target organ damage, often involving exigent neurologic, cardiovascular, or renal manifestations. (nursingcenter.com)
  • Multiparametric magnetic resonance imaging for characterizing renal tumors: A validation study of the algorithm presented by Cornelis et al. (urotoday.com)
  • Differential Prognostic Value of Extrarenal Involvement in Patients With Non-Metastatic Renal Cell Cancer. (urotoday.com)
  • Distinct Predictive Immunogenomic Profiles of Response to Immune Checkpoint Inhibitors and IL2: A Real-world Evidence Study of Patients with Advanced Renal Cancer. (urotoday.com)
  • Phase 2 Trial of Stereotactic Ablative Radiotherapy for Patients with Primary Renal Cancer. (urotoday.com)
  • For SPN, warm ischemia and cold ischemia were used in 72% and 28% of patients, respectively. (elsevierpure.com)
  • The group of 27 patients, 67.33 ± 6.8 years of age, creatinine of 2.15 ± 0.9 mg/dl, following stenting, were followed at intervals with biochemical tests, renal scintigraphy and doppler ultrasonography. (biomedcentral.com)
  • Based on renal scintigraphy and Ccr at subsequent times, it was possibile to evaluate the timecourse of renal function in both kidneys of the stented patients. (biomedcentral.com)
  • 27 patients (diabetes mellitus in 8 cases) were subjected to stenting of the stenotic renal artery while 19 patients (diabetes mellitus in 9 cases) were kept on medical treatment only. (biomedcentral.com)
  • Dyspnea was the functional sign reported in all patients. (bvsalud.org)
  • Renal ischemia also known as nephric ischaemia, is the deficiency of blood in one or both kidneys or nephrons, usually due to functional constriction or actual obstruction of a blood vessel. (wikipedia.org)
  • MRA provides accurate information about the number of renal arteries, the size of the kidneys, and the presence of anatomic variants. (medscape.com)
  • Antidiuretic hormone, nitric oxide, angiotensin II, and prostaglandins are classical hormones/compounds involved in renal fluid handling and are important regulators of HA turnover during variations in hydration status. (diva-portal.org)
  • Next, we examined the renal function-related markers and renal histology to assess the therapeutic effect of the injected cells. (biomedcentral.com)
  • Stenting of the artery is a valid approach, in spite of cases of unexpected adverse evolution of renal function. (biomedcentral.com)
  • There is currently no clear evidence that such interventions prevent further progressive decline of renal function. (biomedcentral.com)
  • A laboratory workup is helpful only for identifying accompanying silent alterations in renal function and elevated lipid profiles. (medscape.com)
  • Therefore, in this study, we aimed to investigate the molecular mechanisms underlying pioglitazone hydrochloride-mediated amelioration of renal IRI with respect to the nuclear factor-kappaB (NF-κB) signaling pathway and inflammatory response using a rat model. (frontiersin.org)
  • Reginald Y. Gohh, MD has been involved in investigating the role of preemptive plasmapheresis in preventing recurrent FSGS in renal transplant recipients. (lifespan.org)
  • Quantitative synthesis showed that running suture was associated with shorter operating and ischaemia time, and lower postoperative complication and transfusion rates than interrupted suture. (bjuinternational.com)
  • A rare complication of IgA vasculitis: renal and intestinal ischemia successfully treated with plasmapheresis. (cdc.gov)
  • Histological and functional evaluation of extremity skeletal muscle at 3, 7, and 21 days after injury, however, demonstrated no significant differences in myocytic degeneration, necrotic formation, and maximal isometric tetanic torque. (bmj.com)
  • Although pharmacological therapy, modern dialysis techniques, and intermittent or continuous renal replacement therapies exist, the therapeutic approaches for AKI remain very limited. (biomedcentral.com)
  • In conclusion, CFH is a possible factor contributing to postoperative AKI after LuTx and promotes AKI in an experimental model of mild transient renal ischemia. (stanford.edu)