Functional kidney tubules proximal. Medical search. Frequent questions

It is found in membranes of intestinal epithelial cells, proximal kidney tubules and liver hepatocytes. (collie-online.com)
It includes primary human proximal tubule epithelial cells and renal microvascular endothelial cells in co-culture, allowing for cell-cell interactions found in vivo . (openwetware.org)
[2] The introduction of media flow through the chip leads to greater polarization, cell height, and cilia formation than kidney epithelial cells in other methods of culture. (openwetware.org)
Now, in close collaboration with Roche scientist Annie Moisan, they have leveraged their bioprinting and materials expertise to construct a functional 3D renal architecture containing living human epithelial cells, which line the surface of tubules in the kidney. (harvard.edu)
The epithelial cells of proximal tubules perform the functions of both copper uptake from the primary urine and release to the blood. (researchgate.net)
4,6,7 It has been proposed that some of these MSC may actually differentiate into functional renal tubular epithelial cells, though this theory remains controversial. (vin.com)
Among the different cells that make up these filtration units, the epithelial cells of the proximal tubul e of the nephron are responsible for reabsorbing water and solutes, representing 90% of the total renal mass. (ibecbarcelona.eu)

In TIO most tumors overexpress the protein fibroblast growth factor-23 (FGF-23) inhibiting renal phosphate reabsorption in the proximal tubules and acting as a phosphaturic factor [ 1 , 3 , 11 ]. (hindawi.com)
The primary transport protein responsible for phosphate reabsorption in the kidney is the type II sodium-phosphate cotransporter (NPT2a) localized in the proximal tubule. (hindawi.com)
Carbonic anhydrase plays an important role in bicarbonate reabsorption from the proximal tubule ( Ives, 2001 ). (aspetjournals.org)
Tubular reabsorption - The tubules in the nephrons reabsorb the filtered blood in nearby blood vessels. (healthpages.org)
Over 65% of renal reabsorption is performed by specialized cell-populations in the proximal nephron that control homeostatic regulation of water, glucose, salts, and amino acids. (rebuildingakidney.org)
The kidneys are excretory organs that perform three main functions to produce urine, filtration, reabsorption and secretion. (onteenstoday.com)
One functional component of the kidney, the nephron, carries out tasks such as filtration and reabsorption. (j-organoid.org)

Every human kidney has over one million nephrons, which perform the vital function of transferring components between blood and urine. (harvard.edu)
Using fugitive ink, a convoluted hollow channel is fabricated to mimic the winding shape of natural proximal tubules found inside a human kidney's nephrons. (harvard.edu)
Each kidney contains around 1 million individual nephrons, the kidneys' microscopic functional units that filter blood to produce urine. (innerbody.com)
Each kidney contains approximately 1.2 million nephrons. (marlerblog.com)
As seen in other kidney diseases, in STEC-HUS patients the progression to CKD is the consequence of renal mass reduction due to the loss of nephrons during the acute stage. (marlerblog.com)
The kidneys remove urea from the blood through tiny filtering units called nephrons. (onteenstoday.com)
The nephrons work through a two-step process: the glomerulus filters your blood, and the tubule returns needed substances to your blood and removes wastes. (onteenstoday.com)
Renal corpuscle, also called malpighian body, filtration unit of vertebrate nephrons, functional units of the kidney. (onteenstoday.com)
Each kidney consists of millions of filtrating units called nephrons. (biopassionate.net)
Presently, kidney organoids contain not only nephrons and ureteric buds but also stromal cells. (j-organoid.org)
The human kidney contains approximately one million nephrons, each composed of at least 20 different cell types. (j-organoid.org)
In healthy adults, each of o ur kidneys contains an average of 1.5 million nephrons, the basic functional units of the kidney that constantly filter waste products from the blood. (ibecbarcelona.eu)
There are about 1,000,000 nephrons in each human kidney . (healthykidneyclub.com)
Nephrons are the basic structural and functional units of the kidney. (healthykidneyclub.com)
The approximately 1 million nephrons in each human kidney form 10-20 cone-shaped tissue units called renal pyramids that span both the inner and outer portions of the kidney, the renal medulla and renal cortex. (healthykidneyclub.com)

Without functional proximal tubules, the kidneys cannot produce urine (a condition called anuria). (medlineplus.gov)
Conventional biomarkers for kidney function include serum creatinine (SCr), urine output (changes in which may precede biochemical changes), and urine microscopy. (medscape.com)
The kidneys are highly vascular (contain a lot of blood vessels) and are divided into three main regions: the renal cortex (outer region which contains about 1.25 million renal tubules), renal medulla (middle region which acts as a collecting chamber), and renal pelvis (inner region which receives urine through the major calyces). (healthpages.org)
Ureters - Muscular tubes that transport urine from each kidney to the bladder. (healthpages.org)
Every minute, approximately 1300 mL of blood enter the kidneys, 1299 mL leave the kidney, and approximately 1 mL leaves the body as urine. (healthpages.org)
If the body is dehydrated, the kidneys put less water is in the urine. (healthpages.org)
When the blood becomes too acidic, the kidneys remove more acid from the blood and excrete in as urine. (healthpages.org)
As part of the urinary tract, the kidneys are responsible for blood filtration and excretion of water-soluble waste in the urine. (lecturio.com)
During the neonatal period, kidneys play a key role in detoxification and recirculation of iron species released from red blood cells (RBC) and filtered out by glomeruli to the primary urine. (researchgate.net)
The renal pelvis exits the kidney at the renal hilus, where urine drains into the ureter. (innerbody.com)
A series of tubes called the renal tubule concentrate urine and recover non-waste solutes from the urine. (innerbody.com)
The renal tubule carries urine from the glomerular capsule to the renal pelvis. (innerbody.com)
The tubule cells that line the proximal convoluted tubule reabsorb much of the water and nutrients initially filtered into the urine. (innerbody.com)
Urine next passes through the loop of Henle, a long straight tubule that carries urine into the renal medulla before making a hairpin turn and returning to the renal cortex. (innerbody.com)
Two ureters - (tube-like features) which run from the kidneys to the bladder carrying urine. (onteenstoday.com)
One bladder - which collects urine from the kidneys, via the ureters, and stores it temporarily. (onteenstoday.com)
The kidneys filter out the waste products and excess fluids from the body and dispose of them in the form of urine, via the bladder. (onteenstoday.com)
What color is your urine when your kidneys are failing? (onteenstoday.com)
Light-brown or tea-colored urine can be a sign of kidney disease or failure or muscle breakdown. (onteenstoday.com)
Each kidney weighs about 160 grams and gets rid of between one and one-and-a-half litres of urine per day. (onteenstoday.com)
Urine produced in the kidneys passes through the ureters into the urinary bladder where it is stored until it is released through the urethra. (biopassionate.net)
OAT1 and 3 are among the several important drug transporters in kidney proximal tubules that maintain systemic levels of endogenous substrates (e.g. uric acid), and facilitate the active renal secretion of drugs into the urine. (solvobiotech.com)
OAT1 and 3 are multispecific exchangers or antiporters that transport predominantly anionic substrates against a concentration gradient from the blood into proximal tubule cells for subsequent elimination into the urine. (solvobiotech.com)
Nephron , functional unit of the kidney , the structure that actually produces urine in the process of removing waste and excess substances from the blood. (healthykidneyclub.com)
Kidney stones cause crystals to form in your urine and may block urine flow. (healthykidneyclub.com)
Some of this filtered protein is degraded and reabsorbed by the proximal tubules, but some is excreted in the urine. (msdmanuals.com)
Presence of protein in the urine is toxic to the kidneys and causes renal damage. (msdmanuals.com)

At the far end of the glomerular capsule, opposite the glomerulus, is the mouth of the renal tubule. (innerbody.com)
In kidney, degenerative changes in PCT and DCT, shrinkage of glomerulus, vacuolation in the haematopoietic tissues and excess fat deposition were notable changes. (omicsonline.org)
Each nephron consists of a ball formed of small blood capillaries, called a glomerulus, and a small tube called a renal tubule. (onteenstoday.com)
Each nephron has a glomerulus to filter your blood and a tubule that returns needed substances to your blood and pulls out additional wastes. (onteenstoday.com)
It consists of a knot of capillaries (glomerulus) surrounded by a double-walled capsule (Bowman's capsule) that opens into a tubule. (onteenstoday.com)
It has two parts, namely, glomerulus and renal tubules. (biopassionate.net)
1 Glomerulus 2 Distal tubule Bowman's capsule frenal corpuscle) 3 Permeability controlled by hormones: can absorb additional sodium and water 5 Proximal convoluted tubule Match each of the options above to the items below. (mygradespot.com)
Nephron has two parts - 1- glomerulus 2- renal tubule. (mygradespot.com)
These include the major components of the glomerulus, proximal and distal tubules, loop of Henle, and collecting duct [ 1 ]. (j-organoid.org)

We also established a renal proximal tubule-specific autophagy-related gene 7-knockout mouse model shown to be defective in both basal and cisplatin-induced autophagy in kidneys. (elsevierpure.com)

The nephron is the functional unit of the kidney. (marlerblog.com)
Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic conditions. (lww.com)

The kidneys also reabsorb glucose and amino acids and have hormonal functions via erythropoietin, calcitriol, and vitamin D activation. (medscape.com)

The first models included chips that replicated the function of the liver, gut, kidney and bone marrow. (openwetware.org)
The kidney and liver chips offer a model to test drug toxicity, and the duodenum chip offers a model for drug absorption. (openwetware.org)
The right kidney often sits slightly lower than the left one because of the position of the liver. (healthpages.org)
8,9 Many herbs which we use as bitters such as dandelion, burdock, goldenrod, and milk thistle actually also increase glutathione, or levels of glutathione-S-transferase, while simultaneously supporting function of the liver, kidneys, and intestines. (naturalmedicinejournal.com)
While protocols can vary, for successful and comprehensive detoxification one must focus on supporting all of these critical things: the glutathione system, the phases of cellular detoxification, proper function of cellular membranes, and healthy elimination by the liver, kidneys, and intestines. (naturalmedicinejournal.com)
The left kidney is located slightly more superior than the right kidney due to the larger size of the liver on the right side of the body. (innerbody.com)
Cytopathological study both through light and electron microscopic ( scanning electron microscopy and transmission electron microscopy) observations were based on gill, liver and kidney. (omicsonline.org)
It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. (nih.gov)

Bowman's capsule also has a structural function and creates a urinary space through which filtrate can enter the nephron and pass to the proximal convoluted tubule. (marlerblog.com)
The renal tubule consists of Bowman's capsule, proximal and distal convoluted tubules, Henle's loop, and collecting tubule. (biopassionate.net)

Thiazides and loop diuretics exhibit their diuretic effects from the luminal side by inhibiting the Na + -Cl - cotransporter of the distal tubule and the Na + -K + -2Cl - co-transporter of the loop of Henle, respectively ( Ives, 2001 ). (aspetjournals.org)
2-Distal tubule - Permeability controlled by hormones, absorb additional sodium and water. (mygradespot.com)

The 3B MICROanatomy Kidney is an extremely detailed model which shows the morphologic/functional units of the kidney. (cpr-savers.com)

It is present in both the central nervous system and peripheral organs including the kidney. (degruyter.com)
As a fabrication platform, the approach is flexible, scalable, and adaptable, meaning that in addition to working towards larger, scaled-up kidney constructs, the team also plans to explore development of other types of complex functional human tissues and organs. (harvard.edu)
Both ultimately send feedback signals to the kidneys Kidneys The kidneys are a pair of bean-shaped organs located retroperitoneally against the posterior wall of the abdomen on either side of the spine. (lecturio.com)
The kidneys are a pair of organs found along the posterior muscular wall of the abdominal cavity. (innerbody.com)
Unlike the other abdominal organs, the kidneys lie behind the peritoneum that lines the abdominal cavity and are thus considered to be retroperitoneal organs. (innerbody.com)
From there, WBCs carry the toxin to the kidneys and other organs. (marlerblog.com)
Because this attachment causes these organs to be susceptible to the toxicity of Shiga toxins, this distribution explains the involvement of the gut, kidney, and brain in STEC-associated hemolytic uremic syndrome (HUS). (marlerblog.com)

These findings shed light on the functional and regulatory aspects of SOX9 activation in the human kidney during injury and regeneration. (lu.se)
In contrast to earlier models that featured nephron-like structures, these advances have improved the differentiation efficiency and similarity to the human kidney. (j-organoid.org)
These kidney organoids contain renal structures including proximal tubules (marked with LTL, in green) and podocytes (expressing PODXL, in red) t hat partly resemble the renal structures of the human kidney. (ibecbarcelona.eu)

A functional membrane and transportation system is necessary for the transport of toxins and bile in hepatocytes, and similarly in the proximal tubules for elimination at the level of the kidneys. (naturalmedicinejournal.com)

The process of secreting organic anions through the proximal tubule cells is achieved via unidirectional transcellular transport involving the uptake of organic anions into the cells from the blood across the basolateral membrane, followed by extrusion across the brush-border membrane into the proximal tubule fluid. (aspetjournals.org)
OAT1 and 3 have 12 predicted transmembrane domains and are primarily expressed in the basolateral (blood-side) membrane of proximal tubule cells in the kidney, with highest levels in the middle segment, and are considered as kidney-specific transporters in humans [1, 2]. (solvobiotech.com)

This image shows the kidneys, ureters, and bladder. (healthpages.org)
Tubular secretion - The remaining filtrate which contains waste product passes through the tubules to the collecting ducts and is then taken to the bladder via the ureters. (healthpages.org)
The Excretory system of human beings includes a pair of kidneys, a pair of ureters, a urinary bladder, and a urethra. (biopassionate.net)
A kidney infection can occur if bacteria enter your kidneys by traveling up your ureters. (healthykidneyclub.com)

They are found on epithelial, endothelial, mesangial, and glomerular cells of the kidney, as well as microvascular endothelial cells of the brain and intestine. (marlerblog.com)
Recent studies have demonstrated that transplantation of functional endothelial cells into ischemic kidney provided a dramatic renoprotective effect. (scienceopen.com)

The renal arteries branch directly from the abdominal aorta and enter the kidneys through the renal hilus. (innerbody.com)

Serum creatinine is reflective of glomerular filtration rate (GFR) under steady-state conditions but has less utility in the context of decreasing kidney function. (medscape.com)
10 µg/dL, increase the risk of chronic kidney disease (CKD), with decreased estimated glomerular filtration rate (eGFR) and creatinine clearance. (medscape.com)
Kidney tubuloids derived from adult stem cells offer the advantage of long-term culture and expansion, but they include only tubular structures and lack glomerular components. (j-organoid.org)

Proper blood pressure, which delivers oxygen to the developing tissues during fetal growth, is required for normal development of the kidneys (particularly of the proximal tubules) and other tissues. (medlineplus.gov)
NHE3 is highly expressed in the intestine and kidneys and regulate sodium movements in those tissues. (guidetopharmacology.org)
As much as 1/3 of all blood leaving the heart passes into the kidneys to be filtered before flowing to the rest of the body's tissues. (innerbody.com)

Co-first authors of the study Kimberly Homan, a Wyss Research Associate, and David Kolesky, a Wyss Postdoctoral Fellow, stress that the most exciting aspect of the work is that - far beyond mimicking the form of the kidney's proximal tubule -it is a credible in vitro model that functions like living kidney tissue, representing a significant advance from traditional 2D cell culture. (harvard.edu)

The bean-shaped kidneys are about the size of a closed fist. (healthpages.org)
Grossly, the kidneys are bean-shaped structures and weigh about 150 g in the male and about 135 g in the female. (medscape.com)
The kidneys are bean-shaped with the convex side of each organ located laterally and the concave side medial. (innerbody.com)

How are kidneys involved in excretion? (onteenstoday.com)

Recently, kidney organoids have been grown in vitro from stem cells, but proximal tubule cells form poorly and fail to mature in these models. (rebuildingakidney.org)
The consequence is that there has been little success replicating proximal tubule cells in vitro. (rebuildingakidney.org)
Additional work is focusing on the establishment of a human in vitro entero-hepatic co-culture model in which physical coupling and functional crosstalk are features of the multicellular platform. (bcm.edu)
Confocal microscopy image of a kidney organoid generated in vitro from human pluripotent stem cells that have been differentiated for 20 days using three-dimensional cultures. (ibecbarcelona.eu)

Removal of lead using chelation therapy reverses the proximal reabsorptive defect and removes the intranuclear inclusion bodies of acute lead nephropathy. (medscape.com)
Overflow proteinuria occurs when excessive amounts of small plasma proteins (eg, immunoglobulin light chains produced in multiple myeloma) exceed the reabsorptive capacity of the proximal tubules. (msdmanuals.com)

In acute kidney injury (AKI), the serum creatinine level can take several hours or days to reach a new steady state and does not reflect the true decrease in GFR. (medscape.com)
We address this question by pharmacologic and genetic blockade of autophagy using mouse models of cisplatin- and ischemia-reperfusion-induced acute kidney injury. (elsevierpure.com)
Chloroquine, a pharmacological inhibitor of autophagy, blocked autophagic flux and enhanced acute kidney injury in both models. (elsevierpure.com)
Rapamycin, however, activated autophagy and protected against cisplatin-induced acute kidney injury. (elsevierpure.com)
Compared with wild-type littermates, these knockout mice were markedly more sensitive to cisplatin-induced acute kidney injury as indicated by renal functional loss, tissue damage, and apoptosis. (elsevierpure.com)
Mechanistically, these knockout mice had heightened activation of p53 and c-Jun N terminal kinase, the signaling pathways contributing to cisplatin acute kidney injury. (elsevierpure.com)
Thus, our results establish a renoprotective role of tubular cell autophagy in acute kidney injury where it may interfere with cell killing mechanisms. (elsevierpure.com)
[2] Within the microvasculature of the kidney these clots disturb blood flow to the organ, causing acute kidney injury and kidney failure. (marlerblog.com)

The kidney anatomy is shown in the image below. (medscape.com)

The embryonic kidney consists of the metanephric mesenchyme and ureteric buds. (j-organoid.org)

Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
We are therefore exploring whether transport proteins might represent a particularly attractive source for identification of novel biomarkers for kidney cancer. (lu.se)

The active endocytic machinery of kidney proximal tubules avidly internalizes filtered proteins, which may also be the case for filtered nanoparticles. (harvard.edu)
Lead is absorbed by the proximal tubular cells of the renal tubules, where it binds to specific lead-binding proteins. (medscape.com)
5% false discovery rate) between risk of MACE and eight proteins: matrix metalloproteinase (MMP)-12, IL-27 subunit α (IL-27a), kidney injury molecule (KIM)-1, fibroblast growth factor (FGF)-23, protein S100-A12, TNF receptor (TNFR)-1, TNFR-2 and TNF-related apoptosis-inducing ligand receptor (TRAIL-R)2. (springer.com)

Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. (scienceopen.com)

They then radiate into interlobular arteries, which extend into the cortex of the kidney to finally become afferent arterioles, then peritubular capillaries to efferent arterioles. (medscape.com)
The efferent arterioles separate into the peritubular capillaries that surround the renal tubules. (innerbody.com)

Kidneys play an especial role in copper redistribution in the organism. (researchgate.net)

Inside our kidneys, the renal arteries diverge into the smaller afferent arterioles of the kidneys. (innerbody.com)

Since the first publication on generating kidney-like cell aggregates from pluripotent stem cells, various modifications have been made to develop more complex and detailed kidney structures. (j-organoid.org)
H uman mini-kidneys -also called kidney organoids- are created using bioengineering techniques from human stem cells, and capture some aspects of the complexity of this organ. (ibecbarcelona.eu)

Serum creatinine measurement is not reliably indicative of underlying pathophysiology (ie, it does not allow differentiation of hemodynamically mediated changes in kidney function, such as prerenal azotemia from intrinsic renal failure or obstructive uropathy from structural kidney damage). (medscape.com)
Recent data shows that changes in kidney proximal tubule transport and metabolism, such as inhibition of sugar transport, is an effective therapeutic strategy in patients with diabetic and non-diabetic kidney disease. (au.dk)

In particular, kidney structures called proximal tubules are absent or underdeveloped. (medlineplus.gov)
The kidneys are paired retroperitoneal structures that are normally located between the transverse processes of T12-L3 vertebrae, with the left kidney typically somewhat more superior in position than the right. (medscape.com)
The kidney structures are greatly magnified. (cpr-savers.com)

Their blood pressure usually normalizes, but they quickly develop chronic kidney disease, which is characterized by reduced kidney function that worsens over time. (medlineplus.gov)
The association between lead exposure and GFR was evaluated in North American children with CKD in the Chronic Kidney Disease in Children (CKiD) study. (medscape.com)
Chronic kidney disease affects more than 697 million people around the world. (ibecbarcelona.eu)
Using innovative techniques such as single cell RNA-sequencing, the researchers unraveled the crucial role tha t lipid metabolism genes play in protecting against chronic kidney failure. (ibecbarcelona.eu)
In almost all cases of chronic kidney disease, damage occurs in these cells, but until now, it was not known which cellular mechanisms were respon sible for such dysfunction. (ibecbarcelona.eu)
Specifically, in the kid neys of mice with chronic kidney disease, they detected that a greater proportion of the proximal tubule cells had a different molecular signature than that found in the kidneys of healthy animals. (ibecbarcelona.eu)
Chronic kidney disease may lessen your kidney function. (healthykidneyclub.com)

The renal pyramids are aligned with their bases facing outward toward the renal cortex and their apexes point inward toward the center of the kidney. (innerbody.com)

An increase in the serum creatinine level represents a delayed indication of a functional change in GFR that lags behind structural changes that occur early in AKI. (medscape.com)
Lead accumulates in the mitochondria and causes both structural and functional alterations. (medscape.com)
These organoids mimic the structural similarities and developmental processes of the kidneys, while reflecting their physiological properties. (j-organoid.org)
Despite the enormous financial and personal burden that this entails, until now the biological mechanisms behind this condition were unknown, due to the structural and functional complexity of the kidney. (ibecbarcelona.eu)

Excretory pathway in kidney - Blood is carried by the renal artery to the nephron from there to renal pyramid leading to pelvis to the ureter, then to the urinary bladder and finally to the urethra which passes it to outside. (onteenstoday.com)

These genes are involved in the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body and plays a role in kidney development before birth. (medlineplus.gov)
In organoids, this cascade of developmental regulators is perturbed, and proximal-distal cell fates form abnormally, as is evident by co- expression of normally segregated genes. (rebuildingakidney.org)
Noting these observations, the IBEC researchers went one s tep further and, using human mini-kidneys, demonstrated that these changes were due to a decrease in the expression of some of the genes that regulate lipid metabolism in proximal tubule cells. (ibecbarcelona.eu)

Transmission electron microscopic study of gill showed severe damages which included degenerative changes in mitochondria, cellular vacuolation, damage in tubule vascular system, presence of lipid droplets, elongated nucleus, but in case of field experiment dilated mitochondria and cytoplasmic vacuolation were more prominent. (omicsonline.org)

Toxic nephropathies are estimated to cause fewer than 1% of all cases of end-stage kidney disease. (medscape.com)
In this project, we aim understand the mechanism by which common amino acid-sugar conjugates alter or propagate kidney disease. (au.dk)
My research goal is to understand the mechanisms of kidney disease to develop new therapies for renal failure. (au.dk)
a critical steppingstone to generate functional cells for replacement therapies and disease modeling. (rebuildingakidney.org)
In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. (karger.com)
Vitamin D has to be metabolically activated in the kidney, and patients with CKD including diabetic kidney disease (DKD) are not able to produce enough of the active form of vitamin D (1,25(OH) 2 D). Vice versa, the kidneys are assumed to be a classical 1,25(OH) 2 D target. (karger.com)
Impairment of the capability of the kidney to produce and reuptake enough calcitriol and therefore maintain vitamin D, phosphate, and calcium homeostasis is one of the principal pathophysiological components of metabolic bone disease in CKD. (karger.com)
DKD, one of the most common forms of CKD, accounts for almost 50% of end-stage kidney disease in developed countries requiring renal replacement therapy. (karger.com)
End-stage renal disease is a complete loss of kidney function. (healthykidneyclub.com)
Polycystic kidney disease , a genetic condition, causes cysts to form on the kidneys. (healthykidneyclub.com)

The nephron is made of 2 main parts: the renal corpuscle and the renal tubule. (innerbody.com)

The current review focuses on the role of the eCB system in normal kidney function and various diseases, such as diabetes and obesity, that directly contributes to the development of renal pathologies. (degruyter.com)
To test whether such interactions affect kidney function, we injected mice with either 5 nm dextran-based nanoparticles (DNP) that are similar in composition to FDA-approved materials or poly(amido amine) dendrimer nanoparticles (PNP) of comparable size. (harvard.edu)
We conclude that there are no major detrimental renal effects of DNP on overall kidney function, but changes in endocytosis-mediating protein expression do occur. (harvard.edu)
Since most ingested K is excreted through the kidneys, decreased renal function is a major factor in increased serum levels, and target values for its intake according to the degree of renal dysfunction have been established. (mdpi.com)
Biomarkers of kidney function can be used to estimate the severity and nature of kidney injury. (medscape.com)
Serum creatinine may not become elevated before substantial kidney function has been lost due to renal reserve. (medscape.com)
The secretion of numerous organic anions, including endogenous metabolites, drugs, and xenobiotics, is an important physiological function of the renal proximal tubule. (aspetjournals.org)
80-100 μg/dL) disrupts both proximal tubular structure and function. (medscape.com)
The kidney is a central hub of mammalian metabolism, but its metabolic function is relatively understudied. (au.dk)
Endpoints of interest were major adverse cardiovascular events (MACE), stroke, myocardial infarction (MI), cardiovascular death (CVD), all-cause death (ACD), kidney function progression (KFP), and hospitalization for heart failure (HHF). (omicsdi.org)
Furthermore, "thanks to a multidisciplinary approach, using an imal models and human mini-kidneys that we generate through bioengineering at IBEC, we discovered that, by correcting this deficiency, the proximal tubule cells could regain their function in the different study models," explains Dr. Montserrat. (ibecbarcelona.eu)
Have your kidney function tested if you're at high risk. (healthykidneyclub.com)
Hypertension causes sclerosis of the glomeruli, which has a negative impact on kidney function largely due to a decrease in nephron number. (healthykidneyclub.com)
Filtration and selective transport of molecules represents a key function of the normal kidney. (lu.se)

The two kidneys together filter 200 litres of fluid every 24 hours. (onteenstoday.com)
Each nephron is composed of a renal corpuscle, the initial filtering component and a renal tubule that processes and carries away the filtered fluid. (healthykidneyclub.com)
The kidney is responsible for maintaining fluid balance within the body. (healthykidneyclub.com)
Fluid-filled sacs called kidney cysts grow on your kidneys. (healthykidneyclub.com)

Finally, the renal vein exits the kidney and joins with the inferior vena cava , which carries blood back to the heart. (innerbody.com)

The current work further expands our bioprinting platform to create functional human tissue architectures with both technological and clinical relevance," said Lewis. (harvard.edu)
The current work further expands our bioprinting platform to create functional human tissue architectures with both technological and clinical relevance," said Lewis, who is also the Hansjörg Wyss Professor of Biologically Inspired Engineering at the Harvard John A. Paulson School of Engineering and Applied Sciences. (harvard.edu)
The use of functional tissue-like models during pre-clinical studies will provide unprecedented insights into human-relevant drug response prior to clinical development," said Moisan, a Laboratory Head in Mechanistic Safety at Roche and author of this study. (harvard.edu)
Adipose tissue known as perirenal fat surrounds the kidneys and acts as protective padding. (innerbody.com)
A thin layer of fibrous connective tissue forms the renal capsule surrounding each kidney. (innerbody.com)
Hence, the vitamin D receptor (VDR) is highly expressed in kidney tissue [ 3-5 ]. (karger.com)

Anatomy14

Organisms1

Diseases8

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes5

Disciplines and Occupations1

Information Science2

Epithelial cells7

Reabsorption7

Nephrons15

Urine27

Glomerulus9

Established a renal1

Unit of the kidney2

Reabsorb1

Liver8

Bowman's2

Distal tubule2

Units of the kidney1

Organs7

Human kidney3

Hepatocytes1

Membrane2

Ureters4

Endothelial cells2

Enter the kidneys1

Glomerular3

Tissues3

Kidney's1

Bean-shaped3

Excretion1

Vitro4

Reabsorptive2

Acute8

Anatomy1

Embryonic Kidney1

Biomarkers for kidney2

Proteins3

Tubular cell1

Peritubular capillaries2

Organism1

Afferent arterioles1

Stem cells2

Changes in kidney2

Structures3

Chronic7

Cortex1

Structural4

Passes1

Genes3

Lipid1

Disease10

Nephron is made1

Function14

Fluid4

Inferior1

Tissue6