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  • Methods
  • Methods and Results- In mice, α-MHC-restricted Cre-mediated Txnrd2 deficiency, induced by tamoxifen ( Txnrd2−/−ic ), aggravated systolic dysfunction and cardiomyocyte cell death after ischemia (90 minutes) and reperfusion (24 hours). (ahajournals.org)
  • renal
  • AGP and AAT administered at reperfusion prevented apoptosis at 2 hours and 24 hours, as evaluated by the presence of internucleosomal DNA cleavage, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling, and the determination of renal caspase-1- and caspase-3-like activity. (ahajournals.org)
  • protection
  • However, the inhibition of PI3K by wortmanin could only reduce functional recovery in RPO supplemented groups partially, suggesting that there may be more than one pathway of RPO-mediated protection involved. (biomedcentral.com)
  • model
  • We present a hybrid three-dimensional (3D) theoretical approach, the density functional theory (DFT) integrated with the reference interaction site model (RISM), to investigate the nucleation of CO2 and CH4 hydrates. (jove.com)
  • hearts
  • It was recently shown that ERK1/2 was not activated shortly after anesthetic preconditioning but that it was significantly activated later after ischemia and reperfusion in anesthetic preconditioned hearts. (asahq.org)
  • minutes
  • In group III, 30 minutes before the start of reperfusion, 10 mg/kg melatonin was administered intraperitonally. (biomedcentral.com)
  • PKB/Akt phosphorylation (Thr 308) was found to be significantly higher in the dietary RPO supplemented group when compared to the SFO supplemented group at 10 minutes into reperfusion. (biomedcentral.com)
  • capable
  • Magnetic resonance imaging (MRI) provides exquisite anatomic detail of various organs and is capable of providing additional functional information. (physiology.org)