• Massive ex vivo expansion of epidermal cells (called keratinocytes) is needed for the production of grafts. (cea.fr)
  • It is performed using a skin sample from the patient that contains adult keratinocytes and a minority population of keratinocyte stem cells. (cea.fr)
  • In the future, keratinocytes produced from pluripotent stem cells could be an alternative to adult stem cells in certain reconstructed tissue bio-engineering applications. (cea.fr)
  • One of the difficulties encountered in this area is that fact that the keratinocytes obtained do not have all the functions of adult stem cells. (cea.fr)
  • The study has shown that manipulation of KLF4 expression is also suitable for these cells, as reducing its expression in keratinocytes derived from embryonic stem cells (ESC) improves their proliferation capacity and their ability to reconstruct skin. (cea.fr)
  • The models tested included melanoma cells, neonatal melanocytes and keratinocytes, and immortalized HaCaT keratinocytes. (biologists.com)
  • C7 is primarily provided by keratinocytes, making this cell type the target of choice for gene therapy approaches. (uc3m.es)
  • Ex vivo gene-corrected bulk keratinocytes achieved normal human skin regeneration upon transplantation onto immunodeficient mice, opening up the way for a polyclonal therapy scenario. (uc3m.es)
  • It appears to be particularly important for the normal function of cells called keratinocytes, which are found in the outer layer of the skin (the epidermis). (medlineplus.gov)
  • For unknown reasons, this abnormal calcium storage affects keratinocytes more than other types of cells. (medlineplus.gov)
  • San Diego headquartered Organovo designs and creates functional human tissues for use in drug testing and medical research. (singularityhub.com)
  • The aim of this study was to investigate whether mast cells accumulate in these tissues and whether their localisation is associated with extracellular matrix components. (bmj.com)
  • Additionally, very similar protein control mechanisms are at work to mature important cells in other tissues such as pancreatic islets, the cell type that fails to function effectively in type 2 diabetes. (science20.com)
  • Further studies will now be required to fully understand the functional consequences in skin and other tissues, and to establish methods to assess anti-ageing strategies in human skin. (ncl.ac.uk)
  • these systems integrate engineered human tissues into physiological microenvironment supplied by a vasculature-like microfluidic perfusion. (nature.com)
  • The WAT-on-a-chip is a multilayer device that features tissue chambers tailored specifically for the maintenance of 3D tissues based on human primary adipocytes, with supporting nourishment provided through perfused media channels. (nature.com)
  • Skin malignancies, including epidermal squamous cell carcinoma (SCC), alone account for nearly as many cancers as all other tissues combined. (stanford.edu)
  • The physical substance of the human organism, composed of living cells and extracellular materials and organized into tissues, organs, and systems. (rincondelvago.com)
  • These cells, which can be derived from adult tissues (most often the skin), have the potential to become any kind of cell found in the adult body. (sciencedaily.com)
  • The differentiation of naïve T cells into an activated memory phenotype is characterized by an extensive change in the expression of trafficking determinants, resulting in the acquisition of homing receptors that enable the cells to migrate from the circulation into peripheral tissues. (biomedcentral.com)
  • Studies of human lung disease are currently limited by accessibility to the relevant patient tissues. (ca.gov)
  • Tissues in which cells select for the defective PORCN gene show anomalies. (medscape.com)
  • With the addition of four proteins, adult human skin cells can be transformed into neurons over a month-long period. (stanforddaily.com)
  • The researchers showed they could convert human embryonic stem cells to neurons by infecting them with a virus that expressed the same proteins used in the study. (stanforddaily.com)
  • This treatment, nicknamed "BAM" after an acronym of the three proteins, converted the embryonic stem cells into functional neurons within six days. (stanforddaily.com)
  • it triggered the skin cells' transformation into functional neurons within about four to five weeks. (stanforddaily.com)
  • The cells expressed electrical activity characteristic of neurons and even integrated and interacted with mouse neurons on a laboratory dish. (stanforddaily.com)
  • While they found that approximately 20 percent of mouse skin cells transform directly into functional neurons, under current culture conditions only about two to four percent of human skin cells do the same. (stanforddaily.com)
  • These cells are known as induced neurons, or iN cells. (science20.com)
  • However, this method generates a low number of cells, and those that are produced are not fully functional, which is a requirement in order to be useful models of disease: for example, cortical neurons for stroke, or motor neurons for motor neuron disease. (science20.com)
  • Generation of functional neurons from feeder-free, keratinocyte-derived equine induced pluripotent stem cells. (sciencedaily.com)
  • Although, there is still an incomplete understanding of how the teamwork between astrocytes, neurons, and other cells in the brain is carried out and what consequences occur when astrocytes stop working properly. (lu.se)
  • Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
  • First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
  • Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
  • This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. (lu.se)
  • The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
  • A CEA-Jacob team has just published a paper in which it demonstrates the central role of the transcription factor KLF4 in regulating the proliferation of epidermal stem cells and their ability to regenerate this tissue. (cea.fr)
  • Deposition of collagen and proliferation of smooth muscle cells are the response to chronic inflammation and injury of the submucosa leading to fibrosis and thickening of the submucosa and the smooth muscle layers of the bowel wall. (bmj.com)
  • This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
  • Lipids, proteins, carbohydrates and DNA are all susceptible to oxidative damage and this damage can change gene transcription along with cell proliferation and differentiation and is involved in several diseases including diabetes and obesity, cancer and neurological disorders (Kregel, 2007). (promocell.com)
  • Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
  • These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)
  • The appropriate storage and release of calcium is essential for many cell activities, including cell growth and division (proliferation), cell movement (migration), and attachment of cells to one another (cell adhesion). (medlineplus.gov)
  • In addition to proliferation and adhesion, calcium regulation in these cells appears to play an important role in maintaining the skin's barrier function, helping to keep foreign invaders such as bacteria out of the body. (medlineplus.gov)
  • Неходжкінські лімфоми Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (msdmanuals.com)
  • They coaxed mouse embryonic stem cells to become cells that resembled primordial germ cells (PGCs)-an important stage in the development of both eggs and sperm. (scientificamerican.com)
  • generated haploid male gametes from mouse embryonic stem cells that can produce viable and fertile offspring, demonstrating functional reproduction of meiosis in vitro. (scientificamerican.com)
  • When they were first discovered in 2006, iPS cells looked like a perfect solution to the ethical debate over the use of embryonic stem cells, but the process of producing non-mutated cells has proved challenging. (ibtimes.com)
  • Wnt signaling is critical for normal embryonic development of the skin, bones, and other structures. (medscape.com)
  • In the skin, these abnormalities follow the embryonic lines of Blaschko. (medscape.com)
  • These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)
  • In vitro, we found that VEGF enhanced endothelial cell expression of the chemokines monocyte chemoattractant protein 1 and IL-8, and in combination with IFN-γ synergistically induced endothelial cell production of the potent T cell chemoattractant IFN-inducible protein-10 (IP-10). (jci.org)
  • The latter encompass human skin regenerated on immune deficient mice as well as organotypic constructs with epithelial and stromal cells embedded within architecturally faithful mesenchyma in vitro. (stanford.edu)
  • Peptide fractions extracted from Flathead by-products were evaluated for in vitro free radical scavenging and cancer cell cytotoxic activities. (springer.com)
  • Opportunities to study human lung disease either in vivo or in vitro are currently limited. (ca.gov)
  • Our report demonstrating the generation of mature multiciliated cells in respiratory epithelium from iPSCs is a significant advance toward modeling a number of human respiratory diseases in vitro. (ca.gov)
  • In vitro experiments were performed using OGD/R-induced PC12 cells to further investigate the effects of GB on ferroptosis and its mechanisms. (bvsalud.org)
  • In this thesis, human glia-to-neuron direct conversion and engineered viral vectors are explored using pre-clinical in vitro and ex vivo models. (lu.se)
  • The findings, reported yesterday in Nature, suggest a process that doesn't require the reprogrammed adult somatic cells called induced pluripotent stem (iPS) cells. (stanforddaily.com)
  • The reprogrammed cells are pluripotent, which means they can be induced to become any type of cell in the body. (sciencedaily.com)
  • Induced pluripotent stem cells, or iPS cells, are produced by manipulating ordinary human skin or blood cells back to a state in which they are able to differentiate into a number of different cell types. (ibtimes.com)
  • In the current work, the investigators started with human pluripotent stem cells (hPSCs). (sciencedaily.com)
  • Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. (ca.gov)
  • The ability to take a skin cell and reprogram it into an induced pluripotent stem cell, a cell theoretically capable of generating any cell in the body, provides an invaluable tool for studying such lung diseases. (ca.gov)
  • Using induced pluripotent stem cells (iPSCs), we generated mature multiciliated cells in a functional airway epithelium. (ca.gov)
  • My Ph.D. studies have focused on developing ways to generate human astrocytes from pluripotent stem cells and fibroblasts for modeling diseases affecting the human brain. (lu.se)
  • By using a new approach, we developed a rapid and efficient method to generate functional and mature astrocytes from human pluripotent stem cells through overexpression of certain transcription factors that control the development of astrocytes. (lu.se)
  • 15, 2021 Using a new single-cell technique, researchers have uncovered a way to understand the programming behind how stem cells make particular cell types. (sciencedaily.com)
  • In a study published on June 7, 2021, in the journal Nature Communications , the investigators reported that they have developed a new way to create beta cells that is much more efficient than previous methods. (sciencedaily.com)
  • 1. A single functional stem cell is able to regenerate the skin throughout a person's life. (cea.fr)
  • 2. University of Évry, University of Paris-Saclay, INSERM U861, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem), 91100 Corbeil Essonne, France. (cea.fr)
  • 3. Centre for the Study of Stem Cells (CECS), Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I Stem), 91100 Corbeil Essonne, France. (cea.fr)
  • But some scientists are not convinced by the report, which is published today in Cell Stem Cell . (scientificamerican.com)
  • The results are super-exciting and important," says Jacob Hanna, a stem-cell scientist at the Weizmann Institute of Science in Rehovot, Israel. (scientificamerican.com)
  • Now, Xiao-Yang Zhao, a development biologist at the Southern Medical University in Guangzhou, and Qi Zhou, a cloning specialist and stem-cell biologist at the Institute of Zoology in Beijing, along with colleagues from Nanjing Medical University, say that they have trumped Saitou's work by carrying out more of the process in a dish. (scientificamerican.com)
  • A new method of generating mature nerve cells from skin cells could greatly enhance understanding of neurodegenerative diseases, and could accelerate the development of new drugs and stem cell-based regenerative medicine. (science20.com)
  • Within a stem cell, there are mechanisms that tell it when to divide, and when to stop dividing and transform into another cell type, a process known as cell differentiation. (science20.com)
  • The control of this transition from epithelial stem cell to differentiated corneocyte, which is abnormal in epidermal cancers, is not well understood. (stanford.edu)
  • We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
  • The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)
  • Horses suffering from neurological conditions similar to those that affect humans could be helped by a breakthrough from stem cell scientists. (sciencedaily.com)
  • Vets around the world are already using stem cell therapies to treat horses for other types of conditions. (sciencedaily.com)
  • Our research is an important step towards realising that potential for horses and provides an opportunity to validate stem-cell based therapies before clinical studies in humans. (sciencedaily.com)
  • With advancements in stem cell technology, the possibility to generate astrocytes from human stem cells emerged. (lu.se)
  • Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)
  • The role of mtDNA and nuclear genome in human aging was examined by their intercellular transfer using skin fibroblasts and mtDNA-less HeLa cells (rho o-HeLa cells). (nih.gov)
  • We found in vivo age-related reductions in the activity of cytochrome c oxidase in human skin fibroblasts obtained from 16 donors of various ages (0-97 years). (nih.gov)
  • These observations support the idea that accumulation of nuclear recessive somatic mutations, but not mtDNA mutations, is responsible for the in vivo age-related mitochondrial dysfunction observed in human skin fibroblasts. (nih.gov)
  • The intensity of glutamate and especially aspartate-like immunoreactivities seemed to be increased in the epidermis and dermis of the inflamed as compared to the normal skin, and this increase was particularly pronounced in the HLA-DR positive (dendritic) cells in the epidermis. (nih.gov)
  • Pereira's research also involves reprogramming skin cells into dendritic cells, which are the sentinels of the immune system. (lu.se)
  • In cancer patients dendritic cells may become dysfunctional or excluded from tumors. (lu.se)
  • Therefore, new ways are needed to reprogram other cells into immune cells with the same capacity as the "natural" dendritic cells. (lu.se)
  • By using skin cells as the starting cell-type, he managed to identify the three molecules needed to "program" dendritic cells in just nine days. (lu.se)
  • In the next step, he used the same molecules to reprogram cancer cells into dendritic cells. (lu.se)
  • In recent years, much has been learned of the characteristics of immune responses to skin sensitizing chemicals and of the roles played by dendritic cells, cytokines and chemokines. (cdc.gov)
  • Mechanisms of skin sensitization and allergic epidermal Langerhans cells (LC), although other cuta- contact dermatitis neous (dermal) dendritic cells (DC) may also contrib- ute. (cdc.gov)
  • Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)
  • By manipulating the signals which transcription factors send to the cells, Dr Philpott and her collaborators were able to promote cell differentiation and maturation, even in the presence of conflicting signals that were directing the cell to continue dividing. (science20.com)
  • We've found that not only do you have to think about how you start the process of cell differentiation in stem cells, but you also have to think about what you need to do to make differentiation complete - we can learn a lot from how cells in developing embryos manage this," said Dr Philpott. (science20.com)
  • In stratified epithelia proliferative basal cells adherent to the underlying basement membrane undergo cell cycle arrest then outward migration and terminal differentiation. (stanford.edu)
  • May 25, 2023 The many types of cells in the human body are produced through the process of differentiation, in which stem cells are converted to more specialized types. (sciencedaily.com)
  • We developed a step-wise differentiation protocol ending in an air-liquid interface to generate a pseudostratified polarized layer of endodermal-derived epithelial cells, the cells that reside in the respiratory tract. (ca.gov)
  • CPA3 functions together with endopeptidases secreted from mast cells such as chymases and tryptases to degrade proteins and peptides, including the apolipoprotein B component of LDL particles and angiotensin I. Upon mast cell activation and degranulation, CPA3, the chymases, and tryptases are released in complexes with heparin proteoglycan. (wikipedia.org)
  • Fibrosis is characterised by an excessive production of extracellular matrix components, and cells in the tissue are constantly interacting with these extracellular matrix proteins. (bmj.com)
  • More recently, it was found that by adding these proteins to skin cells, they can be reprogrammed to form other cell types, including nerve cells. (science20.com)
  • However, by engineering proteins which cannot be modified by phosphate and adding them to human cells, the researchers found they could produce nerve cells that were significantly more mature, and therefore more useful as models for disease such as Alzheimer's. (science20.com)
  • However, the livers still worked as proven by human liver proteins found in the rats' blood serum. (slashgear.com)
  • Like lipids, proteins are an important constituent of the cell membrane. (rincondelvago.com)
  • Proteins also perform numerous functional roles in the body. (rincondelvago.com)
  • The reprogrammed cancer cells thereby lose their ability to become tumors, and instead activate the immune system to respond to mutated proteins in the tumor. (lu.se)
  • Despite its significance, many WAT-related pathophysiogical mechanisms in humans are still not understood, largely due to the reliance on non-human animal models. (nature.com)
  • Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
  • In: Mukhtar H (ed) Skin cancer: mechanisms and human relevance. (springer.com)
  • Furthermore, the ready access of skin- and gut-homing CD4+ memory T cells to the CNS compartment via CSF has implications for the mechanisms of action of immunotherapeutic strategies, such as oral tolerance or therapeutic immunization, where immunogens are administered using an oral or subcutaneous route. (biomedcentral.com)
  • While trafficking of T cells to the skin and gut is well characterized, less is known about the mechanisms governing homing of T cells across the choroid plexus into the CSF during immune surveillance of the healthy brain [ 11 ]. (biomedcentral.com)
  • However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
  • 6FLHQWLILF VWUDWHJ\ The Agency pursues three main objectives: the identification of the causes of human cancer, the elucidation of the mechanisms of carcinogenesis and the development of scientific strategies for cancer prevention. (who.int)
  • This article seeks to consider skin sensitization and ACD in holistic fashion, bridging experimental observations with clinical disease and basic mechanisms with practical toxicology. (cdc.gov)
  • the chemical allergen must gain access to the viable the immunological mechanisms of skin sensitization epidermis. (cdc.gov)
  • Deletion of the proximal enhancer decreases CCL5 expression and augments the cytotoxic activity of tissue-resident T and NK cells, which coincides with reduced melanoma metastasis in mouse models. (nature.com)
  • Other significant skin lesions are actinic keratosis and melanoma. (medscape.com)
  • Silver staining of melanin for micro-CT provides proof-of-principle for whole-body, three-dimensional computational phenomic analysis of a particular cell type at cellular resolution, with potential applications in other model organisms and human melanoma biopsies. (datadryad.org)
  • Here, we initially determined that VEGF is functional in the trafficking of human T cells into skin allografts in vivo in the humanized SCID mouse. (jci.org)
  • Anti-VEGF failed to inhibit T cell activation responses in vivo, but inhibited intragraft expression of several endothelial cell adhesion molecules and chemokines, including IP-10. (jci.org)
  • reported that NLRP1A generates a functional caspase-1-containing inflammasome in vivo to drive IL-1β-dependent inflammatory disease ( 12 ). (frontiersin.org)
  • Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. (lu.se)
  • These data establish a method for the ex vivo generation of graft-reactive, functional mouse and human T(regs) that uses a clinically approved agent, making pharmacological PDE inhibition a potential strategy for T(reg)-based therapies. (lu.se)
  • The "CPA3" gene expression has only been detected in mast cells and mast-cell-like lines, and CPA3 is located in secretory granules. (wikipedia.org)
  • A new mast cell subtype reported to appear in mucosa is implicated in allergic inflammation and these mast cells have high levels of CPA3. (wikipedia.org)
  • Low density lipoprotein degradation by secretory granules of rat mast cells. (wikipedia.org)
  • METHODS Mast cells were visualised by immunohistochemical staining of the mast cell specific proteases chymase and tryptase. (bmj.com)
  • All mast cells in the muscularis propria were colocalised with patches of laminin. (bmj.com)
  • In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)
  • No colocalisation of mast cells was found with fibronectin or vitronectin. (bmj.com)
  • CONCLUSIONS The large accumulation of mast cells in the muscle layer of strictured bowel suggests a functional role for these cells in the hypertrophic and fibrotic response of the smooth muscle cells. (bmj.com)
  • The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)
  • In fibrosing colonopathy, a complication observed in children with cystic fibrosis treated with high strength pancreatic enzyme replacement therapy, an accumulation of mast cells was observed in the intestinal strictures. (bmj.com)
  • These studies provide evidence that mast cells with their plethora of mediators may be involved in intestinal fibrosis, a notion supported by the observation of mast cell hyperplasia and activation in a variety of clinical and experimental situations in which fibrosis is prominent. (bmj.com)
  • However, liver cirrhosis and intestinal stricture formation are not common in mast cell disease, indicating that besides mast cells additional factors or specific stimulation of mast cells may be necessary to induce severe fibrosis. (bmj.com)
  • It has also been reported in blocking of IgE to Fc epsilon Receptor and degranulation of mast cells. (thermofisher.com)
  • The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. (thermofisher.com)
  • Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
  • In addition to its roles in the regulation of inflammatory diseases and the maintenance of local immune cells, CCL5 expressed by cancer cells plays diverse roles in shaping cancer microenvironments toward their own survival. (nature.com)
  • The functional role of glutamate and aspartate in normal skin, and the significance of the increase in the levels of these amino acids in several cell populations in the inflammatory skin is not known, but modulatory or protective roles may be considered. (nih.gov)
  • Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
  • associated with skin-homing) as well as the expression of integrin α4β7 and CCR9 (associated with gut-homing) was analyzed on CD4+ memory T cells in CSF from individuals with non-inflammatory neurological diseases using flow cytometry. (biomedcentral.com)
  • The program will achieve its goals by developing a comprehensive understanding of the wound environment, including cellular elements, matrix, inflammatory mediators, growth factors, nutrients, substrate utilization, biofilms, and ultimately processes of morphogenesis leading to anatomic and functional restoration. (technovelgy.com)
  • CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)
  • Although biochemical functions of the human PORCN gene are not well characterized, Wnt signaling may be involved in the phenotypic expression of focal dermal hypoplasia where defective/deficient Wnt signaling could affect cell fate or result in failure of a progenitor cell line to expand. (medscape.com)
  • The discoveries of a French research team from the CEA, INSERM and the University of Paris, produced in collaboration with I-Stem, the AFM-Téléthon laboratory, and the University of Évry, opens perspectives for regenerative cutaneous medicine, in particular for the bio-engineering of skin grafts for tissue reconstruction. (cea.fr)
  • This work has been extended to other types of cells of interest for cutaneous cell therapy. (cea.fr)
  • For instance, studies in mice have demonstrated that CD4+ T cells activated in cutaneous lymph nodes upregulate trafficking determinants specific for the skin, such as P-selectin ligand, while T cells responding to antigen in intestinal lymph nodes express high levels the gut-associated adhesion molecule integrin α4β7 and acquire responsiveness to the intestinal CC-chemokine ligand CCL25 [ 2 ]. (biomedcentral.com)
  • Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the first and second most common types of skin cancer, respectively. (medscape.com)
  • Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and one of the most common cancers overall in the United States. (medscape.com)
  • A biopsy should be performed for any lesion suspected of being a cutaneous neoplasm to rule out basal cell carcinoma and other dermal lesions. (medscape.com)
  • The development of skin sensitization is associated with, and requires, the activation and clonal expansion of allergen responsive T lymphocytes and it is these cells that orchestrate the cutaneous allergic reaction. (cdc.gov)
  • Skin lesions in neurofibromatosis type 2: diagnostic and prognostic significance of cutaneous (plexiform) schwannomas. (cdc.gov)
  • The researchers found that BAM treatment to skin cells from fetuses and newborns didn't have the same effect as it did on the stem cells. (stanforddaily.com)
  • By studying how nerves form in developing tadpoles, researchers from the University of Cambridge were able to identify ways to speed up the cellular processes by which human nerve cells mature. (science20.com)
  • Using cells scraped from a person's skin, researchers grew miniature human livers in a lab and then successfully transplanted them into living rats. (slashgear.com)
  • The study was recently published in Cell Reports , where researchers detail the experiment and its results. (slashgear.com)
  • Cell assays and primary cells provide the tools researchers need to study the oxidative process and its association with skin aging. (promocell.com)
  • Skin aging is a multi-faceted process, and researchers are still working to fully understand the complex interactions that take place. (promocell.com)
  • Researchers who are the first to create working nerve cells from horse stem cells say the advance may pave the way for cell therapies that target conditions similar to motor neuron disease. (sciencedaily.com)
  • The researchers took skin cells from a young horse and turned them into stem cells using a technique that was originally developed for human cells. (sciencedaily.com)
  • Researchers at the Center for iPS Cell Research and Application at Kyoto University in Japan presented data at a meeting of the American Society of Hematology showing they were able to create the cells in the laboratory and confirm they had the same life span as normal human platelets when infused in mice. (ibtimes.com)
  • The Japanese researchers set out to create an immortalized cell line with a large number of high-quality megakaryocytes -- precursor cells that develop into platelets -- from stem cells that can be grown indefinitely and differentiate into a variety of cell types in the body. (ibtimes.com)
  • To address the problem, the researchers took a stepwise approach to create beta cells. (sciencedaily.com)
  • The researchers will continue to study this technique in the lab to further optimize the production of beta cells. (sciencedaily.com)
  • Currently, researchers have only the crude measure of whether cells die during the test. (princeton.edu)
  • Different skin types respond to extrinsic factors in different ways, with type I and II (fair) skin experiencing increased extrinsic aging in response to the same stimuli (Naidoo, 2017). (promocell.com)
  • Scientists are developing a promising approach for treating type 1 diabetes by using stem cells to create insulin-producing cells (called beta cells) that could replace nonfunctional pancreatic cells. (sciencedaily.com)
  • Using various growth factors and chemicals, the investigators coaxed hPSCs into beta cells in a stepwise fashion that mimicked pancreatic development. (sciencedaily.com)
  • The results indicate that the sea anemone venom is cytotoxic to human cancer cells. (scielo.br)
  • This thesis presents three different approaches based on genome editing with the aim of treating RDEB, focused on genetically corrected epidermal stem cells to achieve long-term healthy skin regeneration. (uc3m.es)
  • The first strategy used TALENs and showed the feasibility of an exon deletion-based approach to correct RDEB epidermal stem cells as safe clonal therapy. (uc3m.es)
  • Taken together, the different approaches described show epidermal stem cells correction efficient enough to make skin equivalents with therapeutic potential for RDEB patients. (uc3m.es)
  • The team first made mouse PGCs, and then added cells taken from the testicular tissue of newborn mice, as well as other biological molecules. (scientificamerican.com)
  • Last week, Vladimir Mironov, head of 3D Bioprinting Solutions, announced his laboratory is ready to start printing a human thyroid gland after their successful experiments on mice. (singularityhub.com)
  • Saline, IgG, or anti-human VEGF were received by huSCID mice bearing human skin transplants. (jci.org)
  • Treatment of huSCID mice with anti-human VEGF inhibited both CD3 + T cell ( f ) and CD68 + monocyte macrophage ( i ) infiltration of skin. (jci.org)
  • A recent study carried out in mice showed that complex II activity is lower in the skin of naturally aged older mice compared to younger mice. (ncl.ac.uk)
  • To address this and to also study the oncogenic potential of unregulated function of dominant regulators of epithelial homeostasis noted above, we developed Multi-Functional Human Tissue Genetics noted above which, when combined with skin tissue regeneration on immune deficient mice, has permitted the molecular reconstruction of events sufficient to trigger human cancer. (stanford.edu)
  • We generated Nlrp1b (the mouse homologue of human NLRP1 ) gain-of-function knock-in ( Nlrp1b KI) mice with UVB irradiation-induced autoinflammatory skin lesions. (frontiersin.org)
  • The skin inflammation and hyperkeratosis from UVB irradiation in the Nlrp1b KI mice were inhibited by both intraperitoneal and subcutaneous administration of anti-IL-1β antibodies before UVB irradiation. (frontiersin.org)
  • The previously reported pathogenic mutation in NLRP1 in humans, and the missense mutation we inserted into the BALB/c mice in this study. (frontiersin.org)
  • They then tested the cultured platelets by infusing them into immunodeficient mouse models and confirmed that they had the same life span as human platelets infused in mice. (ibtimes.com)
  • After the cells were created, they were transplanted into a mouse model of type 1 diabetes, The model mice had a modified immune system that would not reject transplanted human cells. (sciencedaily.com)
  • 2,4,5- Trichlorophenol has caused liver and kidney damage, has promoted the development of papillomas when applied dermally to mice, and is an irritant to the eyes, skin, nose and throat of humans. (cdc.gov)
  • Testing in mice has produced increased incidences of hepatocellular carcinomas, adenomas, hepatomas, and reticulum cell sarcomas. (cdc.gov)
  • The enzyme now called CPA3 was originally named mast cell carboxypeptidase A, and another protein was initially called CPA3. (wikipedia.org)
  • The scientists found that the reason for this is the amount of enzyme protein was decreased and furthermore this decrease was only observed in those cells that had stopped proliferating. (ncl.ac.uk)
  • Intarasirisawat R, Benjakul S, Visessanguan W, Wu J (2012) Antioxidative and functional properties of protein hydrolysate from defatted skipjack ( Katsuwonous pelamis ) roe. (springer.com)
  • Robust multiciliogenesis occurred when notch signaling was inhibited and was confirmed by (i) the assembly of multiple pericentrin-stained centrioles at the apical surface, (ii) expression of transcription factor forkhead box protein J1, and (iii) presence of multiple acetylated tubulin-labeled cilia projections in individual cells. (ca.gov)
  • This protein is an adenosine triphosphate (ATP)-powered calcium pump, which uses energy from ATP molecules to pump charged calcium atoms (calcium ions) across cell membranes. (medlineplus.gov)
  • Specifically, the hSPCA1 protein transports calcium ions into a cell structure called the Golgi apparatus, where they are stored until needed. (medlineplus.gov)
  • The hSPCA1 protein is present in cells throughout the body. (medlineplus.gov)
  • Mutations in this gene reduce the amount of functional hSPCA1 protein, which impairs the storage of calcium ions in the Golgi apparatus. (medlineplus.gov)
  • However, it is unclear how a reduction of hSPCA1 protein function affects the skin barrier, and how its impairment is involved in Hailey-Hailey disease. (medlineplus.gov)
  • They began by extracting stem cells from the living organism via its fat cells. (singularityhub.com)
  • Among the different subtypes described, the Recessive Dystrophic Epidermolysis Bullosa (RDEB) is the most severe subtype, with an increased risk of developing squamous cell carcinoma (SCC). (uc3m.es)
  • Human skin completely renews itself every month thanks to the presence of stem cells in the deepest layer, which generate all the upper layers of this tissue. (cea.fr)
  • Recent studies using neutralizing anti-CCL5 antibodies have suggested that the constitutive expression of CCL5 plays a regulatory role in maintaining tissue-resident memory (Trm) T cells in the human vaginal tract 9 and mouse skin 10 , suggesting that constitutive CCL5 expression in noninflamed conditions, hereafter referred to as homeostatic CCL5 expression, might be important for homeostasis of tissue-resident lymphocytes. (nature.com)
  • Advances in tissue engineering technology have led to the production of novel human skin equivalents and organoids that reproduce cell-cell interactions with tissue-scale tensional homeostasis, and enable us to evaluate skin tissue morphology, functionality, drug response and wound healing. (mdpi.com)
  • Our experimental focus is on the mammalian setting using multiomics, informatics, mouse genetics, human genetics, single cell studies, and new human tissue platforms. (stanford.edu)
  • These new models, which we term Multi-Functional Human Tissue Genetics, allow up to 10 alleles or more to be altered simultaneously, permitting genetic experiments with an unprecedented degree of rapidity and complexity. (stanford.edu)
  • However, the skin is the largest organ in the human body, and a large area of metabolic tissue. (promocell.com)
  • The age-related alteration of collagen-rich extracellular matrix - promoted by oxidative stress - impairs the skin's structural integrity and creates a tissue microenvironment that promotes age-related skin diseases such as poor wound healing and skin cancer. (promocell.com)
  • Circulating memory T cells can be divided into tissue-specific subsets, which traffic through distinct tissue compartments during physiologic immune surveillance, based on their expression of adhesion molecules and chemokine receptors. (biomedcentral.com)
  • Consequently, circulating T cells can be divided into tissue specific subsets, each of which have the ability to traffic through certain tissue compartments, but which are excluded from others. (biomedcentral.com)
  • The ultimate goal is to design softer devices that move with living tissue, maintaining a connection without damaging human cells. (princeton.edu)
  • It is very difficult to develop therapeutics for central nervous system disorders owing to several challenges in studying the human brain due to its exceptionally high complexity that is not present in other animal species, and inaccessibility to tissue samples from patients and healthy individuals. (lu.se)
  • In 1962, Goltz reported 3 female children with linear areas of thinning of the skin and herniations of adipose tissue. (medscape.com)
  • Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
  • However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
  • UVB irradiation and the IL-1β pathway are important in the pathogenesis of NLRP1-associated autoinflammatory skin lesions. (frontiersin.org)
  • When you reprogramme cells, you're essentially converting them from one form to another but often the cells you end up with look like they come from embryos rather than looking and acting like more mature adult cells," said Dr Anna Philpott of the Department of Oncology, who led the research. (science20.com)
  • In order to increase our understanding of diseases like Alzheimer's, we need to be able to work with cells that look and behave like those you would see in older individuals who have developed the disease, so producing more 'adult' cells after reprogramming is really important. (science20.com)
  • These results indicate that the two intestinal secretory peptides antagonistically regulate adult lifespan and intestinal senescence through multiple pathways, irrespective of insulin, which implicates a complementary gradient distribution of each of the hormone-producing EEs, consistent with local requirements for cell activity along the posterior midgut. (bioone.org)
  • The efficacy of these treatments has not been completely proven and they use adult stem cells, which are harder to maintain and are more restricted in the types of cells that they can become. (sciencedaily.com)
  • Reuters) - Scientists have for the first time created blood platelet cells by reprogramming stem cells derived from adult cells, offering the potential for a renewable supply of the fragile blood component. (ibtimes.com)
  • According to a new solicitation by DARPA , adult stem cells are seen as the regenerative regimen of choice. (technovelgy.com)
  • Thus, VEGF appears to be functional in acute allograft rejection via its effects on leukocyte trafficking. (jci.org)
  • He has succeeded in converting human skin cells into blood stem cells, which is a first step towards creating fully functional blood stem cells in test tubes. (lu.se)
  • The nerve cells generated by this new method show the same functional characteristics as the mature cells found in the body, making them much better models for the study of age-related diseases such as Parkinson's and Alzheimer's, and for the testing of new drugs. (science20.com)
  • Eventually, the technique could also be used to generate mature nerve cells for transplantation into patients with a range of neurodegenerative diseases. (science20.com)
  • In addition, for age-related diseases such as Parkinson's and Alzheimer's, both of which affect millions worldwide, mature nerve cells which show the same characteristics as those found in the body are crucial in order to enhance understanding of the disease and ultimately determine the best way to treat it. (science20.com)
  • The investigators say the methods reported in this paper may also be useful for developing specialized cells to treat other diseases. (sciencedaily.com)
  • The development of this model will enable the future study of many lung diseases (especially those where defective cilia are involved, such as primary ciliary dyskinesia) that have been difficult to study in human models from a developmental perspective. (ca.gov)
  • Whole-organism, high-resolution phenotyping is a challenging ideal, but provides superior context for functional studies of mutations, diseases, and environmental influences. (datadryad.org)
  • Instead, by developing models in the dish with high biological relevance and predictive value for the human brain, we can accelerate our knowledge about what occurs during diseases affecting humans. (lu.se)
  • We focused on one of the main cell types found in our brains, the astrocyte, which over the last decade has emerged as an important contributor to a wide range of neurological diseases. (lu.se)
  • He expressed hope that one day the cells could be used for human therapies. (stanforddaily.com)
  • Stem cells are an extremely promising approach for developing many cell therapies, including better treatments for type 1 diabetes," says Salk Professor Juan Carlos Izpisua Belmonte, the paper's senior author. (sciencedaily.com)
  • The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)
  • To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
  • Reprogramming skin cells to blood stem cells could potentially provide an unlimited source of cells for transplantation to patients with blood disorders. (lu.se)
  • Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)
  • Using iPSC stem cells (ones acquires from skin cells), the scientists were able to create what they call mini livers that were then transplanted into rats. (slashgear.com)
  • Epidermolysis Bullosa (EB) is a heterogeneous family of rare genetic skin disorders characterized by loss of dermal-epidermal adhesion, blistering of the skin, erosions and scar formation after minor trauma. (uc3m.es)
  • We reasoned that a bias (either enrichment or depletion) of CSF T cell expression of known organ-specific trafficking determinants might suggest that homing of T cells to the subarachnoid space could be governed by a CNS-specific adhesion molecule or chemokine receptor. (biomedcentral.com)
  • Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)
  • Problems with calcium regulation impair many cell functions, including cell adhesion. (medlineplus.gov)
  • In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)
  • Інфекція вірусом імунодефіциту людини (ВІЛ) Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
  • As well as making more mature nerves, Dr Philpott's lab is now using similar methods to improve the function of insulin-producing pancreas cells for future therapeutic applications. (science20.com)
  • Dr Xavier Donadeu from the Roslin Institute, an author of the study, said: "Stem cells hold huge therapeutic potential both for people and animals. (sciencedaily.com)
  • Such research may provide a novel preventive and therapeutic approach for diabetic retinopathy, because natural products may have few side effects and are safe for human consumption compared with synthetic compounds. (rsc.org)
  • CCL5 is a unique chemokine with distinct stage and cell-type specificities for regulating inflammation, but how these specificities are achieved and how CCL5 modulates immune responses is not well understood. (nature.com)
  • Other studies reported that some cancer cells could repress their own CCL5 expression to hinder migration of anticancer immune cells toward cancer sites 15 , 16 . (nature.com)
  • Therefore, host CCL5 can obviously work as an anticancer molecule to mount relevant immune responses against some cancer cells. (nature.com)
  • Endocrine functions of white adipocytes, and other WAT-resident cells in the stromal vascular fraction, are performed by the release of a variety of adipokines (adipose-associated cytokines) which affect the functioning of the brain, liver, pancreas and immune system 9 . (nature.com)
  • An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination. (ictv.global)
  • They play a key role in orchestrating the immune response by "informing" other immune cells about the threat from foreign substances in the body. (lu.se)
  • In other words, using the molecules as a trojan horse to "force" cancer cells to develop into immune cells. (lu.se)
  • Results showed that in cultured human-derived retinal pigment epithelial ARPE-19 cells , the extract of Chlorella zofingiensis and its nutritional ingredient astaxanthin exhibited significant inhibitory effects on the formation of endogenous N ε -carboxymethyllysine (CML), a key AGE representative, through the suppression of intracellular oxidative stress. (rsc.org)
  • Melanin-rich zebrafish melanophores are used to study pigment development, human skin color, and as a large-scale screening phenotype. (datadryad.org)
  • The cytotoxicity on different cell lines was assayed using the 3-(4, 5-dimethylthiazol-2yl)-2, 5-diphenyltetrazolium bromide (MTT) assay which measures survival based on the detection of mitochondrial activity and by the crystal violet assay, which measures survival based on the ability of cells to remain adherent to microplates. (scielo.br)
  • Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores. (medlineplus.gov)
  • Other scientists raise specific concerns that mainly relate to the timing of the processes that lead to the sperm cells. (scientificamerican.com)
  • For the first time, scientists at Newcastle University have identified that the activity of a key metabolic enzyme found in the batteries of human skin cells declines with age. (ncl.ac.uk)
  • Horse stem cells have been produced in the laboratory before but this is the first time that scientists have created working cells of a specific type from them. (sciencedaily.com)
  • Although scientists know that microbial ecology plays an important role in maintaining human health, there are remaining scientific questions. (cdc.gov)
  • A few sea anemone species can cause a mild to severe sting that leads to pain, erythema, ulcer and sometimes necrosis, for example, Anemonia sulcata and Phyllodiscus semoni which are dangerous to humans (4, 5). (scielo.br)
  • Free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), can lead to damage of biomolecules which then affects gene expression, cell metabolism and distinct physiological functions. (promocell.com)
  • As intelligent as are many other mammals-such as chimpanzees and dolphins-none have achieved the intellectual status of the human species. (rincondelvago.com)
  • A related, often sympatric species is Borrelia bissettii , but this species has not been associated with human disease. (cdc.gov)
  • They were able to produce a cell line that turned off certain genes to generate functional platelets. (ibtimes.com)
  • 3 When the reaction occurs in living organisms, these adducts can generate cross-links between key molecules, leading to their structural modifications and functional impairments. (rsc.org)
  • This layer includes secretory cells called Clara cells and goblet cells and multiciliated cells which generate flow in the fluid lining the lungs. (ca.gov)
  • After beginning her research journey as a master's student within our Ph.D. Preparatory Program, she dedicated the last several years to developing more efficient methods that can be used to generate functional and mature astrocytes for disease modeling of neurological disorders. (lu.se)
  • Clara, goblet, and basal cells were all present, confirming the generation of a complete polarized epithelial-cell layer. (ca.gov)
  • Chemical and functional properties of food components. (springer.com)
  • CASRN: 505-60-2) or as it is commonly called, `mustard gas', is one of a class of vesicant chemical warfare agents with the ability to form vesicles or blisters on exposed skin. (cdc.gov)
  • A more detailed appreciation of responses induced by chemical allergens has in turn facilitated the design of novel approaches to the toxicological evaluation of skin sensitization. (cdc.gov)
  • This change in T cell homing potential is affected by the microenvironment where initial antigen recognition occurred, as memory T cells preferentially return to regions of the body similar to those where the initial antigen was encountered [ 1 ]. (biomedcentral.com)
  • Enteroendocrine cells (EEs) are evolutionarily conserved gastrointestinal secretory cells that show scattered distribution in the intestinal epithelium. (bioone.org)
  • The following product was used in this experiment: FceR1 alpha Monoclonal Antibody (MAR-1), Functional Grade, eBioscience™ from Thermo Fisher Scientific, catalog # 16-5898-82, RRID AB_469137. (thermofisher.com)
  • Cloning and characterization of the novel gene for mast cell carboxypeptidase A". The Journal of Clinical Investigation. (wikipedia.org)
  • More research is needed to assess safety issues before clinical trials can be initiated in humans. (sciencedaily.com)
  • Levels of AGEs in serum, 5,6 skin 7 or cornea 8 were found to be correlated with the onset or clinical grade of diabetic retinopathy. (rsc.org)
  • Report of 19 human cases with clinical and pathological observations. (cdc.gov)
  • Human Vaccinia virus and Pseudocowpox virus co-infection: clinical description and phylogenetic characterization. (cdc.gov)
  • Finally, progress has been made in the characterization of skin sensitization in humans and in the clinical management of ACD. (cdc.gov)
  • Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • 2-4 The pathogenesis, factors, and cell types involved in this process are largely unknown. (bmj.com)
  • This effect on longevity is apparently correlated with the midgut senescence phenotypes as a result of direct hormone action through both hormone receptors expressed in the enteroblasts or other midgut cell types. (bioone.org)
  • Multicentre case-control studies clearly demonstrated a cervical cancer risk associated with infection with a variety of human papillomaviruses (HPV) other than types 16 and 18. (who.int)
  • The living hair roots are anchored deeply in the skin of the scalp and form complex "mini-organs" that are composed of different cell types to produce the visible hair fibers. (henkel-northamerica.com)
  • Astrocytes are one of the major cell types in the central nervous system and are indispensable for brain development and function. (lu.se)
  • Research on the various cell types in the brain, such as astrocytes, has been hindered by difficulties in obtaining the actual cells to study. (lu.se)
  • This study opens perspectives for regenerative skin medicine. (cea.fr)
  • This expansion phase involves a risk: it may be accompanied by a quantitative loss or degradation of stem cells, leading to a loss of regenerative potential. (cea.fr)
  • Finally, in the third chapter, an HDRbased approach offers the most accurate way to correct the disease-causing mutations, with gene correction efficiencies above the threshold (30%) needed to sustain the dermalepidermal junction of the skin. (uc3m.es)
  • More than 200 mutations in the ATP2C1 gene have been found to cause Hailey-Hailey disease, a rare skin condition characterized by red, raw, and blistered areas of skin that can become infected. (medlineplus.gov)
  • Although ATP2C1 gene mutations probably also affect the transport of manganese within cells, abnormal manganese regulation is not thought to contribute to the signs and symptoms of Hailey-Hailey disease. (medlineplus.gov)
  • Direct neuronal conversion of resident glial cells is advantageous since they are ubiquitously distributed brain cells able to self-renew and replenish their number, making them ideal candidates for endogenous repair. (lu.se)
  • He receives the award for his work on reprogramming blood cells and the development of immunotherapies based on this technology. (lu.se)
  • He was in high school when he heard about Dolly, one of the world's most extreme examples of cell reprogramming. (lu.se)
  • Filipe Pereira has found his niche at the interface of cellular reprogramming and blood cell identity. (lu.se)
  • In the present study, the venoms from five sea anemones (Heteractis crispa, Heteractis magnifica, Heteractis malu, Cryptodendrum adhaesivum and Entacmaea quadricolor) were obtained by the milking technique, and the potential of these venoms to kill cancer cells was tested on three cell lines (A549 lung cancer, T47D breast cancer and A431 skin cancer). (scielo.br)
  • A study, published online in the Journal of Investigative Dermatology , has found that the activity of mitochondrial complex II significantly decreases in older skin. (ncl.ac.uk)
  • Our study shows, for the first time, in human skin that with increasing age there is a specific decrease in the activity of a key metabolic enzyme found in the batteries of the skin cells. (ncl.ac.uk)
  • The livers 'remained functional,' according to the study, for the four days they spent as transplants in the rats. (slashgear.com)
  • The study is published in the journal Stem Cells and Development . (sciencedaily.com)
  • The next step will be to conduct a trial to determine whether our platelets can function in the human body," said Dr. Koji Eto, professor at the Kyoto center and senior author of the study. (ibtimes.com)
  • In the present study, for the first time, protective effects of three microalgal strains, including their extracts and active compounds, against both endogenous and exogenous AGEs in cell -based models were investigated. (rsc.org)
  • In a study of the US Medicare population, the treatment of nonmelanoma skin cancers ranked fifth among the most expensive cancers to treat in the head-and-neck region. (medscape.com)
  • This sparked Filipe Pereira's curiosity about the human body, and he put aside his plans to study architecture, choosing instead biology and later pursue a doctorate in epigenetics. (lu.se)
  • The presence of glutamate/aspartate-like immunoreactivity was studied in normal human skin and in skin with gold-induced inflammation. (nih.gov)
  • Oxidative stress results from an imbalance of pro- and anti-oxidants and leads to faster skin aging, inflammation and disease. (promocell.com)
  • Some progress has been made in defining trafficking determinants for inflamed CNS microvessels: CD8+ T cells activated in cervical lymph nodes draining intracerebral tumors in the mouse acquire a phenotype characterized by high expression of the two integrins α4 and α1 as well as a modest increase in the expression of P-selectin ligand [ 12 ]. (biomedcentral.com)
  • In healthy human adults, WAT comprises approximately 20-25% of the total body mass, thus constituting the second largest organ, after the skin. (nature.com)
  • The skin is the largest organ of the human body, covering an area of approximately 2 square meters in average. (uc3m.es)
  • Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. (nih.gov)
  • Stem cells are our master cells, which can develop into almost any cell type within the body. (science20.com)
  • Encuentra aquí información de Human Body para tu escuela ¡Entra ya! (rincondelvago.com)
  • A brief treatment of the human body follows. (rincondelvago.com)
  • For information on the structure and function of the cells that constitute the body, see Cells. (rincondelvago.com)
  • Like all chordates, the human animal has a bilaterally symmetrical body that is characterized at some point during its development by a dorsal supporting rod (the notochord), gill slits in the region of the pharynx, and a hollow dorsal nerve cord. (rincondelvago.com)
  • Characteristic of the vertebrate form, the human body has an internal skeleton that includes a backbone of vertebrae. (rincondelvago.com)
  • Typical of mammalian structure, the human body shows such characteristics as hair, mammary glands, and highly developed sense organs. (rincondelvago.com)
  • Among the mammals, only human beings have a predominantly two-legged (bipedal) posture, a fact that has greatly modified the general mammalian body plan. (rincondelvago.com)
  • Water is found in the extracellular fluids of the body (the blood plasma, the lymph, and the interstitial fluid) and within the cells themselves. (rincondelvago.com)
  • The human body is about 60 percent water by weight. (rincondelvago.com)
  • Lipids-chiefly fats, phospholipids, and steroids-are major structural components of the human body. (rincondelvago.com)
  • Carbohydrates are present in the human body largely as fuels, either as simple sugars circulating through the bloodstream or as glycogen, a storage compound found in the liver and the muscles. (rincondelvago.com)
  • 7 , 8 In systemic mast cell disease, association of fibrosis and mast cell infiltrates has been documented in the liver, spleen, lymph nodes, and bone marrow. (bmj.com)
  • Actinic keratosis and basal cell carcinoma are easily excised and have a very good prognosis, while cSCC has a poor prognosis, especially if it invades the lymph nodes and adjacent vital structures. (medscape.com)
  • The induction of sensitization and internalize antigen encountered in the skin and to and the elicitation of allergic contact reactions are transport it, via afferent lymphatics, to regional lymph dependent upon, and are orchestrated by, T lympho- nodes. (cdc.gov)
  • In the case of thyroid dysfunction caused by cancer, not even a donor transplant helps because patients who receive organ transplants have to undergo immunosuppression therapy, which can speed up the development of cancer cells. (singularityhub.com)
  • In this regard, emerging technologies of chimeric human organ production via blastocyst complementation (BC) holds great promise. (frontiersin.org)
  • In this review, we summarize the history of interspecies chimerism in various animal models to find hints for BC application and describe the challenges and prospects of utilizing BC for human organ generation. (frontiersin.org)
  • These are mature nerve cells generated from human cells using enhanced transcription factors. (science20.com)
  • The team used them to create nerve cells in the laboratory and tested whether they were functional by showing that they could transmit nerve signals in a test tube. (sciencedaily.com)
  • By comparison, techniques used to create nerve cells from hPSCs have yields of about 80 percent. (sciencedaily.com)