• HMOX1 and HMOX2 belong to the heme oxygenase family. (genetex.com)
  • Heme oxygenase 1 (HMOX1, commonly HO-1) is a member of the heat shock protein (HSP) family identified as HSP32. (wikipedia.org)
  • HO-1 is a 32kDa enzyme which contains 288 amino acid residues encoded by the HMOX1 gene. (wikipedia.org)
  • Heme oxygenase-1 (Hmox1) is a stress-inducible protein crucial in heme catabolism. (springer.com)
  • This was accompanied by higher numbers of Ly6C hi monocytes in peripheral blood, as well as higher expression of monocyte chemoattractant protein-1 and adhesion molecules in the hearts of MI-operated Hmox1 −/− mice. (springer.com)
  • Heme oxygenase-1 (Hmox1) catalyzes the conversion of heme to biliverdin, carbon monoxide (CO), and ferrous iron (Fe 2+ ). (springer.com)
  • The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
  • Human heme oxygenase-1 (hHO-1/HMOX1) can protect transplanted organs by its strong anti-oxidative, anti-apoptotic, and anti-inflammatory effects. (korea.ac.kr)
  • Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. (genetex.com)
  • Heme oxygenase, or haem oxygenase, (HMOX, commonly abbreviated as HO) is an enzyme that catalyzes the degradation of heme to produce biliverdin, ferrous ion, and carbon monoxide. (wikipedia.org)
  • Heme oxygenase (alternatively spelled using haem or oxidase) catalyzes the degradation of heme to biliverdin/bilirubin, ferrous ion, and carbon monoxide. (wikipedia.org)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • the classic example is the healing process of a contusion, which forms different chromogens as it gradually heals: (red) heme to (green) biliverdin to (yellow) bilirubin which is widely known for jaundice. (wikipedia.org)
  • Heme oxygenase (HO)-1 is a stress-inducible protein which oxidatively degrades heme into biliverdin and CO. This study aimed to examine whether the HO-1 induction changes hepatic vascular responses through vasorelaxing action of CO. Isolated perfused rat livers were used to assess the vascular resistance under the unstimulated baseline and ET-1-stimulated conditions. (elsevierpure.com)
  • Heme oxygenase 1 in erythropoiesis: an important regulator beyond catalyzing heme catabolism. (nih.gov)
  • The eukaryotic enzyme binds FAD, FMN, heme (iron protoporphyrin IX) and tetrahydrobiopterin, and its two domains are linked via a regulatory calmodulin-binding domain. (cathdb.info)
  • The elucidation and description of the molecular and structural features of gasotransmitters, their production pathways, signaling mechanisms, cellular and molecular targets, and functional impact in prokaryotic and eukaryotic cells are the focus of this book. (rsc.org)
  • It is followed by the accumulation of bilirubin, which is a secondary product of the activity of heme oxygenase-1, an enzyme that catalyzes the breakdown of heme released from disrupted erythrocytes and taken up by hepatic macrophages. (researchgate.net)
  • Heme oxygenase 2 (HMOX2 or HO-2) is a constitutive isoform that is expressed under homeostatic conditions in the testes, gastrointestinal tract, endothelial cells and the brain. (wikipedia.org)
  • Furthermore, an increased protein expression of heme oxygenase-1 in the liver tissues of the I/R mice was attenuated by the administration of GP. (spandidos-publications.com)
  • Heme oxygenase-1 (HO-1) and p-NF-κB protein expression in hearts, superoxide dismutase (SOD) activity and malondialdehyde (MDA) level in serum were used to evaluate the anti-oxidative properties of the extract. (biomedcentral.com)
  • In addition, the extract increased SOD activity in serum, HO-1 protein expression in hearts, and decreased TNF-α, IL-6, COX-2, p-NF-κB and p-ERK1/2 protein expression. (biomedcentral.com)
  • In the present study, sublethal concentrations of PAT were examined in neonatal rat cardiac myocytes for PAT-induced changes in cellular glutathione levels, heme oxygenase and stress protein expression. (cdc.gov)
  • [ 1 ] Clinically, biomarkers can be used to screen for, diagnose, or monitor the activity of diseases as well as guide molecularly targeted therapy or assess therapeutic response. (medscape.com)
  • In this study, we aim to leverage these metabolic changes as potential biomarkers for assessing ovarian cancer.A functional module-based approach was utilized to identify key gene expression pathways that distinguish different stages of ovarian cancer (OC) within a tissue biopsy cohort. (stanford.edu)
  • This method allowed for the precise quantification of targeted metabolite biomarkers using an OC blood cohort comprising control samples (n = 464), benign samples (n = 3), and OC samples (n = 13).Eleven functional modules were identified as significant differentiators (false discovery rate, FDR (stanford.edu)
  • 7. Beneficial use of serum ferritin and heme oxygenase-1 as biomarkers in adult-onset Still's disease: A multicenter retrospective study: Y. Kirino, et al. (nbsbioscience.cn)
  • 6. Induction of HO-1 by 5, 8-Dihydroxy-4,7-Dimethoxyflavone via Activation of ROS/p38 MAPK/Nrf2 Attenuates Thrombin-Induced Connective Tissue Growth Factor Expression in Human Cardiac Fibroblasts: C. Yang, et al. (nbsbioscience.cn)
  • 11. Haemolysis and haem oxygenase-1 induction during persistent 'asymptomatic' malaria infection in Burkinabé children: J.P. Mooney, et al. (nbsbioscience.cn)
  • The stress protein heme oxygenase is especially susceptible to induction by metals. (cdc.gov)
  • Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A. Sci Rep. 2020 May 12;10(1):7849. (rvc.ac.uk)
  • Association between heme oxygenase one and sepsis development in patients with moderate-to-critical COVID-19: a single-center, retrospective observational study. (nih.gov)
  • Sepsis, the most common cause of indirect ARDS [ 1 ], has received the most attention regarding the contribution of systemic illness to damage of the RBC. (biomedcentral.com)
  • Whereas HO-1 has innumerable inducers, only adrenal glucocorticoids are known to induce HO-2 whereas certain other molecules may increase its catalytic velocity. (wikipedia.org)
  • Drummond and Kappas demonstrated that PAT as well as other antimony -containing compounds were potent inducers of heme oxygenase in the liver and kidney of rats, but the effects of PAT on the heart were not examined. (cdc.gov)
  • These results provide evidence that overproduction of CO accounts for the mechanisms for HO-1-mediated microvascular hyporeactivity, suggesting its pathophysiological significance for functional alterations in hepatoportal vascular system under stress conditions. (elsevierpure.com)
  • 10. Endothelin-1-induced hypertrophic alterations and heme oxygenase-1 expression in cardiomyoblasts are counteracted by beta estradiol: in vitro and in vivo studies: T. Barta, et al. (nbsbioscience.cn)
  • Antimony -containing compounds produce cardiac functional alterations and toxicity in both experimental animals and humans. (cdc.gov)
  • The Rouault lab discovered that animals that lacked IRP2 developed adult-onset neurodegeneration with prominent motor neuron disease, and studies demonstrated that functional iron deficiency adversely affected mitochondrial function in neurons. (nih.gov)
  • After exposed to 40 μmol/kg of hemin, the liver increased HO-1 expression time-dependently that peaked at 12 hrs. (elsevierpure.com)
  • Iron-regulatory proteins 1 and 2 (IRP1 and IRP2) regulate the expression of numerous proteins of iron metabolism. (nih.gov)
  • Early work involved cloning and characterization of iron regulatory proteins 1 and 2 (IRPs), and elucidation of how these proteins sense cytosolic iron levels and regulate expression of iron metabolism genes. (nih.gov)
  • At 24 h post-operatively, we assessed the serum levels of creatinine and urea nitrogen, expression levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and NF-κB-related (p-IKK-β and IκB-α) proteins, and mRNA expression levels of the inflammatory cytokines, including TNF-α and MCP-1, in the renal tissue of various study groups. (frontiersin.org)
  • The hormone resistin is a member of a novel family of cysteine-rich secreted proteins associated with pulmonary inflammation (FIZZ3) and expressed in the murine small bowel and adipose tissue ( 1 ). (diabetesjournals.org)
  • Its activation is tightly controlled by numerous other signaling proteins including protein kinase C (PKC), Sab/SH3BP, and caveolin-1. (medscape.com)
  • This review article will summarize the most recent findings on the functional roles of arginases in vascular diseases and/or dysfunctions and the underlying mechanisms in relation to oxidative stress and inflammations. (frontiersin.org)
  • The vertical axis represents relative risk, level of probable pathological organism response where normal level is 1. (anti-agingfirewalls.com)
  • HO-1 and their products exert beneficial effects through the protection against oxidative injury, regulation of apoptosis, modulation of inflammation as well as contribution to angiogenesis. (springer.com)
  • 1 In addition, FAs modulate vascular inflammation, a key mechanism of atherosclerosis, cerebral small vessel pathologies, and stroke, by altering intracellular signal transduction or controlling lipid mediators such as prostaglandins, thromboxanes, or leukotrienes. (j-stroke.org)
  • Our results indicate that an 18 hr exposure to low concentrations of PAT (5-25 uM) increases cellular glutathione levels, heat shock protein 70 and heme oxygenase activity in cardiac myocytes in a concentration-dependent manner. (cdc.gov)
  • Bioactive phospholipids enhance migration and adhesion of human leukemic cells by inhibiting Heme oxygenase 1 (HO-1) and inducible nitric oxygenase synthase (iNOS) in a p38 MAPK-dependent manner. (livedna.net)
  • Some heme-degrading prokaryotic enzymes produce products such as formaldehyde rather than CO. As an example, certain pathogens such as Escherichia coli O157:H7 can express the non-CO producing ChuW isoform. (wikipedia.org)
  • Many pathogens are susceptible to CO toxicity, therefore expressing non-CO producing heme degradation enzymes evades self-inflicted toxicity while meeting nutritional iron needs. (wikipedia.org)
  • HO-1 is a stress-induced isoform present throughout the body with highest concentrations in the spleen, liver, and kidneys, and on the cellular level is primarily located in the endoplasmic reticulum, although it has also been reported in the mitochondria, cell nucleus, and plasma membrane. (wikipedia.org)
  • Ischemia/reperfusion (I/R) is a predominant cause of hepatic injury, which is of clinical significance following liver surgery, hemorrhagic shock and liver transplantation ( 1 ). (spandidos-publications.com)
  • Recombinant protein encompassing a sequence within the center region of human Heme Oxygenase 1. (genetex.com)
  • Heme Oxygenase 1 antibody detects Heme Oxygenase 1 protein at cytoplasm on human renal carcinoma by immunohistochemical analysis. (genetex.com)
  • Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation. (nih.gov)
  • Her laboratory specialises in investigating the functional relevance of molecular signalling pathways in human and animal endothelial cells and a range of other vascular cell types. (rvc.ac.uk)
  • The group uses in vitro, ex vivo and in vivo cell and molecular approaches to delineate the signalling pathways controlling gene expression and functional responses of human and murine large vessel and microvascular endothelial cells.Caroline was an associate editor of the Biochemical Journal for over 10 years and is a founder member of the European Vascular Biology Organisation and of the London Vascular Biology Forum. (rvc.ac.uk)
  • Pituitary sex hormones enhance the pro metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase 1. (livedna.net)
  • Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: Therapeutic implications. (livedna.net)
  • Herein, we successfully generated shTNFRI-Fc-F2A-HA-hHO-1 transgenic (TG) pigs expressing both shTNFRI-Fc and hemagglutinin-tagged-human heme oxygenase-1 (HA-hHO-1) by using an F2A self-cleaving peptide. (korea.ac.kr)
  • Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
  • Hypoxia-induced oxidative stress promotes therapy resistance via upregulation of heme oxygenase-1 in multiple myeloma. (nih.gov)
  • These results show that shTNFRI-Fc and HA-hHO-1 TG pigs generated by the F2A self-cleaving peptide express both shTNFRI-Fc and HA-hHO-1 molecules, which provides protection against oxidative and inflammatory injury. (korea.ac.kr)
  • Urine appears to be the major route of excretion, with a urine:fecal ratio of approximately 3:1 in humans. (cdc.gov)
  • A controversial third heme oxygenase (HO-3) is considered to be catalytically inactive and has been speculated to work in heme sensing or detoxification. (wikipedia.org)
  • encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
  • Below 1, there is a "health reserve," such as an enhanced ability to do exercise or enhanced resistance to disease. (anti-agingfirewalls.com)
  • The epidemiology and ( 1 , 2 ), antimicrobial drug resistance ( 3 ), epidemiology, and mode of transmission of M. ulcerans disease are not fully microbial evolution ( 4 - 7 ). (cdc.gov)
  • Wild-type (WT) and Heme Oxygenase 1 knockout (KO) HeLa cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Heme Oxygenase 1 antibody (GTX101147) diluted at 1:500. (genetex.com)
  • Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Heme Oxygenase 1 antibody (GTX101147) diluted at 1:1500. (genetex.com)
  • An increase in the serum creatinine level represents a delayed indication of a functional change in GFR that lags behind structural changes that occur early in AKI. (medscape.com)
  • 4. Associations between blood heavy metal(loid)s and serum heme oxygenase-1 in pregnant women: Do their distribution patterns matter? (nbsbioscience.cn)
  • 9. ELISA Development for Serum Hemeoxygenase-1 and Its Application to Patients with Acute Respiratory Distress Syndrome: Y. Hara, et al. (nbsbioscience.cn)
  • HO-1 may also serve as a chaperone protein, engage in protein-protein interactions, be secreted into the extracellular space, and participate in other cellular functions beyond its catalytic activity. (wikipedia.org)
  • According to immunohistochemical analysis, both hepatocytes and Kupffer cells constituted major cellular components responsible for the HO-1 overexpression. (elsevierpure.com)
  • Molecular and cellular biochemistry 2015 Sep 407 (1-2): 51-6. (cdc.gov)
  • Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. (genetex.com)
  • In general, aside from sharing the functionality of catabolizing heme, all HMOX isoforms share are signature 24-residue sequence considered to be essential for the enzymatic activity. (wikipedia.org)
  • The activity of HO-1 is dependent upon NADPH-Cytochrome P450 Reductase. (wikipedia.org)
  • 9(1): 86, 2022 03 14. (bvsalud.org)
  • Di Pietro C, Öz H, Rodrigues G, Huang P, Zhang P, Murray T, Egan M , Bruscia E. 674 Loss of functional cystic fibrosis transmembrane conductance regulator leads to a calpain-dependent degradation of ezrin in activated cystic fibrosis macrophages Journal Of Cystic Fibrosis 2022, 21: s369. (yalemedicine.org)
  • Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1. (livedna.net)
  • Pioglitazone also decreased the mRNA expression of TNF-α and MCP-1 in the renal tissue. (frontiersin.org)
  • In mouse models, loss of IRP2 results in mild anemia, erythropoietic protoporphyria, and adult-onset neurodegeneration-all likely the result of functional iron deficiency. (nih.gov)
  • IRPs bind to RNA stem-loops known as iron-responsive elements (IREs) in transcripts that encode iron metabolism genes, including ferritin, transferrin receptor 1, ferroportin, HIF2 alpha, and several other transcripts. (nih.gov)
  • subunits are in red and blue, and the iron-containing heme groups in green. (ipfs.io)
  • Each heme group contains one iron atom, that can bind one oxygen molecule through ion -induced dipole forces. (ipfs.io)
  • The enzyme consists of linked oxygenase and reductase domains. (cathdb.info)
  • Our results suggested that beneficial effect of this extract might be associated with an improved anti-oxidation and anti-inflammatory effect via downregulation of NF-κB/COX-2 signaling by activating HO-1/CO in hearts. (biomedcentral.com)
  • Our results demonstrate that ω3-PUFAs correlated with stroke severity on admission and functional outcomes at 3 months. (j-stroke.org)
  • Protective Effects of Heme Oxygenase-1 in Acute Lung Injury. (ac.ir)
  • 5. Dual-Functional Dendrimer Micelles with Glycyrrhizic Acid for Anti-Inflammatory Therapy of Acute Lung Injury: M. Choi, et al. (nbsbioscience.cn)
  • We investigated whether plasma FA composition was related to stroke severity and functional outcome in acute ischemic stroke patients. (j-stroke.org)
  • The normal process of fracture repair begins with an immediate inflammatory response as the innate immune system (macrophages, monocytes, neutrophils, and NK cells) responds with a variety of cytokines that recruit and activate several cell types, including osteoprogenitor mesenchymal stem cells (MSCs), to the site of injury [ 1 , 2 ]. (hindawi.com)
  • Multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have the capacity to differentiate into a variety of cell types (Figure 1 ), including adipocytes, chondrocytes, and osteocytes [ 9 , 10 ]. (hindawi.com)
  • 1. Does a negative correlation of heme oxygenase-1 with hematoma thickness in chronic subdural hematomas affect neovascularization and microvascular leakage? (nbsbioscience.cn)
  • Part A, Clinical and molecular teratology 2015 Jan 103 (1): 37-44. (cdc.gov)
  • Genetics and molecular research : GMR 2014 13 (1): 2200-7. (cdc.gov)
  • Green: Heme Oxygenase 1 stained by Heme Oxygenase 1 antibody (GTX101147) diluted at 1:500. (genetex.com)
  • Crystal structure of activated ribulose-1,5-bisphosphate carboxylase/oxyge nase from green alga Chlamydomonas reinhardtii complexed with 2-carboxyarabinitol-1,5-bisphosphate. (bio.net)