The authors also presented information on structural modeling and functional diversity of a special group of snake proteins called 3FTxs (Three-finger toxins), broadly classified as neurotoxins, cytotoxins, cardiotoxins and anticoagulants. (activemotif.jp)
Cardiotoxins (cytotoxins, CT) are β-structured proteins isolated from the venom of cobra. (actanaturae.ru)
Venom5
Snake venom is complex, containing a deadly concoction of proteins. (activemotif.jp)
The study presents high-quality genomic and transcriptomic information about the Indian cobra, making it possible to catalog venom-ome-specific toxins (VSTs) which are toxins that show venom-specific gland expression. (activemotif.jp)
Out of these, exclusive expression in the venom gland was reported for 19 toxin genes that likely encode core venom effector toxin proteins. (activemotif.jp)
Most venom components appear to bind to multiple physiologic receptors, and attempts to classify venom as toxic to a specific system (eg, neurotoxin, hemotoxin, cardiotoxin, myotoxin) are misleading and can lead to errors in clinical judgment. (merckmanuals.com)
Our team has identified and studied several haemotoxic venom proteins, including a molecule called snaclec from the venom of the Bitis gabonica rhinoceros that blocks a specific protein on platelets and endothelial cells to induce bleeding. (reading.ac.uk)
Snake1
Snake venoms are complex substances, chiefly proteins, with enzymatic activity. (merckmanuals.com)
Vascular2
Dual effect of cobra cardiotoxin on vascular smooth muscle and endothelium. (mcmaster.ca)
Moreover, the combination ameliorated the TNF-α-induced protein expressions and circulating levels of vascular cell adhesion molecule 1 and monocyte chemotactic protein-1 in EA.hy 926 cells, mice aorta and serum. (bvsalud.org)
Genes1
The extracellular vesicles of bacteria mediate the traffic of proteins and genes, participate in cell-to-cell interactions, as well as in the pathogenesis and development of resistance to antibiotics. (actanaturae.ru)
Genome4
They used integrated genomic and transcriptomic analysis to create a map of the Indian cobra genome, one of the "big four" medically important snakes for the pharmaceutical industry. (activemotif.jp)
Using a combination of various cutting-edge tools, including Hi-C for genome-wide chromatin conformation, the authors generated the near-chromosomal de novo genome assembly for the Indian cobra, and assigned portions of the genome, called scaffolds, to chromosomes. (activemotif.jp)
Collectively, the generated assembly allowed for gene mapping of the chromosomes, analysis of genomic features like GC content, and comparisons of the Indian cobra genome with other species for evolutionary studies by a process called whole-genome synteny comparison. (activemotif.jp)
Here we generally review application of these systems for genome editing in conventional model objects of current biology, functional genome screening, cell-based human hereditary disease modeling, epigenome studies and visualization of cellular processes. (actanaturae.ru)
Genomic1
However, knowing nucleotide sequences isn't enough for understanding of particular genomic elements functional relationship and their role in phenotype formation and disease pathogenesis. (actanaturae.ru)
Amino-acid1
Cardiotoxin III (CTX III, also known as cytotoxin 3) is a sixty amino-acid polypeptide toxin from the Taiwan Cobra Naja atra. (wikipedia.org)
Chemical1
Furthermore, combined curcumin and resveratrol significantly inhibited TNF-α-induced nuclear factor-kappaB (NF-κB) p65 nuclear protein expression than that by the individual chemical alone in EA.hy 926 cells, indicating that the synergistic effect of the combination may result from that curcumin reduces the required minimum concentration for resveratrol to inhibit the nuclear translocation of NF-κB. (bvsalud.org)
Membrane4
The major research interest aims to study the structure and functional relationship of various proteins and biological assemblies, including viruses, membrane proteins, protein-DNA/RNA interactions, enzymes, and other functional important proteins related to diseases and drug discovery by protein crystallography (PX), X-ray absorption fine structure (XAFS), circular dichroism (CD), small angle scattering (SAS) and Infarred spectra (IR) using synchrotron light source from NSRRC and SPring-8. (nsrrc.org.tw)
In recent years and in the future, the research focuses on the structural and functional relationships between important membrane proteins, viruses, protein and nucleic acid complexes, as well as a long-term cooperation with the biotechnology industry for new drug development. (nsrrc.org.tw)
the membrane proteins accounting for the electron transfer chain, oxygen defense system and drug targets. (nsrrc.org.tw)
The protein dysferlin, the product of the Limb Girdle Muscular Dystrophy type 2 locus, has been shown to be necessary for efficient, calcium-sensitive,membrane resealing. (silverchair.com)
Complexes1
An agent-based system to discover protein-protein interactions, identify protein complexes and proteins with multiple peptide mass fingerprints. (csie.org)
Structural1
My research fields range from synchrotron X-ray protein crystallography to molecular biophysics, structural biology and biochemistry. (nsrrc.org.tw)
Proteomic2
The investigators identified IQGAP1, a scaffold protein, as a gasdermin D (GSDMD)-interacting protein through a nonbiased proteomic analysis. (nih.gov)
Quantitative proteomic and genomic profiling reveals metastasis-related protein expression patterns in gastric cancer cells. (csie.org)
Molecular1
In this study, we determine the catalytic mechanism of RVV-X by using a density functional theory/molecular mechanics (DFT:MM) methodology to calculate its free energy profile. (bvsalud.org)
Methodology1
Another interest focuses on investigating the methodology for resolving the protein crystallization and phase problem in protein crystallography, which applies to obtain the correct phases routinely and efficiently for structure determination of biological macromolecules. (nsrrc.org.tw)
System1
Most venom components appear to bind to multiple physiologic receptors, and attempts to classify venom as toxic to a specific system (eg, neurotoxin, hemotoxin, cardiotoxin, myotoxin) are misleading and can lead to errors in clinical judgment. (msdmanuals.com)
Muscle4
Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo. (duke.edu)
Here, we describe a platform for engineering and testing highly functional biomimetic muscle tissues with a resident satellite cell niche and capacity for robust myogenesis and self-regeneration in vitro. (duke.edu)
Using a mouse dorsal window implantation model and transduction with fluorescent intracellular calcium indicator, GCaMP3, we nondestructively monitored, in real time, vascular integration and the functional state of engineered muscle in vivo. (duke.edu)
We successfully applied our segmentation pipeline to uncover myofiber regeneration differences between two different muscle injury models, cardiotoxin and glycerol. (nature.com)
Highly2
CTX III is highly basic and hydrophobic protein. (wikipedia.org)
We now show that the related protein myoferlin is highly expressed in myoblasts undergoing fusion, and is expressed at the site of myoblasts fusing to myotubes. (silverchair.com)
Cookies1
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features. (auhs.edu)