• Here, by investigating intersubject variation in brain structure across a large number of individuals, we reveal modes of structural variation that map onto fine-grained functional organization across the entire brain, and specifically in the cerebellum, visual areas, and default-mode network. (nih.gov)
  • Topographic mapping of neural circuits is fundamental in shaping the structural and functional organization of brain regions. (mdpi.com)
  • Mapping the Functional Connectome: Applications of resting-state fMRI to understanding brain function and organization. (mpg.de)
  • Such structural organization may be suitable for the coordination of VLCFAs. (elifesciences.org)
  • The positioning framework, the evolutionary organization theoretic framework, and functional maps are combined in Section 6 to develop a process for competitive strategy-making in a technology company. (bartleby.com)
  • Alexander's research focuses on the use of magnetic resonance imaging (MRI) for mapping and measuring the functional and structural organization of the human brain. (wisc.edu)
  • Previously, using simultaneous resting-state functional magnetic resonance imaging (fMRI) and photometry-based neuronal calcium recordings in the anesthetized rat, we identified blood oxygenation level-dependent (BOLD) responses directly related to slow calcium waves, revealing a cortex-wide and spatially organized correlate of locally recorded neuronal activity (Schwalm et al. (elifesciences.org)
  • We analyzed structural magnetic resonance images (MRI) of 38 subjects with MinD and 80 healthy controls (aged 60-79 years) using voxel-based morphometry (VBM) and region-of-interest (ROI) analyses of gray matter density and cortical thickness. (psychiatrist.com)
  • All subjects underwent diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) scans. (researchsquare.com)
  • It introduces structural and functional brain imaging with magnetic resonance imaging (MRI) to users with a non-medical or MR-physics background. (lu.se)
  • 2023. Electron holographic mapping of structural reconstrucion at mono- and bilayer steps of h- BN . (hlrs.de)
  • Chu, SH , Parhi, KK & Lenglet, C 2018, ' Function-specific and Enhanced Brain Structural Connectivity Mapping via Joint Modeling of Diffusion and Functional MRI ', Scientific reports , vol. 8, no. 1, 4741. (umn.edu)
  • Imaging studies of major depressive disorder have reported structural and functional abnormalities in a variety of spatially diverse brain regions. (psychiatryonline.org)
  • In the present study, the authors applied a novel multimodal meta-analytic approach to test the hypothesis that major depression exhibits spatially convergent structural and functional brain abnormalities. (psychiatryonline.org)
  • Coordinate-based meta-analysis identified spatially convergent structural (VBM) and functional (VBP) abnormalities in major depression. (psychiatryonline.org)
  • A deletion of genetic material from part of the long (q) arm of chromosome 14 can cause FOXG1 syndrome, which is a rare disorder characterized by impaired development and structural brain abnormalities. (medlineplus.gov)
  • A loss of the FOXG1 gene disrupts normal brain development starting before birth, which appears to underlie the structural brain abnormalities and severe developmental problems characteristic of FOXG1 syndrome. (medlineplus.gov)
  • A new method called lesion network mapping is clearing the cobwebs off the lesion study and uniting it with modern brain connectivity data. (scientificamerican.com)
  • To test this, the authors overlaid these lesion locations on a map of the brain known as the connectome -a structural map of region to region connectivity derived from functional MRI data. (scientificamerican.com)
  • The Mouse Connectome Project at USC is part of a larger effort funded by the National Institutes of Health to map all the connections of the brain to understand how different structures network to regulate behavior. (genengnews.com)
  • The following sections will provide the theoretical and empirical background for training-related neuroplasticity, describe MRI methodology that can be used to map neural changes, and address developmental/maturational effects on training-related plasticity. (frontiersin.org)
  • We aimed to compare the resting-state structural and functional connectivity (FC) of olfactory neural pathways in patients with nIHH and KS. (researchsquare.com)
  • The proposed framework explicitly models the interactions between structural and functional connectivity measures thereby improving anatomical circuit estimation. (umn.edu)
  • In contrast to correlation-based or independent component analysis (ICA) functional connectivity mapping, detailed anatomical connectivity patterns are revealed for each functional module. (umn.edu)
  • We further reveal fine-grained anatomical signatures of functional connectivity. (nih.gov)
  • MRI is not limited by anatomical and structural information. (phddata.org)
  • This work brings the ability to improve image quality and overcome typical challenges of ultra-high field MRI for both anatomical and functional applications. (phddata.org)
  • This study provides further evidence that changes in functional connectivity are dependent on the brain's current state, directly linked to the generation of slow waves. (elifesciences.org)
  • It can study the brain's anatomy, functionality, connectivity (functional and structural), and chemical metabolism. (phddata.org)
  • Both structural and functional MRI methods can provide valuable insights into the underlying mechanisms of experience-dependent plasticity in adults as well as children, due to their non-invasive nature and sensitivity to brain tissue contrasts. (frontiersin.org)
  • Spatial and temporal dynamics of learning-induced functional and structural plasticity. (mpg.de)
  • Learning-dependent structural plasticity in patients with idiopathic Parkinson's disease during complex balance training. (mpg.de)
  • The proposed method jointly analyzes whole brain dMRI and fMRI data, allowing the estimation of complete function-specific structural networks instead of interactively investigating the connectivity of individual cortical/sub-cortical areas. (umn.edu)
  • Mapping distinct cortical areas using functional connectivity. (mpg.de)
  • During slow wave activity, we find a correlation between the occurring slow wave events and the strength of functional connectivity between different cortical areas. (elifesciences.org)
  • TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. (uzh.ch)
  • A better map is a resource scientists can use to better understand the hippocampus and how its degeneration leads to diseases," says Michael S. Bienkowski, Ph.D., lead author of the study and a researcher at the USC Institute for Neuroimaging and Informatics in the Keck School of Medicine of USC. (genengnews.com)
  • The aim of the present study was to investigate the effect of prolonged exposure to hypoxia on cerebral glucose metabolism, which probably precedes structural and functional impairment. (who.int)
  • Insights into the brain of an elite athlete: Evidence from structural MRI. (mpg.de)
  • We employ a multidisciplinary approach including kinase biochemistry and biology, structural biology (X-ray crystallography and cryo-electron microscopy), assay development, high-throughput screening, proteomics, imaging and chemical biology to gain high-resolution insights into kinase/pseudokinase signaling proteins. (edu.au)
  • Identifying spatiotemporal patterns of functional connectivity using dictionary learning. (mpg.de)
  • To integrate mouse hippocampal gene expression and connectivity, we mapped the distribution of distinct gene expression patterns in mouse hippocampus and subiculum to create the Hippocampus Gene Expression Atlas (HGEA). (genengnews.com)
  • Diffusion tensor MRI (DT-MRI) is used to study the patterns of structural connectivity between brain activity regions. (wisc.edu)
  • A joint structural-functional brain network model is presented, which enables the discovery of function-specific brain circuits, and recovers structural connections that are under-estimated by diffusion MRI (dMRI). (umn.edu)
  • Incorporating information from functional MRI (fMRI) into diffusion MRI to estimate brain circuits is a challenging task. (umn.edu)
  • In particular, diffusion MRI paired with tractography has facilitated a non-invasive exploration of structural brain anatomy, which has helped build evidence for the existence of many association, projection and commissural fiber tracts. (edu.mt)
  • Main Outcomes and Measures - Brain mapping algorithms and statistical models were used to evaluate the relationships between maternal depression and anxiety and 1-month infant white matter microstructure, as measured by diffusion tensor imaging and neurite orientation dispersion and density imaging parameters. (wisc.edu)
  • I use functional data such as EEG, MEG and fMRI in addition to structural data derived from MRI and diffusion MRI. (ncl.ac.uk)
  • The course introduces and discusses fMRI (functional MRI), dMRI (diffusion MRI) and sMRI (structural MRI) from a theoretical perspective, and also discusses how these modalities can be integrated. (lu.se)
  • Structural basis for small molecule targeting of Doublecortin like kinase 1 with DCLK1-IN-1. (edu.au)
  • However, the pathogenic mechanisms of these mutations are restricted to clinical description due to limited structural and biochemical characterization. (elifesciences.org)
  • Functional and structural characterization of human adrenoleukodystrophy protein (ALDP). (elifesciences.org)
  • Objective 2: Develop computational and visualization tools to curate, integrate, and query the genetic, genomic, and phenotypic relationships in small grains germplasm, and deploy machine learning and artificial intelligence approaches to enhance functional annotations and discover biological interactions. (usda.gov)
  • Sub-objective 2.A: Develop methods and pipelines to link genetic, genomic, functional, and phenotypic information and to enhance pangenome-centric focus. (usda.gov)
  • Sub-objective 2.B: Implement web-based and computational tools to integrate and visualize genomic data linked with genetic, expression, functional, and diversity data. (usda.gov)
  • Driven by stakeholder input, GrainGenes will maintain a central location for curated genomic, genetic, functional, and phenotypic data sets, downloadable in standardized formats, enhanced by intuitive query and visualization tools. (usda.gov)
  • Included is construction of complete genetic, physical, and transcript maps, and the analysis of this structural genomic information on a global scale such as in GENOME WIDE ASSOCIATION STUDIES. (bvsalud.org)
  • Intrinsic functional-connectivity networks for diagnosis: just beatiful pictures? (crossref.org)
  • Dynamic modulation of intrinsic functional connectivity by transcranial direct current stimulation. (mpg.de)
  • Development in the area of structural biology methods combined with new computational possibilities has highlighted the importance of combining different methods in order to maximize the output. (lu.se)
  • With the rapid progress and improvements in the fields of macromolecular crystallography, Cryo-EM, small angle scattering, electron diffraction and use of XFELs, the new LINXS theme INTEGRATIVE STRUCTURAL BIOLOGY is formed to advance cutting-edge research and to encourage new users to utilize integrative structure biology to address key scientific questions. (lu.se)
  • Both experienced specialists and researchers with more recently established interests in integrative structural biology are expected to greatly benefit from the symposium. (lu.se)
  • Future studies may reveal whether functional differences underlie the phenotypic differences. (bvsalud.org)
  • Electrophysiologic studies may be useful for mapping arrhythmia circuits. (medscape.com)
  • Additionally, depending on the program that is used, you can also display molecular surfaces, functional components, or electron density maps. (linux-magazine.com)
  • Figure 1: The various representations of the simple hydrocarbon molecule, ethylene, from the simple molecular formula through a structural formula, to visualization. (linux-magazine.com)
  • Representing the electron distribution around the nuclear framework of the molecule is another excellent capability of molecular visualization: If you want to understand how electrostatic attraction and repulsion processes act within the molecule, an electron density map is a big help. (linux-magazine.com)
  • Novel imaging modalities hold great promise to visualize and quantify structural, functional, and molecular organ damage. (springeropen.com)
  • Molecular modeling of the Jak3 kinase domains and structural basis for severe combined immunodeficiency. (lu.se)
  • These findings suggest that down-up transitions of neuronal excitability can drive cortex-wide functional connectivity. (elifesciences.org)
  • LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification. (lu.se)
  • Structural analysis reveals that Pentamer is a flexible molecule, and suggests sites for engineering stabilizing mutations. (rcsb.org)
  • Carli ALE, Hardy JM, Hoblos H, Ernst M, Lucet IS, Buchert M. Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis. (edu.au)
  • The structure and functional studies of disease-causing mutations are solid and will appeal to the transporter and medical genetics communities. (elifesciences.org)
  • Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. (lu.se)
  • Physiological studies in humans and rodents have suggested that there is both structural and functional heterogeneity along the longitudinal axis of the hippocampus. (genengnews.com)
  • Anatomic imaging methods are used to assess longitudinal structural changes in brain regions. (wisc.edu)
  • His current work is focused on two broad goals: (1) mapping variants and genes that confer risk to human disease, with ongoing projects focused on coronary artery disease and cardiometabolic traits in unique and underrepresented populations, and (2) developing methods for the detection and interpretation of human genome variation, with an emphasis on structural variation and other difficult-to-detect forms, and on comprehensive trait association in human disease studies. (yale.edu)
  • Results on a phantom (Fibercup) also indicate improvements in structural connectivity mapping by rejecting false-positive connections with insufficient support from fMRI, and enhancing under-estimated connectivity with strong functional correlation. (umn.edu)
  • First, the best correlation of LS with histopathology required plotting the DPOAE data at f1 with respect to the chinchilla-place map. (cdc.gov)
  • For example, within the cerebellum, a structural separation emerges between lobules that are functionally connected to distinct, mainly sensorimotor, cognitive and limbic regions of the cerebral cortex and subcortex. (nih.gov)
  • We also identify immunogenic surfaces important for cellular interactions by epitope mapping and functional assays. (rcsb.org)
  • The key elements of this framework, structural analysis of industry and development of competitive strategy, are developed in this section. (bartleby.com)
  • We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. (uzh.ch)
  • The ubiquity of fluctuating activity states which influence ongoing brain dynamics calls for a state-dependent assessment of resting state functional connectivity ( Tagliazucchi and Laufs, 2014 ). (elifesciences.org)
  • Dynamics of Evolution of Poliovirus Neutralizing Antigenic Sites and Other Capsid Functional Domains during a Large and Prolonged Outbreak. (cdc.gov)
  • Usually, seed regions for tractography are selected from fMRI activation maps to extract the white matter pathways of interest. (umn.edu)
  • and slow wave activity, dominated by a cortex-wide BOLD component, suggesting a strong functional coupling of inter-cortical activity. (elifesciences.org)
  • Functional connectivity glyphs for brain visualization. (mpg.de)
  • Visualization programs now add scale to the structural formula ( Figure 1 ). (linux-magazine.com)
  • Structural modes of variation also replicate the fine-grained functional architecture seen in eight well defined visual areas in both task and resting-state fMRI. (nih.gov)
  • A classic "T-O" map with Jerusalem at centre, east toward the top, Europe the bottom left and Africa on the right. (newworldencyclopedia.org)
  • Polar maps of the Arctic or Antarctic regions are conventionally centred on the pole, in which case the direction north would be towards or away from the centre of the map, respectively. (newworldencyclopedia.org)
  • According to meta-analyses 5-10 of structural brain changes in MDD, we hypothesized disease-specific decreases of gray matter density in the bilateral anterior cingulate cortex (ACC), hippocampus, and amygdalae and the right dorsomedial frontal cortex. (psychiatrist.com)
  • Structural and functional connectivity data analyses were then performed. (researchsquare.com)
  • Structural mapping of GABRB3 variants reveals genotype-phenotype correlations. (bvsalud.org)
  • All missense variants were mapped onto the 3-dimensional structure of the GABRB3 subunit, and clinical phenotypes associated with the different key structural domains were investigated. (bvsalud.org)
  • Interestingly, phenotypes correlated with structural locations of the variants. (bvsalud.org)
  • Significant changes in brain activation, structure, microstructure, and structural and functional connectivity were reported with different types of trainings in the majority (87%) of the studies. (frontiersin.org)
  • Production and purification of the PEAK pseudokinases for structural and functional studies. (edu.au)
  • The abundance of studies covering structural and functional aspects of submarine canyons allowed us to identify the existing knowledge clusters, historical trends, and emergent topics. (researchgate.net)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • Sub-objective 1.B: Integrate genetic, diversity, functional, and phenotypic data into GrainGenes with a pangenome-centric focus. (usda.gov)
  • Structural brain changes within a functional network of motor sequence learning. (mpg.de)
  • Road maps are perhaps the most widely used maps today, and form a subset of navigational maps, which also include aeronautical and nautical charts, railroad network maps, and hiking and bicycling maps. (newworldencyclopedia.org)
  • Structural and functional basis for JAK3-deficient severe combined immunodeficiency. (lu.se)
  • In a first couple of examples, I will show how distance and shape restraints from SANS have helped to improve the uniqueness of structural models for two multi-protein-RNA complexes, in combination with NMR restraints and building blocks from crystallography [1, 2]. (lu.se)