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  • Gene
  • We provide evidence that this pattern of gene expression divergence seems to involve genes with a role in otc viagra cell polarity and that likely function in the maintenance of cell-wall integrity. (realpick.icu)
  • binds
  • Chemical shift perturbation studies demonstrate that a proline-rich peptide corresponding to residues R125-G139 of intact DtxR binds to the C-terminal domain in a pocket formed by residues in β-strands 2, 3, and 5, and helix 3. (pnas.org)
  • We also present evidence that this prokaryotic SH3-like domain binds to a proline-rich segment that is located in the region linking the N- and C-terminal domains of DtxR and is conserved in all known DtxR homologues. (pnas.org)
  • mutations
  • A limited number of mutations in the C-terminal domain ( 12 ) or the linker region ( 13 ) affect repressor activity, but the structural nature of this regulation by the C-terminal domain has been obscure. (pnas.org)
  • Compared to those of other B. anthracis strains, the genome exhibits unique mutations in multiple targets potentially affecting proteolytic functions. (jove.com)
  • This is mostly due to mutations in the Bcr-Abl kinase domain that render it unable to bind to Gleevec[ 6 - 8 ]. (pubmedcentralcanada.ca)
  • Pathophysiological conditions involving abnormal expression of the light chains, as well as cardiomyopathies resulting from point mutations in the light and heavy chains of myosin, will benefit from a deeper understanding of how the different light chains and domains in myosin interact to perform work with maximum contractile efficiency. (grantome.com)
  • We will discuss the structure and function of Arrow/Lrp5/Lrp6, their interactions with Wnt, Fz and the intracellular β-catenin signaling apparatus, their biogenesis and modulation by extracellular antagonists, and, finally, the roles of LRP5 mutations in human diseases. (biologists.org)
  • residues
  • The solution structure of the C-terminal domain, consisting of residues N130-L226 plus a 13-residue N-terminal extension, has been determined by using NMR spectroscopy. (pnas.org)
  • Residues before A147 are highly mobile and adopt a random coil conformation, but residues A147-L226 form a single structured domain consisting of five β-strands and three helices arranged into a partially orthogonal, two-sheet β-barrel, similar to the structure observed in the crystalline Co 2+ complex of full-length DtxR. (pnas.org)
  • From the sequential assignment of resonances in heteronuclear NMR spectra of a recombinant C-terminal domain (residues N130-L226), we have shown that this isolated domain contains five β-strands and three helices ( 14 ). (pnas.org)
  • NMR chemical shift perturbation studies demonstrate that a synthetic peptide corresponding to this internal ligand interacts with specific amino acid residues in the C-terminal domain. (pnas.org)
  • This site comprises two basic residues, lysine-297 and arginine-340, on the alpha-adaptin trunk domain. (genes2cognition.org)
  • Kinase Domain
  • Ligand engagement both regulates and, in turn, is regulated by the level of activity of the kinase domain. (springer.com)
  • The Abl family of tyrosine kinases is regulated by a complex set of intramolecular interactions that impinge both directly and indirectly on the Abl kinase domain and lead to effective inhibition of tyrosine kinase activity both in vitro and in vivo. (springer.com)
  • Vigneri and Wang have previously shown that nuclear entrapment of Bcr-Abl in K562 cells results in apoptosis, and requires an active tyrosine kinase domain to do so[ 2 ]. (pubmedcentralcanada.ca)
  • fold
  • The SH3 domain is structured in a beta-barrel fold, which is made up of 5-6 beta strands organized in tightly packed anti-parallel beta sheets. (wikibooks.org)
  • The structure of the SH3 domain is a classical fold that is common in eukaryotes and prokaryotes. (wikibooks.org)
  • endocytosis
  • Furthermore, overexpression of the appendage domain of alpha-adaptin in cells depleted of alpha-adaptin could rescue the clathrin-mediated endocytosis of HM1.24 but not of the transferrin receptor. (genes2cognition.org)
  • vesicle
  • Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function," Journal of Experimental Medicine , vol. 202, no. 11, pp. 1587-1597, 2005. (hindawi.com)
  • phosphatidylinositol
  • The phosphatidylinositol 3-kinase (PI3K) enhancer (PIKE) is small guanosine triphosphatase (GTPase) that associates with nuclear-localized PI3K and increases its lipid kinase activity and its ability to promote cellular proliferation. (sciencemag.org)
  • family
  • Evidence that has accumulated over the last years points to c-Abl and Arg (ABL1 and ABL2) as being particular forms of the Src family of kinases. (springer.com)
  • Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. (springer.com)
  • In addition to Nedd4, N4WBP5 can interact with the WW domains of a number of Nedd4 family members and is ubiquitinated. (embl-heidelberg.de)
  • Members of this family which also includes MIA, MIA2, and TANGO share a Src homology-3 (SH3)-like domain. (mpbio.com)
  • region
  • Myosin is believed to generate force and movement by the rotation of a long a-helical region that extends from the C-terminus of the motor domain, and is stabilized by the essential light chain (ELC) and the regulatory light chain (RLC). (grantome.com)
  • amplify
  • The role of the light chain-binding domain or """"""""lever arm"""""""" is to amplify small conformational changes originating at the nucleotide binding site into larger movements of the lever arm. (grantome.com)
  • apoptosis
  • Apoptosis induced by 4NLS-Bcr-Abl was evaluated 24 hours post-transfection by morphologic determination, DNA staining, and caspase-3 assay. (pubmedcentralcanada.ca)
  • In the nucleus, Bcr-Abl may cause apoptosis due to nuclear Abl's ability to stabilize p73 and activate its pro-apoptotic functions. (pubmedcentralcanada.ca)
  • biological
  • The results of this study, combined with previous x-ray studies of intact DtxR, provide insights into a possible biological function of the C-terminal domain in regulating repressor activity. (pnas.org)
  • role
  • Their functions are deeply involved in cellular processes by playing a crucial role as hubs in cellular networks. (wikibooks.org)
  • form
  • Our results suggest a model of network evolution where general function of the SH3 domain network is conserved over its specific form. (harvard.edu)
  • SH3 Interactome Conserves General Function Over Specific Form" by Xiaofeng Xin, David Gfeller et al. (umt.edu)
  • resistance
  • Although Gleevec is currently the "gold standard" drug of choice for Bcr-Abl-positive CML[ 3 - 5 ], resistance to treatment with Gleevec occurs. (pubmedcentralcanada.ca)
  • We show that inclusion of only a few 2′-F substituents can optimize aptamer properties far beyond simple nuclease resistance and that SFM4-3 should prove valuable for the further exploration and production of aptamers with properties optimized for various applications. (scripps.edu)