Function regulatory homeodomain sequences. Medical search. Frequent questions

Hox proteins are a subset of transcription factors, which are proteins that are capable of binding to specific nucleotide sequences on DNA called enhancers through which they either activate or repress hundreds of other genes. (wikipedia.org)
10 20 30 40 50 60 Homeobox genes, and thus the homeodomain protein motif, are found in most eukaryotes. (wikipedia.org)
Thus, LMX1B regulates the expression of multiple podocyte genes critical for podocyte differentiation and function. (nih.gov)
Genes are often organized by function on the chromosome. (sdbonline.org)
The phenomenon of a group of genes with the same function and location on the chromosome signifies a so-called gene complex. (sdbonline.org)
All genes in the ANTP-C and BX-C code for homeodomain proteins. (sdbonline.org)
Each gene in any given cluster or complex of genes will have a similar function and structure to the others in its group. (sdbonline.org)
This means that the genes evolved by duplication, the more recently evolved genes emulating the structure and function of what earlier proved to be successful. (sdbonline.org)
The expression patterns suggest that both genes are under the same regulatory control as are the E(spl) bHLH genes and thus, might play a part in Notch mediated cell differentiation. (sdbonline.org)
Insulator pairing can be very specific and strongly orientation-dependent, dictating not only how chromosomes are organized physically, but also which regulatory DNA elements activate or repress which genes. (jefferson.edu)
We also study how chromatin modification systems such as Polycomb-group proteins function in the context of this 3-D architecture, and how DNA binding proteins cooperate with each other to recognize and activate or repress specific genes. (jefferson.edu)
Both of these kinds of elements function in a variety of genes, and in mammals as well as in Drosophila, to regulate developmental processes such as stem cell maintenance and differentiation. (jefferson.edu)
These enhancers direct expression patterns at different positions along the anterior posterior axis (Figure 3), and a major goal is to understand the cis-regulatory logic that controls the differential positioning of different target genes. (nyu.edu)
Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. (lookformedical.com)
The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
The genes encode homeodomain-containing transcription factors that control cell fates by regulating the transcription of downstream target genes. (nih.gov)
The changes provide powerful assays for identifying the trans -acting factors that regulate the homeotic genes and the cis -acting sequences through which they act. (nih.gov)
Assays in transgenes in Drosophila previously identified cis -acting transcriptional regulatory elements from homeotic genes. (nih.gov)
While these transgenic assays have been important in defining the structure of the cis -regulatory elements and identifying trans -acting factors that bind to them, their functions within the context of the endogenous genes remain poorly understood. (nih.gov)
Using this database, researchers can quickly retrieve the expression level data for target genes in different tissues and in response to different treatments to elucidate gene functions and explore the biology of rapeseed at the transcriptome level. (preprints.org)
We present evidence that zinc supplementation to HIPK2i cells increased p53 reactivity to conformation-sensitive PAb1620 (wild-type conformation) antibody and restored p53 sequence-specific DNA binding in vivo and transcription of target genes in response to Adriamycin treatment. (aacrjournals.org)
NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
the primary pair-rule genes even-skipped, hairy and runt , and the segment polarity genes wingless and engrailed were examined in embryos lacking germline and zygotic dri function. (sdbonline.org)
Considering the predicted functions of candidate genes, their potential undesirable pleiotropic effects should be further investigated across tissues and developmental stages. (biomedcentral.com)
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. (thermofisher.com)
Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)

In Drosophila, a cascade of nuclear regulatory events establishes very early differences in cell fates by producing intricate patterns of gene expression. (jefferson.edu)
Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
The trans -acting factors are also conserved between Drosophila and human and have important functions, not only in development but also in stem-cell maintenance and cancer. (nih.gov)
Our lab is determining how regions outside the DNA-binding homeodomain of the Drosophila Hox protein Ultrabithroax (Ubx) enhance DNA binding specificity and respond to conformational changes, tissue-specific alternative splicing, protein interactions, and cell signaling cascades. (tamu.edu)
With the completed genome sequences of Saccharomyces cerevisiae (budding yeast), Caenorhabditis elegans and Drosophila melanogaster , complete proteomes from representatives of three eukaryotic kingdoms (plants, fungi and animals) are now available for comprehensive comparative studies. (biomedcentral.com)
The Drosophila homolog of YY1, Pleiohomeotic (Pho), is usually a sequence-specific DNA-binding protein that mediates the recruitment of other PcG proteins, like PRC2, to a subset of target chromatin websites [47?9]. (acthreceptor.com)

We and others have shown that these regulatory systems have a major impact on the packaging and utilization of the genome. (jefferson.edu)
The second aspect of genome regulation that we study is the organization of chromosomal loops by chromatin insulators, which impacts several chromosome functions. (jefferson.edu)
Cancer genome sequencing reveals diverse acquired mutations in CTCF , which we have shown, functions as a tumour suppressor gene. (preprints.org)
The recent completion of the Arabidopsis thaliana genome sequence allowed the first prediction of a full plant proteome. (biomedcentral.com)
As the authors point out, the function of approximately 40-50% of the proteins encoded by each genome cannot be determined on the basis of similarities to proteins of known function. (biomedcentral.com)

This applies to both their primary structure, implying similarity in mechanism, and often their developmental function. (jefferson.edu)

The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. (embl-heidelberg.de)
Recombinant HIPKs and DYRK1A are auto-activated and phosphorylate the negative elongation factor SPT5, the transcription factor c-Myc, and the C-terminal domain of RNA polymerase II, suggesting a direct function in transcriptional regulation. (nature.com)

[ 3 ] Loss of function mutations in this gene are implicated in pediatric retinoblastoma. (medscape.com)
Mutations that disrupt PTEN function define a condition called PTEN hamartoma syndrome, which also includes Cowden syndrome , Bannayan-Riley-Ruvalcaba syndrome, and Proteus/Proteus-like syndrome. (medscape.com)

For example, homeodomain SSTFs in combination of and signaling dominate the early patterning events in embryonic forelimb myogenesis, followed by the rise in importance of zinc-finger and helix-turn-helix SSTFs in fetal claims. (physiciansontherise.org)
A variety of prominent transcription factor families are present in all four species, including Myb, basic helix-loop-helix, basic leucine zipper, C2H2 zinc finger and homeodomain transcription factors. (biomedcentral.com)

LMX1B encodes a LIM-homeodomain transcription factor. (nih.gov)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)

This amino acid sequence folds into a "helix-turn-helix" (i.e. homeodomain fold) motif that is stabilized by a third helix. (wikipedia.org)
As in m4 , the sequence motif of the Brd box is found twice in the 3'-UTR of malpha mRNA at similar positions but without a GY box. (sdbonline.org)

There are many superfamilies of Znf motifs, varying in both sequence and structure. (embl-heidelberg.de)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl-heidelberg.de)
Furthermore, in transcripts of both Brd and m4 there are three common regulatory sequence motifs within the 3' UTR. (sdbonline.org)
While collecting an ever-growing number of Bcd-dependent elements, we are using data mining techniques to identify sequence motifs or binding site arrangements that correlate with target gene positioning. (nyu.edu)

ESs are remarkably variable in sequence and size across eukaryotic evolution with largely unknown functions. (nih.gov)
This is a major function of insulators in eukaryotic genomes, to stabilize boundaries between repressive and active chromatin. (jefferson.edu)
A comparative study based on four fully sequenced eukaryotic genomes has revealed profound differences in the sets of transcription factors used by plants, fungi and animals. (biomedcentral.com)
Nonetheless, this study reveals striking differences in the regulatory machineries utilized by three different eukaryotic kingdoms. (biomedcentral.com)

Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. (lookformedical.com)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
It is also called nucleotide sequence. (lookformedical.com)
Associations of DPP9 with human liver cancer, exonic single nucleotide polymorphisms (SNPs) in DPP9 and loss of function (LoF) variants have not been explored. (preprints.org)
Sequence analysis showed that only one single nucleotide mutation (C → T) between 9930 and nps was found in the second exon of Csa3G748220 , a plant-specific class I HD-Zip gene. (biomedcentral.com)

Since then, they have been found to be involved in the regulation of cell proliferation, migration and apoptosis as important post-transcriptional regulatory factors [ 15 ]. (ersjournals.com)
This project seeks to elucidate transcriptional and post-transcriptional regulatory networks that determine cell fate and guide the development of photoreceptors from retinal progenitor cells. (nih.gov)

Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl-heidelberg.de)

We used a large number of existing chromosomal aberrations in the Scr homeotic gene to investigate the functions of the cis -acting elements within the endogenous gene. (nih.gov)

Homeodomain-interacting protein kinases (HIPKs) are an evolutionarily conserved kinase family comprising the members HIPK1, HIPK2, and HIPK3 in vertebrates, and, additionally, HIPK4 in mammals. (nature.com)
Within the HIPK family, HIPK1 and HIPK2 are the most closely related members, sharing about 93% sequence identity in their kinase domains, while HIPK3 is slightly less conserved with 87% identity. (nature.com)
Homeodomain-interacting protein kinase-2 (HIPK2) is a positive regulator of p53 oncosuppressor function. (aacrjournals.org)

Chromosome Architecture and Gene Regulation by Chromatin Insulators, Epigenetic Gene Regulation by Polycomb-group Proteins, and Cooperative DNA binding by Sequence-specific Transcription Factors. (jefferson.edu)
These include gene expression (by either facilitating or blocking interactions between enhancers and promoters), DNA recombination and repair (by influencing which linearly distant DNA sequences are accessible to each other and which are not), chromatin compaction during mitosis and meiosis, and epigenetic maintenance of gene expression. (jefferson.edu)

We identified several LMX1B binding sites in the putative regulatory regions of both CD2AP and NPHS2 (podocin) and demonstrated that LMX1B binds to these sequences in vitro and can activate transcription through them in cotransfection assays. (nih.gov)
Many of these regulatory mechanisms involve intramolecular interactions between the structured homeodomain and intrinsically disordered (unstructured) regions of the Ubx. (tamu.edu)
In mouse embryos, YY1 was found to co-localize with other PcG proteins and with H3K27me3 to upstream regulatory regions of Hoxc8 and Hoxa5 [51]. (acthreceptor.com)

Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
We conducted RNA sequencing (RNA-Seq) of 103 tissues from rapeseed cultivar ZhongShuang11 (ZS11) at seven developmental stages (seed germination, seedling, bolting, initial flowering, full-bloom, podding, and maturation). (preprints.org)
The differential regulation of aos and btd domains by dri occurs at a time when Dri is found in all somatic nuclei of the embryo, so that Dri must be acting to permit the proper function of other developmental regulatory factors. (sdbonline.org)
In particular, the existence of a great variety of transcription factors that are unique to distinct kingdoms, such as the large plant-specific AP2/EREBP and WRKY families and the animal-specific nuclear hormone receptors, reflects the need for specific solutions that meet the regulatory challenges connected with entirely different developmental programs and life styles. (biomedcentral.com)

Engineering chimeric, "humanized" yeast ribosomes for ES9S reveals that an evolutionary change in the sequence of ES9S endows species-specific binding of Hoxa9 mRNA to the ribosome. (nih.gov)
The function of the RNA-binding protein TEL1 in moss reveals ancient regulatory mechanisms of shoot development. (viaf.org)

It recognizes ATC sequences that consist of stretches of A's, T's, and C's on one DNA strand. (bdbiosciences.com)

That is, the regulatory scheme in which they function solves a common problem of developing multi-cellular organisms. (jefferson.edu)

Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). (nature.com)
We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)

In many cases, different parts of each gene's transcription pattern are controlled by cis-acting regulatory elements (enhancers) that contain binding sites for factors positioned higher in the hierarchy. (nyu.edu)
Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network. (xenbase.org)
Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. (xenbase.org)

By way of its interaction with YY1, ASXL2 could potentially regulate YY1's ability to bind regulatory components or other PcG proteins, thereby BCRP list regulating PRC2 binding. (acthreceptor.com)

Additionally, the two crops had different root regulatory mechanisms of microRNAs (miRNAs) to N deficiency. (frontiersin.org)

The 14/SATB1 monoclonal antibody specifically binds to the special AT-rich sequence binding protein 1 that is encoded by the SATB1 (SATB homeobox 1) gene. (bdbiosciences.com)
In characterizing ribosome binding to a regulatory element within a Homeobox (Hox) 5' UTR, we identify a modular stem-loop within this element that binds to a single ES, ES9S. (nih.gov)

The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. (thermofisher.com)

Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)

Several reports suggest that it can function as a protein-protein interacton domain and it was recently demonstrated that the PHD finger of p300 can cooperate with the adjacent BROMO domain in nucleosome binding in vitro. (embl-heidelberg.de)

Ribosomes have been suggested to directly control gene regulation, but regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. (nih.gov)
Tissue-specific regulation of protein function During animal development, the Hox transcription factor family determines the identity and guides the formation of many different types of tissues. (tamu.edu)
ASXL proteins may have evolved new functions, not possessed by Asx, to meet the distinct wants of PRC2 regulation in mammals. (acthreceptor.com)

These brief peptide sequences in the antigen are often presented over the cell surface area of APCs by using MHCII substances, which are necessary for activation of Compact disc4+ T cells (102). (exposed-skin-care.net)

Among various projects, the collaborative consensus coding sequence project ( CCDS ) takes an extremely conservative strategy. (wikidoc.org)

In this study, we used next generation RNA sequencing of lineage-traced cells isolated through fluorescent-activated cell sorting (FACS-Seq) to perform differential manifestation and co-expression analysis during distinct phases of embryonic development. (physiciansontherise.org)

Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)
This research holds great potential for elucidating how genetic variation and regulatory elements lead to diverse visual phenotypes. (nih.gov)
Our understanding of the landscape of pediatric cancer genomics has improved markedly in the past 20 years with the advent of next generation sequencing and other high throughput genetic sequencing. (medscape.com)

Niklas KJ, Bondos SE, Dunker AK, Newman SA (2015) Rethinking gene regulatory networks in light of alternative splicing, post-translational modifications, and intrinsically disordered protein domains. (tamu.edu)

These regulatory proteins are conserved across the evolutionary distance separating flies and humans. (jefferson.edu)

Technological advances coupled with decreased prices in next-generation sequencing possess resulted in advancement of advanced approaches for network evaluation of cell particular adjustments in organ advancement and disease17. (physiciansontherise.org)

The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox). (wikipedia.org)
The function of this domain is not yet known but in analogy with the LIM domain it could be involved in protein-protein interaction and be important for the assembly or activity of multicomponent complexes involved in transcriptional activation or repression. (embl-heidelberg.de)
In accordance with the close relationship between HIPKs and other DYRK subfamily members, DYRK1A, a class I DYRK member, shares a sequence identity with HIPK3 of 38% within the catalytic domain. (nature.com)

Plaza S., Prince F., Adachi Y., Punzo C., Cribbs D., Gehring W.J. Cross-regulatory Protein-Protein Interactions between Hox and Pax Transcription factors. (umassmed.edu)

We summarise the pathophysiological regulatory processes of ncRNAs, especially miRNAs, lncRNAs and circRNAs, in hyperplasia, hypertrophy, ECM production and cytokine production in asthmatic ASMCs. (ersjournals.com)

The discovery of differences in the response to different agents raises the question whether some of the p53 oncosuppressor functions might be exerted by different posttranslational modifications. (biomedcentral.com)

Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. (lookformedical.com)

This study characterized the canopy-layer specific transcriptome of five sorghum genotypes using RNA sequencing. (biomedcentral.com)

We are using state-of-the-art next generation sequencing combined with bioinformatic strategies, and developing stem cell-based approaches for gene therapy and drug discovery. (nih.gov)

We also wish to elucidate how photoreceptor function is maintained throughout life. (nih.gov)

Many promoter analyses have suggested other hydathode functions in metabolite transport and auxin metabolism, but experimental demonstration is still lacking. (researchgate.net)

phylogenetic trees (maximum-likelihood and Bayesian methods) built using these cytochrome oxidase subunit I sequences and others available from GenBank show some support for the subfamilies Cranchiinae and Taoniinae, and that within the latter, the hooked taxa group together. (tonmo.com)

SSTFs integrate external signals during patterning with shifting gene expression networks that coordinate the migration, proliferation, differentiation, and integration of cell types into fully functioning organs and multi-system limb constructions. (physiciansontherise.org)

Activation of Typical T Cells in Adipose Tissues Compact disc4+ Purpureaside C T Cell Activation TCRs recognize the current presence of a particular antigen by binding to brief peptide sequences in the antigen that's shown on APCs. (exposed-skin-care.net)
A specific kind of network, co-expression systems, are created from transcriptomics data to reveal patterns of gene manifestation in dynamic systems18C20, and have been used to identify cell-type specific patterns of gene manifestation during development ISA-2011B and the changes in regulatory relationships responsible for cell-state phenotypes21,22, among additional uses. (physiciansontherise.org)
pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)

The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. (wikipedia.org)
Nuclear receptors that bind OXYSTEROLS and function as heterodimers with RETINOID X RECEPTORS. (bvsalud.org)

Anatomy1

Organisms1

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes18

Information Science3

Genes26

Drosophila6

Genome5

Similarity1

Transcriptional regulation2

Mutations2

Zinc finger2

Encodes3

Motif2

Motifs4

Eukaryotic4

Homeobox protein1

Nucleotide4

Post-transcriptional regulatory2

Amino acid seq1

Chromosomal1

HIPK23

Chromatin2

Regions3

Developmental4

Reveals2

Recognizes1

Organisms1

Specificity2

Enhancers3

Regulate1

Mechanisms1

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Antibody1

Proteins encoded1

Vitro1

Regulation3

Substances1

Consensus1

Differential1

Genetic3

Gene regulato1

Humans1

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Domain3

Protein interactions1

MiRNAs1

Oncosuppressor1

Apoptosis1

Transcriptome1

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Auxin1

Cytochrome1

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Cell4

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