Function presence receptors laminin. Medical search. Frequent questions

2008), such as cell receptors this kind of as integrins, DDR and GPVI, (Leitinger and Hohenester, 2007) as well as other critical ECM molecules, this kind of as fibronectin, laminin and proteoglycans. (dot1linhibitor.com)
ECM components (i.e., fibronectin or collagens) directly interact with membrane receptors (i.e., integrins), particularly, by influencing cell behavior. (springer.com)

BMs are specialized structures that underlie epithelia and surround organs and mainly comprise collagen IV, laminins, and heparan sulfate proteoglycans (HSPG). (nature.com)
AAV2 for example can attach to heparan sulfate proteoglycan (HSPG) cell surface receptors, fibroblast growth factor receptor-1 (FGFR1), hepatocyte growth factor (HGF) receptor, and laminin receptor, whereas ανβ5 integrin and α5β1 integrin can act as co-receptors. (progen.com)

Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)

In Sierra Leone during 2015-2018, we assessed LF patients' day-of-admission plasma samples for levels of proteins necessary for coagulation, fibrinolysis, and platelet function. (cdc.gov)
To gain an insight into the noncholinergic, cell adhesion promoting functions of acetylcholinesterase, we sought proteins interacting with it. (tu-darmstadt.de)
ADOS Proteins kinases are putative goals of brand-new herpesviral drugs because of their important function in the legislation of HCMV replication [3,4,5,6,7,8]. (niepokorny.org)
The inferred regulatory function of these OM proteins suggests that the difference between the two biominerals is due to the modeling of the matrix network, rather than the presence of specific structural components. (biomedcentral.com)
Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. (cancer-genetics.org)
The presence of these proteins accounts for the transparency of the lens. (lookformedical.com)
Various diverse extracellular proteins possess Ca(2+)-binding epidermal growth factor (EGF)-like domains, the function of which remains uncertain. (embl.de)
Several ECM proteins such as laminin, tenascin and thrombospondin contain domains with homology to epidermal growth factor (EGF) and exhibit growth promoting activity. (embl.de)
Proteins are a diverse group of macromolecules with many different functions (Mbuthia, 2012). (graduateway.com)
The color violet will indicate the presence of proteins. (graduateway.com)
I used the color reaction after adding the reagent to determine the presence of proteins in each substance (Mbuthia, 2012). (graduateway.com)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)

A basement membrane, mainly containing laminin and collagen, formed afterward by differentiated myoepithelial cells, keeps the polarity of this primary duct tree. (wikipedia.org)
Oligomeric endostatin (NC1 and dimer) have been shown to be primarily associated with laminin in the basement membrane (Javaherian et al. (justia.com)
Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)
Depending on the serotype, different receptors and co-receptors located in the host membrane mediate the entry process. (progen.com)

Introduction of biological practical sequences Animal collagen may be the big cIAP-1 Antagonist supplier structural protein delivering physical help of tissues, and in addition has a variety of biological functions by interacting with cell surface receptors and also other extracellular matrix molecules. (dot1linhibitor.com)

Integrin α7β1 plays an important role in maintaining adult skeletal muscle integrity and like dystrophin, provides anchorage and bidirectional signaling as a laminin receptor. (uea.ac.uk)
The existence of developmentally regulated alternative splice variants makes the α7β1 integrin a complex integrin to study its function in skeletal muscle. (uea.ac.uk)
In this study we show that increased levels of the adult extracellular variant X2 interfere with muscle integrity, while the presence of embryonic integrin α7 extracellular variant X1 results in normal skeletal muscle architecture. (uea.ac.uk)
In addition we investigate the dosage effect of integrin α5 in integrin α7 knockout (KO) mice to understand the cross talk between these two integrins and to correlate with previous data suggesting a gain of function phenotype by that existence of integrin α5 at the myotendinious junction (MTJ) in α7KO muscle (Nawrotzki et al. (uea.ac.uk)
It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. (cancer-genetics.org)

By a yeast two-hybrid approach, we identified an interaction between the AChE and an 898 bp fragment of laminin-beta1 chain, an extracellular matrix protein involved in neuronal differentiation and adhesion processes. (tu-darmstadt.de)
Such biological functions depend on their lectinic properties (recognition of N-acetyllactosamine sequences displayed on the cell surface, in the extracellular matrix, or intracellular glycoconjugates) ( Table 1 ). (encyclopedia.pub)
Considering the fact that bacteria are single-cell organisms without an extracellular matrix, bacterial collagens don't have similar functions as animal collagens. (dot1linhibitor.com)
The extracellular matrix is essential for the architecture of the tissue and a myriad of associated biological functions. (springer.com)

In contrast, the intestinal SALSA was more enriched with the scavenger receptor cysteine-rich domains. (researchgate.net)

Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)
The existence of multiple molecular forms, the homology with other neuronal cell adhesion molecules, and the early expression pattern, suggest that AChE may function in cell adhesion, and thus in neurite growth, guidance and even synaptogenesis. (tu-darmstadt.de)
The BBB also controls the exchange and movement of nutrients, hormones and other molecules into and out of the brain for proper functioning of the CNS 1 . (researchsquare.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)

In Drosophila with depleted RACK1 in all muscle cells or, specifically, in SC lineage resulted in a delayed recovery of skeletal muscle after physical damage as well as the low presence of active SC in the wound area. (sdbonline.org)
[ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)

In this study, we demonstrate that the cross-linking of cell surface high-affinity IgE-R on mast cells derived from mouse bone marrow cultured for 3 wk in the presence of WEHI-3-conditioned media acts as a highly sensitive physiologic stimulus for this attachment and that receptor activation is also induced by calcium ionophore A23187. (aai.org)
Hence, the high-affinity IgE-R on the mast cell functions not only in exocytosis but also facilitates the process of mast cell adherence to laminin. (aai.org)
It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation. (embl.de)

The overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is usually associated with aggressive and infiltrating breast cancer (BC) phenotype, and metastases. (dovepress.com)
Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). (cancer-genetics.org)
The on-and-off switch is operated by transforming growth factor (TGF) β3 levels, which are undetectable in plasma and high in serum, and by TGFβ receptor (TβR) type II levels, which are low in epidermal cells and high in dermal cells. (rupress.org)

P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)

The uPA converts cell surface-bound plasminogen to plasmin, a process that is regulated by the binding of plasminogen to specific receptors on the cell surface, however, the identity of the plasminogen receptors that function in this capacity is unclear. (oncotarget.com)
Plasminogen receptor profiling revealed RAS-dependent increases in both S100A10 and cytokeratin 8. (oncotarget.com)

Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)

CD44 is a transmembrane molecule with multiple, in part poorly understood functions. (nature.com)

HomB protein contributes to the colonization and persistence of H. pylori , and the presence of homB genes affects the number of bacteria adhering to the host cells. (nature.com)
The impaired homeostasis and platelet dysfunction implicate alterations in the protein C pathway, which might contribute to the loss of endothelial barrier function in fatal infections. (cdc.gov)
Laminin 411 markedly induced the expression of the genes Foxa2 and Sox17 , markers for pancreatic precursor cells, efficiently induced IPC differentiation from MSCs, and up-regulated insulin expression at both mRNA and protein levels. (biomedcentral.com)
Mutations in GPR56 , an orphan G-protein-coupled receptor (GPCR), cause bilateral frontoparietal polymicrogyria (BFPP), a disorder characterized by mental retardation, seizures, motor developmental delay, and ataxia. (jneurosci.org)
It is likely that endostatin has a number of biological functions mediated by different regions of the protein. (justia.com)
Determination of presence of protein in a variety of food substances by the use of Biuret Reagent Biol. (graduateway.com)
Determination of Presence of Protein," GraduateWay , 02-Dec-2016. (graduateway.com)
Gene therapy displacement of endogenous MCUb with a dominant-negative MCUb transgene (MCUb W246R/V251E ) in vivo rescued T2D cardiomyocytes from metabolic inflexibility and stimulated cardiac contractile function and adrenergic responsiveness by enhancing phospholamban phosphorylation via protein kinase A. We conclude that MCUb represents one newly discovered molecular effector at the interface of metabolism and cardiac function, and its repression improves the outcome of the chronically stressed diabetic heart. (diabetesjournals.org)

Regulation of adhesion of mouse bone marrow-derived mast cells to laminin. (aai.org)

We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)

Furthermore, the expression of the genes known to govern insulin expression including Pdx1 and Ngn3 was markedly induced by laminin 411, which suggests that Pdx 1 and Ngn 3 signaling pathways are involved in laminin 411 induced-insulin expression machinery. (biomedcentral.com)
Our results demonstrate that laminin 411 acts as a potent differentiation inducer of IPCs from UC-MSCs via the Pdx1 and Ngn3 signaling pathways. (biomedcentral.com)

These novel finding highlights a potential clinical application of laminin 411 induced-IPCs in the treatment of T1DM, which calls for further studies. (biomedcentral.com)
Patients with DH and CD may have the same association with histocompatibility antigens (HLA), the presence of circulating IgA against transglutaminase autoantigens and clinical remission on gluten-free diet. (scielo.br)
therefore, our data suggest that sensory neuron dysfunction contributes to the clinical manifestations of neurological disorders in which Na V 1.1 function is compromised. (elifesciences.org)

Thus, alongside ECs, pericytes are a significant source of the islet BM, which is essential for proper β-cell function. (nature.com)

The tissue tropism of the different AAV serotypes is determined by the different cell surface receptors used for the attachment to the target cell. (progen.com)
To address this and to also study the oncogenic potential of unregulated function of dominant regulators of epithelial homeostasis noted above, we developed Multi-Functional Human Tissue Genetics noted above which, when combined with skin tissue regeneration on immune deficient mice, has permitted the molecular reconstruction of events sufficient to trigger human cancer. (stanford.edu)

This association may be important for some of the biological functions displayed by endostatin. (justia.com)
The detection of harmful stimuli such as noxious chemicals and changes in temperature and pressure are fundamental biological processes carried out by numerous cell types through diverse specialized receptors. (elifesciences.org)

In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)

In female mammals, growth and development of mammary glands occur primarily postnatally, with mammary function in the mature animal being tightly coupled to reproductive strategy. (frontiersin.org)
Interestingly, plasma concentrations of interleukin (IL)-27 known to exert primarily regulatory functions were also elevated in active pemphigus patients, pointing to a rather inflammatory role of IL-27 in disease pathogenesis. (uni-marburg.de)
Diabetes results in a cardiomyopathy characterized by decreased cardiomyocyte function, increased myocardial fatty acid utilization, decreased glucose utilization, increased myocardial oxygen consumption, and decreased cardiac efficiency ( 4 , 5 ), primarily as the result of changes in metabolism and Ca 2+ handling within the myocyte ( 3 , 6 , 7 ). (diabetesjournals.org)

conversely, its contribution to peripheral sensory neuron function is more enigmatic. (elifesciences.org)
Thus, Na V 1.1 haploinsufficiency in sensory neurons impairs both proprioceptor function and motor behaviors. (elifesciences.org)

Their expression profiles are consistent with the hypothesis that the neurexins and AChE have a function in early neuronal differentiation and axonogenesis. (tu-darmstadt.de)
In addition with their main function in the legislation of cell routine progression, particular types of CDKs and cyclins get excited about transcription also, splicing, epigenetic legislation, neuronal features, stem cell regeneration, spermatogenesis, and differentiation [10]. (niepokorny.org)

Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
Using a recombinant endonuclease-deficient Cas9-based gene promoter pulldown approach coupled with mass spectrometry, we found that MCUb is upregulated in the T2D heart due to loss of glucose homeostasis regulator nuclear receptor corepressor 2 repression, and chromatin immunoprecipitation assays identified peroxisome proliferator-activated receptor α as a mediator of MCUb gene expression in T2D cardiomyocytes. (diabetesjournals.org)

The occurrence of PV being associated with the presence of specific HLA class II alleles thereby reflects the high relevance of autoreactive CD4+ T cells in disease pathogenesis. (uni-marburg.de)

More importantly, administration of laminin 411-induced IPCs rapidly and significantly down-regulated fasting blood glucose levels, significantly reduced the HbA1c concentration and markedly improved the symptoms and survival of T1DM rats. (biomedcentral.com)

After the attachment of AAV to the cell surface receptor of the target cell, the virus gets internalized by endocytosis. (progen.com)

This suggests that while a combination of Piezo2 and other Na V isoforms is sufficient to elicit activity in response to transient stimuli, Na V 1.1 is required for transmission of receptor potentials generated during sustained muscle stretch. (elifesciences.org)

however, little is known about a role of laminin 411 in the regulation of IPC differentiation from human MSCs. (biomedcentral.com)
UC-MSCs were then cultured in the IPC induction and differentiation medium in the presence of laminin 411. (biomedcentral.com)
The function of histone modifying epigenetic regulators and noncoding RNA as central mediators of epithelial stem cell renewal and differentiation represent major emerging areas of study in the lab. (stanford.edu)

Triple-helix folding was substantially slower while in the presence of an interruption, as well as longer 15 residue interruption showed a higher delay than the 4-residue interruption. (dot1linhibitor.com)

Here, macrophages and T cells accumulate in the lamina propria of the intestinal tract, activate each other, destroy the regular architecture of the gut wall, and disturb the intestinal function. (nature.com)

In concordance with this observation, augmented surface expression of the C-C chemokine receptor 2 (CCR2) of mDC suggest an increased migration activity to inflamed peripheral tissues, such as the skin. (uni-marburg.de)

Besides this principal role, called the classical function, AChE shows also other non-classical functions related to processes during embryonic development and diseases. (tu-darmstadt.de)

An individual with proteinuria in the setting of a regular glomerular filtration rate (GFR) is at high risk of progressive loss of kidney function. (medscape.com)
[ 1 ] Reducing proteinuria in such cases has a protective effect against further loss of kidney function. (medscape.com)
Transient proteinuria occurs in persons with normal kidney function, bland urine sediment, and normal blood pressure. (medscape.com)
In order to establish the presence of nephrotic syndrome, laboratory tests should confirm the existence of (1) nephrotic-range proteinuria, (2) hypoalbuminemia, and (3) hyperlipidemia. (medscape.com)
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) can reduce hypertension and may also contribute to reducing proteinuria. (medscape.com)

This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)

The presence of more than two nipples is known as polythelia and the presence of more than two complex mammary glands as polymastia. (wikipedia.org)

Certainly, the presence of bone metastasis usually leads to worse outcome and shorter median survival [ 11 , 15 , 16 ]. (hindawi.com)

These patients require close follow-up and may need a kidney biopsy if they have abnormal urine microscopy results and/or impairment of kidney function. (medscape.com)

We used histological, molecular, and behavioral approaches to characterize the defects caused by loss of GPR56 and also examined the potential cellular functions of this molecule in vitro and in vivo . (jneurosci.org)

Our results have thus identified mucosal body compartments, where SALSA is particularly abundant, and suggest that SALSA exhibits varying functions in the different mucosal locations. (researchgate.net)
The presence of two disulfide bonds results in a highly folded structure. (justia.com)

We have reported that mast cells adhere to laminin after activation with PMA. (aai.org)
however, culture of mast cells with TGF-beta 1 was determined to enhance IgE-mediated adherence to laminin. (aai.org)
Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)

Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)

It also has been shown that cell surface glypicans are low-affinity endostatin receptors (Karumanchi et al. (justia.com)

The role of HomA and HomB in pathogenesis concerning their structure and function has not been evaluated yet. (nature.com)

Anatomy7

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes4

Disciplines and Occupations1

Information Science2

Fibronectin2

Heparan sulfate2

Hepatocyte growth1

Proteins12

Membrane4

Collagen1

Integrin5

Extracellular matrix4

Scavenger receptor1

Molecules6

Skeletal muscle2

High-affinity3

Epidermal3

Soluble1

Plasminogen2

Vascular1

Poorly understood1

Protein8

Adhesion1

Regulate1

Pathways2

Clinical3

Pericytes1

Tissue2

Biological2

Genes1

Primarily3

Sensory2

Neuronal2

Gene expression2

Specific1

Importantly1

Attachment1

Suggests1

Differentiation3

Residue1

Intestinal1

Expression1

Embryonic1

Proteinuria5

Invasion1

Mammary1

Survival1

Kidney function1

Cellular functions1

Results2

Cells3

Activation1

Cell surface1

Role1