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  • nitric oxide dioxy
  • The net reaction for the reaction catalyzed by nitric oxide dioxygenase is shown below: 2NO + 2O2 + NAD(P)H → 2NO3− + NAD(P)+ + H+ Nitric oxide is a ubiquitous small molecule that is integrated in a wide variety of physiological processes including smooth muscle vasodilation, platelet disaggregation, neurotransmission, and immune response to bacterial infection. (wikipedia.org)
  • A 'nitric oxide dioxygenase' is an enzyme that is capable of carrying out this reaction. (wikipedia.org)
  • Additionally, flavoHbs have been shown to protect bacteria, yeast, and Dictyostelium discoideum against growth inhibition and damage mediated via NO. Nitric oxide dioxygenase was discovered, and first reported in 1998, as an inducible O2-dependent enzymatic activity that protected bacteria against nitric oxide toxicity. (wikipedia.org)
  • Historically, nitric oxide dioxygenase (around 1.8 billion years ago) served to provide the modern day analogue of hemoglobin/myoglobin function for oxygen storage and transport. (wikipedia.org)
  • humans
  • We aimed to determine whether FTO mutations are disproportionately represented in lean or obese humans and to use these mutations to understand structure-function relationships within FTO. (diabetesjournals.org)
  • In mammals and humans, 2OG-dependent dioxygenase have functional roles in biosyntheses (e.g. collagen biosynthesis and L-carnitine biosynthesis), post-translational modifications (e.g. protein hydroxylation), epigenetic regulations (e.g. histone and DNA demethylation), as well as sensors of energy metabolism. (wikipedia.org)
  • Inflammation
  • However, tolerogenic populations of pDCs are found that suppress atherosclerosis-associated inflammation through down-regulation of function and proliferation of proinflammatory T cell subsets and induction of regulatory T cells with potent immunomodulatory properties. (frontiersin.org)
  • hydroxylase
  • In benzoate and toluate 1,2-dioxygenase systems, a single protein containing reductase and Rieske-type ferredoxin domains transfers the electrons from NADH to the hydroxylase component. (wikipedia.org)
  • biological function
  • While peroxidations had been described as early as 1855, the enzymatic nature and biological function of peroxidases would only be investigated much later [ 11 , 20 , 21 ]. (hindawi.com)
  • inhibit
  • These recently classified metabolites are distinguished from the many other dihydroxy-PUFA with three conjugated double bonds that do not have this critical E,Z,E configuration: they inhibit the function of platelets and therefore may be involved in controlling and prove useful for inhibiting human diseases which involve the pathological activation of these blood-borne elements. (wikipedia.org)
  • cellular
  • Since NADPH and α-KG function in cellular detoxification processes in response to oxidative stress, IDH1 also indirectly participates in mitigating oxidative damage. (wikipedia.org)
  • genes
  • It remains possible that the SNPs influence the expression and/or function of neighboring genes and that such an effect might underlie the association with adiposity. (diabetesjournals.org)