Function of cyclic nucleotide phosphodiesterases. Medical search. Frequent questions

PDEs are a diverse family of enzymes that have different tissue distributions and functions but that all exert their effect by lowering intracellular levels of cyclic nucleotides, such as cyclic guanosine monophosphate (cGMP). (medscape.com)
Apart from these remarkable actions of vinpocetine it also acts though PDE1 inhibition Phosphodiesterases (PDEs) are the enzymes which reduce the level of cyclic nucleotides by their metabolism (Oliva Jr et al. (researchsquare.com)
Our research interests are in the field of cyclic nucleotide signaling and cardiovascular biology, with a particular focus on cyclic nucleotide phosphodiesterases (PDEs) that catalyze the hydrolysis of cyclic nucleotide second messengers (cAMP and cGMP). (rochester.edu)
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. (thermofisher.com)
cAMP-dependent phosphodiesterases (PDEs) are essential components of the cAMP signaling cascade and fine-tune cyclic nucleotide signaling. (sdbonline.org)
The dnc gene encodes for at least eight isoforms with high homology to the human phosphodiesterase 4 class of PDEs. (sdbonline.org)
The homeostatic role of phosphodiesterases (PDEs) as related to the intracellular levels of cAMP and cGMP was first described by Sutherland (Sutherland, Rall, 1958) who, due to this, was awarded the Nobel Prize for Physiology and Medicine in 1971. (biomedjournal.com)
Phosphodiesterases (PDEs) hydrolyze the phosphodiester bond of cAMP and cGMP to form the inactive 5′-AMP and 5′-GMP. (biomedjournal.com)
The family of phosphodiesterases (PDEs) are regulatory hydrolase enzymes that play a crucial role in modulating cyclic nucleotides, including cGMP and cAMP, which are involved in a wide range of physiological processes. (protheragen.com)
2005 ). cAMP and cGMP are hydrolyzed by phosphodiesterase (PDE) enzymes, and inhibitors of PDEs (PDE-Is) produce cognition-enhancing effects in animal models of cognition. (springer.com)

As in somatic cells, sperm intracellular cAMP concentration is regulated by the opposite action of two enzymes: the adenylyl cyclases (AC), which synthesize cAMP from ATP, and the phosphodiesterases (PDE), which break the phosphodiester bond of cAMP to form 5'-adenosine monophosphate (AMP). (plos.org)
Thus, our discovery of the role of functional interaction between intracellular signaling pathways mediated by calcium ions (Ca 2+) and cyclic adenosine monophosphate (cAMP) (Ca 2+ /cAMP signaling interaction) in these cellular responses, opened a great avenue for the development of new antitumor therapeutic strategies. (researchgate.net)
The full mechanism of action of this drug is not fully established, however, it is known that apremilast is an inhibitor of phosphodiesterase 4 (PDE4), which mediates the activity of cyclic adenosine monophosphate (cAMP), a second messenger. (drugbank.com)
Fertel and Weiss, 1976) therefore preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). (biomedjournal.com)
Activation of Gs or Gi/o protein-coupled receptors (GPCRs) leads to changes of intracellular cyclic adenosine monophosphate (cAMP) levels. (bvsalud.org)
Increases in 3'5'-cyclic adenosine monophosphate (cAMP) and 3'5'-cyclic guanosine monophosphate (cGMP) inhibit platelet aggregation and are pharmacological targets for antiplatelet therapy. (bvsalud.org)
The second messenger cyclic adenosine monophosphate (cAMP) is a key mediator in many GPCR signaling pathways. (bvsalud.org)

two of them play a dual role in cyclic guanosine monophosphate (cGMP) and cAMP signaling, whereas only Dunce (Dnc) is cAMP specific. (sdbonline.org)
6. Mewe M., Bauer C.K., Müller D., Middendorff R. Regulation of spontaneous contractile activity in the bovine epididymal duct by cyclic guanosine 5'-monophosphate-dependent pathways. (abvpress.ru)
Phosphodiesterase 9 (PDE9), a specifically hydrolytic enzyme with the highest affinity for cyclic guanosine monophosphate (cGMP) among the phosphodiesterase family, controls cGMP in cardiac myocytes and is strongly upregulated in human heart failure, suggesting its potential as a promising therapeutic target in heart failure. (protheragen.com)

It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide exchange factors like EPAC. (plos.org)
This protein functions in the cellular export of its substrate, cyclic nucleotides. (wikipedia.org)
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. (creativebiomart.net)
2] Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development. (axonmedchem.com)
As a postdoctoral fellow and research faculty member, he made major contributions to understanding cyclic AMP-dependent protein kinases and contributed significantly to work that later led to the Nobel Prize for Dr. Krebs. (aspet.org)
We therefore immunized young female Cnp −/− mice lacking the structural myelin protein 2′-3′-cyclic nucleotide 3′-phosphodiesterase (Cnp) with a "cocktail" of NMDAR1 peptides. (nature.com)
Evidence is provided that Hangover acts as a nuclear RNA binding protein and the phosphodiesterase 4d ortholog dunce as a target RNA. (sdbonline.org)
cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP. (sigmaaldrich.com)
Multiple cyclic nucleotide phosphodiesterase activities from rat tissues and occurrence of a calcium-plus-magnesium-ion-dependent phosphodiesterase and its protein activator. (innspub.net)

Phosphodiesterase type 5 (PDE5) inhibitors are the principal oral agents used in ED. (medscape.com)
Eli Lilly, Indianapolis, IN, USA), both of which are phosphodiesterase-5 (PDE5) inhibitors, are currently in Phase III clinical trials and could prove more potent, and produce fewer side effects, than sildenafil. (health.am)
Phosphodiesterase inhibitors (PDIs) have important vascular and myocardial protective effects and thus have shown therapeutic usefulness in the clinical settings for treatment of patients with heart failure, pulmonary hypertension, and coronary artery disease. (biomedjournal.com)
Table 1 summarizes the functions of each PDE and the cardiovascular effects of specific inhibitors. (biomedjournal.com)
The potential activity for selective phosphodiesterase inhibitors as therapeutic agents was predicted as early as 1977 by Weiss and Hait (Weiss and Hait, 1977). (biomedjournal.com)
2. Benau D., Szabo E.I., Terner C. Endogenous inhibitors of cyclic adenosine 3',5'-monophosphate-phosphodiesterase in rat epididymis. (abvpress.ru)
A cell-based high-throughput screen (HTS) was developed to detect phosphodiesterase 8 (PDE8) and PDE4/8 combination inhibitors. (sigmaaldrich.com)
Selective phosphodiesterase (PDE) inhibitors improve the formation of hippocampus-dependent memories in several rodent models of cognition. (springer.com)

This study was designed to investigate the effects of Hunteria umbellata (HU) seeds and Cylicodiscus gabunensis (CG) stem barks aqueous extracts on key enzymes relevant to erectile dysfunction (phosphodiesterase-5 and arginase) and type-2 diabetes (α-amylase and α-glucosidase). (degruyter.com)
In ascertaining the erectogenic and antidiabetic properties of the extracts, the effects of the extracts on activities of some enzymes relevant to erectile dysfunction (arginase and phosphodiesterase-5) and type-2 diabetes (α-amylase and α-glucosidase) were determined. (degruyter.com)
1] Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes. (axonmedchem.com)
2001). The substrate specificities include the enzymes which are specific for cAMP hydrolysis, those for cyclic GMP hydrolysis (Mehats et al. (biomedjournal.com)
The just means the cell possesses to degrade the indication mediated by cyclic nucleotides is certainly through the actions of a big category of Cefdinir enzymes, the cyclic nucleotide phosphodiesterases [2]. (oscars2019info.com)

Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. (drugbank.com)
Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor. (wikipedia.org)
A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE) selectively in the brain. (biomedjournal.com)
We tested the hypothesis that sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, promotes functional recovery and neurogenesis after stroke. (nih.gov)

7] Ghiadoni L, Versari D, Taddei S. Phosphodiesterase 5 inhibition in essential hypertension. (degruyter.com)
Our research programs have been among the pioneers in elucidating the function, regulation, and underlying mechanism of different PDE activation/ inhibition in the pathogenesis of cardiovascular diseases. (rochester.edu)
Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. (taconic.com)
Both the naphthoquinones displayed substantial inhibition of phosphodiesterase-1 with IC 50 value of 65 ± 3.01 and 30.10 ± 2.12 µM, respectively when compared with the standard EDTA (IC 50 = 24 ± 0.22). (innspub.net)
Both rolipram and sildenafil improved object retrieval performance, thus demonstrating the cognition-enhancing effects of PDE inhibition on a prefrontal task of executive function in monkeys. (springer.com)

Phosphodiesterase 11A (PDE11A), an enzyme that degrades cyclic nucleotides (cAMP and cGMP), is the only PDE whose mRNA expression in brain is restricted to the hippocampal formation. (frontiersin.org)

Cyclic AMP (cAMP) and cGMP regulate a myriad of cellular functions, such as metabolism, contractility, motility, and transcription in virtually all cell types, including those of the cardiovascular system. (aspetjournals.org)
It has been well known that secondary messengers i.e. cAMP (cyclic AMP) and cGMP (cyclic GMP) regulate brain function and has a potential to rescue neurons under stress. (researchsquare.com)
cAMP and cGMP regulate a wide variety of cardiac functions, from the short-term effects on myocyte contraction/ relaxation to long-term effects such as gene expression and structural remodeling ( Figure 2 ). (rochester.edu)
miR-1202 may regulate OA development via histone acetyltransferase pathway binding function and cellular senescence pathway. (biomedcentral.com)
WNT signal transduction is an elaborate and complex aggregation of signaling pathways that regulate a wide range of cellular functions during development and in adult organisms. (kjpp.net)

In 1977, Dr. Beavo joined the department of pharmacology at the University of Washington, where his research revealed 11 diverse families of cyclic-nucleotide phosphodiesterases with different substrate specificity and regulation. (aspet.org)

In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. (plos.org)
Sperm intracellular cAMP levels depend on the activity of adenylyl cyclases, mostly SACY, though transmembrane-containing adenylyl cyclases are also present, and on the activity of cyclic nucleotide phosphodiesterases (PDE) whose role is to degrade cAMP into 5'-AMP. (plos.org)
Within these neurons, two cyclic AMP (cAMP)-dependent mechanisms balance the degree of tolerance. (sdbonline.org)
In neuronal cell lines, ethanol exposure reduces cyclic AMP (cAMP) levels, which results in cellular tolerance. (sdbonline.org)
cAMP is also involved in regulating neuronal, glandular, cardiovascular, immune and other functions. (enzolifesciences.com)
7. Swinnen J.V., Joseph D.R., Conti M. Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. (abvpress.ru)
Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system. (bardonreorg.hu)
Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. (sigmaaldrich.com)
Phosphodiesterase (PDE) 8A and PDE8B are high-affinity cAMP-specific phosphodiesterases that are highly expressed in Leydig cells. (ece-inhibitor.com)
The cyclic nucleotides cAMP and cGMP participate in the main pathways regulating cardiac and vascular functions and they act as second messengers for sympathetic and parasympathetic systems, nitric oxide (NO) and natriuretic peptides (NPs). (protheragen.com)
History The cyclic nucleotides, cGMP and cAMP are essential second messengers recognized to control many mobile procedures, such as irritation. (oscars2019info.com)

Goupil S, Maréchal L, El Hajj H, Tremblay M-È, Richard FJ, Leclerc P (2016) Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. (plos.org)
1998. Structure, function and localization of Helicobacter pylori urease. (innspub.net)

Cyclic GMP: synthesis, metabolism, and function. (urologi.or.id)

These DEMs such as has-miR-1202 were mainly enriched in GO functions like histone acetyltransferase binding and KEGG pathways like cellular senescence. (biomedcentral.com)
The cyclic nucleotide signalling Rabbit Polyclonal to MOBKL2A/B program is certainly both interlinked and complicated with a great many other pathways [1], their alerts getting managed by regulating the synthesis and break down of these molecules tightly. (oscars2019info.com)

The versatility and specificity of cyclic nucleotide signaling is achieved through specific compartmentalization of different cyclic nucleotide pools that are controlled by distinct PDE isoforms. (rochester.edu)

This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. (wikipedia.org)
Furthermore, this increase in cGMP degradation is paralleled by the phosphorylation of phosphodiesterase type 5 at Ser-92. (rupress.org)
It is most well recognized as a key signaling trigger in the relaxation of smooth muscle cells (resulting in vasodilation) in response to nitric oxide, and as a sodium ion channel regulator (via its degradation by phosphodiesterases) critical to phototransduction. (enzolifesciences.com)

Interestingly, while genes involved in immune system function were down-regulated in the brains of mature males, changes in the expression levels of several receptors and channels were observed suggesting that some rewiring is occurring in the brain at sexual maturity. (biomedcentral.com)
Some of these genes have previously described functions while many others have roles that have yet to be characterized in a reproductive context. (biomedcentral.com)

Cyclic AMP (adenosine 3', 5'-cyclic monophosphate) is an important player in sperm function. (plos.org)
3. Razzaboni B., Terner C. Cyclic adenosine 3',5'-monophosphate-phosphodiesterases in epididymis and prostate of castrate and of aged rats. (abvpress.ru)

The long-term objective of our laboratory is to identify novel RNA-based molecular mechanisms that control gene expression and conduct pathophysiological function in cardiac system, as well as to develop novel therapeutic approaches for the prevention or treatment of human cardiovascular diseases. (rochester.edu)

Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. (taconic.com)

Considerable effort over the last 20 years has allowed identification of the cellular components involved in the synthesis of cyclic nucleotides, as well as effectors of cyclic nucleotide-mediated signaling. (aspetjournals.org)
GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
Proteomic mass spectrometry permits the unbiased identification of cellular and biochemical changes in the brain as a function of ageing. (biomedcentral.com)
To understand how cellular stress changes neuronal function, Hangover function was analyzed on a cellular and neuronal level. (sdbonline.org)

The differentially expressed miRNAs (DEMs) as well as miRNA-mRNAs interactions were investigated, followed by function and pathway investigation. (biomedcentral.com)
However, the precise function of CLN5 in the cell and the pathway(s) regulating its function are not well understood. (frontiersin.org)

Because cell behavior is a dynamic process influenced by numerous factors, we will attempt to emphasize how changes in the activity, expression, and targeting of PDE influence cyclic nucleotide-mediated regulation of the behavior of these cells. (aspetjournals.org)
However, when intact platelets were incubated with NO and then lysed, enhanced activity of phosphodiesterase type 5 was detected in the cytosol. (rupress.org)
Thus, our data suggest that NO-induced desensitization of the cGMP response is caused by the phosphorylation and subsequent activity increase of phosphodiesterase type 5. (rupress.org)
Evidence for androgen-dependent phosphodiesterase activity in rat seminal vesicle and epididymis. (abvpress.ru)

At Vanderbilt, Dr. Beavo discovered that methylxanthines, like IBMX, inhibit phosphodiesterases, laying the key groundwork for this pharmacology. (aspet.org)
Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function. (urologi.or.id)

They are essential regulators of cyclic nucleotide signaling with diverse physiological functions. (axonmedchem.com)

On-demand IC351 (Cialis®) enhances erectile function in patients with erectile dysfunction. (urologi.or.id)

A major function of the brain is to establish the appropriate developmental and endocrine status for reproduction, and then to co-ordinate this with aspects of behavior and sexual maturation. (biomedcentral.com)

Most of the effects of the signaling molecule nitric oxide (NO) are mediated by cGMP, which is synthesized by soluble guanylyl cyclase and degraded by phosphodiesterases. (rupress.org)
Here we show that in platelets and aortic tissue, NO led to a biphasic response characterized by a tremendous increase in cGMP (up to 100-fold) in less than 30 s and a rapid decline, reflecting the tightly controlled balance of guanylyl cyclase and phosphodiesterase activities. (rupress.org)
Guanylyl cyclases (GCs) synthesize cyclic GMP (cGMP) and, together with cyclic nucleotide phosphodiesterases, are responsible for regulating levels of this intracellular messenger which mediates myriad functions across eukaryotes. (crick.ac.uk)

Our laboratory is interested in the understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in c. (rochester.edu)
Dr. Beavo is being recognized for his research on the identification, regulation and functions of cyclic nucleotide phosphodiesterases, work on cyclic nucleotides, and for his strong commitment to mentoring. (aspet.org)

More recently, a central role for cyclic nucleotide phosphodiesterase (PDE) has also been elaborated in many cell types, including those involved in regulating the activities of the cardiovascular system. (aspetjournals.org)
We aim to reveal new molecular targets for pharmacologic modulation of specific cyclic nucleotide signaling in the treatment of cardiovascular diseases. (rochester.edu)

He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)

A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction. (rochester.edu)

At least seven phosphodiesterase (PDE) classes are known, many with subtypes identified by structure and function. (medscape.com)

Thirty single-nucleotide polymorphisms were used to cdc.gov/EID/content/16/7/1130-Techapp.pdf) were used track the spread of the seventh pandemic caused by Vibrio to type a collection of 64 seventh pandemic V. cholerae cholerae . (cdc.gov)

Organisms1

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes12

Information Science3

PDEs10

Adenosine monophosphate7

Guanosine3

Protein9

Inhibitors8

Enzymes5

Inhibitor4

Inhibition5

Degrades cyclic1

Regulate5

Substrate1

CAMP11

Localization2

Metabolism1

Pathways2

Specificity1

Degradation3

Genes2

Monophosphate2

Therapeutic1

PDE5A1

Cellular4

Pathway2

Activity4

Pharmacology2

Physiological1

Erectile dysfunction1

Behavior1

Guanylyl3

Regulation2

Cardiovascular2

Molecular1

Role1

Subtypes1

Type1