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  • alleles
  • ADRs induced by several drugs have been shown to have significant associations with specific alleles of human leukocyte antigen (HLA) genes. (hindawi.com)
  • In this review, we summarized the alleles of HLA genes which have been proposed to have association with ADRs caused by different drugs. (hindawi.com)
  • A total of more than 1500 alleles of HLA-B gene have been identified [ 2 ]. (hindawi.com)
  • Disruption of 3 or all 4 Sun1 / 2 wild-type alleles revealed a gene dosage effect on synaptic nuclear anchorage. (pnas.org)
  • Genome
  • 2015. Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties. . (ncbs.res.in)
  • Yeast haploinsufficient genes do exhibit enhanced retention after whole-genome duplication compared to haplosufficient genes if they encode members of stable protein complexes, but the same phenomenon is absent if the genes do not encode protein complex members, suggesting that the dosage balance effect rather than the dosage effect is the underlying cause of the phenomenon. (genetics.org)
  • GENE duplication is the primary source of new genes ( O hno 1970 ) and duplicate genes are prevalent in virtually every sequenced genome in every domain of life ( Z hang 2003 ). (genetics.org)
  • The likelihood of gene duplication during evolution is measured by gene duplicability, which is the product of the rate of mutation producing duplicate genes and the probability that the duplicates are fixed and retained in the genome ( H e and Z hang 2005a ). (genetics.org)
  • whereas
  • Whereas a mammalian KASH protein has been found to have a critical function in myonuclear anchorage ( 7 - 9 ), the roles of SUN proteins in this process remain unclear. (pnas.org)
  • Silencing of the TOC1 gene causes arrhythmia in constant darkness and in various intensities of red light, whereas in blue light, the clock runs faster in silenced plants than in wild-type plants. (plantcell.org)
  • Our results show that TOC1 RNA interference and toc1-2 mutant plants displayed an important reduction in sensitivity to red and far-red light in the control of hypocotyl elongation, whereas increments in TOC1 gene dosage clearly enhanced light sensitivity. (plantcell.org)
  • elegans
  • The functions of SUN proteins in nuclear positioning were first revealed by genetic analysis of the unc-84 gene in C. elegans . (pnas.org)
  • In C. elegans , UNC-84 has been shown to recruit KASH proteins ANC-1 and UNC-83 to the outer NE for critical functions in both nuclear anchorage and nuclear migration ( 10 , 12 , 13 ). (pnas.org)
  • downstream
  • These data further support a role for Btk in regulating TLR-induced cytokine production from APCs and provide downstream targets for analysis of Btk function. (labome.org)
  • mechanism
  • Dissecting the mechanism by overexpressing the H-locus, we identified one gene has being the main driver, MRPA, responsible for Sb III sequestration. (uantwerpen.be)
  • Gene dosage is thus a very important mechanism for the acquisition of antimony resistance and MRPA amplification is the first one emerging in natural and experimental conditions. (uantwerpen.be)
  • role
  • To examine the role of the TOC1 ( TIMING OF CAB EXPRESSION1 ) gene in the Arabidopsis circadian system, we generated a series of transgenic plants expressing a gradation in TOC1 levels. (plantcell.org)
  • Dynamics
  • 2015. Effects of Four Different Regulatory Mechanisms on the Dynamics of Gene Regulatory Cascades. . (ncbs.res.in)
  • duplication
  • The gene duplication occurred in 1.35 percent of the 324 patients studied, but was not present in nearly 9,000 control subjects who did not have these birth defects. (eurekalert.org)
  • In cases like this, gene duplication may enhance the organismal fitness immediately, driving the adaptive fixation of duplicate genes. (genetics.org)
  • results
  • 3The results showed that 23 genes were upregulated at least twofold by ischaemia treatment and that 12 genes were downregulated at least threefold by ischaemia treatment compared with controls. (academicconcepts.net)
  • These results clearly indicate that SUN1 and SUN2 function critically in skeletal muscle cells for Syne-1 localization at the NE, which is essential for proper myonuclear positioning. (pnas.org)
  • cell
  • The major functions of plasminogen (Plg) in fibrinolysis and cell migration depend on its binding to carboxy-terminal lysyl residues. (jci.org)
  • 9 Although Rho GTPases are involved in regulating cell functions at different levels, each isoform demonstrates substantial cross-reactivity with each other. (bloodjournal.org)
  • suppressor
  • The ability of plasma carboxypeptidase B (pCPB) to remove these residues suggests that it may act as a suppressor of these Plg functions. (jci.org)
  • found
  • We found that one of the genes, ceh-10 , specifies CAN fate. (genetics.org)
  • HLA genes are found to be numerous and highly polymorphic in order to bind various kinds of peptides originated from self or foreign antigens. (hindawi.com)
  • analysis
  • Analysis of the function of TCR-ITAMs has revealed that individual motifs bind with different affinities to the same effector (ZAP-70) and bind selectively to other potential effector molecules ( 4 )( 5 ). (rupress.org)
  • In its analysis, the team showed that the cause of these birth defects in a subset of children with these defects of testis and penile development resulted from a change in the number of copies of a gene, VAMP7. (eurekalert.org)
  • promoter
  • We cloned and sequenced the promoter of the DBR2 gene from varieties of both the LAP and the HAP groups. (deepdyve.com)
  • Lin Z, Edenberg H, Carr L. A novel negative element in the promoter of the mouse alcohol dehydrogenase gene Adh-1. (labome.org)
  • proteins
  • To understand these diseases, it is necessary to define the normal functions of aggregation-prone regions of proteins and how these proteins are perturbed in disease states. (jneurosci.org)
  • levels
  • By measuring the steady-state-RNA levels in human DS tissues and cells [ 14 - 17 ] and in tissues from mouse models of DS [ 18 - 22 ] it has been established that the trisomy causes an overall 50% increase in the RNA levels of Hsa21 genes. (biomedcentral.com)
  • human
  • For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B 57:01 ). (hindawi.com)
  • normal function
  • Here, we show that Mrj deficiency prevents normal keratin turnover, resulting in the formation of large keratin aggregates that are toxic to trophoblast cells, inhibiting their normal function. (biologists.org)