Function chemokines cx3c. Medical search. Frequent questions

Fractalkine, also known as CX3CL1, is a cytokine protein containing a CX3C chemokine motif atop a mucin stalk. (irvinesci.com)
The Periodic Table of Cytokine and Chemokine Families poster includes members of the tumor necrosis factor (TNF) superfamily, and cytokines belonging to the different families of interleukins, interferons, and chemokines. (rndsystems.com)
This review aims to describe the roles of key cytokines and chemokines in commonly used experimental models of pancreatitis and how the cytokine profile is affected by the choice of a specific model. (pancreapedia.org)
In the context of AP, the most extensively investigated chemokines are CC-ligand 2 (CCL2, also known as monocyte chemoattractant protein-1 or MCP-1), CXC-ligand 1 (CXCL1, also known as cytokine-induced neutrophil chemoattractant or CINC in rat and keratinocyte cytokine or KC in mouse), and CXC-ligand 2 (CXCL2, also known as macrophage inflammatory protein 2-alpha or MIP2a). (pancreapedia.org)

As the name suggests, this receptor binds the inflammatory chemokine CX3CL1 (also called neurotactin in mice or fractalkine in humans). (wikipedia.org)
In the recognition of immune cells during inflammation, the function of CX3CL1-CX3CR1 axis in the bloodstream is mainly recruitment of immune cells by migration through chemotaxis and diapedesis. (wikipedia.org)
The CX3CL1/CX3CR1 axis role in the nervous system is to mediate communication between microglia, neuroglia and neurons for regulation of microglia activity, hence this axis plays a neurodegenerative and neuroprotective function based on the physiological state. (wikipedia.org)
CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. (fishersci.com)
Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1. (fishersci.com)
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. (novoprolabs.com)
Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. (novoprolabs.com)
Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1). (prosci-inc.com)
The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo. (ox.ac.uk)

CX3C motif chemokine receptor 1 (CX3CR1), also known as the fractalkine receptor or G-protein coupled receptor 13 (GPR13), is a transmembrane protein of the G protein-coupled receptor 1 (GPCR1) family and the only known member of the CX3C chemokine receptor subfamily. (wikipedia.org)

The shedded form carries out typical function of conventional chemokines, the chemotaxis, while the membrane-bound protein behaves as adhesion molecule for facilitation of diapedesis. (wikipedia.org)
Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis. (cusabio.com)
Chemokines also use this mechanism to induce targeted chemotaxis in response cells. (creative-proteomics.com)
In addition to the mediation of migration of leukocytes to the inflammatory sites (chemotaxis), chemokine receptors play a role in leukocyte homing, human immunodeficiency virus entry, angiogenesis, tumor growth and metastasis, development, and inflammation of the central nervous system. (utoledo.edu)
1999). "Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis" . (wikidoc.org)
The presence or absence of a glutamate-leucine-arginine sequence further divides chemokines into 'ELR' and 'non-ELR' chemokines, with ELR-chemokines exhibiting highest activity in chemotaxis assays (65, 130). (pancreapedia.org)

The final columns in the poster show proteins belonging to one of the four chemokine subfamilies. (rndsystems.com)
These subfamilies are known as the C, CX3C, CC, or CXC subfamilies, and are based on the number and spacing of conserved cysteine residues located in the amino-terminus. (rndsystems.com)
Chemokines regulate the transport activation and sometimes proliferation of several cell types including myeloid lymphoid GW788388 endothelial and epithelial cells1 2 There are four chemokine subfamilies - CXC C CX3C and CC - based on the positions of conserved cysteine residues near the amino terminus of the proteins1 (TABLE 1). (cancerrealitycheck.com)
A sample of 16 proteins that belong to the CC, CXC, or CX3C subfamilies are inspected. (sabanciuniv.edu)
leukocyte migration and are defined by the presence of variations on a conserved cysteine motif in their mature sequences (1), and the large chemokine family is divided into four subfamilies (CC, CXC, XC and CX3C) according to the specific nature of this motif. (eyesoftheelephants.com)
Nineteen chemokine receptors have been identified and cloned, and these receptors have been classified into four subfamilies (CXC, CC, CX3C, and C) based on the chemokine subclass specificity. (utoledo.edu)

Chemokine (CXC motif) ligand 1 (CXCL1) acts as a key chemoattractant for neutrophils by binding specifically to its corresponding G protein-coupled receptor chemokine (CXC motif) receptor 2 (CXCR2) (11, 12). (researchsquare.com)
Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils. (cusabio.com)
The chemokine receptor 4 (CXCR4) is unique in that it specifically interacts with the endogenous ligand CXCL12 (Oberlin et al. (scienceexhibitions.org)
1996 CXCR4 also known as "fusin " is one of the most well-studied chemokine receptors due to its AMG-47a earlier found role like a coreceptor for HIV access (Feng Broder AMG-47a Kennedy & Berger 1996 The chemokine stromal cell-derived element-1 right now renamed as CXCL12 was founded as the specific ligand for CXCR4 (Bleul Fuhlbrigge Casasnovas Aiuti & Springer 1996 Oberlin et al. (scienceexhibitions.org)
This pathway highlights the different classes of chemokines, their receptors, and how chemokine signaling activates JAK/Stat, Ras, ERK, and Akt pathways.Chemokines are classified into four groups based on the pattern of their cysteine residues, namely CXC (α chemokines), CC (β chemokines), CX3C and C. Their receptors are class A GPCRs, however not all receptors are selective for a single ligand. (creative-proteomics.com)
In addition to the 18 signaling receptors for chemokines (4), there also exists a small subfamily of atypical chemokine receptors (ACKRs)2 that are characterized by an inability to mount classical receptor signaling following ligand binding (4,C8). (eyesoftheelephants.com)
This receptor binds essentially all inflammatory CC-chemokines with high affinity but does not mount classical signaling responses following ligand binding (9,C11). (eyesoftheelephants.com)
With the signaling chemokine receptors, a number of regions are known to be involved in ligand binding. (eyesoftheelephants.com)
Chemokine (C-C motif) ligand 2 (CCL2, also known as monocyte chemoattractant protein-1) recruits and activates monocytes during the inflammatory response. (wwec2012.net)
Table 1 Chemokine (C-C motif) ligand 2 (CCL2) like a potential restorative target for prostate malignancy* is located on chromosome 17q11.2-q12. (wwec2012.net)

The CX3CR1 receptor is part of the G-protein chemokine receptor family with the metabotropic function. (wikipedia.org)
The transmembrane chemokine receptor CX3CR1 mediates the adhesive and chemoattractant functions of fractalkine. (irvinesci.com)
CX3CR1 Antibody: CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. (prosci-inc.com)
IL-15 and IL-2 oppositely regulate expression of the chemokine receptor CX3CR1. (prosci-inc.com)

Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
They activate seven transmembrane G proteinCcoupled receptors and are classified based on the relative position of cysteine residues near the N terminus into four major family members: CC, CXC, C, and CX3C (4). (wwec2012.net)
Chemokines (chemotactic cytokines) are positively charged polypeptides with highly conserved cysteine (C) residues within the N-terminal sequence, classifying them as 'C', 'CC', 'CXC' or 'CX3C' types (102, 143). (pancreapedia.org)

2013 Although CXCR4 is known to bind only CXCL12 in 2005 another chemokine receptor CXC receptor 7 (CXCR7 ACKR3 RDC1 CMKOR1 or GPR159) was founded like a receptor for CXCL12 (Balabanian et al. (scienceexhibitions.org)
CXCL8 and CXCL6 bind to the chemokine receptors CXCR1 and CXCR2 whereas CXCL1 and other CXC-chemokines that have a Glu-Leu-Arg (ELR) motif at their amino terminus (CXCL2 -3 and-5) bind to and activate CXCR2 only2. (cancerrealitycheck.com)
A chemokine may therefore bind a number of receptors and exhibit agonist behavior with some and antagonist behavior with others. (creative-proteomics.com)
A basis for the construction of hybrids of chemokines to bind and/or activate various chemokine receptors is presented. (sabanciuniv.edu)
They function to mediate migration of leukocytes to the sites of injury and infection in response to a gradient concentration of chemokines, a group of small proteins that specifically bind the chemokine receptors. (utoledo.edu)
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)

Chemokine receptors that are specific for CC CHEMOKINES. (lookformedical.com)
CXCR receptors that are specific for CHEMOKINE CXCL16. (bvsalud.org)

Chemokines can be either homeostatic or inflammatory, or display both qualities simultaneously. (researchsquare.com)
Given this complexity, it is common to simplify chemokine, and chemokine receptor, biology by referring to them as being either homeostatic or inflammatory according to the contexts in which they predominantly function (2, 3). (eyesoftheelephants.com)

Soluble fractalkine functions as a chemoattractant for T cells and monocytes. (irvinesci.com)
Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. (creative-proteomics.com)
A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. (lookformedical.com)
Our previous studies showed that the expression of the monocyte-chemoattractant protein (MCP)-1, a chemokine, which triggers the infiltration and activation of cells of the monocyte-macrophage lineage, is abrogated in human papillomavirus (HPV)-positive premalignant and malignant cells. (biomedcentral.com)

Both diseases are characterized by the extravasation of leukocytes from the vascular endothelium into the synovial tissue, a process that involves numerous chemokines and their receptors acting as synovial chemotactic mediators (5). (researchsquare.com)
A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. (lookformedical.com)
Chemokines have substantial effects as chemotactic factors on normal development, swelling, atherosclerosis, and angiogenesis (4). (wwec2012.net)
PF4 is chemotactic for neutrophils , fibroblasts and monocytes , and interacts with a splice variant of the chemokine receptor CXCR3 , known as CXCR3B. (wikidoc.org)

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. (fishersci.com)
Chemokines and chemokine receptors are critical players in the disease processes of two inflammatory joint diseases: rheumatoid arthritis (RA) and osteoarthritis (OA) (1). (researchsquare.com)
Inherited genetic variants such as single-nucleotide polymorphisms (SNPs) of candidate genes, encoding various cytokines, chemokines, and inflammatory regulators, have become a subject of interest of genetic studies searching for independent predictors of GVHD development and HSCT outcome [ 4 - 7 ]. (hindawi.com)
Chemokines are a family of proteins involved in inflammatory and immune response. (sabanciuniv.edu)
In contrast, inflammatory chemokines and their receptors are largely involved in responding to tissue insults, injuries, or infections. (eyesoftheelephants.com)
Inflammatory chemokines are not expressed at high levels at steady state but are rapidly and substantially transcriptionally activated following an inflammatory insult. (eyesoftheelephants.com)
These chemokines then attract inflammatory leukocytes bearing their cognate receptors, and these cells remove pathogens, engulf debris, and assist in the process of tissue repair. (eyesoftheelephants.com)
We and others have demonstrated that ACKR2 is a highly efficient binder, internalizer, and scavenger of inflammatory CC-chemokines (12, 13). (eyesoftheelephants.com)
In keeping with its chemokine scavenging role, numerous studies utilizing ACKR2-deficient Etizolam mice have demonstrated the fundamental importance of ACKR2 for the resolution of inflammatory responses (15, 23,C28). (eyesoftheelephants.com)
Although it was initially assumed that this involved the scavenging and degradation of chemokines throughout an inflamed area, it now appears that ACKR2 plays a more subtle role in this context by minimizing inflammatory leukocyte Etizolam interaction with lymphatic endothelial cell surfaces and therefore ensuring the openness of lymphatic channels (29,C31). (eyesoftheelephants.com)
Thus in ACKR2-deficient mice, lymphatic vessels Rabbit Polyclonal to Cytochrome P450 4Z1 become congested by inappropriate association with inflammatory leukocytes, and this impairs drainage of fluid, cytokines, chemokines, and cells from inflamed sites thus accounting for the impaired resolution of the inflammatory response. (eyesoftheelephants.com)
The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammatory conditions. (wikidoc.org)
Pancreatic acinar cell injury triggers the synthesis and release of pro-inflammatory cytokines and chemokines (32, 36, 39, 41, 82). (pancreapedia.org)
Another mechanism whereby injured pancreatic acinar cells trigger the inflammatory response is through synthesis and release of cytokines (36) and chemokines (11), and upregulation of adhesion molecules such as the intercellular adhesion molecule-1 (ICAM-1) (136), which together promote neutrophil and monocyte infiltration (27, 71) and exacerbate tissue injury (10, 27, 37). (pancreapedia.org)

Chemokines are abundant in RA synovial fluid, while OA synovial fluid also reveals the presence of chondrocytes, synovial cells and other cells capable of both expressing and responding to chemokines (2-4). (researchsquare.com)
Chemokines are well-recognized for their ability to recruit different leukocytes (6) and for their involvement in the migration of circulating cells into or within tissue (7, 8). (researchsquare.com)
Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines. (novoprolabs.com)
Gilman 1987 present on the prospective cells (Baggiolini 1998 Chemokine receptors are grouped into four different family members as CXC CX3C CC and XC based on the chemokines they primarily interact with for signaling. (scienceexhibitions.org)
In part the endogenous transcription of chemokine genes in melanoma cells is due to altered NF-κB activation. (cancerrealitycheck.com)
Chemokines main function is to attract immune system cells at sites of inflammation. (creative-proteomics.com)
In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. (creative-proteomics.com)
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (creative-proteomics.com)
Chemokine signaling pathways are widely used to regulate the excessive biological processes of hematopoietic cells, leading to cell activation, differentiation and survival, and providing directional clues for cell transportation, which are essential for protective host responses. (creative-proteomics.com)
Encyclopedia of Biological Chemistry 2nd Ed. Editor-in-Chiefs: William Lennarz M. Lane Hardcover ISBN: 9780123786302 eBook ISBN: 9780123786319 Imprint: Academic Press Published Date: 15th February 2013 Page Count: 3232 Abstract Chemokine receptors are seven-transmembrane proteins expressed on neutrophils, lymphocytes, dendritic cells, and many other cell types. (utoledo.edu)
Moreover, the availability of p53 is apparently important for chemokine regulation, since TNF-α can induce MCP-1 only in human keratinocytes expressing the viral oncoprotein E7, but not in HPV16 E6 positive cells, where p53 becomes degraded. (biomedcentral.com)
These data support the concept that p53 inactivation during carcinogenesis also affects immune surveillance by interfering with chemokine expression and in turn communication with cells of the immunological compartment. (biomedcentral.com)
Chemokines play a crucial role in innate and adaptive immunity by attracting and activating specific subsets of effector leukocytes, cells from the monocyte/macrophage lineage as well as natural killer cells. (biomedcentral.com)
Both oncoproteins exert pleiotropic functions on their host cells, such as inactivation of the major tumour suppressors, p53 and retinoblastoma protein (pRB), respectively [ 10 ]. (biomedcentral.com)
It functions as the receptor for HTLV-1 and is consequently expressed on neoplastic cells in adult T cell lymphoma/leukemia. (wikidoc.org)
The notion of applying small molecule inhibitors to interrupt ATM function and sensitize tumefaction cells to radio /chemo therapeutic agents is not a novel concept. (hdacassay.com)
The ATM signal transduction was also inhibited by the compound pathway in cells, disturbed cell cycle checkpoint function and sensitive tumefaction cells to IR. (hdacassay.com)
CP466722 is just a fast reversible inhibitor of ATM function and transient coverage used in clonogenic survival assays suggests that temporary inhibition of ATM function is enough to sensitize cells to IR. (hdacassay.com)
Identification of CP466722 Urogenital pelvic malignancy supplies a new chemical structure that inhibits ATM function in cells and may now be modified to generate more potent and specific agencies that could possibly be able to enhancing cyst cell killing in vivo. (hdacassay.com)

The purpose of the present study was to determine whether mechanisms important for chemokine interactions with conventional chemokine receptors are conserved in the related atypical receptor ACKR2. (eyesoftheelephants.com)

A CC-type chemokine with specificity for CCR10 RECEPTORS. (lookformedical.com)
A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. (lookformedical.com)
A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
CCR receptors with specificity for CHEMOKINE CCL27. (lookformedical.com)
CCR receptors with specificity for a broad variety of CC CHEMOKINES. (lookformedical.com)
Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
CCR receptors with specificity for CHEMOKINE CCL2 and several other CCL2-related chemokines. (lookformedical.com)
CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. (lookformedical.com)

The biological functions of chemokines are mediated through seven-transmembrane G-protein-coupled receptors. (cancerrealitycheck.com)

of transcription of genes that encode cytokines chemokines adhesion factors and inhibitors of apoptosis. (cancerrealitycheck.com)

Chemokine receptors are pertussis toxin-sensitive GTP-binding proteins of Gi type. (scienceexhibitions.org)
The mechanisms of binding and activation in the chemokine family are investigated using the gaussian network model of proteins, a low-resolution model that monitors the collective motions in proteins. (sabanciuniv.edu)
It is particularly suitable for elucidating the global dynamic characteristics of large proteins or the common properties of a group of related proteins such as the chemokine family presently investigated. (sabanciuniv.edu)
Chemokine receptors belong to the G-protein-coupled seven-transmembrane receptor superfamily, which has more than 600 members that use the heterotrimeric G proteins to initiate signals. (utoledo.edu)

This subfamily currently comprises four receptors namely the Duffy antigen receptor for chemokines (DARC/ACKR1), D6/ACKR2, CXCR7/ACKR3, and CCRL1/ACKR4. (eyesoftheelephants.com)

Based on Luminex technology platform, Creative Proteomics provides analysis services for key targets of Chemokine signaling pathway. (creative-proteomics.com)
We provide Luminex technology for Chemokine signaling pathway analysis. (creative-proteomics.com)

Its unique CX(3)C chemokine domain is attached to a 241-amino acid mucin stalk, a 19-amino acid transmembrane domain, and a 37-amino acid intracellular domain of unknown function. (ox.ac.uk)

1996 Although CXCL12 is the only known chemokine that binds CXCR4 recent studies suggest that extracellular ubiquitin also functions as an immune modulator through CXCR4-mediated signaling (Saini Marchese & Majetschak AMG-47a 2010 Tripathi et al. (scienceexhibitions.org)

Many members of the TNF superfamily regulate apoptosis and/or immune cell functions, such as T cell co-stimulation, natural killer cell activation, and B cell homeostasis. (rndsystems.com)
Transcription factors (TFs) function by recognizing and binding specific sequences to regulate gene expression. (biomedcentral.com)

A CC-type chemokine secreted by activated MONOCYTES and T-LYMPHOCYTES. (lookformedical.com)
Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils. (lookformedical.com)

The transcription of chemokine genes is often inhibited by transforming growth factor-β (TGF-β) and glucocorticoids1. (cancerrealitycheck.com)
This constitutive expression of chemokines occurs due to transcriptional activation of the encoding genes. (cancerrealitycheck.com)
Tumour angiogenesis growth and metastasis are facilitated by the NF-κB-modulated transcription of chemokine genes. (cancerrealitycheck.com)
This chemokine is encoded by multiple genes. (lookformedical.com)

The protein encoded by this gene is a member of the beta chemokine receptor family. (wikidoc.org)

Homeostatic chemokines are constitutively produced. (researchsquare.com)
In this review I explore the mechanisms by which constitutively activated kinases that GW788388 function upstream of the NF-κB cascade facilitate chemokine-mediated tumorigenesis. (cancerrealitycheck.com)

Inhibition of CCL2 considerably decreases macrophage infiltration, decreases osteoclast function, and inhibits prostate malignancy growth in bone in preclinical animal models. (wwec2012.net)

VPF In this review I discuss the factors that lie upstream of the NF-κB cascade that are activated during tumorigenesis and the role of the putative NF-κB enhanceosome in constitutive chemokine gene transcription during tumorigenesis. (cancerrealitycheck.com)
Improved Epigallocatechin gallate service of transcription elements, such as ATF-2, was quantitatively evaluated as a function of i) human being cell collection particular stress-response, ii) SiO2NP size and iii) focus. (irjs.info)

Chemokines have been implicated in many aspects of tumorigenesis cell biology, including tasks in the rules of malignancy cell growth, angiogenesis, metastasis, and sponsor immune response (5). (wwec2012.net)

Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation. (rochester.edu)

After chemokine binding the heterotrimeric G protein is activated from the exchange of GDP for GTP and dissociates into the GTP-bound α and the βγ subunits (Goldsmith & Dhanasekaran 2007 Mellado Rodriguez-Frade Manes & Martinez 2001 The dissociated βγ subunit activates two major transmission transduction enzymes a phospholipase C-β (PLC-β) which is definitely specific for phosphatidylinositol and a phosphatidylinositol-3-OH kinase (PI3K). (scienceexhibitions.org)

Chemokines are a class of cytokines with small molecular weights, whose main role is to recruit white blood cell subpopulations under steady-state and pathological conditions. (creative-proteomics.com)

2000). "Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity" . (wikidoc.org)

Mammals have 45 chemokines and 18 receptors that involve themselves, in sometimes very complex ways, in regulating leukocyte migration. (eyesoftheelephants.com)

C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene . (wikidoc.org)
This gene is mapped to the chemokine receptor gene cluster region. (wikidoc.org)

Table 1 CXC- C- CX3C- and CC-chemokine and receptor families As the CXC-chemokines CXCL1 and GW788388 CXCL8 have been associated with tumour growth metastasis and angiogenesis I concentrate on these important chemokines. (cancerrealitycheck.com)

They are involved in various neural activities and immunological functions. (frontiersin.org)

2006 CXCR7 functions to control the CXCL12 gradients through high-affinity binding and quick degradation (Hoffmann et al. (scienceexhibitions.org)

The chemokine receptor is expressed on the cell surface and is a 7-pass transmembrane protein coupled to the G protein. (creative-proteomics.com)

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. (krakow.pl)

This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin -like molecules. (wikidoc.org)

Anatomy39

Organisms7

Diseases7

Chemicals and Drugs101

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes25

Disciplines and Occupations1

Information Science3

Cytokine4

CX3CL19

Motif chemokine1

Chemotaxis6

Subfamilies6

Ligand10

CX3CR14

Cysteine3

Bind6

Receptors that are specific2

Either homeostatic or inflammatory2

Chemoattractant4

Chemotactic4

Inflammatory15

Cells19

Important for chemokine1

Specificity8

Seven transmembrane G-protein-c1

Adhesion1

Proteins4

Subfamily1

Signaling pathway2

Mucin stalk1

Binds1

Regulate2

Lymphocytes2

Genes4

Family1

Constitutively2

CCL21

Transcription2

Malignancy1

Hematopoietic1

Heterotrimeric1

Pathological1

Tissue1

Migration1

Gene2

CXCL11

Immunological1

High-affinity1

Transmembrane protein1

Endothelial1

PLATELETS1