Loading...
  • Biol
  • A unique protein with RGDS, coiled-coil, and epidermal growth factor-like domains and a carboxyl terminus similar to the globular domain of complement C1q and collagens type VIII and X". J Biol Chem. (wikipedia.org)
  • gene
  • alpha-2-HS-glycoprotein (AHSG) also known as fetuin-A is a protein that in humans is encoded by the AHSG gene. (wikipedia.org)
  • Furthermore, members of the skeletal muscle lipid droplet-associated proteins family associate with other proteins, as activator of adipose triglyceride lipase and its coactivator comparative gene identification-58, to regulate lipolysis in skeletal muscle. (wikipedia.org)
  • Multimerin 1, also known as elastin microfibril interfacer 4 (EMILIN-4), is a protein that, in humans, is encoded by the MMRN1 gene. (wikipedia.org)
  • In humans, GHBP is formed by post-translational modification after the complete transcription and translation of the growth hormone receptor (GHR) gene into the cell-surface receptor protein. (wikipedia.org)
  • A precursor messenger RNA (mRNA) from the complete gene first is transcribed and then spliced to encode the full receptor protein. (wikipedia.org)
  • The reaction sequence is carried out by a series of individual soluble proteins that are each encoded by a discrete gene, and the pathway intermediates are shuttled between the enzymes. (wikipedia.org)
  • Four alternatively spliced transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
  • The UBC9 protein encoded by the UBE2I gene constitutes a core machinery in the cell's sumoylation pathway. (wikipedia.org)
  • The protein UBC9 encoded by the UBE2I gene has been shown to be targeted by multiple viruses, including HIV and HPV. (wikipedia.org)
  • Solute carrier family 22 (organic cation transporter), member 21 is a protein that in the house mouse is encoded by the Slc22a21 gene. (wikipedia.org)
  • SCAMP
  • Remarkably, neuronal expression of human SCAMP genes rescues selected behavioral phenotypes of the mutants, suggesting the conserved function of SCAMPs across species. (frontiersin.org)
  • platelet
  • [ 3 ] As such, von Willebrand factor functions in both primary (involving platelet adhesion and platelet plug formation) and secondary (involving FVIII) hemostasis. (medscape.com)
  • This facilitates both platelet adhesion and platelet aggregation, making high molecular weight multimers most important for normal platelet function. (medscape.com)
  • molecules
  • Protein-protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect. (wikipedia.org)
  • SCAMPs
  • These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. (wikipedia.org)
  • transmembrane
  • They are still transmembrane carrier proteins, but these are gated transmembrane channels, meaning they do not internally translocate, nor require ATP to function. (wikipedia.org)
  • For example, a deletion within the mRNA that encodes part of the transmembrane domain of the protein effectively leads to non-translation of the intracellular domain due to the presence of a stop codon. (wikipedia.org)
  • kinase
  • RT "Regulation of 5'AMP-activated protein kinase activity and substrate RT utilization in exercising human skeletal muscle. (genome.jp)
  • reductase
  • In many metabolic reactions, a protein that acts as an electron carrier binds to an enzyme that acts its reductase. (wikipedia.org)
  • In the case of the mitochondrial P450 systems, the specific residues involved in the binding of the electron transfer protein adrenodoxin to its reductase were identified as two basic Arg residues on the surface of the reductase and two acidic Asp residues on the adrenodoxin. (wikipedia.org)
  • More recent work on the phylogeny of the reductase has shown that these residues involved in protein-protein interactions have been conserved througout the evolution of this enzyme. (wikipedia.org)
  • cellular
  • CRBP I/II, cellular-binding proteins involved in transport of retinol and metabolites into retinyl esters for storage or into retinoic acid. (wikipedia.org)
  • CRABPs, cellular retinoic acid-binding proteins capable of binding retinol and retinoic acid with high affinity. (wikipedia.org)
  • bind
  • The molecule or ion to be transported (the substrate) must first bind at a binding site at the carrier molecule, with a certain binding affinity. (wikipedia.org)
  • They are carrier proteins that bind retinol. (wikipedia.org)
  • In the test tube AHSG can bind multiple ligands and therefore has been claimed to be involved in several functions, such as endocytosis, brain development and the formation of bone tissue. (wikipedia.org)
  • thioester
  • In a second step, an E1 activating complex binds to SUMO at its di-glycine and passes it on to the E2 protein Ubc9, where it forms a thioester bond with a cysteine residue within Ubc9's catalytic pocket. (wikipedia.org)
  • Tissue
  • Retinol-binding proteins have been identified within the uterus, embryo, and extraembryonic tissue of the bovine, ovine, and porcine, clearly indicating that RBP plays a role in proper retinol exposure to the embryo and successful transport at the maternal-fetal interface. (wikipedia.org)
  • It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. (wikipedia.org)
  • enzymatic
  • On the other hand, each enzymatic activity (Condensation reaction, Reduction Reaction, Dehydration reaction) is found as a discrete protein in type II systems. (wikipedia.org)
  • molecular
  • This is a gain of function mutation in the von Willebrand factor causing spontaneous binding to platelets and rapid clearance of both platelets and high molecular weight von Willebrand factor multimers. (medscape.com)
  • Protein recognition by a pattern-generating fluorescent molecular probe. (weizmann.ac.il)
  • Many molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. (wikipedia.org)
  • All this information enables the creation of large protein interaction networks - similar to metabolic or genetic/epigenetic networks - that empower the current knowledge on biochemical cascades and molecular etiology of disease, as well as the discovery of putative protein targets of therapeutic interest. (wikipedia.org)
  • atypical
  • Purpose Review aberrations of insulin signaling to atypical proteins kinase C (aPKC) in muscles and liver that generate cardiovascular risk elements, including, weight problems, hypertriglyceridemia, hypercholesterolemia, insulin level of resistance and blood sugar intolerance in type 2 diabetes mellitus (T2DM), and obesity-associated metabolic symptoms (MetSyn). (biomasswars.com)
  • complexes
  • PRC1 and PRC2 are two protein complexes that modify the expression of p16 through the interaction of various transcription factors that execute methylation patterns that can repress transcription of p16. (wikipedia.org)
  • pathogen
  • Pneumolysin (PLY), an associate from the category of Gram-positive bacterial, cholesterol-dependent, -barrel pore-forming cytolysins, may be the main proteins virulence aspect from the dangerous respiratory pathogen, (pneumococcus). (biomasswars.com)
  • They contain DNA that codes for specific proteins (antigens) from a pathogen. (wikipedia.org)
  • mutations
  • Carriers of germline mutations in CDKN2A have besides their high risks of melanoma also increased risks of pancreatic, lung, laryngeal and oropharyngeal cancers and tobacco smoking exacerbates carriers' susceptibility for such non-melanoma cancers. (wikipedia.org)
  • binds
  • Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15). (wikipedia.org)
  • Normally, CDK4/6 binds cyclin D and forms an active protein complex that phosphorylates retinoblastoma protein (pRB). (wikipedia.org)
  • belongs
  • This protein belongs to the LDLR family and is made up of a number of functionally distinct domains, including 3 EGF-like domains, 7 LDL-R class A domains, and 6 LDL-R class B repeats. (wikipedia.org)
  • modification
  • We investigated the interaction of PEGylated and un-PEGylated PLGA NPs with Recombinant Human Mannose-Binding Protein (HMBP) in an effort to understand the effect of surface modification on their binding to the protein. (scirp.org)
  • Dolichols play a role in the co-translational modification of proteins known as N-glycosylation in the form of dolichol phosphate. (wikipedia.org)
  • Regulation of p16 is complex and involves the interaction of several transcription factors, as well as several proteins involved in epigenetic modification through methylation and repression of the promoter region. (wikipedia.org)
  • receptor
  • 168 of 444 (37.8%) LPS-induced proteins were significantly reduced with the treatment of RGFP966, which mainly concentrated on Toll-like receptor signaling pathway. (hindawi.com)
  • These effects may be mediated by the defective functioning of estrogen via the estrogen receptor, which contains a zinc finger protein. (wikipedia.org)
  • The H3 receptor is coupled to the Gi G-protein, so it leads to inhibition of the formation of cAMP. (wikipedia.org)
  • e.g. a truncation of the receptor protein at residue number 660 leads to domains 3,4 and 5 of the EGF precursor domain being missing. (wikipedia.org)
  • This precludes the movement of the receptor from the ER to the Golgi, and leads to degradation of the receptor protein. (wikipedia.org)
  • recognises
  • The George Fleming Prize recognises Dr Mobasheri's work in water channel proteins, which he found to play an important role in maintaining the function of cartilage cells following physical exercise in horses. (thefreedictionary.com)
  • cells
  • Taking a systems approach, we develop and summarise the view that "serum ferritin" actually originates from damaged cells (and thus reflects cellular damage), that it contains some iron but has lost or liberated most of its normal content, and that since the protein part of ferritin is assumed to be benign, that it is this (initially) free iron that correlates with and is causative of disease. (rsc.org)
  • HTLV-I provirus was more methylated in primary ATL cells than in carrier state, indicating the association with disease progression. (biomedcentral.com)
  • Metabolism is usually divided into two categories: catabolism, the breaking down of organic matter for example, the breaking down of glucose to pyruvate, by cellular respiration, and anabolism, the building up of components of cells such as proteins and nucleic acids. (wikipedia.org)
  • The protein was detected in and purified from cultures of Phytohaemagglutinin-activated human T-cell leukemia SKW-3 cells. (wikipedia.org)
  • Subsequent studies have defined LECT2 as a hepatokine, i.e. a substance made and released into the circulation by liver hepatocyte cells that regulates the function of other cells: it is a hepatocyte-derived, hormone-like, signaling protein. (wikipedia.org)
  • Using very sensitive methods, LECT2 protein can also be detected at low levels in the endothelial cells of hepatic arteries and veins including central veins. (wikipedia.org)
  • The DNA is injected into cells, whose "inner machinery" uses the DNA to synthesize the proteins. (wikipedia.org)
  • Because these proteins are recognised as foreign, when they are processed by the host cells and displayed on their surface, the immune system is alerted, which then triggers immune responses. (wikipedia.org)
  • One way of enhancing protein expression is by optimising the codon usage of pathogenic mRNAs for eukaryotic cells. (wikipedia.org)
  • essential
  • These biochemicals can be joined together to make polymers such as DNA and proteins, essential macromolecules of life. (wikipedia.org)
  • Because the plasmid is the "vehicle" from which the immunogen is expressed, optimising vector design for maximal protein expression is essential. (wikipedia.org)
  • mutation
  • B) DNA sequencing chromatograms showing the SH2B3 D231fs mutation in the proband and a heterozygous carrier compared with a control SH2B3 wild-type DNA sample. (nih.gov)
  • domain
  • Both the cyclooxygenase and the peroxidase active sites are located in the catalytic domain, which accounts for approximately 80% of the protein. (wikipedia.org)
  • The C-terminal domain of Beta2-adaptin is a protein domain is involved in cell trafficking by aiding import and export of substances in and out of the cell. (wikipedia.org)
  • A third domain of the protein is rich in O-linked oligosaccharides but appears to show little function. (wikipedia.org)
  • found
  • Serum ferritin" presents a paradox, as the iron storage protein ferritin is not synthesised in serum yet is to be found there. (rsc.org)
  • Unlike this family of peptidases, however, ALEC2 has not been found to possess enzymatic activity and does not appear to share any functions with M23 metalloendopeptidases. (wikipedia.org)
  • humans
  • Night blindness may be a feature of severe zinc deficiency, however most reports of night blindness and abnormal dark adaptation in humans with zinc deficiency have occurred in combination with other nutritional deficiencies (e.g. vitamin A). Impaired immune function in people with zinc deficiency can lead to the development of respiratory, gastrointestinal, or other infections, e.g., pneumonia. (wikipedia.org)
  • important
  • The high degree of conservation of the polarity of syntaxin 3 and 4 suggests that their function and proper localization may play an important role in epithelial polarization. (rupress.org)
  • compound
  • Compound semiconductors and germanium, whose carrier mobility is superior to that of silicon, are called post-silicon materials, and research into them is proceeding in various countries as next-generation channel materials. (nanowerk.com)
  • Their research has endeavored to integrate high-performance semiconductors on a silicon substrate with compound semiconductors or germanium that have a variety of functions as photonic materials. (nanowerk.com)
  • role
  • For instance, artificial parthenogenesis proved that it was possible to separate the sperm's function as initiator of development from its role as carrier of the male hereditary characters. (devbio.com)
  • known
  • Biochemical and biotechnological development has allowed novel approaches to this issue, in the form of engineered O2 carriers, widely known as "blood substitutes. (wikipedia.org)
  • mammals
  • In mammals (in contrast, for instance, to some functions in insects 1-4 ), ferritin is supposed to be a cellular means of storing iron, 5 not of transporting it, yet serum ferritin levels are widely measured as indicators of iron status. (rsc.org)
  • structure
  • However, their binding is shown to have different effect on the structure of the protein. (scirp.org)
  • On the other hand the fluorescence emission of the protein increased upon binding to the PLGA-PEG-NH2 indicating conformational changes in the protein structure. (scirp.org)
  • results
  • Collectively, these results identify a book function of HSPA5 in ferroptosis and recommend a potential healing strategy for conquering gemcitabine resistance. (biomasswars.com)
  • small
  • Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. (wikipedia.org)
  • next
  • as well as the downstream molecule extracellular indication regulated proteins kinase (ERK) 1/2, which induced the upregulation of p53 and Bcl-2-linked X proteins, mediating the next mobile apoptosis and proliferation in IECs. (biomasswars.com)
  • The work is being funded by the Ministry of Defence, which had been considering creating a new deep water channel through the Tudor warship's resting place for its next generation of aircraft carriers. (thefreedictionary.com)