• Severe, life threatening, and in some cases fatal hepatotoxicity, including fulminant and cholestatic hepatitis, hepatic necrosis and hepatic failure and severe, life threatening skin reactions have been reported with the use of nevirapine. (antimicrobe.org)
  • Objective: The efficacy of lamivudine for fulminant hepatitis B has been reported in Europe and West Asia. (elsevierpure.com)
  • However, in these reports, the main infection genotype is D. Furthermore, if lamivudine improves survival, prognostic factors fof fulminant hepatitis B may differ from those reported previously. (elsevierpure.com)
  • The aim of this study was to clarify the prognostic factors and the efficacy of lamivudine for fulminant hepatitis B in Japan, where the main infection genotype is B. Methods: This study was a retrospective cohort study. (elsevierpure.com)
  • There were no differences in clinical features at the time of the diagnosis of fulminant hepatitis B between patients treated with and without lamivudine. (elsevierpure.com)
  • Conclusion: This study suggests the efficacy of lamivudine for fulminant hepatitis B in the area where the main infection genotype is B. We consider that lamivudine is worth administering to patients with fulminant hepatitis B. (elsevierpure.com)
  • Dive into the research topics of 'Lamivudine treatment improves the prognosis of fulminant hepatitis B'. Together they form a unique fingerprint. (elsevierpure.com)
  • Lamivudine treatment improves the prognosis of fulminant hepatitis B . Internal Medicine , 47 (14), 1293-1299. (elsevierpure.com)
  • The availability of histopathological liver specimens from cases of Labrea Hepatitis, showing a specific picture of microvesicular steatosis (morula-like cells) and eosinophilic necrosis, has been pointed out by Brazilian authors 9 . (scielo.br)
  • This pattern are different from those of massive and submassive necroses found in ordinary fulminant viral hepatitis. (scielo.br)
  • Figure 1 shows the presence of "morula-like" cells in hepatic tissue in the fulminant form of hepatitis A (HAV), B (HBV), C (HCV) and Delta (HDV). (scielo.br)
  • Nevirapine is associated with fatal fulminant & cholestatic hepatitis, hepatic necrosis, & hepatic failure. (medquizzes.net)
  • Extremely elevated ALT levels are common in toxic hepatitis and hepatic ischemia secondary to circulatory collapse and heatstroke. (clinlabnavigator.com)
  • Fulminant herpes hepatitis with disseminated extrahepatic involvement in pregnancy is rare and carries a high mortality risk. (thieme-connect.de)
  • Fulminant herpes simplex virus (HSV) hepatitis with disseminated extrahepatic involvement is a rare complication of herpes virus infection, traditionally described in significantly immunocompromised hosts. (thieme-connect.de)
  • 2 ] The current treatment recommendation for fulminant HSV hepatitis in pregnancy is intravenous (IV) acyclovir, with the addition of foscarnet for acyclovir-resistant cases. (thieme-connect.de)
  • What are the characteristics of fulminant hepatitis? (freezingblue.com)
  • RNA interference targeting Fas protects mice from fulminant hepatitis. (the-scientist.com)
  • In the February 10 Nature Medicine , Erwei Song and colleagues at Harvard Medical School , Boston, Massachusetts, USA, show that RNA interference (RNAi) targeting the gene Fas (also known as Tnfrsf6, encoding the apoptosis Fas receptor) can protect mice from fulminant hepatitis ( Nature Medicine , DOI:10.1038/nm828, February 10, 2003). (the-scientist.com)
  • The most serious adverse reactions associated with nevirapine are hepatitis, hepatic failure, Stevens-Johnson syndrome, toxic epidermal necrolysis, and hypersensitivity reactions. (drugcentral.org)
  • Fulminant hepatic failure (FHF) is usually defined as the severe impairment of hepatic functions or severe necrosis of hepatocytes in the absence of preexisting liver disease. (medscape.com)
  • Renal Toxicity: Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia. (drugs.com)
  • Hepatic or renal impairment: avoid. (empr.com)
  • There are no significant changes in the pharmacokinetics of nevirapine with mild or moderate hepatic impairment. (antimicrobe.org)
  • Nevirapine should not be given to patients with severe hepatic impairment. (antimicrobe.org)
  • Renal and hepatic impairment. (azurewebsites.net)
  • Severe hepatic impairment. (tajgenerics.com)
  • Severe hepatic (impairment), renal or cardiac failure. (ibnhayyanpharma.com)
  • HA549 trade name] is not recommended for patients with moderate or severe hepatic impairment because there are insufficient data to determine whether dose adjustment is necessary. (who.int)
  • See in single cell hepatocellular necrosis. (symptoma.com)
  • Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. (springer.com)
  • Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
  • Potassium excretion is increased initially upon administration of methazolamide and in patients with cirrhosis or hepatic insufficiency could precipitate a hepatic coma. (druglib.com)
  • Cirrhosis is defined histologically as a diffuse hepatic process characterized by fibrosis and conversion of the normal liver architecture into structurally abnormal nodules. (medscape.com)
  • The etiology of pediatric fulminant hepatic failure differs significantly from adults in developed countries. (medscape.com)
  • Behavioral treatment involving parents improves long-term success with transplantation is no further improvement in renal or hepatic failure, chronic diagnosis symptoms fever anorexia, vomiting. (elastizell.com)
  • Post mortem showed fulminant hepatic failure and acute tubular necrosis of kidneys. (gastrores.org)
  • With anti-HBe antibody and high viral load, he had fulminant hepatic failure without proximate cause. (bvsalud.org)
  • The patient was a 24-year-old gravida 1 with no significant medical history who presented to our hospital as a transfer of care at 27 2/7 weeks' gestation with fever of unknown origin, hepatic failure, and leukopenia. (thieme-connect.de)
  • Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
  • Fulminant hepatic failure (FHF) is an acute and eventually fatal illness, caused by a severe hepatocyte damage with massive necrosis. (uandes.cl)
  • FHF usually begins with exposure of a susceptible person to an agent capable of producing severe hepatic injury, although the exact etiology remains unidentified in many cases of FHF. (medscape.com)
  • The major pathologic findings were in the liver, which cm2 floor area) plastic cages in an isolation room within an showed centrilobular necrosis, steatosis, and basophilic animal biosafety level 3 facility. (cdc.gov)
  • Nevirapine is an inducer of hepatic cytochrome P450 3A. (antimicrobe.org)
  • Hepatic Reaction In controlled clinical trials, symptomatic hepatic events regardless of severity occurred in 4% (range 0% to 11%) of subjects who received nevirapine and 1% of subjects in control groups. (drugcentral.org)
  • The liver has dual inflow supply, with approximately two-thirds from the low pressure, low O 2 portal vein, and one-third from the systemic pressure, high O 2 hepatic artery. (basicmedicalkey.com)
  • All specimens showed a diffuse small-droplet fatty change, lytic and eosinophylic necroses with different degrees of intensity, were also seen, without evidence of massive or submassive necrosis. (scielo.br)
  • Autopsy specimen of liver revealed submassive hepatic necrosis with faint regeneration. (bvsalud.org)
  • Subsequent angiography confirmed occlusion at the hepatic arterial anastomosis. (medscape.com)
  • In addition, they showed that treatment with Fas siRNA abrogated hepatocyte necrosis and inflammatory infiltration and protected mice. (the-scientist.com)
  • Despite supportive care and appropriate antiviral therapy, the patient's hepatic dysfunction worsened (AST 2290 U/L, ALT 783 U/L, lactate dehydrogenase 6551 U/L, and total bilirubin 7.5 mg/dL) with associated coagulopathy (international normalized ratio [INR] 1.9). (thieme-connect.de)
  • causes associated with liver disease can be categorized according to cause as prehepatic, hepatic, or posthepatic. (msdvetmanual.com)
  • This categorization is relative to the normal directional flow of from the portal vein to the liver (portal tracts), across the sinusoids, with egress through the hepatic vein into the vena cava. (msdvetmanual.com)
  • The lobule, often used interchangeably with acinus, is a term based on the concept of the hexagon in which hepatic cords radiate from the central vein toward the portal tracts. (basicmedicalkey.com)
  • During angiography, a catheter is placed selectively via either the transjugular or transfemoral route into the hepatic vein to measure portal pressure. (medscape.com)
  • The venous return is via the left, right, and middle hepatic veins which join to form the inferior vena cava as it enters the heart at the right atrium. (basicmedicalkey.com)
  • Ultrasonography (US), CT, MRI, cholangiography, angiography and scintigraphy are the most common radiological modalities used to evaluate the hepatic graft. (medscape.com)
  • between the cursors) of the hepatic graft. (medscape.com)
  • Pressure equalization occurs in the sinusoids, along with the nutrient and O 2 gradient from portal tracts to terminal hepatic venules. (basicmedicalkey.com)
  • Microscopically, the hepatic cords are lined by reticulin fibers and separated by sinusoids. (basicmedicalkey.com)
  • 4 ] Ultimately, only delivery resulted in resolution of maternal hepatic and neurologic dysfunction. (thieme-connect.de)
  • 56°C for 30 min) fetal bovine serum (FBS) to prepare an cacodylate buffer, stained en bloc in 1% uranyl acetate in approximate 10% (wt/vol) tissue homogenate. (cdc.gov)
  • The animals were fulminant illness developed in all animals, and they died 6-9 days after infection. (cdc.gov)
  • The best ALT discriminant value for recognizing acute hepatic injury is 300 U/L. (clinlabnavigator.com)