ReductaseTriphosphatePurineMonophosphateSubstratesTriphosphatesAICARGenomicPathwaysMetabolicMetabolismSequenceTranscriptionAnalogCDNAQuality AssessmentHumanListChemicalGrowthPurine ribonucleosidePhosphateDeoxyribonucleosideMonophosphatesInhibitsDiphosphateCytostaticVitroTRNAVirusesReactionFormVaccinesSevereTermsCriticalSectionsVersion
Reductase1
- Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary). (jax.org)
Triphosphate2
- It is turned into ribonucleoside triphosphate (NHC-TP), which is its active form, by metabolism. (zaharaheckscher.com)
- Molnupiravir is a prodrug that is metabolised to the ribonucleoside analogue N-hydroxycytidine (NHC) which distributes into cells where it is phosphorylated to form the pharmacologically active ribonucleoside triphosphate (NHC-TP). (azurewebsites.net)
Purine2
- A purine ribonucleoside 5'-monophosphate having hypoxanthine as the nucleobase. (ebi.ac.uk)
- Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity with decreasing activity in the order uridine, xanthosine, inosine, adenosine, cytidine, guanosine. (string-db.org)
Monophosphate1
- Ribonucleoside monophosphate (rNMP) incorporation in genomic DNA poses a significant threat to genomic integrity. (brad.ac.uk)
Substrates2
- Instead nucleoside 2',3'-cyclic phosphates were obtained in good yield with the ribonucleoside substrates. (uwaterloo.ca)
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (embl.de)
Triphosphates1
- Attempts to prepare nucleoside triphosphates by subjecting unprotected ribonucleosides and 2'-deoxyribonucleosides to activated cyclic trimetaphosphate failed. (uwaterloo.ca)
AICAR2
- In the present study, the effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on long-chain fatty acid oxidation by hepatocytes isolated from suckled neonatal pig liver (a low ketogenic and lipogen. (biomedcentral.com)
- AICAR, also known as 5-aminoimidazole-4-carboxamide ribonucleoside, is a short peptide that is involved in many metabolic processes and energy homeostasis. (suaway.com)
Genomic1
- Ribose-seq is a mapping technique used in genetics research to determine the full profile of embedded ribonucleotides, specifically ribonucleoside monophosphates (rNMPs), in genomic DNA. (wikipedia.org)
Pathways1
- The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. (planteome.org)
Metabolic2
- Link to all annotated objects annotated to ribonucleoside bisphosphate metabolic process. (planteome.org)
- Link to all direct and indirect annotations to ribonucleoside bisphosphate metabolic process. (planteome.org)
Metabolism1
- In the first step of its metabolism, N-hydroxycytidine (NHC), which is similar to ribonucleosides, is made. (zaharaheckscher.com)
Sequence1
- This overlapping fragments covering the full-length S-gene feature makes viruses highly adaptable and contributes to sequence (see Nested RT-PCR below and Figure 1) were difficulties in preventing and controlling viral disease. (cdc.gov)
Transcription1
- The deoxynucleotides were characterized via steady-state kinetics and PCR, while the ribonucleosides were characterized by the transcription of both a short, model RNA as well as full length tRNA. (univ-grenoble-alpes.fr)
Analog1
CDNA1
- RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences. (linuxfocus.org)
Quality Assessment1
- Included articles underwent full-text review, data abstraction, and quality assessment. (cdc.gov)
Human1
- The first discovery of ribonucleoside monophosphates (rNMPs) embedded into DNA was in mitochondrial DNA from mouse and human cells in 1973 by Lawrence Grossman, Robert Watson, and Jerome Vinograd. (wikipedia.org)
List1
- For the full list of excipients, see section 6.1. (who.int)
Chemical1
- Although the full scope of epigenetics has not yet been determined, it is generally defined as chemical modification that mainly includes DNA and RNA methylation, histone modification, noncoding RNA modification and chromatin rearrangement. (biomedcentral.com)
Growth1
- Feed intake control is vital to ensuring optimal nutrition and achieving full potential for growth and development in poultry. (biomedcentral.com)
Purine ribonucleoside2
Phosphate1
- Adenosine diphosphate (ADP) is a nucleoside phosphate comprised of a ribonucleoside and two phosphate groups. (quick-advices.com)
Deoxyribonucleoside2
- The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). (planteome.org)
- This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. (nih.gov)
Monophosphates3
- Ribose-seq is a mapping technique used in genetics research to determine the full profile of embedded ribonucleotides, specifically ribonucleoside monophosphates (rNMPs), in genomic DNA. (wikipedia.org)
- The first discovery of ribonucleoside monophosphates (rNMPs) embedded into DNA was in mitochondrial DNA from mouse and human cells in 1973 by Lawrence Grossman, Robert Watson, and Jerome Vinograd. (wikipedia.org)
- These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. (nih.gov)
Inhibits3
- EIDD-2801 is an investigational, orally-bioavailable form of a potent ribonucleoside analog that inhibits the replication of multiple RNA viruses including SARS-CoV-2, the causative agent of COVID-19. (chronicleshealth.com)
- We report that 5-nitroindole ribonucleoside triphosphate (1) can be universally incorporated opposite each native RNA base by the RNA-dependent RNA polymerase (RdRP) from poliovirus, and inhibits this enzyme more potently than the triphosphate metabolite of the antiviral drug, ribavirin. (psu.edu)
- Molnupiravir is an orally administered form of patent ribonucleoside that inhibits replication of SARS-COV-2, the causative agent of Covid-19. (ukrai.com.np)
Diphosphate1
- Belongs to the ribonucleoside diphosphate reductase large chain family. (assaygenie.kr)
Cytostatic1
- 3. 6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents. (nih.gov)
Vitro1
- The replicative form of M13 synthesized in vitro consists of a full-length, linear, complementary strand annealed to a viral strand. (nih.gov)
TRNA4
- A Platform for Discovery and Quantification of Modified Ribonucleosides in RNA: Application to Stress-Induced Reprogramming of tRNA Modifications. (nih.gov)
- Here we describe an analytical platform for systems-level quantitative analysis of modified ribonucleosides in any RNA species, with a focus on stress-induced reprogramming of tRNA as part of a system of translational control of cell stress response. (nih.gov)
- This chapter emphasizes strategies and caveats for each of the seven steps of the platform workflow: (1) RNA isolation, (2) RNA purification, (3) RNA hydrolysis to individual ribonucleosides, (4) chromatographic resolution of ribonucleosides, (5) identification of the full set of modified ribonucleosides, (6) mass spectrometric quantification of ribonucleosides, (6) interrogation of ribonucleoside datasets, and (7) mapping the location of stress-sensitive modifications in individual tRNA molecules. (nih.gov)
- Among the >120 modified ribonucleosides in the prokaryotic epitranscriptome, many tRNA modifications are critical to bacterial survival, which makes their synthetic enzymes ideal targets for antibiotic development. (rcsb.org)
Viruses1
- This overlapping fragments covering the full-length S-gene feature makes viruses highly adaptable and contributes to sequence (see Nested RT-PCR below and Figure 1) were difficulties in preventing and controlling viral disease. (cdc.gov)
Reaction1
- ribonucleoside triphosphates are not required in this second stage nor does rifampicin inhibit the reaction. (nih.gov)
Form1
- Two cDNA segments were ligated together to form the full-length Aed a 1 gene. (keyopinionleaders.com)
Vaccines3
- Remdesivir (an antiviral agent), baricitinib (an immunomodulatory drug), and 2 mRNA vaccines have gained full FDA approval for prevention and treatment of COVID-19 disease. (medscape.com)
- The FDA has granted either full approval and/or emergency use authorization for the vaccines listed below. (medscape.com)
- Co-vax and such vaccines have been a full-throttle to increase vaccination rates. (ukrai.com.np)
Severe1
- A cheaper, oral alternative can be of great help to stop the severe effects of covid until full treatment/immunization is available. (ukrai.com.np)
Terms1
- See terms of use for full details. (brenda-enzymes.org)
Critical1
- A wide range of sessions will be delivered in both interdisciplinary and single discipline format to provide critical thinking from professors and young scientists across the full spectrum of disciplines and professions involved in sport and exercise. (tf.hu)
Sections1
- Sections or subsections omitted from the full prescribing information are not listed. (nih.gov)
Version1
- An InChIKey is a simplified version of a full InChI, designed for easier web searching. (guidetoimmunopharmacology.org)