• Biocon Biologics Ltd), BT-ON013 - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
  • The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)
  • We applied four, five or six cycles of moderately high doses of doxorubicin and cyclophosphamide supported by granulocyte-macrophage colony-stimulating factor (GM-CSF). (coek.info)
  • In patients with breast cancer receiving adjuvant 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel (FEC-D), we evaluated the impact of chemotherapy total cumulative dose (TCD), and early (FEC) versus late (D only) dose reductions, on survival outcomes. (jnccn.org)
  • The initial dose of Herzuma is 4 mg/kg over 90 minute IV infusion, then 2 mg/kg over 30 minute IV infusion weekly for 12 weeks (with paclitaxel or docetaxel) or 18 weeks (with docetaxel and carboplatin ). (rxlist.com)
  • 85% for historical regimens (ie, cyclophosphamide/methotrexate/fluorouracil) are known to affect breast cancer survival. (jnccn.org)
  • Landmark meta-analyses by the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) initially showed a 20% to 25% relative risk reduction in breast cancer mortality for first-generation regimens (ie, cyclophosphamide/methotrexate/fluorouracil [CMF]) and increased benefit with the addition of anthracyclines and taxanes. (jnccn.org)
  • Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
  • In the use of chemotherapy drugs, anthracyclines, such as doxorubicin and epirubicin, are generally used in combination with drugs such as cyclophosphamide, epirubicin, and fluorouracil. (encyclopedia.pub)
  • The current trial, BNIT-BR-003, will evaluate the safety and biological activity of a fixed dose of MVA-BN®-HER2 following adjuvant chemotherapy in patients with HER-2-positive breast cancer. (stanford.edu)
  • Advise male patients with female partners of reproductive potential to use effective contraception during treatment and for 3 months after the last dose of ELLENCE. (pfizermedicalinformation.com)
  • This phase II/III trial compares the side effects and activity of oral azacitidine in combination with the standard drug therapy (reduced dose rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone [R-miniCHOP]) versus R-miniCHOP alone in treating patients 75 years or older with newly diagnosed diffuse large B cell lymphoma . (uci.edu)
  • Each multiple-dose vial of HERZUMA delivers 420 mg trastuzumab-pkrb, 839 mg α,α-trehalose dihydrate, 9.5 mg L-histidine HCl, 6.1 mg L-histidine, and 1.7 mg polysorbate 20. (rxlist.com)
  • 1 mg / ml ( ) , injection solution for 2.57 epirubicin ( 10mg vial ) , injection 2.58 epirubicin ( 50mg vial ) , injection 2.59 equine anti rabies immunoglobulin, ( not less than 300iu / ml ) , injection 2.6 erythromycin stearate tab 250 mg 2.61 erythromycin stearate ( 500 mg ) , tablet 2.62 erythropoietin ( 4000 iu inj vial ) , injection 2.63 ethinyl estriadiol+norethisterone tab ( 35 mcg +1mg ) , tablet 2.64 etiophylline and theophylline ( paediatric ) , syrup 2.65 etiophylline theophylline sr tab. (tendersinmadhyapradesh.com)
  • Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. (researchwap.com)
  • Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)
  • Purpose: To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC). (the-medical-dictionary.com)
  • Fifteen patients could receive high-dose ICE followed by PBSCT twice, and 3 patients could receive it once. (the-medical-dictionary.com)
  • Conclusion: Double-cycle, high-dose ICE therapy followed by PBSCT is tolerable and feasible even after conventional chemotherapy or chemoradiotherapy in patients with SCLC. (the-medical-dictionary.com)
  • Hyperfractionated radiation involves lower doses administered more frequently, resulting in less severe side effects. (vacancer.com)
  • However, in many cases, chemotherapy or radiotherapy alone cannot achieve a satisfactory therapeutic outcome, namely the complete remission of tumors, and induces severe side effects at therapeutically effective doses. (biomedcentral.com)
  • In today's world of advancing technology, three-dimensional conformal radiation therapy (3D-CRT)planning systems are able to generate treatment schemes that are supposedly conformal to the tumor/target volume thereby limitingthe dose that reaches the surrounding normal tissues. (oncolink.org)
  • Because only a fraction of the cells in a tumor die with each treatment (fractional kill), repeated doses must be administered to continue to reduce the size of the tumor. (worldsbest.rehab)
  • The recommended initial loading dose of [BT-ON013 trade name] is 8 mg/kg body weight. (who.int)
  • Intensity-modulated radiation therapy (IMRT) spares normal tissues, reducing mouth sores, while still delivering the full radiation dose or even an increased dose to the cancer. (vacancer.com)
  • Theproblem with tumoricidal doses of external beam radiation is that normal tissues can also be affected. (oncolink.org)
  • This would, thus, allow the radiation oncologists to increase the doses to thetarget (the prostate, in this case), while minimizing dose to the normal tissues in proximity (bladder, intestine and rectum). (oncolink.org)
  • Rats in group (8) received combination of V. amygdalina and O. gratissimum at a dose of 250 mg/kg each for ten consecutive before administering CP (200 mg/kg) on the tenth day. (researchwap.com)
  • It has been known that radiation could eradicate tumors -- the radiation treatments just needed to utilize a "high enough" dose. (oncolink.org)
  • Performance status is often used as a measure to determine whether a person can receive chemotherapy, or whether dose reduction is required. (worldsbest.rehab)
  • One week after the last weekly dose of Herzuma, administer 6 mg/kg as an IV infusion over 30-90 minutes every three weeks to complete a total of 52 weeks of therapy. (rxlist.com)
  • This threshold, in addition to early versus late dose reductions, are poorly defined for third-generation anthracycline/taxane-based chemotherapy. (jnccn.org)
  • Complete 2-year data was obtained on 99 3D-CRT patients, while 94 conventional RT patients had full 2-year follow-up. (oncolink.org)
  • In limited-stage SCLC, the overall survival rate has been significantly improved by adding dose-hyperfractionated thoracic radiotherapy and prophylactic cranial irradiation to systemic chemotherapy. (ersjournals.com)
  • An increase in the total dose of chemotherapy seemed unlikely since other studies with dose-intensive chemotherapy failed to significantly improve survival [2,3]. (coek.info)
  • Many natural products have been widely reported to ameliorate at varying degrees the side effects of oxazophosphorines e.g. cyclophosphamide and ifosphamide (Łukasz and Piotr, 2012). (researchwap.com)
  • If HERZUMA is reconstituted with SWFI without preservative, the reconstituted solution is considered single-dose. (rxlist.com)
  • Full articles were obtained and references were checked for additional information when appropriate. (biomedcentral.com)