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  • liver
  • The metabolism of free fructose in liver exploits the ability of aldolase B to use fructose 1-phosphate as a substrate . (wikipedia.org)
  • Sakakibara M, Mukai T, Hori K: Nucleotide sequence of a cDNA clone for human aldolase: a messenger RNA in the liver. (drugbank.ca)
  • When unoccupied by FBP, aldolases promote the formation of a lysosomal complex containing at least v-ATPase, ragulator, axin, liver kinase B1 (LKB1) and AMPK, which has previously been shown to be required for AMPK activation6, 7. (xmu.edu.cn)
  • glucose
  • Here, we describe an AMP/ADP-independent mechanism that triggers AMPK activation by sensing the absence of fructose-1,6-bisphosphate (FBP), with AMPK being progressively activated as extracellular glucose and intracellular FBP decrease. (xmu.edu.cn)
  • Knockdown of aldolases activates AMPK even in cells with abundant glucose, whereas the catalysis-defective D34S aldolase mutant, which still binds FBP, blocks AMPK activation. (xmu.edu.cn)
  • FBPA
  • Although aldolase activity increased by 25% in vector control rice roots treated with 0.1 μ M GA3, FBPA activity increased very little by 0.1 μ M GA3 treatment in the root of aldolase-antisense transgenic rice. (deepdyve.com)
  • Here we report the crystal structure of FBPA/P at 1.5-Å resolution in the aldolase form, where a critical lysine residue forms a Schiff base with DHAP. (sigmaaldrich.com)
  • pathway
  • These results suggest that the activation of glycolytic pathway function accelerates root growth and that GA3-induced root aldolase may be modulated through OsCDPK13. (deepdyve.com)
  • Human
  • Mukai T, Arai Y, Yatsuki H, Joh K, Hori K: An additional promoter functions in the human aldolase A gene, but not in rat. (drugbank.ca)
  • Maire P, Gautron S, Hakim V, Gregori C, Mennecier F, Kahn A: Characterization of three optional promoters in the 5' region of the human aldolase A gene. (drugbank.ca)