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  • histological
  • Surprisingly, detailed analyses of NebΔSH3 mice revealed no structural or histological skeletal muscle abnormalities and no changes in gene expression or localization of interaction partners of the nebulin SH3 domain, including myopalladin, palladin, zyxin and N-WASP. (nih.gov)
  • Secondary measures will be evaluated in a nested subgroup (n=20) and will consist of biochemical/histological analyses of collected muscle, urine and blood samples at baseline and at ICU discharge. (bmj.com)
  • membranes
  • The complete extraction of PKc from skeletal muscle membranes required a high concentration of Triton X100. (edu.au)
  • So, impulses travel along muscle cell membranes just as they do along nerve cell membranes. (eku.edu)
  • mammalian
  • Human iPSC-derived skeletal muscle cells offer new opportunities for clarifying basic aspects of skeletal muscle development in humans, which is by far the least documented mammalian species. (biomedcentral.com)
  • The overall goal of this research is to elucidate molecular mechanisms by which Ca2+, cooperation, and protein phosphorylations regulate contraction of mammalian myocardium. (grantome.com)
  • high frequency
  • Their results, which are systematic, elegant, and convincing, go a long way toward resolving the basis for the observed greater increase in initial Ca 2+ concentration caused by insertion of a doublet of high-frequency action potentials. (rupress.org)
  • protein
  • Lawrence JC Jr (2001) mTOR-dependent control of skeletal muscle protein synthesis. (springer.com)
  • The build-up of muscle mass depends on protein synthesis. (dissertation.com)
  • By contrast, protein synthesis is blocked during contraction, mainly due to the inhibition of translation elongation. (dissertation.com)
  • Cleland, Perry J F 1990 , 'Contraction-induced glucose transport into skeletal muscle : the involvement of protein kinase C', PhD thesis, University of Tasmania. (edu.au)
  • increase muscle contraction force via activation of stimulatory G protein (G s )-coupled receptors (GPCRs), which in turn activates adenylyl cyclases (ACs). (aspetjournals.org)
  • Absence of dystrophin leads to disruption of the dystrophin-associated protein complex and substantial changes in skeletal muscle pathology. (jove.com)
  • Muscle cells, ensheathed by endomysium, consist of many fibrils (or myofibrils), and these myofibrils are made up of long protein molecules called myofilaments. (eku.edu)
  • gene expression
  • To examine the pathogenic pathways and identify new or modifying factors involved in muscular dystrophy, expression microarrays were used to compare individual gene expression profiles of skeletal muscle biopsies from 12 DMD patients and 12 unaffected control patients. (jove.com)
  • Myocyte
  • On the functional side, depolarization-induced intracellular Ca 2+ transients mediating E-C coupling were recorded using Fura-2 ratiometric Ca 2+ imaging, and myocyte contraction was captured by digital photomicrography. (biomedcentral.com)
  • However, Ca 2+ transients become effective in triggering myocyte contraction after 1 week of differentiation, when nascent myofibrils show alternate A-I bands. (biomedcentral.com)
  • insulin
  • Muscles treated with TPA showed an increased basal rate of 3-0-methylglucose uptake, responded partially to insulin, but did not respond to contraction. (edu.au)
  • represents
  • Skeletal muscle represents the largest organ in the body, comprises 36-42% of body weight, and has recently been recognized as having an endocrine function. (rian.ie)
  • gastrocnemius
  • PKc was partially purified from gastrocnemius-plantarissoleus skeletal muscle preparations by DE52 anion exchange chromatography. (edu.au)
  • Electrical-induced contraction of the gastrocnemius' - plantaris-soleus muscle group resulted in a time-dependent translocation of PKc and a 2-fold increase in the concentration of both diacylglycerol and phosphatidic acid. (edu.au)
  • Animals were sacrificed at 15 wks and soleus, white gastrocnemius and red gastrocnemius muscles were collected for fatty acid analyses. (biomedcentral.com)
  • intracellular
  • Analysis of the intracellular distribution showed that a large proportion of the enzyme activity (60%) was associated with the membrane component of resting muscle. (edu.au)
  • In skeletal muscle, the β-AR-dependent increase of intracellular cAMP is followed by the efflux of cyclic nucleotide via probenecid-sensitive transporters ( Godinho and Costa, 2003 ). (aspetjournals.org)
  • connective tissue
  • The fibres and muscles are surrounded by connective tissue layers called fasciae . (wikipedia.org)
  • Connective tissue is present in all muscles as fascia . (wikipedia.org)
  • Myofascial force transmission causes interaction between adjacent muscles and connective tissue: Effects of blunt dissection and compartmental fasciotomy on length force characteristics of rat extensor digitorum longus muscle. (utwente.nl)
  • This connective tissue also ensheaths the entire muscle & is called epimysium. (eku.edu)
  • Each muscle is surrounded by a connective tissue sheath called the epimysium. (eku.edu)
  • Fascia, connective tissue outside the epimysium, surrounds and separates the muscles. (eku.edu)
  • longitudinal
  • For some longitudinal muscles, such as the biceps brachii , this is a relatively simple concept. (wikipedia.org)
  • The images acquired through a high speed camera were correlated with a custom-made algorithm and the longitudinal strain predictions were employed for measuring the spontaneous contraction. (hindawi.com)
  • Muscle activation timing for a longitudinal study after stroke. (utwente.nl)
  • calcium
  • In skeletal muscle, calcium release occurs at specialized structures where the membrane of transverse (T) tubules, i.e., invaginations of the plasmalemma, comes close to that of the SR. There, voltage-sensing proteins of the T membrane (Ca V 1.1 in skeletal muscles) interact with the SR calcium release channels (also called RYRs). (rupress.org)
  • membrane
  • (B) Tetrads of particles (Ca V s) in a freeze-fractured T tubule membrane from toadfish muscle, presented with the same orientation and magnification. (rupress.org)
  • and, if the threshold potential is reached, an action potential occurs, an impulse travels along the muscle cell membrane, and the muscle contracts. (eku.edu)
  • action potentials
  • has shown that this initial burst of action potentials contributes to the rate of force development in fast-twitch skeletal muscles. (rupress.org)
  • Scans of isometric muscle contractions were recorded, with ECG electrodes placed on each side of the probe to detect associated motor unit action potentials.The measurements of the time delay between EMG and ultrasound response shows that there are an expected time delay between 6.68ms and 15.38ms, depending on the propagation velocity of the motor unit action potentials. (bibsys.no)
  • composition
  • 8. Gollnick PD, Armstrong RB, Saubert CW, Piehl K, Saltin B. Enzyme activity and fibre composition in skeletal muscle of untrained and trained men. (edu.pl)