• Sperm cell membranes are high in polyunsaturated fatty acids and are sensitive to oxygen free radical induced damage mediated by lipid peroxidation. (scialert.net)
  • Free radical-scavenging, inhibition power of lipid peroxidation and reducing power were also determined. (ishs.org)
  • The studies demonstrate that D. salina exhibits potent protective effects on UVB radiation-induced corneal oxidative damage in mice, likely due to both the increase of antioxidant enzyme activity and the inhibition of lipid peroxidation. (molvis.org)
  • Between the results of lipoxgenase inhibition and the lipid peroxidation a linear correlation was found. (google.com)
  • White mulberry Morus alba and jackfruit Artocarpus heterophyllus are two of seven chosen Vietnamese folk plants which showed the highest tyrosinase inhibition activity. (scirp.org)
  • Because it promotes the lightening of pigment spots, tyrosinase inhibition is one of the mechanisms of depigmenting cosmetic products. (bvsalud.org)
  • Thus, this study demonstrated for the first time that the glycolic extracts of C. pachystachya have promising chemical and biological characteristics for the development of a multifunctional cosmetic with antioxidant and tyrosinase-inhibition activities. (bvsalud.org)
  • Tyrosinase inhibition. (bvsalud.org)
  • Oxygen free radicals are naturally produced by mitochondrial and sperm plasma membrane and have beneficial and detrimental effects that cannot be overlooked. (scialert.net)
  • mechanistically, rotenone-induced destruction of dopaminergic neurons has been attributed to its inhibition of the activity of neuronal mitochondrial complex I. However, the role of microglia, the resident brain immune cells in rotenone-induced neurodegeneration, has not been reported. (jneurosci.org)
  • This is further demonstrated by IL-1 beta-induced inhibition of glucose oxidation by purified beta-cells, mitochondrial aconitase activity of dispersed islet cells, and mitochondrial aconitase activity of Rin-m5F cells, all of which are prevented by NMMA. (jci.org)
  • Rotenone's toxicity in humans, animals, and fish is via inhibition of mitochondrial respiratory chain complex I, with cell death by apoptosis due to excess generation of free radicals. (merckvetmanual.com)
  • Radiosensitizers are chemical agents that have the potential to increase the lethal effect of radicals induced during irradiation [1-6].The extent of radiation damage to cells is dependent on the amount of oxygen available to the cell [1,2,7,8]. (who.int)
  • The mass fractions of total phenolic com-pounds, anthocyanins and resveratrol (HPLC-DAD), as well as the antioxidant properties (DPPH · , · OH and ABTS + radical scavenging capacity) were determined. (researchgate.net)
  • Newly synthesized imidazole derivatives were screened for their in-vitro antioxidant activity by DPPH free radical scavenging assay method and α-amylase inhibition activity by DNS method. (ias.ac.in)
  • SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)
  • REGU®-AGE PF has been developed specifically to address these multiple conditions and delivers on the following parameters: inhibition of oxygen free radicals, stimulating effect on fibroblasts proliferation, inhibition of collagenases and elastases to protect the collagen and elastin matrix, improvement of capillary circulation. (dsm.com)
  • The excessive generation of oxygen free radicals in the form of ROS by abnormal spermatozoa and by contaminating leukocytes has been identified as one of the few defined etiologies for male infertility. (scialert.net)
  • However, the over production of oxygen free radicals in sperm membrane decreases the antioxidant defense activity thereby leading to low sperm motility and viability, DNA fragmentation and protein denaturation. (scialert.net)
  • 26. Chang T.M. A nanobiotechnologic therapeutic that transport oxygen and remove oxygen radicals: for stroke, hemorrhagic shock and related conditions // In: Artificial cells: biotechnology, nanomedicine, regenerative medicine, blood substitutes, bioencapsulation and cell/stem cell therapy. (medline.ru)
  • Deltamethrin exposure promoted free radical formation in rat brain and reactive oxygen species generation in PC12 cells. (cdc.gov)
  • At therapeutic doses of metronidazole (4.98-24.86 μg/mL) significant inhibition of the production of reactive oxygen species was noted in both methods. (who.int)
  • Under aerobic conditions, there is enough oxygen to react with all the free radicals and addition of metronidazole, or any other sensitizers, yields no further benefit. (who.int)
  • We hypothesized that doping would increase toxicity and decrease antioxidant abilities as a result of increased oxygen vacancies and inhibition of +3 to +4 transition. (cdc.gov)
  • In the aim to study the contribution of phenolic compounds in the inhibition of seeds germination of wheat ( Triticum aestivum L. ) under water deficit, we have forwarded quantitatively and qualitatively the change of the phenolic compounds levels in the seeds of two varieties (Achtar and Tigre) submitted to water stress induced by PEG-6000 during the germination stage. (scirp.org)
  • Given that the outer layers of mature seeds are rich in phenolic compounds, the content and nature of these compounds appear to be indexes for explain their involvement in the inhibition of seed germination. (scirp.org)
  • The biological material for the present study consisted of seeds of Triticum aestivum L. So, the major aim of the study has been to investigate whether phenolic compounds are involved in the inhibition of wheat seed germination under water stress simulated with PEG-6000. (scirp.org)
  • To counteract the negative effects of excess ROS, spermatozoa and seminal plasma have several mechanisms to neutralize free radicals. (scialert.net)
  • To counteract oxidative damage, spermatozoa and seminal plasma have several mechanisms to neutralize free radicals. (scialert.net)
  • Metronidazole, being electron-affinic, can accept an electron from neutral free radical centres to generate a reactive cation that binds to an anion such as hydroxyl (OH-), causing a permanent lesion. (who.int)
  • Sigma Chemical Company, Germany, un- radical centres to generate a reactive cation less otherwise mentioned. (who.int)
  • 0.05) were observed in respect of the free radical scavenging capacity of most investigated cranberry cultivars. (researchgate.net)
  • A structure-activity relationship for the estimation of rate constants for the gasphase reactions of OH radicals with organic compounds. (cdc.gov)
  • Also, for unknown reasons a small proportion of normal oxidative reactions result in the formation of free radicals. (positivehealth.com)
  • Hence, we suggest that, by designing highly potent and specific inhibitors of TryR enzyme, inhibition of T[SH] 2 reduction and overall inhibition of most of the downstream pathways including Fe/S protein activation reactions, can be accomplished. (frontiersin.org)
  • 19. Alayash A.I. Redox and Radical Reactions of Hemoglobin Solutions: Toxicities and Protective Strategies // In: Blood Substitutes. (medline.ru)
  • These readily undergo iron-catalyzed secondary free radical reactions leading to truncated products which retain the signature PE headgroup and which can readily react with nucleophilic moieties in proteins via their truncated electrophilic acyl chains. (cdc.gov)
  • Furthermore, inhibition of NADPH oxidase or scavenging of superoxide significantly reduced the rotenone-induced neurotoxicity. (jneurosci.org)
  • Ultraviolet radiation can cause change in physical texture and appearance of the skin via complex signaling cascades, which results in the production of free radicals. (ijpsonline.com)
  • Free radicals can form naturally since some of the body's molecules have weak bonds that spontaneously break and cause the molecule to become a free radical. (positivehealth.com)
  • We also produce other Tempo molecules that have specialist applications in polymer inhibition. (nufarm.com)
  • Free radical-scavenging inhibition percentage at 50% was about 0.50, 0.268, 4.17 and 21.50 in sweet potatoes steamed with cloves, Guinea pepper, nutmeg and turmeric respectively. (ishs.org)
  • Metronidazole selectively radiosensitizes of metronidazole (in a range of therapeutic hypoxic cells without influencing the ra- concentrations) on PMN-generated free diation response of normal well-oxygenated radicals during phagocytosis activity in cells [ 5,7-9 ]. (who.int)
  • These results show that LPS should not be expected to affect the free radical biology of lactoferrin, which is a crucial physiologic function of this protein. (nih.gov)
  • The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain. (cdc.gov)
  • To this end, we examined translocation of Nrf2 and production of free radicals in rat brain exposed to DM. (cdc.gov)
  • Furthermore, Nrf2 translocation was accompanied by the expression of heme oxygenase-1 gene, an Nrf2-regulated gene linked to free radical production. (cdc.gov)
  • The purpose of this investigation was to determine if the beta-cell, which is selectively destroyed during insulin-dependent diabetes mellitus, is both a source of IL-1 beta-induced nitric oxide production and also a site of action of this free radical. (jci.org)
  • Selective inhibition of the copper efflux in microbes is expected to raise their copper levels, accelerate the Fenton reaction, and augment the production of free radicals. (biorxiv.org)
  • À des doses thérapeutiques de métronidazole (4,98-24,86 μg/mL), on a observé une inhibition significative de la production d'espèces réactives de l'oxygène avec les deux méthodes. (who.int)
  • Electron spin resonance, used to assess the effects of CeO2 on free radical production, showed that with doping, antioxidant potential decreased. (cdc.gov)
  • PMN results in the production of super- cer cells are known to be relatively resistant oxide radicals [ 7,8 ]. (who.int)
  • Inhibition of calcification in vivo by acyl azide cross-linking of a collagen-glycosaminoglycan sponge. (cdc.gov)
  • essential nutritional dietary compounds such as vitamin C, and small plant-derived substances which intercept free radicals and prevent them from causing damage. (positivehealth.com)
  • Vitamin E is a fat-soluble vitamin that acts as an antioxidant and free-radical scavenger in lipophilic environments. (medscape.com)
  • The slower absorption rate and intact protein cage of the ferritin iron help protect the intestinal lining from free radical damage. (florahealth.com)
  • These work by either stopping free radical damage by donating an electron without becoming a damaging free radical themselves, or by preventing oxidation commencing. (positivehealth.com)
  • T[SH] 2 reduction reaction was introduced with a perturbation in the form of its inhibition to predict the overall behavior of the model. (frontiersin.org)
  • [ 8 ] Caspase inhibition in clonal striatal cells showed no correlation between the reduction of aggregates in the cells and increased survival. (medscape.com)
  • Pretreatment of beta-cells, purified by FACS with IL-1 beta results in a 40% inhibition of glucose-stimulated insulin secretion that is prevented by the nitric oxide synthase inhibitor, NG-monomethyl-L-arginine (NMMA). (jci.org)
  • 1980. Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. (cdc.gov)
  • The in vitro analysis indicated a 1.5 times increase in collagenase inhibition upon using (3) as compared to ascorbic acid (standard). (ijpsonline.com)
  • Nitric oxide has recently been implicated as the effector molecule that mediates IL-1 beta-induced inhibition of glucose-stimulated insulin secretion and beta-cell specific destruction. (jci.org)
  • 2 of free radicals from the stimulation of available to the cell [ 1,2,7,8 ]. (who.int)
  • Finally, a great number of chemicals, especially human-produced synthetic compounds can cause free radical formation. (positivehealth.com)
  • The rapidly growing volume of evidence in the scientific literature about the nature and role of free radicals has lead to an increasing awareness of their importance in health and disease. (positivehealth.com)
  • The combination of DNBP plus Tempo stable free radical is the most cost-effective system for many styrene plants. (nufarm.com)
  • Plants-based chemicals i.e. phytochemicals have become an efficient source to balance free radicals and consequently, to negate the age-related diseases caused by free radicals. (ijpsonline.com)
  • Furthermore, due to inhibition, the T[SH] 2 synthesis rate was observed to be gradually decreased by 8 to 14-fold. (frontiersin.org)
  • 1989. Free radical activation of monomethyl and dimethyl hydrazines in isolated hepatocytes and liver microsomes. (cdc.gov)
  • This has also caused an elevated level of free radicals which apparently affected the activation of Fe/S cluster proteins. (frontiersin.org)
  • Inhibition of LPS priming was observed whether apolactoferrin or iron-saturated lactoferrin was used. (nih.gov)
  • Similar inhibition of LPS priming was observed when neutrophils were incubated with other serum proteins (e.g., albumin, apotransferrin, or iron-saturated transferrin). (nih.gov)
  • Inhibition of ferritin iron absorption only occurs when relatively large (greater than 10x) amounts of other iron sources are in competition in the digestive tract. (florahealth.com)