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  • Rodent
  • We critically examine and summarize several rodent models of transient global ischemia, resulting in selective neuronal injury within vulnerable brain regions, and focal ischemia, typically giving rise to localized brain infarction. (ahajournals.org)
  • Development
  • We, therefore, encourage the AMDCC to continue its development of new models, and we suggest that amplification of the renin-angiotensin system may offer valuable insights into the pathophysiology of this complex disease. (ahajournals.org)
  • ischemic
  • The use of physiologically regulated, reproducible animal models is crucial to the study of ischemic brain injury--both the mechanisms governing its occurrence and potential therapeutic strategies. (ahajournals.org)
  • We explore the utility of individual models and emphasize the necessity for meticulous experimental control of those variables that modulate the severity of ischemic brain injury. (ahajournals.org)
  • This technique has proved helpful in identifying acutely ischemic and contused myocardium in animal models. (ahajournals.org)
  • human
  • The main reason for scientific research is to understand "how," whether the "how" relates to human disease or the operation of the universe. (ahajournals.org)
  • No reasonable person would argue against the value of the model organisms in providing fundamental insights into biological processes that are generalizable to human biology ( Table 1 ). (ahajournals.org)
  • Leads
  • In this model, AF itself leads to a progressive shortening of the effective refractory period (ERP) and a gradual increase in AF stability. (ahajournals.org)