Fraser SyndromeMutationPoint MutationSkeletonMutation, MissenseFrameshift MutationSyndactylyDNA Mutational AnalysisGerm-Line MutationPedigreeExtracellular Matrix ProteinsPolymorphism, Single-Stranded ConformationalHeterozygoteExonsPolymerase Chain ReactionGlomerular Basement MembraneBase SequenceEye AbnormalitiesSyndromeMolecular Sequence DataGenes, p53Mutation RateAmino Acid SubstitutionGenetic TestingAllelesGenotypeHomozygoteCodon, NonsensePhenotypeSequence Analysis, DNAAmino Acid SequenceUreterGenes, RecessiveMutagenesis, Site-DirectedSequence DeletionCodonMutagenesisDNA PrimersGenes, DominantGenetic Predisposition to DiseaseDNA, NeoplasmZebrafish ProteinsZebrafishGene DeletionDNA-Binding ProteinsChromosome MappingMembrane ProteinsProtein Structure, TertiaryFounder EffectConsanguinityFamily HealthHeterozygote DetectionPolymorphism, GeneticDisease Models, AnimalCell LineGene FrequencyDNAModels, MolecularEscherichia coliNuclear ProteinsTumor Suppressor Protein p53Transcription FactorsGenetic LinkageAge of OnsetGenes, BRCA1Gene Expression Regulation, DevelopmentalProto-Oncogene Proteins B-rafSuppression, GeneticGenetic Diseases, X-LinkedSequence Homology, Amino AcidGenetic Complementation TestAsian Continental Ancestry GroupMicrosatellite RepeatsBinding SitesPolymorphism, Restriction Fragment LengthMutant ProteinsCarrier ProteinsGenes, APCDNA, MitochondrialPenetranceSequence AlignmentExomeCloning, MolecularGenes, rasIntronsMutagensModels, GeneticLoss of HeterozygosityProto-Oncogene ProteinsBacterial ProteinsProtein BindingTransfectionColorectal Neoplasms, Hereditary NonpolyposisEye ProteinsGenetic VariationSaccharomyces cerevisiaePlasmidsMutagenesis, InsertionalRNA, MessengerImmunohistochemistry