• Methyltransferase is a potential virulence factor in this pathogen, which causes Tularemia, an infection common in wild rodents, especially rabbits, that can be transmitted to humans though bites, touch, eating or drinking contaminated food or water, or even breathing in the bacteria. (sciencedaily.com)
  • However, some bacteria such as Francisella tularensis (causative of tularemia ) and Burkholderia spp. (immunology.org)
  • A member of the genus Francisella , F. tularensis is the causative agent of tularemia or rabbit fever. (loinc.org)
  • Tularemia, sometimes referred to as "rabbit fever" after its most common reservoir, is a relatively rare zoonotic disease caused by the bacterium Francisella tularensis. (cdc.gov)
  • Francisella tularensis can cause the zoonotic disease tularemia and is partitioned into subspecies due to differences in chromosomal organization and virulence. (nebraska.edu)
  • Francisella tularensis is the causative pathogen of tularemia and a Tier 1 bioterror agent on the CDC list. (openmicrobiologyjournal.com)
  • Francisella tularensis is an intracellular bacterial pathogen which causes a potentially lethal disease named tularemia. (am-online.org)
  • Francisella tularensis, the etiologic agent of tularemia and a Class A Select Agent, is divided into three subspecies and multiple subpopulations that differ in virulence and geographic distribution. (nau.edu)
  • Francisella tularensis is the etiological agent of tularemia, a serious disease in several Northern hemisphere countries. (bibbase.org)
  • article{karlsson_sequencing_2000, title = {Sequencing of the {Francisella} tularensis {Strain} {Schu} 4 {Genome} {Reveals} the {Shikimate} and {Purine} {Metabolic} {Pathways}, {Targets} for the {Construction} of a {Rationally} {Attenuated} {Auxotrophic} {Vaccine}}, volume = {5}, issn = {1090-6592}, url = {https://www.liebertpub.com/doi/10.1089/10906590050145249}, doi = {10.1089/10906590050145249}, abstract = {Francisella tularensis is the etiological agent of tularemia, a serious disease in several Northern hemisphere countries. (bibbase.org)
  • His current research focuses on understanding the role of bacterial virulence factors in pathogenesis and host response, and the development of subunit and live vaccines to prevent tularemia and glanders due to the select agents Francisella tularensis and Burkholderia mallei , respectively. (vt.edu)
  • At the Annual Biophysical Society Meeting in San Francisco, Geoffrey K. Feld, a Postdoctoral researcher in the Physical&Life Sciences Directorate at Lawrence Livermore National Laboratory (LLNL), described the team's work to uncover the secrets of the bacterium Francisella tularensis , which causes tularemia. (science20.com)
  • Francisella tularensis is a gram negative, facultative intracellular bacterium that is the etiological agent of tularemia. (biomedcentral.com)
  • Francisella tularensis is the etiological agent of the severe, febrile disease tularemia. (biomedcentral.com)
  • Tularemia, a bacterial zoonosis, is caused by Francisella tularensis, one of the most infectious pathogenic bacteria known. (cdc.gov)
  • Responsible for tularemia, Francisella tularensis bacteria are highly infectious Gram-negative, category A bioterrorism agents. (encyclopedia.pub)
  • The facultative intracellular Gram-negative coccobacillus Francisella tularensis is the etiologic agent of tularemia [ 1 ]. (encyclopedia.pub)
  • Tularemia in squirrels is a highly infectious zoonotic disease caused by the bacteria Francisella tularensis. (squirrelarena.com)
  • Two-component systems allow bacteria to detect, evaluate and protect themselves against changes in the environment, such as exposure to antibiotics and also to trigger production of virulence factors. (ncsu.edu)
  • To sustain their virulence mechanisms, many bacteria can sequester free iron in the mammalian host, through the elaboration of iron-binding siderophores. (immunology.org)
  • Therefore, it is essential to develop a diagnostic test to identify the main species of bacteria and the presence of virulence genes related to diseases in fish. (fapesp.br)
  • This is important for highly pathogenic bacteria such as Bacillus anthracis, Brucella species, and Francisella tularensis. (rki.de)
  • Our preliminary data indicate that F. tularensis bacteria lacking these proteins are diminished in their ability to infect or survive in human immune cells, which indicates that these proteins may also contribute to F. tularensis virulence," Feld said. (science20.com)
  • 10 bacteria are sufficient to induce severe infection) and its potential use as a biological weapon, the aerosolizable and high-mortality rate Francisella pathogen has been classified as a class A bioterrorism agent by the U.S.A. Centers for Disease Control and Prevention (CDC). (encyclopedia.pub)
  • Gram-negative bacteria have an additional outer membrane containing lipopolysaccharide (endotoxin), increasing the virulence of these bacteria. (msdmanuals.com)
  • Whilst many bacterial pathogens are intracellular in nature, others do not need to invade the host cell, but instead use various secretion processes which effect the delivery of toxins and other virulence factors into the host cell. (immunology.org)
  • The BioHealthBase Bioinformatics Resource Center (BRC) (www.biohealthbase.org) is a public bioinformatics database and analysis resource for the study of specific biodefense and public health pathogens - Influenza virus, Francisella tularensis, Mycobacterium tuberculosis, Microsporidia species and ricin toxin. (mssm.edu)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology of these pathogens, their virulence mechanisms, and the host's response to infection. (cshlpress.com)
  • Achaogen in San Francisco, CA is working on "preclinical development of novel therapeutics that reduce the virulence of, and inhibit resistance in, Class A Bacterial Pathogens. (defenseindustrydaily.com)
  • Achaogen in San Francisco, CA won a $24.6 million cost-reimbursement contract for preclinical development of novel broad-spectrum small-molecule therapeutics that reduce the virulence of, and inhibit resistance in, Class A Bacterial Pathogens. (defenseindustrydaily.com)
  • A common virulence strategy of intracellular pathogens is to favorably modulate the intracellular milieu of hosts for their own benefit. (biomedcentral.com)
  • Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. (ncsu.edu)
  • These findings not only provide insights into the evolution of virulence in Francisella, but have broader implications regarding the molecular mechanisms that mediate host-pathogen relationships," she added. (sciencedaily.com)
  • Another serious human pathogen, Bacillus anthracis, causative of anthrax , has well-developed virulence mechanisms involving the secretion of three proteins, one of which, protective antigen (PA), binds host cell receptors to effect entry of either lethal factor (LF) or edema factor (EF). (immunology.org)
  • The goal of the BioHealthBase is to facilitate the development of therapeutics, diagnostics and vaccines by integrating all available data in the context of host-pathogen interactions, thus allowing researchers to understand the root causes of virulence and pathogenicity. (mssm.edu)
  • Genes located on plasmids pOM1 and pNFL10, which had been previously isolated from low virulence strains of F. tularensis, were absent but all of the other known F. tularensis genes were represented in the assembled data. (bibbase.org)
  • To identify the Toxoplasma loci involved in virulence, virulence was mapped in F1 progeny derived from crosses between type II and type III strains and five virulence loci were identified. (saeijlab.com)
  • We recently described a Francisella pathogenicity island (FPI) harboring several genes necessary for intracellular growth. (biomedcentral.com)
  • Francisella tularensis is a pathogenic species of Gram-negative coccobacillus, an aerobic bacterium. (wikipedia.org)
  • Multiple other Francisella species have been isolated from animal and environmental samples. (unboundmedicine.com)
  • Moreover, the sets of genetic markers for virulence, were almost identical for the respective species. (rki.de)
  • The long reads of ONT allowed to assemble not only chromosomes of all species to near closure, but also virulence plasmids of Ba. (rki.de)
  • We designed TaqMan real-time PCR genotyping assays using eleven single nucleotide polymorphisms (SNPs) that were potentially specific to closely related groups within the genus Francisella, including numerous subpopulations within F. tularensis species. (nau.edu)
  • The virulence of each species varies. (squirrelarena.com)
  • When a pathogenic microorganism ( bacterium , viru s or protozoal parasite ) infects the human body, a battle ensues between the host's innate & adaptive immune systems and the pathogen's assorted virulence mechanisms and factors . (immunology.org)
  • causative of melioidosis or glanders ) have multiple secretion processes through which they deliver virulence factors into the host cell. (immunology.org)
  • Some studies have been conducted to describe and identify the virulence factors of F. tularensis . (am-online.org)
  • This review focuses on the main virulence factors of F. tularensis which are involved in intramacrophage replication and its survival mechanisms during infection. (am-online.org)
  • As in the case of the majority of virulence factors, the expression of T6SS is tightly controlled either at transcriptional or post-transcriptional level. (biomedcentral.com)
  • Genomic analysis of pasteurella atlantica provides insight on its virulence factors and phylogeny and highlights the potential of reverse vaccinology in aquaculture. (uib.no)
  • We sought to identify L.p. virulence factors that were required for replication in amoebae in order to highlight the genes necessary for production of the most infectious form of the bacterium. (elsevierpure.com)
  • Polymorphic secreted kinases are key virulence factors in toxoplasmosis. (saeijlab.com)
  • One assay differentiates F. tularensis, F. novicida, and F. hispaniensis from the more genetically distant F. philomiragia and Francisella-like endosymbionts. (nau.edu)
  • F. novicida is closely related to F. tularensis but has low virulence for humans while being highly virulent in mice. (biomedcentral.com)
  • He and his co-investigators, James "Randy" Heflin, a professor in the Department of Physics in the university's College of Science, and Abey Bandera, a research assistant professor in the veterinary college, are working to develop nanoscale optical fiber biosensor tests, or assays, for detection of Francisella tularensis, Burkholderia mallei , and B. pseudomallei . (vt.edu)
  • Although antibiotics and vaccines control their prevalence to some extent, the emergence of new virulence mechanisms and new forms of resistance to antibacterial agents makes research in this field critical to understanding and controlling infectious diseases. (cshlpress.com)
  • The functions of novel proteins putatively involved in F. tularensis virulence are revealed by X-ray crystallography. (science20.com)
  • We, and others, established that Toxoplasma virulence caused by high parasite burdens in mice, is largely determined by two proteins that cooperatively block mouse innate immune mechanisms that would otherwise destroy the vacuole in which the parasite lives. (saeijlab.com)
  • Virulence generally involves the employment of various mechanisms to destroy, or cause the malfunction of, host cells. (immunology.org)
  • Thus to protect itself from such virulence mechanisms, the host cell fights back by synthesising siderocalin receptors which competitively bind iron. (immunology.org)
  • The molecular mechanisms for their virulence and resistance to antibiotics remain largely unknown. (encyclopedia.pub)
  • The three types have been shown to differ widely in a number of phenotypes in mice such as virulence, persistence, migratory capacity, attraction of different cell-types and induction of cytokine expression. (saeijlab.com)
  • Clinical presentation will vary depending on the route of transmission and the virulence of the infecting strain. (cdc.gov)