• Single-cell sequencing is a high-throughput technique that enables detection of genomic, transcriptomic, and epigenomic information at the individual cell level, offering significant advantages in detecting cellular heterogeneity, precise cell classification, and identifying rare subpopulations. (frontiersin.org)
  • In addition, clonal evolution in the primary tumor is partly fueled by intratumoral heterogeneity. (biomedcentral.com)
  • There are two not mutually exclusive models explaining tumor heterogeneity: the cancer stem cell and the clonal evolution model. (por-journal.com)
  • In these examples, all the individuals are clones, and the clonal population may cover a large area. (wikipedia.org)
  • To better understand the immunological mechanism operating at the chronic active lesion edge and to identify new therapeutical targets, she recently built a detailed cellular blueprint of multiple sclerosis lesions using single-nucleus RNA sequencing of human MS tissue and identified C1q as critical mediator of microglia activation. (the-asci.org)
  • Elle s'est intéressé également à l'impact de la fragmentation des populations sur la capacité reproductrice et la structure de la variabilité génétique chez les essences méridionales à la zone de transition entre l'érablière à bouleau jaune et la sapinière à bouleau blanc. (uqat.ca)
  • L'atteinte de cette limite est caractérisée par une diminution progressive de la taille des populations et une fragmentation de plus en plus importante de celles-ci le long d'un gradient latitudinal. (uqat.ca)
  • La fragmentation de plus en plus importante de ces populations au fur et à mesure ou on progresse vers le nord pourrait avoir un impact sur la diversité et la structure génétique. (uqat.ca)
  • En effet une diminution du flux génique (via le pollen ou les graines) peut entraîner une diminution de la diversité génétique intra populations et une différentiation de plus en plus grande entre les populations. (uqat.ca)
  • Par contre, peu ou pas de modifications au niveau de la structure génétique serait observée dans les populations qui sont déjà en structure de métapopulations dans les habitats non perturbés. (uqat.ca)
  • Les espèces longévives pourraient être non affectées par la fragmentation pendant des décennies et les effets de la fragmentation sur les populations marginales demeureraient imperceptibles pendant des années. (uqat.ca)
  • Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
  • GBMs have a high rate of cellular proliferation and a marked propensity to invade remote brain structures. (123dok.net)
  • Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
  • Asexual reproduction is a type of reproduction that does not involve the fusion of gametes or change in the number of chromosomes. (wikipedia.org)
  • The offspring that arise by asexual reproduction from either unicellular or multicellular organisms inherit the full set of genes of their single parent and thus the newly created individual is genetically and physically similar to the parent or an exact clone of the parent. (wikipedia.org)
  • Asexual reproduction is the primary form of reproduction for single-celled organisms such as archaea and bacteria. (wikipedia.org)
  • In vertebrates, the most common form of asexual reproduction is parthenogenesis, which is typically used as an alternative to sexual reproduction in times when reproductive opportunities are limited. (wikipedia.org)
  • Vegetative propagation is a type of asexual reproduction found in plants where new individuals are formed without the production of seeds or spores and thus without syngamy or meiosis. (wikipedia.org)
  • Since sexual reproduction is often more narrowly defined as the fusion of gametes (fertilization), spore formation in plant sporophytes and algae might be considered a form of asexual reproduction (agamogenesis) despite being the result of meiosis and undergoing a reduction in ploidy. (wikipedia.org)
  • Many cellular processes, including ribosome biogenesis, are regulated through post-transcriptional RNA modifications. (nature.com)
  • It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. (lecturio.com)
  • A better understanding of the mechanisms underlying the initiation and progression of GBMs at the molecular and cellular levels will open up new opportunities to develop therapeutic strategies. (123dok.net)
  • Reproduction allows an organism to pass on its genes to future generations. (elifesciences.org)
  • While all prokaryotes reproduce without the formation and fusion of gametes, mechanisms for lateral gene transfer such as conjugation, transformation and transduction can be likened to sexual reproduction in the sense of genetic recombination in meiosis. (wikipedia.org)
  • These spores grow into multicellular individuals (called gametophytes in the case of plants) without a fertilization event. (wikipedia.org)
  • Multiple fission at the cellular level occurs in many protists, e.g. sporozoans and algae. (wikipedia.org)
  • The spatial patterns of clonally replicated ramets of genets suggest that these species fall between the so-called phalanx patterns where genets abut one another but do not extensively mix, because of limited ramet fragmentation, and the guerrilla patterns where extensive genet fragmentation and dispersal results in greater mixing of different genets. (bvsalud.org)
  • Asexual reproduction is a type of reproduction that does not involve the fusion of gametes or change in the number of chromosomes. (wikipedia.org)
  • The offspring that arise by asexual reproduction from either unicellular or multicellular organisms inherit the full set of genes of their single parent and thus the newly created individual is genetically and physically similar to the parent or an exact clone of the parent. (wikipedia.org)
  • Asexual reproduction is the primary form of reproduction for single-celled organisms such as archaea and bacteria. (wikipedia.org)
  • In vertebrates, the most common form of asexual reproduction is parthenogenesis, which is typically used as an alternative to sexual reproduction in times when reproductive opportunities are limited. (wikipedia.org)
  • Internal budding is a process of asexual reproduction, favoured by parasites such as Toxoplasma gondii. (wikipedia.org)
  • Vegetative propagation is a type of asexual reproduction found in plants where new individuals are formed without the production of seeds or spores and thus without syngamy or meiosis. (wikipedia.org)
  • Since sexual reproduction is often more narrowly defined as the fusion of gametes (fertilization), spore formation in plant sporophytes and algae might be considered a form of asexual reproduction (agamogenesis) despite being the result of meiosis and undergoing a reduction in ploidy. (wikipedia.org)
  • CONCLUSIONS: These four Sphagnum species all exhibit a similar reproductive patterns that result from a mixture of sexual and asexual reproduction. (bvsalud.org)
  • Here we develop and utilize a capture-based sequencing panel, which covers host hotspot genes and the full-length genome of human T-cell leukemia virus type-1 (HTLV-1), to investigate the clonal architecture of adult T-cell leukemia-lymphoma (ATL). (nature.com)
  • Since early breast cancer DCCs often display close-to-normal genomes 5 , 15 , we use mammary epithelial cells isolated from reduction mammoplasties and available immortalized premalignant breast cancer cell lines as cellular models for functional testing of candidate mechanisms in vitro. (nature.com)
  • Examples of vegetative reproduction include the formation of miniaturized plants called plantlets on specialized leaves, for example in kalanchoe (Bryophyllum daigremontianum) and many produce new plants from rhizomes or stolon (for example in strawberry). (wikipedia.org)