Fractures alendronate. Medical search. Frequent questions

Although comparative trials between Prolia and bisphosphonates showed superior bone mineral density increases with Prolia at key skeletal sites, direct comparative studies with fracture as an endpoint are lacking. (amgen.com)
Alendronate belongs to a class of drugs called bisphosphonates. (rxlist.com)
If bisphosphonates therapy also reduced the risk of non-vertebral fractures by 20% among osteopenic women with high bone turnover, then the costs per QALY gained were $34,000 and $50,000 for women age 70 with high bone turnover and T-scores of -2.0 and -1.5, respectively. (healthpartners.com)
Since then, SSBT after prolonged use of bisphosphonates (BPs) has been considered to be one of the causes of low-energy femoral fractures, called "atypical femoral fracture" (AFF). (hindawi.com)
Alendronate (sold under various names, including Fosamax), risedronate (sold under names including Actonel) and ibandronate (Boniva) are all bisphosphonates that are taken orally. (everydayhealth.com)
Bisphosphonates are a group of medicines used to treat osteopenia or osteoporosis, which are conditions associated with thin or fragile bones that are at increased risk for fracture. (rheumatology.org)
Bisphosphonates work by reducing the turnover of bone which lowers the risk of fracture. (rheumatology.org)
In recent years, a number of side effects have been associated with Fosamax and other bisphosphonates, such as an increased risk of low-trauma femur fractures and a rare jaw bone condition, known as osteonecrosis of the jaw . (aboutlawsuits.com)
NaturalNews) The long-term use of osteoporosis drugs known as bisphosphonates can actually weaken bones by impairing their ability to heal, leading to fractures, according to a study conducted by researchers from New York-Presbyterian Hospital/Weill Cornell Medical Center. (naturalnews.com)
Bisphosphonates deactivate those cells used to break down bone and therefore prevent fractures caused by brittleness of the bone. (sciencedaily.com)
Although, for some time, there have been doubts that bisphosphonates can be the cause of other forms of fractures such as fatigue fractures, by virtue of the fact that they also inhibit natural degradation of bone. (sciencedaily.com)
Of these 59 patients, 78 % had been administered with bisphosphonates whereas only 5% of all forms of fractures within the general population had received the same treatment. (sciencedaily.com)
The connection between the bisphosphonates and the fractures is so strong they we propose that a causal connection can be confirmed. (sciencedaily.com)
However, this study also indicates that the risk of fatigue fractures diminishes once a patient ceases to be administered bisphosphonates. (sciencedaily.com)
The principal effects of bisphosphonates remain: They significantly reduce the risk of fractures at the onset of osteoporosis. (sciencedaily.com)
Bisphosphonates prevent many more fractures than they cause. (sciencedaily.com)
In October 2010, the FDA updated the label on Fosamax, Fosamax Plus D, and other bisphosphonates, warning about the risk of atypical femur fractures. (yourlawyer.com)
In addition to atypical femur fractures, bisphosphonates have also been linked to osteonecrosis of the jaw (ONJ) and esophageal cancer. (yourlawyer.com)
Another recent study, published in the Archives of Internal Medicine, found that 82 percent of patients with atypical femur fractures had been taking bisphosphonates. (yourlawyer.com)
Drug therapies for osteoporosis include bisphosphonates, such as alendronate and risedronate. (naturalmedicinejournal.com)
And that Bisphosphonates like Fosomax, Boniva, Reclast and Actonel will prevent bone fractures. (xtend-life.com)
Bisphosphonates are associated with a small risk of atypical femoral shaft fractures, which increases with duration of use. (aafp.org)
The authors evaluated prescription data and found that of 52,595 women receiving bisphosphonates for more than five years, only 71 (0.13%) sustained an atypical fracture. (aafp.org)
After adjusting for sex and for corticosteroid and vitamin D use, the use of bisphosphonates was associated with an odds ratio of 49.7 for an atypical fracture compared with the no-fracture group (95% CI, 15.9 to 155.1). (aafp.org)
However, the odds ratio for a classic fracture was 0.5 (95% CI, 0.3 to 0.9), suggesting a 50% reduction in these types of fractures in women receiving bisphosphonates. (aafp.org)
The authors calculated that the relative risk for atypical fracture in women receiving bisphosphonates was 47.5 (95% CI, 25.6 to 87.3). (aafp.org)
The increase in the elderly population across the globe and consequently the higher rates of osteoporosis, has meant that a large number of people are being subjected to treatment with bisphosphonates, particularly alendronate and risedronate. (bvsalud.org)
Bone biopsies conducted on patients who, over a long period, have been given bisphosphonates for treatment of osteoporosis and who had suffered fractures, detected the presence of giant osteoclasts suggesting that prolonged use could cause osteoclastic mutations and bone fractures 8 . (bvsalud.org)

One systematic review involving postmenopausal women found that compared with control (i.e, placebo, calcium, or calcium plus vitamin D) risedronate reduced vertebral and nonvertebral fractures after four years. (aafp.org)
NICE technology appraisal guidance on preventing osteoporotic fragility fractures in postmenopausal women (alendronate, denosumab, etidronate, risedronate, raloxifene, strontium ranelate and teriparatide). (nice.org.uk)
Bisphosphonate medications include alendronate (Fosamax), risedronate (Actonel), and ibandronate (Boniva). (rheumatology.org)
For osteoporosis treatment, alendronate is given 70 mg by mouth once a week, and risedronate is given by mouth 35 mg weekly or 150 mg monthly. (rheumatology.org)
Fosamax (alendronate sodium) and Actonel (risedronate) are among the most commonly used bisphosphonate medications in the United States. (aboutlawsuits.com)
Why these trends have occurred is not entirely clear,' the authors wrote, noting that it occurred after the release of bisphosphonate drugs, such as alendronate and risedronate. (healthleadersmedia.com)
Alendronate (Fosamax) and risedronate (Actonel) may cause bone and joint pain. (aafp.org)

Fosamax has been linked to a rare type of leg fracture that cuts straight across the upper thigh bone after little or no trauma (subtrochanteric fractures). (wikipedia.org)
Fosamax helps to reduce the risk of fracture in people with osteoporosis and some other bone conditions. (drugs.com)
I was on Fosamax only 10 months when I suffered a spontaneous fracture of my left femur/hip. (aboutlawsuits.com)
Fifty-nine of the patients were women, and 25 were taking the bisphosphonate drug Fosamax, known generically as bisphosphonate alendronate. (naturalnews.com)
Of the 20 people who had suffered a stress fracture due to very little or even no trauma, 19 were taking Fosamax. (naturalnews.com)
The researchers also found that Fosamax patients with this type of fracture had been taking the drug longer by an average of 6.9 years, compared with an average of 2.5 years in those with other kinds of fractures. (naturalnews.com)
The correlation between Fosamax and stress fractures was found to be independent of age, race, weight or osteoporosis history. (naturalnews.com)
While the correlation with fractures has so far only emerged in Fosamax, researchers noted that other bisphosphonate drugs are less widely prescribed and have not been on the market as long, so the effects may not have had time to show up. (naturalnews.com)
Another woman has filed a lawsuit alleging that her use of Fosamax (alendronate) led to a left femur fracture and other complications. (yourlawyer.com)
According to court documents, Merck allegedly was aware that taking Fosamax could result in severely suppressed bone turnover and multiple stress fractures, but never adequately warned consumers or the public. (yourlawyer.com)
The national law firm recently filed another lawsuit on behalf of a woman who took Fosamax and subsequently suffered a femur fracture. (yourlawyer.com)

METHODS We enrolled 4093 postmenopausal women with osteoporosis and a fragility fracture and randomly assigned them in a 1:1 ratio to receive monthly subcutaneous romosozumab (210 mg) or weekly oral alendronate (70 mg) in a blinded fashion for 12 months, followed by open-label alendronate in both groups. (edu.au)
CONCLUSIONS In postmenopausal women with osteoporosis who were at high risk for fracture, romosozumab treatment for 12 months followed by alendronate resulted in a significantly lower risk of fracture than alendronate alone. (edu.au)
One large RCT involving postmenopausal women with osteoporosis found that raloxifene reduced vertebral fractures compared with placebo, but no significant difference was found in nonvertebral fractures. (aafp.org)
THOUSAND OAKS, Calif. , May 8, 2023 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced new data from a real-world study of nearly half of a million postmenopausal women with osteoporosis in the U.S. medicare program showing Prolia ® (denosumab) injection reduced fracture risk in patients versus oral alendronate, a frequently prescribed bisphosphonate treatment. (amgen.com)
Studies show that drug therapies reduce fractures in postmenopausal women with osteoporosis. (uspreventiveservicestaskforce.org)
BACKGROUND: Prolia is a prescription medicine approved in June 2010 to treat postmenopausal women with osteoporosis at high risk for bone fracture. (medlineplus.gov)

Two systematic reviews involving postmenopausal women found that alendronate reduced vertebral and nonvertebral fractures compared with placebo after one to four years. (aafp.org)
One randomized controlled trial (RCT) involving women with prior vertebral fractures found that parathyroid hormone reduced the proportion of women with vertebral and nonvertebral fractures compared with placebo. (aafp.org)
One systematic review involving postmenopausal women found that etidronate reduced vertebral fractures compared with control (placebo, calcium, or calcium plus vitamin D) over two years but found no significant difference in nonvertebral fractures. (aafp.org)
Calcium Plus Vitamin D . One large RCT involving women 69 to 106 years of age living in nursing homes found that calcium plus vitamin D 3 reduced hip fractures and all nonvertebral fractures after 18 months to three years compared with placebo. (aafp.org)
One smaller RCT involving women and men 65 years or older found that calcium plus vitamin D 3 reduced nonvertebral fractures after three years compared with placebo but found no significant difference in hip fractures. (aafp.org)
One systematic review involving postmenopausal women found that calcitonin reduced vertebral fractures compared with placebo one to five years after treatment but found no significant difference between calcitonin and placebo in nonvertebral fractures. (aafp.org)
One systematic review involving postmenopausal women found no significant difference between calcium supplementation and placebo in vertebral or nonvertebral fractures after one and one half to four years. (aafp.org)
One large RCT involving postmenopausal women and two large RCTs involving postmenopausal women and older men provided no evidence of a difference between vitamin D 3 and placebo in hip, vertebral, and nonvertebral fractures after two to five years. (aafp.org)
Two systematic reviews and two subsequent RCTs provided insufficient evidence about the effects of hormone therapy on nonvertebral fractures. (aafp.org)
It reduces the incidence of vertebral fractures by 47% and nonvertebral fractures by 50% over 3 years. (medscape.com)
It reduces vertebral fractures by 41% and nonvertebral fractures by 39% over 3 years. (medscape.com)
it has no effects on reduction of nonvertebral fractures. (medscape.com)

Non-spine clinical fractures were confirmed by radiographic reports. (nih.gov)
In postmenopausal women, alendronate sodium tablets, USP increases bone mass and reduces the incidence of fractures, including those of the hip and spine (vertebral compression fractures). (nih.gov)
Because the prevalence of occult, asymptomatic fractures (in particular, spinal compression fractures) is considerable, complete spine radiographs may also be obtained. (medscape.com)
It reduces the incidence of spine fracture by 33% in groups receiving 200 IU/day. (medscape.com)
Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased risk of fractures of the hip, spine, and wrist. (daviddarling.info)
May 5, 2021 Current guidelines for managing osteoporosis specifically call out hip or spine fractures for increasing the risk for subsequent bone breaks. (sciencedaily.com)
Children with this type are very short and have curving of the spine and frequent fractures. (msdmanuals.com)
BMD values at the spine and femoral neck were compared in 34 women with vertebral fracture and 34 controls. (who.int)
Mean BMD (g/cm2), T-score, and Z-score values at both femoral neck and spine were significantly lower in the fracture than the nonfracture group. (who.int)
T-score was not sensitive enough to identify low BMD in the spine, whereas the femoral neck T-score could recognize women at high risk of fracture with higher accuracy. (who.int)
Osteoporosis can lead to broken bones (fractures) in the hip, spine, and wrist. (healthlinkbc.ca)
Minimal trauma fractures most commonly occur in the hip, spine, forearm, humerus and pelvis. (menopause.org.au)
Osteoporosis-related fractures most commonly occur in the hip, wrist, or spine. (rxwiki.com)

Another small RCT involving post-menopausal women found no significant difference between calcium plus vitamin D 3 and placebo in hip fractures after two years. (aafp.org)
However, another systematic review and two subsequent RCTs involving post-menopausal women found no significant difference in vertebral fractures. (aafp.org)
These findings provide important insights into the effectiveness of Prolia versus oral alendronate on osteoporotic fracture outcomes in post-menopausal women with osteoporosis at high risk for fracture using real-world data. (amgen.com)
INTRODUCTION AND HYPOTHESIS: Over half of all fractures among post-menopausal women occur in those who do not have osteoporosis by bone density criteria. (healthpartners.com)
CONCLUSION: Measurement of bone turnover markers has the potential to identify a subset of post-menopausal women without osteoporosis by bone density criteria for whom bisphosphonate therapy to prevent fracture is cost-effective. (healthpartners.com)
Evenity offers a new osteoporosis treatment for post-menopausal women at high risk of bone fracture. (everydayhealth.com)

Serious cardiovascular adverse events, osteonecrosis of the jaw, and atypical femoral fractures were adjudicated. (edu.au)
During the open-label alendronate period, adjudicated events of osteonecrosis of the jaw (1 event each in the romosozumab-to-alendronate and alendronate-to-alendronate groups) and atypical femoral fracture (2 events and 4 events, respectively) were observed. (edu.au)
Physicians should discontinue bisphosphonate therapy in patients who have had a femoral shaft fracture or osteonecrosis of the jaw, and should consider discontinuing bisphosphonate therapy after three to five years in patients with low fracture risk. (aafp.org)

Also, they said, 'publicity and physician education and awareness of osteoporosis and fragility fractures' have also increased since 1995, 'which may be a contributing factor. (healthleadersmedia.com)
Although osteoporosis indicates a high risk of fracture, many fragility fractures occur in people with bone density levels above a T-score of -2.5. (menopause.org.au)

The retrospective, observational study assessed U.S. Medicare beneficiary data on 478,651 postmenopausal women aged 66 or older with no history of prior osteoporosis treatment who initiated Prolia (n=89,115) or oral alendronate (n=389,536) treatment between Jan. 1, 2012 and Dec. 31, 2018 . (amgen.com)

The primary end points were the cumulative incidence of new vertebral fracture at 24 months and the cumulative incidence of clinical fracture (nonvertebral and symptomatic vertebral fracture) at the time of the primary analysis (after clinical fractures had been confirmed in ≥330 patients). (edu.au)
For example, the incidence of hip fracture was as high as 5 cases per 1000 person-year in the first year. (medscape.com)
By making bones stronger, alendronate can help to reduce the incidence of osteoporosis-related fractures. (medbroadcast.com)
Although no research data support the idea that the use of intranasal calcitonin reduces the incidence of fractures, studies do show an increase in BMD with the use of calcitonin. (medscape.com)
Ibandronate increases BMD and reduces the incidence of vertebral fractures. (medscape.com)
That makes the incidence of fracture greater than that of heart attack, stroke, and breast cancer combined. (everydayhealth.com)
c) fracture incidence. (bmj.com)
Overall fracture incidence rates were low (357 classic and 32 atypical fractures per 1 million person-years). (aafp.org)

May is Osteoporosis Awareness and Prevention Month, making this a great time to share these new data about Prolia and the important role it can play in reducing the risk of potentially life-altering fractures in these women at high risk for fracture. (amgen.com)
THOUSAND OAKS, Calif. , April 15, 2019 /PRNewswire/ -- Amgen (NASDAQ: AMGN) today announced that EVENITY™ (romosozumab-aqqg) is now available for shipment to wholesalers in the U.S. EVENITY was approved by the U.S. Food and Drug Administration ( FDA ) on April 9, 2019 , for the treatment of osteoporosis in postmenopausal women at high risk for fracture. (amgen.com)
The approval of EVENITY in the U.S. helps address an unmet need by providing another option for postmenopausal women at high risk for fracture who need to build bone rapidly within 12 months and to reduce the risk of a first or subsequent fracture. (amgen.com)

It can reduce the risk of spinal fractures, but not other types of fractures. (medlineplus.gov)

Atypical Femur Fractures have been reported. (nih.gov)

Atypical femoral shaft fractures occur in the subtrochanteric or diaphyseal region and are associated with minimal trauma. (aafp.org)

An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy? (jabfm.org)
As a consequence, patients with routine stress fractures are unable to properly heal, and minor damage can worsen until a serious fracture occurs. (naturalnews.com)

This effect helps maintain strong bones and reduces the risk of broken bones (fractures). (rxlist.com)
BMD tests can identify osteoporosis, determine your risk for fractures (broken bones), and measure your response to osteoporosis treatment. (daviddarling.info)
Worse still, are you experiencing fractures and broken bones as you age? (xtend-life.com)
end of menstrual periods) who have an increased risk for fractures (broken bones) or who cannot take or did not respond to other medication treatments for osteoporosis. (medlineplus.gov)

Another RCT involving women with osteoporosis found that parathyroid hormone plus estrogen reduced vertebral fractures compared with estrogen alone after three years. (aafp.org)
One systematic review involving postmenopausal women found that hormone therapy reduced vertebral fractures compared with control. (aafp.org)

Children with this type have bones that fracture easily during childhood before puberty. (msdmanuals.com)
Osteoporosis is a condition characterised by weakened bones that fracture easily. (menopause.org.au)

1.5.1 Schedule hip fracture surgery on a planned trauma list. (nice.org.uk)
Patients with low bone density or a history of low-energy trauma fractures are recommended to take these medications. (rheumatology.org)
Researchers reviewed the files of all 70 people who had been admitted to the hospital's Level 1 trauma center between 2002 and 2007 for fractures of the thigh bone (femur). (naturalnews.com)
Alternatively, osteoporosis may also be diagnosed if an individual has a minimal trauma fracture, which is defined as a fall from a standing height (or equivalent trauma). (menopause.org.au)
Fractures of the hands and feet are not considered minimal trauma. (menopause.org.au)
A prior minimal trauma fracture puts an individual at higher risk of further fractures. (menopause.org.au)

The dose of alendronate (initially 5 mg daily) was increased (to 10 mg daily) at 24 months, with maintenance of the double blind. (nih.gov)
The recommended dose of alendronate - cholecalciferol is one tablet once weekly. (medbroadcast.com)

It's intended for women with a history of osteoporotic fracture or multiple risk factors for fracture, or for women who haven't responded to or are intolerant of other osteoporosis therapies . (everydayhealth.com)

Food and drugs containing large amounts of calcium, magnesium or aluminium (antacids) decrease the absorption of alendronate. (wikipedia.org)
Food may reduce the absorption of alendronate, which may lead to lower blood levels of the. (drugs.com)

Treatment with Prolia was also associated with greater reductions in fracture risk over time. (amgen.com)
3 Significant reductions in fracture risk were seen in less than 2 years in therapy trials. (racgp.org.au)

The oral medications are often prescribed to strengthen the bones and reduce the risk of fractures associated with osteoporosis. (aboutlawsuits.com)

Given that most residents in RACFs have OP and 40% of all hip fractures occur in this population, active identification of those warranting and accepting of treatment is encouraged. (racgp.org.au)

Intravenous ranitidine increases the oral bioavailability of alendronate. (wikipedia.org)
Alendronate increases the thickness of bone ( bone mineral density ) by slowing down the cells that usually break down bone ( osteoclasts ). (medbroadcast.com)
In the clinical trials of romosozumab, people taking the drug reduced their risk for fracture by more than 70 percent and had increases in bone density in their spines at around 15 percent - a very significant jump. (everydayhealth.com)
Low bone mass increases the risk of developing osteoporosis and fractures. (naturalmedicinejournal.com)
It increases fracture risk, causing a huge amount of personal suffering and loss of quality of life. (naturalmedicinejournal.com)
Smoking increases rates of bone loss and the chance of experiencing a fracture. (rxwiki.com)

Atypical fractures of the femur have been associated with long-term bisphosphonate therapy. (rheumatology.org)
A nested case-control study from Canada matched 716 women 79 to 88 years of age who sustained a subtrochanteric or femoral shaft fracture after receiving bisphosphonate therapy with 3,580 control patients who did not have fractures. (aafp.org)

Osteoporosis is a bone disease that affects 200 million people worldwide and contributes to 8.9 million fractures annually. (diamond.ac.uk)
Worldwide, osteoporosis causes more than 8.9 million fractures annually (1) and one in three women over the age of 50 will experience a fracture (2). (menopause.org.au)

For patients at low- risk for fracture, consider drug discontinuation after 3 to 5 years of use. (nih.gov)
Patients with new thigh or groin pain should be evaluated to rule out an incomplete femoral fracture. (nih.gov)
Alendronate sodium is not indicated for use in pediatric patients. (nih.gov)
One systematic review involving older community-dwelling patients or nursing home residents found no significant difference in hip fractures after six months to two years between hip protectors and no protectors in RCTs where individuals were randomized. (aafp.org)
Patients were evaluated from treatment initiation to first instance of a fracture outcome, treatment discontinuation or switch, disenrollment from Medicare, or death. (amgen.com)
Osteoporosis is common and the risk of fracture is high among patients who have undergone solid organ transplantation. (medscape.com)
The risk of fracture in patients with organ transplants is very high: almost 5 times and 20 times higher in male and female kidney transplant recipients compared with age- and sex-matched control groups. (medscape.com)
yet the hip fracture risk, which is strongly associated with high mortality and poor prognosis, was concerningly high in those patients (30% higher than in patients on dialysis). (medscape.com)
It inhibits osteoclastic bone resorption and has some analgesic effects in patients with fractures. (medscape.com)
1 Osteoporotic fractures, particularly hip fractures, are associated with limitation of ambulation, chronic pain and disability, loss of independence, and decreased quality of life, and 21% to 30% of patients die within 1 year of a hip fracture. (uspreventiveservicestaskforce.org)
In our patients with osteoporosis who are at risk for fracture, we mostly use the types of drugs that stop your bones from breaking down," says Moseley. (everydayhealth.com)
however, because there are many more people with osteopenia than osteoporosis, patients with osteopenia account for a large number of patients who fracture a bone. (medicinenet.com)
Also, many patients require long-term nursing -home care after a hip fracture . (medicinenet.com)
Interestingly, fractures in patients with osteopenia do not always cause pain . (medicinenet.com)
Patients who do fracture their hip and live to tell about it are more likely to have more co-morbidities, such as heart failure, pulmonary disease, and diabetes. (healthleadersmedia.com)
For example: the percentage of hip fracture patients living with congestive heart failure nearly doubled, from around 13% to more than 25%, between 1986-1988 and 2003-2005. (healthleadersmedia.com)
And the percentage of patients with diabetes and hip fracture increased from 9.6% to 25% for men and more than 19% for women. (healthleadersmedia.com)
And patients with hip fracture are also more likely to have diabetes. (healthleadersmedia.com)
Surgical and medical management of hip fracture patients has improved over the last 20 years, 'including care maps to improve timely surgical intervention, improved surgical devices, and movement toward replacement arthroplasty, combined with a push for earlier weight bearing exercises may have reduced mortality by improving mobilization,' they wrote. (healthleadersmedia.com)
Reimbursement is conditional as it is reserved for patients with low-energy hip fractures. (laegemiddelstyrelsen.dk)
For any other patients who are treated with alendronate, the doctor must apply for single reimbursement, and the guiding criteria for single reimbursement remain unchanged for these patients. (laegemiddelstyrelsen.dk)
Fracture risk calculators such as FRAX and GARVAN help stratify fracture risk and are used to help guide clinicians as to which patients should be commenced on osteoporosis medications. (menopause.org.au)
A case-control study retrospectively reviewed the medical records of 477 patients older than 50 years who were treated in a Swiss hospital for subtrochanteric or femoral shaft fracture. (aafp.org)
Researchers compared bisphosphonate use and duration of therapy in these groups and in 200 patients older than 50 years who did not have fractures. (aafp.org)

Alendronate is approved for the treatment and prevention of postmenopausal osteoporosis, male osteoporosis, and glucocorticoid-induced osteoporosis. (medscape.com)
Key to this is to distinguish evidence about bone density (a risk factor) from evidence about fracture (a health outcome) prevention. (racgp.org.au)
The focus of fracture prevention changes with the setting, age group and patient preferences. (racgp.org.au)

New symptomatic vertebral fractures were based on self-report and confirmed by radiography. (nih.gov)

Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. (nih.gov)
The Fracture Intervention Trial aimed to investigate the effect of alendronate on the risk of morphometric as well as clinically evident fractures in postmenopausal women with low bone mass. (nih.gov)
Women aged 55-81 with low femoral-neck BMD were enrolled in two study groups based on presence or absence of an existing vertebral fracture. (nih.gov)
Results for women with at least one vertebral fracture at baseline are reported here. (nih.gov)
2027 women were randomly assigned placebo (1005) or alendronate (1022) and followed up for 36 months. (nih.gov)
We conclude that among women with low bone mass and existing vertebral fractures, alendronate is well tolerated and substantially reduces the frequency of morphometric and clinical vertebral fractures, as well as other clinical fractures. (nih.gov)
Alendronate sodium tablets, USP are indicated for the treatment of osteoporosis in postmenopausal women. (nih.gov)
What are the effects of treatments to prevent fractures in postmenopausal women? (aafp.org)
One systematic review found limited evidence from two small RCTs involving postmenopausal women that calcitriol reduced vertebral fractures after three years compared with placebo. (aafp.org)
One small RCT involving postmenopausal women found no significant difference between a two-year back strengthening exercise program and usual care in vertebral fractures over 10 years. (aafp.org)
Worldwide, one in three women, over the age of 50, will suffer a fragility fracture due to osteoporosis and with an aging population these numbers will rise. (amgen.com)
RESULTS: For women with high bone turnover, the cost per QALY gained with alendronate compared to no drug therapy among women aged 70 years with T-scores of -2.0 or -1.5 were $58,000 and $80,000 (U.S. 2004 dollars), respectively. (healthpartners.com)
however, men have a higher fracture-related mortality rate than women. (uspreventiveservicestaskforce.org)
The USPSTF found convincing evidence that bone measurement tests are accurate for predicting osteoporotic fractures in women and men. (uspreventiveservicestaskforce.org)
The USPSTF found convincing evidence that screening can detect osteoporosis and that treatment of women with osteoporosis can provide at least a moderate benefit in preventing fractures in women age 65 years and older. (uspreventiveservicestaskforce.org)
The USPSTF found adequate evidence that screening can detect osteoporosis and that treatment provides a moderate benefit in preventing fractures in postmenopausal women younger than age 65 years who are at increased risk of osteoporosis. (uspreventiveservicestaskforce.org)
The authors wrote that there has been a distinct shift in hip fractures after 1995, when hip fractures decreased in both men and women. (healthleadersmedia.com)
In postmenopausal women, a decrease in the number of vertebral 5 and hip fractures 6 has been found with the use of alendronate. (bmj.com)
ABSTRACT Vertebral fracture, the hallmark of osteoporosis, usually occurs in postmenopausal women with low bone mineral density (BMD). (who.int)
The aim this study was to determine which BMD parameter can best predict women at high risk of fracture. (who.int)
This is unacceptable for the millions of women who have suffered from an osteoporosis-related fracture. (amgen.com)
Fractures for postmenopausal women can be life-altering events which can lead to loss of mobility. (amgen.com)

She began treatment with alendronate weekly 5 years ago after dual-energy x-ray absorptiometry (DEXA) revealed a T score in the osteoporosis range (T = -2.60). (medscape.com)

That means someone with osteopenia is more likely to fracture a bone than someone with a normal bone density but is less likely to fracture a bone than someone with osteoporosis. (medicinenet.com)
Osteoporosis is a disease that causes bones to become brittle and more likely to fracture (break). (medlineplus.gov)

May increase bone density and decrease the risk for fractures. (medlineplus.gov)

1 ] reported that long-term alendronate therapy could cause severely suppressed bone turnover (SSBT), resulting in delayed healing of nonspinal fractures. (hindawi.com)

Alendronate inhibits osteoclast-mediated bone-resorption. (wikipedia.org)
But while pyrophosphate inhibits both osteoclastic bone resorption and the mineralization of the bone newly formed by osteoblasts, alendronate specifically inhibits bone resorption without any effect on mineralization at pharmacologically achievable doses. (wikipedia.org)

In addition, longer duration of treatment with Prolia was associated with a greater reduction in major osteoporotic (MOP) fracture risk. (amgen.com)
These tools factor in a variety of established clinical risk factors including the bone density to calculate an individual's risk of developing a major osteoporotic and hip fracture in the next 5 and 10 years. (menopause.org.au)
An accepted recommendation is to initiate treatment if the risk or a major osteoporotic and hip fracture is ³ 20% and 3% respectively (8). (menopause.org.au)

Osteoporosis Canada also recommends that you and your doctor check your fracture risk using a tool such as CAROC (Canadian Association of Radiologists and Osteoporosis Canada) Risk Assessment or FRAX (Fracture Risk Assessment) starting at age 50. (healthlinkbc.ca)

Deciding on a drug therapy to prevent fracture in osteoporosis has been an either/or proposition for doctors. (everydayhealth.com)

Anatomy10

Diseases28

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes7

Health Care3

Bisphosphonates28

Risedronate7

Fosamax11

Postmenopausal women with osteoporosis6

Nonvertebral fractures12

Spine13

Post-menopausal women6

Osteonecrosis of3

Fragility fractures2

Oral alendronate1

Incidence8

High risk for fracture3

Spinal Fractures1

Femur Fractures1

Femoral shaft fractures1

Stress fractures2

Broken bones4

Vertebral fractures compared2

Bones that fracture easily2

Trauma6

Dose of alendronate2

Osteoporotic fracture1

Absorption of alendronate2

Reductions in fracture risk2

Reduce the risk of fractures1

Occur1

Increases6

Bisphosphonate therapy2

Million fractures annually2

Patients24

Prevention3

Symptomatic vertebral1

Women22

Dual-energy x-ray a1

Likely to fracture2

Risk for fractures1

Severely suppressed bone turnover1

Bone resorption2

Major osteoporotic3

FRAX1

Prevent fracture1