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  • bone
  • Using a mouse mutant that fractures spontaneously and dies at a very young age, we identified that a deletion of the GULO gene, which is involved in the synthesis of vitamin C, is the cause of impaired osteoblast differentiation, reduced bone formation, and development of spontaneous fractures. (jax.org)
  • INTRODUCTION: A major public health problem worldwide, osteoporosis is a disease characterized by inadequate bone mass necessary for mechanical support, resulting in bone fracture. (jax.org)
  • Recurrent
  • Nasu-Hakola disease (NHD), also referred to as polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare inherited leukodystrophy characterized by progressive presenile dementia associated with recurrent bone fractures due to polycystic osseous lesions of the lower and upper extremities. (nih.gov)
  • Patients then start suffering from recurrent bone fractures due to polycystic osseous and osteoporotic lesions in the limb bones (osseous stage). (nih.gov)
  • skeletal
  • Although bisphosphonates effectively prevent vertebral fractures, and their safety has been tested in randomized trials, we must emphasize the need for awareness of the possibility that long-term suppression of bone turnover with bisphosphonates may eventually lead to an accumulation of fatigue-induced damage and adverse skeletal effects such as delayed fracture healing. (kjim.org)
  • Many people with this condition have skeletal abnormalities such as an unusually large range of joint movement (hyperextensibility), an abnormal curvature of the spine ( scoliosis ), reduced bone density (osteopenia), and a tendency for bones to fracture easily. (nih.gov)
  • Osteopenia
  • Localized osteopenia is evident in X-rays of tumours or infections of bone, in osteonecrosis (death of bony tissue), in fracture, and in conditions of diminished mechanical demand. (britannica.com)
  • Deficient calcium intake combined with excessive phosphate intake causes osteopenia, fractures, and loss of teeth in dogs, cats, and other animals by excessive compensatory parathyroid hormone action. (britannica.com)
  • lesions
  • In this retrospective case series, clinical, laboratory and imaging data were obtained in patients referred to endocrinology or rheumatology with new fractures ( n = 3) or resorptive bone lesions ( n = 3) that developed while on agents targeting PD-1, CTLA-4 or both. (biomedcentral.com)
  • cell
  • CONCLUSION: The sfx is a mutation of the GULO gene, which leads to ascorbic acid deficiency, impaired osteoblast cell function, and fractures in affected mice. (jax.org)
  • cause
  • There are things you can do to get these two biological mechanisms on an equal footing, so as we age we don't suffer from this and the fractures they can cause. (healthcentral.com)