Fractions synaptic membranes. Medical search. Frequent questions

A breakthrough for the identification of the proteome of the presynaptic active zone was the successful employment of antibodies directed against a cytosolic epitope of membrane integral synaptic vesicle proteins for the immunopurification of synaptic vesicles docked to the presynaptic plasma membrane. (mdpi.com)
I could demonstrate that Rab26 is a neuronal small GTPase Rab protein which is associated with a subset of synaptic vesicles. (uni-goettingen.de)
Furthermore it is selectively targeting recycled synaptic vesicles. (uni-goettingen.de)
Furthermore the identification of the interaction between Rab26 and Atg16L1 made it possible to connect recycled synaptic vesicles with the autophagy pathway. (uni-goettingen.de)
Docking to the plasma membrane prepares vesicles for rapid release. (rupress.org)
In Caenorhabditis elegans motor neurons, dense core vesicles dock at the plasma membrane but are excluded from active zones at synapses. (rupress.org)
In contrast, we see that UNC-13, a docking factor for synaptic vesicles, is not essential for dense core vesicle docking. (rupress.org)
Neurons can release small molecule neurotransmitters very rapidly in part because synaptic vesicles are docked to the membrane at active zones. (rupress.org)
In addition to synaptic vesicles, neurons also contain secretory vesicles, called dense core vesicles, that release neuropeptides and catecholamines ( Burgoyne and Morgan, 2003 ). (rupress.org)
Dense core vesicles are usually found in the cytoplasm and these cytoplasmic vesicles must presumably translocate to the plasma membrane before release ( Zupanc, 1996 ). (rupress.org)
The amino-phospholipid DHA is located at a higher concentration across numerous brain subcellular fractions, such as nerve terminals, microsomes, synaptic vesicles (7), and synaptosomal plasma membranes (eight).Current Expertise concerning the Relation among AD, DHA, and EPA Epidemiological evidence. (trpv1inhibitor.com)
They contained little vesicles of transmitter chemical, and when a spike arrives in the axon, it causes these vesicles to migrate to the surface and be released into the synaptic cleft. (inetsoft.com)
Cerebral cortex of AOM mice was ultrastrcturally characterized by the presence of increased numbers (~by 15%) of enlarged synapses showing abundance of synaptic vesicles in the presynaptic zone. (springeropen.com)
Black widow spiders (Latrodectus) contain latrotoxins that stimulate neuronal calcium channels to result in excessive exocytosis of synaptic vesicles, leading to serious neuromuscular, neurosecretory, and cardiovascular effects. (lessonindiplomacy.com)
This causes several hundreds of vesicles of acetylcholine (ACh) to fuse with the nerve membrane. (openanesthesia.org)
The ACh within these vesicles is released into the synaptic cleft, where they combine with and activate nicotinic receptors on the motor endplate. (openanesthesia.org)

Hippocampal N-methyl-D-aspartate receptors (NMDARs) contribute to the expression of certain types of synaptic plasticity, such as long-term potentiation (LTP). (ox.ac.uk)
These effects are accompanied by imbalances in the activity of specific prenylated proteins, Rab3 and RhoA, involved in neurotransmitter release, and synaptic plasticity, respectively. (nature.com)
These data suggest that changes in ephrinA5/EphA5 interactions and synaptic plasticity within the VMH, a key glucose-sensing region in the brain, may contribute to the impairment in glucagon secretion and counterregulatory responses caused by recurrent hypoglycemia. (diabetesjournals.org)
Sensitivity analysis over several parameters of the model has provided results that may help clarify the dynamics of synaptic transmission, while experiments with the model of the complete synapse seem worth explaining short-term plasticity mechanisms. (biomedcentral.com)
In the long term, we are interested, in particular, in addressing models of synaptic plasticity, i.e. activity dependent mechanisms, which are the bases of memory and learning processes. (biomedcentral.com)
The Ras/MAPK pathway regulates synaptic plasticity and cell survival in neurons of the central nervous system. (rupress.org)
In addition to an essential role in regulating cell growth and differentiation, Ras signaling has more recently been linked to a wide range of neuronal functions including synaptic and behavioral plasticity (for review see Thomas and Huganir, 2004 ). (rupress.org)
Our findings suggest that the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative information processing and contribute to recognition deficits in DISC1 L100P mutant mice. (biomedcentral.com)
Dentate gyrus (DG) granule cells carrying homozygous mutation of L100P exhibit decreased synaptic excitation and intact synaptic inhibition, meanwhile Schaffer collateral-CA1 synapses of L100P mice display impaired synaptic plasticity. (biomedcentral.com)

The majority of cholesterol is present in myelin sheaths and in neuronal membranes, where this lipid fulfills structural and functional tasks. (nature.com)
Moreover, PGRMC1 has been attributed with controlling diverse functions including neuronal guidance, membrane trafficking, modulation of cytochrome P450 activity, progesterone-responsiveness, steroidogenesis and regulation of the mevalonate pathway, etc. [ 1 - 3 ]. (oncotarget.com)
Thus, ACh modulates network dynamics in a biphasic fashion, probably by inhibiting excitatory synaptic transmission and facilitating neuronal excitability through muscarinic signaling pathways. (springer.com)
Here, we show that KRas, but not HRas, acutely translocates from the plasma membrane (PM) to the Golgi complex and early/recycling endosomes in response to neuronal activity. (rupress.org)
We propose the hypothesis that small high-density lipoprotein (HDL) particles reduce the risk of Alzheimer's disease (AD) by virtue of their capacity to exchange lipids, affecting neuronal membrane composition and vascular and synaptic functions. (cdc.gov)

L100P mutant slices exhibit decreased excitatory synaptic transmission (sEPSCs and mEPSCs) in dentate gyrus (DG) and impaired long-term potentiation in the CA1 region of the hippocampus. (biomedcentral.com)
The glutamate AMPA receptors (AMPARs) are critically involved in the excitatory synaptic transmission, and blocking AMPARs at the spinal level reverses neuropathic pain. (aspetjournals.org)

The receptors were first identified as specific molecules through the use of binding studies, in which opiates that had been labeled with radioisotopes were found to bind to brain membrane homogenates. (wikipedia.org)
Secreted phospholipases A 2 (sPLA 2 s) participate in a very broad spectrum of biological processes through their enzymatic activity and as ligands for membrane and soluble receptors. (ijbs.com)
Within the central nervous system, Eph receptors and their ligands, the ephrins, play a key role in cell-to-cell communication as well as in synaptic structure and function. (diabetesjournals.org)
Protein associations shaped by PDZ domains may reveal a system for clustering NMDA receptors and additional substances in the postsynaptic membrane. (holyexperiment.org)
Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)

Prenylation, the covalent binding of farnesyl pyrophosphate (FPP) or geranylgeranyl pyrophosphate (GGPP) moieties to proteins, is a crucial post-translational modification for the regulation of protein localization on cell membranes and, in turn, for key cellular processes. (nature.com)
Combining immunopurification and subsequent analytical mass spectrometry, hundreds of proteins, including synaptic vesicle proteins, components of the presynaptic fusion and retrieval machinery, proteins involved in intracellular and extracellular signaling and a large variety of adhesion molecules, were identified. (mdpi.com)
CAPS function in dense core vesicle docking parallels UNC-13 in synaptic vesicle docking, which suggests that these related proteins act similarly to promote docking of independent vesicle populations. (rupress.org)
Proteins, glycolipids, and phospholipids make up cellular membranes, which are crucial for protecting and limiting metabolic processes within cells while also preserving cellular integrity and homeostasis. (alliedacademies.org)
Most membrane proteins are less abundant and more hydrophobic than typical soluble proteins, which makes study of these proteins more challenging. (alliedacademies.org)
The sample preparation, which includes the enrichment and dissolution of the membrane proteins, is crucial for the successful identification of membrane proteins. (alliedacademies.org)
The enrichment of low-abundance membrane proteins at membrane and/or protein levels and the dissolution of hydrophobic membrane proteins have both been accomplished using a variety of established and recently developed techniques. (alliedacademies.org)
Transmembrane proteins are water insoluble, which makes them difficult to study using mass spectrometry and conventional biochemical methods, but not impossible (MS). In this review, we emphasise the importance of shotgun MS for hastening the discovery and investigation of membrane proteins. (alliedacademies.org)
Undoubtedly, the under-representation of membrane proteins in large-scale proteomic datasets is due to the relatively low abundance of these proteins in un-fractionated samples. (alliedacademies.org)
Even though the majority of membrane proteins cannot be accessed using conventional sample preparation methods, this is a subject that is very important to our discussion and has already been well reviewed. (alliedacademies.org)
This is necessary in order to completely characterise membrane proteins. (alliedacademies.org)
A significant advancement would be the identification of a comprehensive catalogue of membrane proteins, which might give a comprehensive overview of all the proteins at the PM [ 2 ]. (alliedacademies.org)
The hydrophobicity, intricate post-translational modifications (PTMs), and low quantity of membrane proteins make it difficult to analyse them. (alliedacademies.org)
The identification of membrane proteins is now more accurate than in earlier analyses due to improved instrument performance, making it possible to analyse complicated protein mixtures in greater detail. (alliedacademies.org)
With the commercial availability of column ovens, raising the temperature from degrees during micro LC has recently been demonstrated to increase the amount of membrane proteins detected in a typical analysis and should become standard practise. (alliedacademies.org)
1996). Another core PSD proteins that we determined may be the 2B subunit from the NMDA receptor Teniposide (NR2B), which may be the main tyrosine-phosphorylated proteins in the PSD small fraction (Moon et al. (holyexperiment.org)
Here we show that in acute HE, the glutamatergic synapse by itself presents discrete changes in the ultrastructure (electron microscope) and expression of functionally critical synaptic proteins (Western blot). (springeropen.com)
This report is to our knowledge the first to demonstrate distinct changes in the synaptic ultrastructure and composition of synaptic proteins in the acute stage of HE. (springeropen.com)
Such a membrane-anchoring strategy has been adopted by a wide range of signaling proteins ( Fivaz and Meyer, 2003 ) with significant variations in the structure of these motifs (see Table S1). (rupress.org)

A thick material that's coextensive using the PSD fills the synaptic cleft and continues to be proposed to consist of adhesion and extracellular matrix substances. (holyexperiment.org)
The transmitter molecules diffuse across the synaptic cleft and bind to receptor molecules in the membrane of the post-synaptic neuron, and by binding to big molecules in the membrane they change their shape, and that creates holes in the membrane. (inetsoft.com)

How do neurons differentially regulate synaptic vesicle and dense core vesicle release? (rupress.org)
Sheng, Z. H. & Cai, Q. Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. (nature.com)
It's a large number of neurons, but only a small fraction of them. (inetsoft.com)
The plasma membrane of the neuron is highly permeable to K + , and in fact the recorded membrane potential of most neurons (−60 to −75 mV) is close to that predicted by the Nernst equation for K + . However, it is not exactly the same, because K + is not the only ion affecting the membrane potential. (britannica.com)
The discussion above demonstrates that the electrical potential existing in neurons is based on the distribution of ions across the plasma membrane and that this distribution comes about through permeation of the membrane. (britannica.com)
Using subcellular channelrhodopsin-2-assisted circuit mapping in mouse visual cortex, we compared feedforward (FF) or feedback (FB) cortico-cortical (CC) synaptic input to cells projecting back to the input source (looped neurons) with cells projecting to a different cortical or subcortical area. (elifesciences.org)
For example, cuprizone-induced demyelination promotes hyper- and depolarizing shifts of the resting membrane potential of auditory thalamocortical pathway neurons and reduction in action potential firing of primary auditory cortex (A1) neurons 7 . (biorxiv.org)

However, relatively little is known about the synaptic mechanisms responsible for activating these interneurons in addition to the specialized dendrodendritic synapses located on distal dendrites. (jneurosci.org)
Motivated by the need to address some aspects of the functioning of neural synapses, we have developed one such model for synaptic processes in the calyx of Held , which is a glutamatergic synapse in the auditory pathway of the mammalia. (biomedcentral.com)
We suggest that densin-180 participates in particular adhesion between postsynaptic and presynaptic membranes at glutamatergic synapses. (holyexperiment.org)
The structure of dendritic spines suggests a specialized function in compartmentalizing synaptic signals near active synapses. (frontiersin.org)
In addition to biochemical signaling cascades, the excitatory synapses of dendritic spines support electrical signaling via post-synaptic potentials. (frontiersin.org)

Tyrosine phosphorylation of the N-methyl-D-aspartate receptor is enhanced in synaptic membrane fractions of the adult rat hippocampus. (ox.ac.uk)
We therefore hypothesized that tyrosine phosphorylation of the NMDAR may enhance the trafficking of the receptor to the synaptic membrane. (ox.ac.uk)
Progesterone receptor membrane component 1 (PGRMC1) is a multifunctional protein implicated in multiple pathologies, including cancer and Alzheimer's disease. (oncotarget.com)
Progesterone receptor membrane component 1 (PGRMC1) is 195 residue membrane-bound protein which contains a short luminal peptide, a single N -terminal transmembrane domain, and a C -terminal cytochrome b 5 -related heme-binding domain ( Figure 1A ). (oncotarget.com)
The determination of the plasma membrane (PM) proteome, resolution of membrane protein topology, establishment of numerous receptor protein complexes, identification of ligand-receptor pairs, and elucidation of signalling networks originating at the PM have all benefited from recent developments in proteomic mass spectrometry. (alliedacademies.org)
to protein complexes, downstream signalling, receptor traf-ficking and synaptic targeting Glutamate receptor availability de- *Corresponding author. (health-articles.net)

These findings raise the possibility that the pattern of interneuronal activation, and thus lateral inhibition onto principal cells, is not regulated predominately by dendrodendritic synaptic inputs but instead may reflect the temporal coincidence of several types of synaptic inputs to granule cells. (jneurosci.org)

alpha-latrotoxin triggers transmitter release via direct insertion into the presynaptic plasma membrane. (lessonindiplomacy.com)

The compositionality of the approach has permitted us to independently focus on tuning the models of the pre- and post- synaptic traits, and then to naturally connect them, by dealing with "interface" issues. (biomedcentral.com)
A spike of activity traveling along the axon causes charge to be injected into the post-synaptic neuron at the synapse. (inetsoft.com)
These holes allow specific ions to flow in or out of the post-synaptic neuron, and that changes their state of depolarization. (inetsoft.com)

It was previously shown in our laboratory that the small GTPase Rab26 is highly enriched in the synaptic vesicle fraction (Nathan Pavlos, unpublished data). (uni-goettingen.de)
In nerve-injured rats, compared with control rats, the GluA2 protein level was significantly less in the plasma membrane but was greater in the cytosolic vesicle fraction in the dorsal spinal cord. (aspetjournals.org)

Here, we show that the stoichiometry of NR2A and NR2B tyrosine phosphorylation is significantly higher in synaptosomal membranes than intracellular microsomal/light membranes. (ox.ac.uk)
Interestingly, NR2B tyrosine-1472, but not NR1 serine-896 or -897, phosphorylation is significantly higher in synaptosomal membranes than intracellular microsomal/light membranes. (ox.ac.uk)
Furthermore, treatment of hippocampal slices with either a tyrosine phosphatase inhibitor or a tyrosine kinase inhibitor alters NMDAR tyrosine phosphorylation and produces a corresponding change in the concentration of NMDARs in the synaptosomal membrane fraction. (ox.ac.uk)
The Na/K-ATPase activity of the brain synaptic plasma membranes (SPM) is regulated by noradrenaline (NA) and the synaptosomal factor SF (soluble protein obtained from the synaptosome cytosol). (biomedcentral.com)

PKCζ protein level was reduced by ~20% in P2 membrane fraction and elevated by ~30% in S2 cytosolic fraction suggesting its altered intracellular trafficking. (springeropen.com)

In general, each neuron consists of a somatic cellular body, on which a variable number of thin elongated structures, called dendrites, converge and from which a long single structure, called axon, emerges, branching in several synaptic terminals. (biomedcentral.com)
The synaptic terminals of the transmitting neuron (the presynaptic element) send signals by releasing chemical molecules (neurotransmitters) to the dendritic, somatic or axonic, part of the receiving neuron (postsynaptic term) [ 3 ]. (biomedcentral.com)
The effect of an input line on the neuron is controlled by synaptic weight which can be positive or negative, and synaptic weights adapt and by adapting these weights, the whole network learns to perform different kinds of computation, for example, recognizing objects, understanding language, making plans, controlling the movements of your body. (inetsoft.com)
These three characteristics of the neuron-semipermeability of the membrane, osmotic balance, and electroneutrality on each side-create an equilibrium electrical potential at which the inside of the membrane is more negative than the outside. (britannica.com)
When the inside of the plasma membrane has a negative charge compared to the outside, the neuron is said to be polarized. (britannica.com)
There is also a tendency for Cl − to permeate the membrane, since that ion is at higher concentration outside the neuron than inside. (britannica.com)
Remarkably, these effects are not associated with changes in the expression of GABAergic and glutamatergic synaptic components, but with a reduction of parvalbumin (PV) neuron density and PV mRNA levels. (biorxiv.org)

tion containing intracellular membranes. (health-articles.net)

The convergence of two types of excitatory inputs onto GABAergic granule cells provides a novel mechanism for regulating the degree of interglomerular processing of sensory input in the olfactory bulb through piriform cortex/olfactory bulb synaptic interactions. (jneurosci.org)
Although the dendritic arborization of granule cells is relatively small (50-200 μm) ( Shepherd and Greer, 1998 ), a single granule cell may receive synaptic inputs from mitral cells several millimeters away ( Shepherd and Greer, 1998 ), providing a theoretical basis for massive synaptic divergence. (jneurosci.org)

Triton X-100 insoluble fraction) of mature mouse hippocampus reveals an enrichment of Shisa7 in the PSD together with GluA2, GluN2B, PSD-95, and this pattern is distinct from the presynaptic marker Synaptophysin (Syp). (elifesciences.org)

Fatemeh M. Membrane proteome for analysis by later mass spectrometry. (alliedacademies.org)

However, little is known about changes in the composition of synaptic AMPARs in the spinal dorsal horn after peripheral nerve injury. (aspetjournals.org)

Furthermore, the limited Teniposide linkage between sites of vesicle docking in the presynaptic membrane and sites of heavy postsynaptic densities under the postsynaptic membrane may very well be mediated by adhesion substances. (holyexperiment.org)

Osmotic balance is maintained between the extracellular fluid and the cytoplasm by movement of water through the plasma membrane when the total concentration of particles on one side is not equal to that on the other. (britannica.com)
Permeation actually occurs through protein structures embedded in the lipid bilayer and spanning the membrane from cytoplasm to extracellular fluid. (britannica.com)

These include the generation of a variety of lipid mediators, along with membrane remodelling, modification of extracellular non-cellular phospholipid components of pulmonary surfactant, microparticles and lipoproteins, and degradation of microbial membranes and dietary phospholipids. (ijbs.com)
In fact, ions are almost always hydrated in the form of ion-water complexes, which have great difficulty in penetrating the hydrophobic lipid bilayer of the plasma membrane. (britannica.com)
These structures, sometimes pumping ions from one side to the other and sometimes merely providing channels through which diffusing ions can flow past the lipid molecules, maintain the ionic distribution that keeps the membrane polarized, and they also allow the abrupt changes in distribution that create nerve impulses. (britannica.com)
Ras activity relies on proper anchoring to the cytoplasmic leaflet of the plasma membrane (PM) by means of a lipid-based PM targeting motif. (rupress.org)

Noradrenaline (NA) and some other neurotransmitters (acetylcholine, dopamine and serotonin) are involved in the regulation of the Na/K-ATPase activity of the synaptic plasma membranes. (biomedcentral.com)
We employed these six rat clocks to investigate the rejuvenation effects of a porcine plasma fraction treatment in different rat tissues. (bvsalud.org)
Golachowska, M. R., Hoekstra, D. & van IJzendoorn, S. C. Recycling endosomes in apical plasma membrane domain formation and epithelial cell polarity. (nature.com)

If the DNA permeable membrane area is smaller than the area of ion permeable pores: fp f piwe obtain only an upper limit of Pm for DNA. (forexinfolink.com)
This equation, by including relative permeability as an important factor, takes into account the phenomenon that the more permeable a membrane is to a particular ion, the greater is the influence of that ion on the membrane potential. (britannica.com)
6], The pores formed by α-LTX in the membrane are permeable to Ca2+ and therefore allow an influx of Ca2+ into the cell. (lessonindiplomacy.com)
7] So because of the channel and the insertion in the cell membrane the protein makes the cell more permeable to substances that can pass through the channel. (lessonindiplomacy.com)

Given the concentrations of all three ions on each side of the membrane and the relative permeability of the membrane to each ion, researchers can calculate the combined effect of K + , Na + , and Cl − on the membrane potential by using the so-called constant-field equation. (britannica.com)
1]. In rat synaptosomes alpha-latrotoxin induced massive neurotransmitter release, and some release was induced also by high concentrations of fractions C and D. These responses were blocked almost completely by a monospecific anti-alpha-latrotoxin serum, indicating that they were all due to alpha-latrotoxin. (lessonindiplomacy.com)

We wanted to find out in which pathway Rab26 is implicated and if it contributes in regulating the synaptic vesicle (SV) cycle. (uni-goettingen.de)
In addition we could offer an alternative mode of synaptic vesicle endocytosis that bypasses the Rab5-dependent pathway and converges with the late endosome/autolysosome pathway. (uni-goettingen.de)

Measuring all major lipids and apolipoproteins in each size fraction and in the whole serum, using total of 0.1 ml, allowed the volumetric calculation of lipoprotein particle numbers and expression of composition in molar analyte per particle number ratios. (cdc.gov)
Lipoprotein composition within size fractions was expressed in molar ratios of analytes (A-I/A-II, C-II/C-I, C-II/C-III. (cdc.gov)

The effect of neurotransmitters on Na/K-ATPase is of strictly specific character and, is apparently related to the regulation of synaptic transmission. (biomedcentral.com)

In this study, we further analyzed the cognitive and affective behaviors of L100P homozygotes and their WT littermates, and explored the underlying synaptic mechanisms as well. (biomedcentral.com)

We now replace these blots with original data for GluA2, PSD-95, GluN2B and Syp, which were acquired at the time of the original experiment, using the same biochemical enrichment fractions. (elifesciences.org)

Here we describe the application of 2-photon microscopy combined with stimulated emission depletion (STED-2P) to the biophysical study of the relationship between synaptic signals and spine morphology, demonstrating the utility of combining STED-2P with modern optical and electrophysiological techniques. (frontiersin.org)

Here, we discuss the remarkable acceleration of the development of a full membrane proteome by discovery-based proteomic algorithms. (alliedacademies.org)
To better understand membrane protein structure, protein-protein interactions, and signalling networks that emerge from the membrane surface, we briefly discuss recent MS developments to determine the entire membrane proteome. (alliedacademies.org)

However, the GluA1 protein levels in these fractions did not differ significantly between nerve-injured and control rats. (aspetjournals.org)

In the olfactory bulb (OB), locally generated inhibitory synaptic interactions play a central role in shaping mitral and tufted cell responses to sensory stimuli ( Hamilton and Kauer, 1985 , 1989 ). (jneurosci.org)

Caruso later purified the detergent-extracted component of rat brain membrane that eluted with the specifically bound 3H-chlornaltrexamine. (wikipedia.org)
[email protected] decreased in numerous phosphoglyceride fractions [e.g., phosphatidylcholine (Pc) and phosphatidylethanolamine (PE)] in 4 places of your brain with Alzheimer's disease (AD) and in the frontal cortex (2). (trpv1inhibitor.com)
Western blot analysis of HD brain tissue shows full-length huntingtin protein in the nuclear fraction as well as abundant immunopositive bands at lower molecular weight, suggesting proteolytic products in the nucleus. (jci.org)

Purified M2 Ascites liquid was useful for immunoblots of PSD small fraction (at 1:3000 dilution), immunoprecipitation from PSD small fraction (at 1:10 dilution), and immunofluorescent staining (at 1:150 to at least one 1:300 dilution). (holyexperiment.org)
CT245 serum was useful for immunoblots from the PSD small fraction (at 1:25,000 to at least one 1:50,000 dilution) as well as for immunofluorescent staining (at 1:2500 to at least one 1:5000 dilution). (holyexperiment.org)

Taken together, these data support the hypothesis that tyrosine phosphorylation may enhance NMDAR activity by increasing the number of NMDARs at the synaptic membrane. (ox.ac.uk)
We investigated the effect of the anandamide precursor 20:4-NAPE on synaptic activity in naive and inflammatory conditions. (frontiersin.org)

Our model overcomes some limitations of the kinetic ones and, to our knowledge, represents the first model of synaptic processes based on process calculi. (biomedcentral.com)

As stated above, the Nernst potential is the potential difference that exists across a membrane when a particular ion , having reached equilibrium between the tendency to diffuse down its concentration gradient and the tendency to be drawn back by other ions, is in a state of no net flux. (britannica.com)

We have found that the calcium-activated protein for secretion (CAPS) protein is required for dense core vesicle docking but not synaptic vesicle docking. (rupress.org)
Correlations between the neck geometry and the amplitude of synaptic potentials and calcium transients evoked by 2-photon glutamate uncaging were also investigated. (frontiersin.org)

Here, the cloning can be referred to by us of densin-180, a primary PSD protein which has characteristics of the synaptic adhesion molecule. (holyexperiment.org)

Anatomy24

Organisms8

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Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes20

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Post-synaptic3

Vesicle fraction2

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