The fractional concentration of nitric oxide in exhaled breath (FENO) is elevated in patients with steroid-naive atopic asthma and correlates with eosinophilic infiltration of the airway wall. (eur.nl)
Other outcome variables were forced expiratory volume in 1 sec (FEV 1 ), fractional concentration of exhaled nitric oxide (FeNO), quality of life [PAQLQ(S)], children's coping (UCL-A), parents' report of behavioral problems (CBCL), and parenting stress (PSI/NOSI). (amsterdamumc.org)
The resulting recommendations address the investigation of biomarker levels (blood eosinophil count along with fractional concentration of exhaled nitric oxide [FeNO]), clinical features (oral corticosteroid [OCS] dependence, specific comorbid disease entities associated with severe type 2 asthma), and safety considerations. (ox.ac.uk)
The measurement of Fractional Exhaled nitric oxide (FENO) was one of two NHANES 2007-8 examination components on respiratory health sponsored by the National Heart, Lung, and Blood Institute of the National Institute of Health. (cdc.gov)
The objective of the nitric oxide data collection was to produce baseline FENO measurements and reference ranges for the U.S. healthy population as well as those with asthma and COPD, and those who are smokers. (cdc.gov)
Airway inflammation, as assessed by fractional exhaled nitric oxide (FeNO) and bradykinin (BK) levels, had been measured prior to and following every remedy period. (ghsrinhibitor.com)
Clinical characteristics (age, gender, allergy history, body mass index (BMI) and smoking history), clinical indicators [whole blood count, forced expiratory volume in one second as percentage of predicted volume (FEV1% predicted), IgE level, high sensitivity C-reactive protein (hs-CRP) and fractional expiratory nitric oxide (FeNO)] and serum BPI levels were measured to compare among each group. (biomedcentral.com)
The measurement of fractional exhaled NO (FeNO) has been standardized for clinical measurement. (vivatmo-hcp.com)
In the revised version of the German Asthma Guideline , 6 the determination of nitric oxide in breath exhalate (FeNO) is mentioned as part of the initial asthma diagnosis and repeated measurements are recommended. (vivatmo-hcp.com)
The pilot, taking place at Royal Oldham Hospital, offers patients Fractional Exhaled Nitric Oxide (FeNO) testing on the ward to monitor inflammation of the lungs, and offers advice and nicotine replacement therapy with support to be smoke-free and ultimately become healthier as a result. (healthinnovationmanchester.com)
The majority of patients with asthma have Type 2/Th2 allergic/eosinophilic driven airway inflammation and higher levels of nitric oxide (NO) in their exhaled breath.4 By mesuring the concentration of NO in an exhaled breath (fractional exhaled nitric oxide or FeNO), clinicians can evaluate airway inflammation in patients with asthma. (mcarthurmedical.com)
The concentration of LTB4 in sputum and BAL also associated with other biomarkers of inflammation such as myeloperoxidase and elastase activity. (cmdm.tw)
Pulmonary3
A deficiency in airway nitric oxide (NO) could contribute to pulmonary vaso-occlusion in sickle cell disease (SCD). (nih.gov)
The other part discusses diverse sensors that have been developed and used for the detection of respiratory diseases ( e.g. chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary arterial hypertension, tuberculosis, cystic fibrosis, obstructive sleep apnoea syndrome and pneumoconiosis) by analysis of VOCs in exhaled breath. (ersjournals.com)
Detection of volatile organic compounds from exhaled breath by nanomaterial-based sensors is a new diagnostics frontier in the screening of pulmonary diseases. (ersjournals.com)
Breath5
Nitric Oxide (NO) is a chemical normally produced in the respiratory tract and can be detected in the exhaled breath. (cdc.gov)
To obtain a sample of NO produced in the bronchial tubes, the exhaled breath has to be fractionated. (vivatmo-hcp.com)
This review presents and discusses a new frontier for fast, risk-free and potentially inexpensive diagnostics of respiratory diseases by detecting volatile organic compounds (VOCs) present in exhaled breath. (ersjournals.com)
One part of the review is a didactic presentation of the overlaying concept and the chemistry of exhaled breath. (ersjournals.com)
or 2) in exhaled breath, blood or other body fluids, something highly dependent on their tissue-blood and blood-air partition coefficients [ 13 ]. (ersjournals.com)
Bronchial3
Multiple flows fractional exhaled NO (FE(NO)), bronchial NO flux (J'aw(NO)), and alveolar NO concentration (Ca(NO)) were determined prospectively in 16 non-atopic children with SCD in a tertiary ambulatory clinic and compared with those in 10 children with primary ciliary dyskinesia and 22 healthy control subjects. (nih.gov)
Induced sputum differential cytology tests, measurements of exhaled nitric oxide concentration and methacholine bronchial provocation tests were performed. (sdu.edu.cn)
Participants are then asked to blow out all of their air at a constant pressure while exhaled NO from the bronchial tree is measured. (cdc.gov)
Alveolar3
To determine alveolar and airways nitric oxide (NO) levels in children with sickle cell disease (SCD). (nih.gov)
The following parameters were determined using extended NO analysis: airway tissue nitric oxide concentration ( C aw,NO ), airway transfer factor (or diffusing capacity) for nitric oxide ( D aw,NO ), alveolar nitric oxide concentration ( C A,NO ) and fractional exhaled nitric oxide concentration at a flow rate of 50 mL·s -1 ( F eNO,0.05 ). (ersjournals.com)
Using extended nitric oxide analysis, it was possible to attribute the reduction in exhaled nitric oxide levels seen in ex- and current smokers to a lower total airway nitric oxide flux in ex-smokers and reduced airway and alveolar nitric oxide concentrations in current smokers. (ersjournals.com)
Asthma3
Measuring fractional exhaled nitric oxide concentration in asthma: NIOX MINO, NIOX VERO and NObreath. (pcrs-uk.org)
Higher concentrations of leukotriene B4 in EBC of asthmatic patients in comparison with healthy control subjects increase asthma severity in adults. (cmdm.tw)
LTB4 concentrations were also increased in asthmatic children compared to healthy subjects, with differences detected for 2 degrees of asthma severity. (cmdm.tw)
Patients6
LTB4 concentrations in EBC were also increased in COPD patients and asthmatic patients compared to healthy controls. (cmdm.tw)
The patients with acute exacerbations of COPD were found to have significantly increased level of LTB4 but the concentration of LTB4 will decrease during treatment although they remain in higher levels in COPD patients than healthy controls. (cmdm.tw)
EBC concentrations of LTB4, and serum levels of LTB4 were all significantly higher in patients with COPD than in healthy subjects while COPD patients with CVD were not found to have higher concentrations of LTB4. (cmdm.tw)
LTB4 can be recognized in EBC collected from lung cancer, and their concentrations found to be significantly lower than those in BALf patients using diagnosed NSCLC. (cmdm.tw)
The levels of cys-LT, LTB4 and 8-isoprostane in EBC from lung cancer patients showed their concentrations in BALf. (cmdm.tw)
EBC of LTB4 and LTE4 achieved higher concentrations in seasonal allergic rhinitis patients than in healthy subjects and reduced the concentrations after the pollen season as compared with levels in season. (cmdm.tw)
Hyperresponsiveness1
or Airway hyperresponsiveness (methacholine: provocative concentration that causes a positive reaction [PC20] of lesser than 8 mg/mL) documented in the 60 months prior to Visit 1. (who.int)
Expiratory1
We measured the fractional expired concentration of NO (FE(NO)) by chemiluminescence during a slow vital capacity maneuver against a positive pressure of 16 cm H(2)O at an expiratory flow rate of 50 mL/sec in 44 stable ambulatory adults with SCD and 30 healthy controls. (nih.gov)
Lung function1
This study comprised 221 adult subjects from the European Community Respiratory Health Survey II, who were investigated in terms of their exhaled NO, lung function, immunoglobulin E sensitisation and smoking habits. (ersjournals.com)
Substances1
These devices produce aerosolized substances by heating a liquid, which generates a large number of chemicals due to the presence of propylene glycol, vegetable glycerin, nicotine in various concentrations, flavoring agents and other additive compounds (1). (researchsquare.com)
Asthmatic children1
Passive smoking has also been found to reduce levels of exhaled NO in healthy subjects 4 and asthmatic children 5 . (ersjournals.com)
Airways2
During this test, you inhale different concentrations of allergens or medicines that may tighten the muscles in your airways. (medlineplus.gov)
The association between snus (oral tobacco) use and reduced nitric oxide concentrations in the airways and increased nitric oxide transfer from the airways warrants further studies. (ersjournals.com)
It is a well-known fact that smoking is associated with a reduction in exhaled nitric oxide (NO) levels. (ersjournals.com)
A reduction in exhaled nitric oxide (NO) levels was first observed in smokers in the early 1990s 1 , 2 , and this effect was found after both acute and chronic exposure to smoking 3 . (ersjournals.com)
Smoking cessation is accompanied by an increase in exhaled NO levels 6 , and, in one report, NO levels normalised after smoking cessation 7 . (ersjournals.com)
The possible mechanisms by which exhaled NO levels are reduced in smoking subjects are a potential negative feedback mechanism of the NO from the cigarette smoke, which could lead to downregulation of NO synthase (NOS) in the lungs 8 , 9 , an inadequate supply of cofactors necessary for NO production, such as tetrahydrobiopterin 10 , and an increase in the breakdown of NO 11 , 12 . (ersjournals.com)
There is, however, very limited information about the dose-response relationship and the effect of past and passive smoking on exhaled NO levels and flow-independent NO exchange parameters. (ersjournals.com)
This device relies on an electrochemical sensor to detect exhaled NO levels and provides measurements of from 5 to 300 ppb in whole numbers. (cdc.gov)
Adults2
We conclude that exhaled NO is reduced in adults with SCD, and this may play a role in the pathogenesis of acute chest syndrome and chronic sickle cell lung disease. (nih.gov)
2 A study by Gaffin et al reported that for every 10 parts per billion increase in NO 2 concentration, there was a 5% reduction in FEV1/FVC ratio. (niox.com)
Exposures1
Cartier [10] has reviewed the various foods, food addi- single or multiple exposures to high concentrations of tives, and contaminants that have been associated with irritant compounds. (cdc.gov)
Flux2
Maximum total airway nitric oxide flux ( J ' aw,NO ) was calculated from D aw,NO ( C aw,NO - C A,NO ). (ersjournals.com)
The few studies investigating the effects of smoking on flow-independent NO exchange parameters indicate that smoking is related to a lower maximum total airway nitric oxide flux ( J ' aw,NO ) 7 , 14 and to a lower mean airway tissue nitric oxide concentration ( C aw,NO ) 15 . (ersjournals.com)
Nicotine1
6 ] they use disposable cartridges that contain e-liquids with nicotine benzoate salt, which have a much higher nicotine concentration than e-liquids with freebase nicotine. (bcmj.org)
Children1
LTB4 concentrations were found to be higher in children with wheezing episodes than in healthy controls. (cmdm.tw)
Pollen1
3 4 These mixed results, in fact, reflect the complexity in concentration, toxicity/allergenicity and seasonality of both air pollutants and pollen in diverse geographical settings. (bmj.com)
Parameters1
The aim of the present investigation was to study the effect of past, current and passive smoking on exhaled NO in a general population sample using flow-independent NO exchange parameters. (ersjournals.com)
Higher1
microRNAs are present in higher concentration in exosomes that play a major role in various physiological and pathological functions. (researchsquare.com)
Lower1
E-cig aerosol contains ultra-fine particles, heavy metals, volatile organic compounds, and numerous toxic chemicals including acetaldehyde, acrolein, toluene, and formaldehyde in lower concentration than cigarette smoke (2, 3). (researchsquare.com)
Results1
This subsequently, reduces the risk of systemic side effects such as adrenal suppression, weight gain, faltering growth and immunosuppression, along with the psychosocial benefits of improved mood, improved sleep which results in improved concentration, therefore achieving improved outcomes at school. (healthinnovationmanchester.com)
Parts per bil1
The unit of measurement for NO concentration in air is ppb (parts per billion). (vivatmo-hcp.com)
Remain1
Particles that are not deposited remain suspended in the tidal air and are exhaled. (cdc.gov)