• The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
  • Basic helix-loop-helix (bHLH) myogenic regulatory factors coordinate the correct function and organization of many skeletal muscle functions. (biomedcentral.com)
  • Myogenic regulatory factors (MRFs): MyoD, Myf5, Myf6 and Myogenin. (wikipedia.org)
  • Significance Statement: The TDP-43 protein is a constituent of RNA granules involved in regulated translation. (bvsalud.org)
  • MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
  • ATP-dependent Clp protease (ClpP), a mitochondrial matrix protease, plays an important role in regulating mitochondrial protein turnover and bioenergetics activity. (springer.com)
  • Serum response factor (SRF) plays a central role during myogenesis, being required for the expression of striated alpha-actin genes. (wikipedia.org)
  • We have previously shown that MSY3/Csda binds a highly conserved cis-acting element located upstream of the myogenin promoter (myogHCE) and regulates the postnatal down-regulation of myogenin [ 16 ]. (biomedcentral.com)
  • They include: Myocyte enhancer factors (MEFs), which promote myogenesis. (wikipedia.org)
  • Associated Genetic Factors: PAX3 and c-Met Mutations in PAX3 can cause a failure in c-Met expression. (wikipedia.org)
  • PAX3 mediates the transcription of c-Met and is responsible for the activation of MyoD expression-one of the functions of MyoD is to promote the regenerative ability of satellite cells (described below). (wikipedia.org)
  • Associated Genetic Factors: PAX3, c-Met, Mox2, MSX1, Six, Myf5, and MyoD Mox2 (also referred to as MEOX-2) plays an important role in the induction of mesoderm and regional specification. (wikipedia.org)
  • If placed in cell culture, most myoblasts will proliferate if enough fibroblast growth factor (FGF) or another growth factor is present in the medium surrounding the cells. (wikipedia.org)
  • When the growth factor runs out, the myoblasts cease division and undergo terminal differentiation into myotubes. (wikipedia.org)
  • Furthermore, Scylla negatively regulates Inr/TOR signaling by reducing S6K but not PKB activity (Reiling, 2004). (sdbonline.org)
  • They include: Myocyte enhancer factors (MEFs), which promote myogenesis. (wikipedia.org)
  • Serum response factor (SRF) plays a central role during myogenesis, being required for the expression of striated alpha-actin genes. (wikipedia.org)
  • steroids can thereby regulate myogenesis. (wikipedia.org)
  • Myf5 is considered to be the earliest expressed regulatory factor gene in myogenesis. (wikipedia.org)
  • These consequences further reveal the complexity of myogenesis and the importance of each genetic factor in proper muscle development. (wikipedia.org)
  • MAA is shown to have widespread effects on androgen-responsive genes, affecting processes ranging from apoptosis to ion transport, cell adhesion, phosphorylation and transcription, with MAA able to enhance, as well as antagonize, androgenic responses. (nih.gov)
  • RTP801 was described as a hypoxia/HIF-1-inducible factor with a role in apoptosis (Shoshani, 2002). (sdbonline.org)
  • Thyroid hormone (T3) regulates adult intestine development through T3 receptors (TRs). (bvsalud.org)
  • Thus, our results support the hypothesis that DNA sequences ultimately determine the unique epigenomes of different cell types through their interactions with transcriptional factors, epigenome remodeling system and extracellular cues during cell differentiation. (biomedcentral.com)
  • Associated Genetic Factors: PAX3, c-Met, Mox2, MSX1, Six, Myf5, and MyoD Mox2 (also referred to as MEOX-2) plays an important role in the induction of mesoderm and regional specification. (wikipedia.org)
  • Sequence motifs learned by both the cell or mark models are highly similar to known binding motifs of transcription factors known to play important roles in CD 4 + T cell differentiation. (biomedcentral.com)
  • Recent progress in machine-learning has demonstrated that deep convolutional neural networks (CNNs) can achieve very high accuracy in predicting transcription factor (TF) binding affinity [ 10 ] and epigenetic marks in various cell types [ 11 , 12 , 13 ]. (biomedcentral.com)