Fourier transform mass spectrometry. Medical search. Frequent questions

Fourier transform ion cyclotron resonance mass spectrometry reveals substantial differences in the structural motifs of lignite and leonardite humates, which can be used for the standardization and molecular systematics of humic substances and for the directed design of humate-based products. (bgu.ac.il)
Fourier-transform ion cyclotron resonance mass spectrometry is a type of mass analyzer (or mass spectrometer) for determining the mass-to-charge ratio (m/z) of ions based on the cyclotron frequency of the ions in a fixed magnetic field. (wikipedia.org)
In this study, the reproducibility of tryptic digestion of complex solutions was investigated using liquid chromatography Fourier transform ion cyclotron resonance (LC FT-ICR) mass spectrometry. (lu.se)
The analysis was conducted using high resolution mass spectrometry, nominally, Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) with electrospray ionization. (ac.ru)
Covers a method and system for estimating the ion cyclotron resonance parameters in Fourier-transform mass spectrometry. (genomeweb.com)
Metabolomics analysis via Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) ( Marshall, Hendrickson & Jackson, 1998 ) and a supporting suite of geochemical analyses have been conducted through the Environmental Molecular Sciences Laboratory (EMSL) for the field-collected samples. (peerj.com)
My research consists of the continuing development of new theory, techniques, and analytical/biological/environmental applications of Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. (fsu.edu)
Marshall, A. G. Diagnosis of Hemoglobinopathy and beta-Thalassemia by 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry of Hemoglobin from Blood . (fsu.edu)
Marshall, A. G. 126,264 Assigned Chemical Formulas from an Atmospheric Pressure Photoionization 9.4 Tesla Fourier Transform Positive Ion Cyclotron Resonance Mass Spectrum . (fsu.edu)
Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS) offers the highest mass resolution and mass accuracy currently achievable and has become the method of choice for complex mixture analysis. (serdp-estcp.org)
Humic (HA) and fulvic (FA) acids (components of HS) were extracted from the sediment samples followed by in-depth characterisation via UV/VIS, fluorescence spectroscopy, elemental (C, N) and isotopic analysis (δ 13 C, δ 15 N), nuclear magnetic resonance ( 13 C NMR) and Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). All data were analysed by self-organising maps. (ufz.de)
To determine the degree to which responses to single-walled CNTs (SWCNT) and AB are similar or different, the pulmonary response of C57BL/6 mice to repeated exposures to SWCNTs, crocidolite AB, and ultrafine carbon black (UFCB) were compared using high-throughput global high performance liquid chromatography fourier transform ion cyclotron resonance mass spectrometry (HPLC-FTICR-MS) proteomics, histopathology, and bronchoalveolar lavage cytokine analyses. (cdc.gov)
The SOM molecular characteristics were investigated in the solid phase by nuclear magnetic resonance (NMR) and in the WEOM by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). Formerly added charcoal additions reduced the extracted amount of WEOM and altered POM pattern: an increased proportion of C and N stored in coarse, intermediate, and fine POM relative to corresponding total C and N was found in subsoils. (cifor.org)
Different types of mass analysers will also be discussed, including the quadrupole, the 3d and linear ion traps, the time of flight, the orbitrap and the Fourier transform ion cyclotron resonance mass analysers, and their combinations. (lu.se)

Thirty-six strains of aerobic endospore-forming bacteria confirmed by polyphasic taxonomic methods to belong to Bacillus amyloliquefaciens, Bacillus cereus, Bacillus licheniformis, Bacillus megaterium, Bacillus subtilis (including Bacillus niger and Bacillus globigii), Bacillus sphaericus, and Brevi laterosporus were grown axenically on nutrient agar, and vegetative and sporulated biomasses were analyzed by Curie-point pyrolysis mass spectrometry (PyMS) and diffuse reflectance-absorbance Fourier-transform infrared spectroscopy (FT-IR). (nih.gov)
Validated by GC-MS (gas chromatography-mass spectrometry) and FTIR (Fourier transform infrared spectroscopy). (nativeremedies.com)
The chemical structure of the new molecule was fully characterized by proton nuclear magnetic resonance ( 1 H-NMR), carbon-13 nuclear magnetic resonance ( 13 C-NMR), heteronuclear single quantum coherence (HSQC), correlation spectroscopy ( 1 H- 1 H-COSY), distortionless enhancement by polarization transfer (DEPT), mass spectrometry, Fourier-transform infrared (FTIR), and ultraviolet (UV) spectroscopies. (mdpi.com)
Her research interests lie at the interface of biology, chemistry and physics, with a specific focus on developing analytical techniques and workflows to quantify temporal dynamics of intracellular metal species, their subcellular localisation, and identification of key biomolecules involved in their binding and transport with minimal disruption to the system of study through the use of both elemental mass spectrometry and synchrotron X-ray spectroscopy based bioimaging techniques. (rsc.org)
The researchers subjected the materials in the containers to Fourier-transform infrared spectroscopy and gas chromatography /mass spectrometry analysis. (phys.org)
Fourier transform-infrared spectroscopy and electrospray ionisation mass spectrometry evidenced enhanced levels of suberin-like compounds in phenol-treated trees with respect to non-treated trees. (upm.es)
Gas phase products are identified and/or quantified by gas chromatography (GC), mass spectrometry (MS), or Fourier transform infrared spectroscopy (FTIR), liquid phase products by nuclear magnetic resonance (NMR) and liquid chromatography (LC). (empa.ch)
An analytical lab provides a full suite of analytical capabilities, including Fourier transform infrared spectroscopy, Raman spectroscopy, mass spectrometry, and more. (edwardsvacuum.com)
Water and four solutions (50% ethanol, sodium chloride, sodium hydroxide and phosphoric acid) were selected and impurities were measured by gas chromatography mass spectrometry (GC-MS) and liquid chromatography-UV spectroscopy-mass spectrometry (LC-UV-MS) after 70 days at 40°C. Compared with the control, impurities were not detected in the OXYCAPT containers. (ondrugdelivery.com)
The MC of the enamel was determined before and after bleaching using Fourier transform (FT-Raman) spectroscopy and micro energy-dispersive x-ray fluorescence spectrometry (μEDXRF). (bvsalud.org)

this was confirmed using pyrolysis-gas chromatography/mass spectrometry. (nih.gov)
The samples were studied through several lines of chemical analysis, including gas chromatography-mass spectrometry, high-performance liquid chromatography-mass spectrometry, Fourier-transform infrared spectrometry and stable isotope analysis. (phys.org)
Tools used by the Laboratory's forensic scientists include chemical tests, digital photography, comparative microscopes, video spectral comparators, scanning electron microscopes, X-ray fluorescence spectrometry, capillary electrophoresis instrumentation, gas chromatography/mass spectrometry and Fourier transform infrared spectrometry. (ohioattorneygeneral.gov)
Di-n-butyl phthalate may be determined by high resolution gas chromatography with an electron capture detector (HRGC/ECD) (EPA 1984b), gas chromatography/mass spectrometry (GC/MS) (EPA 1994a), gas chromatography with a flame ionization detector (GC/FID) (NIOSH 1994), gas chromatography/Fourier transform infrared spectrometry (GC/FTIR) (EPA 1994b), high performance liquid chromatography/mass spectrometry (HPLC/MS) (Coldham et al. (cdc.gov)

The deuterium enrichment in post-dose saliva is determined by Fourier Transform Infrared (FTIR) spectrometry (portable Agilent FTIR 4500s, Agilent, Santa Clara, United States). (who.int)

The process uses broad-range polymerase chain reaction (PCR) to amplify nucleic acid targets from large groupings of organisms, electrospray ionization mass spectrometry for accurate mass measurements of PCR products, and base composition signature analysis to identify organisms in a sample. (cdc.gov)
We use broad-range PCR to generate amplification products from the broadest possible grouping of organisms, followed by electrospray ionization mass spectrometry and base composition analysis of the products ( 16 , 17 ). (cdc.gov)

Field and laboratory studies include surveys of weld-wire mesh corrosion, rock mass conductivity measurements, and sample analyses using a scanning electron microscope, energy dispersive spectrometry, and Fourier transform infrared spectrometry. (cdc.gov)
Regarding the methods, microhardness 2,5 , scanning electron and polarized light microscopy 7,14 , micro energy-dispersive x-ray fluorescence spectrometry (μEDXRF) 11 , Fourier transform-Raman (FTRaman) spectroscopy10 and atomic absorption spectrometer (AAS) 10 have been used to determine the adverse effects resulting from bleaching techniques. (bvsalud.org)

The inspiration was earlier developments in conventional ICR and Fourier-transform nuclear magnetic resonance (FT-NMR) spectrometry. (wikipedia.org)

The last two features have made the structural characterization of the new peptides by mass spectrometry a real analytical challenge. (springer.com)
Specifically, investigators will talk about the development of an open-source database infrastructure for the storage and management of analytical data, the identification of product- and source-specific marker compounds, and the development of analytical methods exportable to more widely available lower-resolution mass spectrometers. (serdp-estcp.org)
Non-targeted analysis (NTA) is a broad term to describe analytical techniques, typically using high resolution mass spectrometry, that aim to detect and identify unknown compounds in samples without the need for chemical standards. (serdp-estcp.org)
As part of this SERDP project, the development of an open-source database infrastructure for the storage and management of chemical information, analytical method metadata, and consensus mass spectra will be presented. (serdp-estcp.org)
The objectives of this project are (1) to identify product- and source-specific marker compounds that can ultimately be used for forensic investigations and (2) to develop analytical methods that will be exportable to more widely available lower-resolution mass spectrometers. (serdp-estcp.org)
Ultimately, the development of this analytical technique for complex PFAS analysis will provide a greatly augmented mass spectral library and open-source application for assigning elemental compositions to screening data from non-targeted high-resolution mass spectrometry. (serdp-estcp.org)

While at a talk given by Fred McLafferty, a Cornell mass spectrometry guru, Kelleher asked some probing questions about McLafferty's blending of Fourier transform mass spectrometry (FTMS) with electrospray ionization. (the-scientist.com)

FTICR-MS differs significantly from other mass spectrometry techniques in that the ions are not detected by hitting a detector such as an electron multiplier but only by passing near detection plates. (wikipedia.org)
Hunt, D. F. Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis . (fsu.edu)
For the data sets used in this study, known mass differences are detected at electron mass ac- curacy or better. (lu.se)

Wei-Jun Qian is a bioanalytical chemist whose research centers primarily on the development and applications of mass spectrometry-based approaches to better quantify the dynamic changes in protein abundances and protein post-translational modifications in biological and clinical applications. (pnnl.gov)
2021. "Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress. (pnnl.gov)
2021. "Resin Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation. (pnnl.gov)
The mass of the predicted mature protein of Bothrops protease A, a trypsin-like serine peptidase, is 25.4 kDa. (springer.com)
Finally, we monitor H/D exchange by mass spectrometry to identify surface-exposed residues in proteins and protein complexes. (fsu.edu)
Top down versus bottom up protein characterization by tandem high-resolution mass spectrometry," J Amer Chem Soc , 121:806-12, 1999. (the-scientist.com)
We describe a statistical measure, Mass Distance Fingerprint, for automatic de novo detection of predominant peptide mass distances, i.e., putative protein mod- ifications. (lu.se)

mono-n-butyl phthalate is chromatographically resolved by reverse-phase HPLC, detected by negative ion atmospheric pressure chemical ionization (APCI) tandem mass spectrometry, and quantified by isotope dilution. (cdc.gov)

1998), or high performance liquid chromatography/ion-trap mass spectrometry (HPLC/Ion Trap-MS) (Coldham et al. (cdc.gov)

and Nikolić, Goran (Ed.), "Fourier Transform Mass Spectrometry for the Molecular Level Characterization of Natural Organic Matter: Instrument Capabilities, Applications, and Limitations" (2011). (odu.edu)

Covers a method of pulsed multiple-reaction monitoring mass spectrometry that uses pulsed ion injection mode to reduce background and increase signal to allow for quantitation of proteins and peptides at attomole levels. (genomeweb.com)

The comparison of fragmentation mass spectra for unknown compounds against a database of known compound mass spectra is an essential part of most NTA workflows, but there are no open-source tools available to manage, share, and analyze these complex datasets. (serdp-estcp.org)
The novel database infrastructure will enable users to query their unknown mass spectra against a database of known PFAS, as well as provide context for the clear communication of the confidence of those identifications. (serdp-estcp.org)
Interpretation of mass spectra and data treatment will also be covered, together with practical aspects of mass spectrometry method development. (lu.se)
The method's focus is to globally detect mass differences, not to assign peptide sequences or modifications to individual spectra. (lu.se)

Mass spectrometry for small molecules includes an overview of mass spectrometric techniques that can be used for analysis of low molecular weight analytes in both the gas and liquid phase. (lu.se)

This course covers modern mass spectrometry with a particular focus on the analysis of low molecular weight analytes. (lu.se)
For accurate quantitative or qualitative analysis, mass spectrometry is today combined with different chromatographic techniques. (lu.se)
Course organizer Peter Spégel Center for Analysis and Synthesis Department of Chemistry Lund University course gives theoretical and practical knowledge on how mass spectrometry can be used in qualitative and quantitative analyses of small molecules. (lu.se)
Practical parts include analysis of own or supplied samples by chromatography and mass spectrometry, with subsequent data analysis and identification of sample components. (lu.se)
Mass [10] together with information on modifications induced by sample prepa- ration procedures for mass spectrometric analysis, but mass changes are only given as integer values. (lu.se)

gao Z , 2001 , 'Laser ablation mass spectrometry of binary clusters: an investigation of their relative stabilities and reactivities. (edu.au)

Designed to help practitioners using FT-IR capitalize on the plethora of techniques for modern FT-IR spectrometry and plan their experimental procedures correctly, this is a practical, hands-on reference for chemists and analysts. (ellibs.com)
We were the first to apply Fourier transform techniques to mass spectrometry, and more than 800 FT-ICR mass spectrometry systems based on our patents and papers have been bought or built worldwide. (fsu.edu)
To this end database search engines were rapidly developed after the introduction of ionization techniques for biological mass spectrometry [1-5]. (lu.se)

Fourier Transforms in NMR, Optical, and Mass Spectrometry. (oiipdf.com)

A map of mass spectrometry-based in silico fragmentation prediction and compound identification in metabolomics. (tugraz.at)

Consequently, a lot of effort is put into identifying the constituent proteins using mass spectrometric methods. (lu.se)

Next-generation sequencing (NGS) has transformed genomics by allowing researchers to sequence DNA and RNA at highest speed, accuracy, and cost-effectiveness. (bvsalud.org)

In Goran Nikolić (Ed.), Fourier Transforms: Approach to Scientific Principles (pp. 295-320). (odu.edu)

The book starts with an in-depth description of the theory and current instrumentation of FT-IR spectrometry, with full chapters devoted to signal-to-noise ratio and photometric accuracy. (ellibs.com)
The emphasis is on understanding the fundamental processes involved, the instrumentation used, including different ionization sources and mass analyzers, and interpretation of generated data. (lu.se)

Current field studies demonstrate a correlation of rock mass conductivity to the degree of weld-wire mesh corrosion and the relationship of ground conductivity surveys to support corrosion potential. (cdc.gov)
The objective of this work was to determine the correlation between the mass (M) of respir. (cdc.gov)

The bleaching mechanism is based on the decomposition of peroxides into free radicals, which react with the organic pigment molecules, transforming them into smaller and less pigmented compounds 2 . (bvsalud.org)

Finally, NGS has transformed the field of genomics, resulting in new discoveries and applications in medicine, environmental sciences, and other fields. (bvsalud.org)
Mass spectrometres with different designs and their advantages and shortcomings in different applications will be covered. (lu.se)

The most comprehensive collection of chemical and biological modi- fications being relevant to mass spectrometry can be found in UniMod [12]. (lu.se)

The useful signal is extracted from this data by performing a Fourier transform to give a mass spectrum. (wikipedia.org)

Regarding only snake venoms, several high mass enzymes have been found to be glycosylated. (springer.com)
At our National NSF High-Field FT-ICR Mass Spectrometry Facility at the National High Magnetic Field Laboratory, we currently offer 9.4, 9.4, 14.5, and 21 tesla (highest magnetic field in the world for FT/ICR) instruments. (fsu.edu)
The Mass Distance Fin- gerprint is calculated from high accuracy measured peptide masses. (lu.se)
In proteomics, high throughput approaches using mass spectrometry have be- come widely used. (lu.se)

The results have shown that direct comparison of discrete stoichiometries assigned to the mass lists obtained by the different laboratories yielded poor results with low values of the Jaccard similarity score - not exceeding 0.56 (not more than 56 % of the similar peaks). (ac.ru)

The reliable similarity among the data obtained in this intercomparison study was achieved only by transforming a singular point (stoichiometry) in van Krevelen diagram into a sizeable pixel (a number of closely located stoichiometries), which can be calculated from the population density distribution. (ac.ru)

These experimental observations provide a range for the up- and clown-regulations that are possible to study with electrospray ionization LC FT-ICR mass spectrometry. (lu.se)

The novel cassette was found to result in a slightly higher mass of collected respirable material (for the same sampling duration), though this is likely due to the conductive material of the cassettes, which prevents particle wall losses in comparison to the more commonly used styrene cassette material. (cdc.gov)

In the simplest idealized form, the relationship between the cyclotron frequency and the mass-to-charge ratio is given by f = q B 2 π m , {\displaystyle f={\frac {qB}{2\pi m}},} where f = cyclotron frequency, q = ion charge, B = magnetic field strength and m = ion mass. (wikipedia.org)

These results provide engineers with a means to map corrosion potential of the rock mass, and identify a number of paths for design of focused mitigation efforts for problem areas. (cdc.gov)

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes2

Disciplines and Occupations1

Information Science3

Cyclotron resonance14

Spectroscopy10

Chromatography-mass4

FTIR1

Electrospray Ionization M2

Energy dispersive2

Nuclear magnetic1

Analytical6

FTMS1

Electron3

Protein7

Tandem1

HPLC1

Characterization1

Peptides1

Spectra4

Liquid1

Analysis5

Clusters1

Techniques3

Optical1

Fragmentation1

Proteins1

Sequence1

Approach1

Instrumentation2

Correlation2

Compounds1

Applications2

Biological1

Spectrum1

High4

Laboratories1

Data1

Study1

Found1

Field1

Identify1