Loading...
  • phosphatidylinositol 3-kina
  • The phosphatidylinositol 3-kinase (PI3K) enhancer (PIKE) is small guanosine triphosphatase (GTPase) that associates with nuclear-localized PI3K and increases its lipid kinase activity and its ability to promote cellular proliferation. (sciencemag.org)
  • We now report that tau can bind to SH3 domains derived from the p85α subunit of phosphatidylinositol 3-kinase, phospholipase Cγ1, and the N-terminal (but not the C-terminal) SH3 of Grb2 as well as to the kinases Fyn, cSrc, and Fgr. (edu.au)
  • peptides
  • The structures of the human amphiphysin-1 SH3 domain complexed with 884 peptides were first modeled using virtual mutagenesis and optimized by molecular mechanics (MM) minimization. (genes2cognition.org)
  • Our study demonstrates that the analysis of the MIECs between peptides and the SH3 domain can successfully characterize the binding interface, and it provides a framework to derive integrated prediction models for different domain-peptide systems. (genes2cognition.org)
  • The experimentally determined binding of tau peptides is well accounted for when modeled into the peptide binding cleft in the SH3 domain of Fyn. (edu.au)
  • Sequence
  • The detailed analysis of the dimer interface and a chemical cross-linking study suggest that the C-terminal domain is responsible for stabilizing the dimeric form of KorB in solution to facilitate binding to the palindromic operator sequence. (mdc-berlin.de)
  • A domain sequence that has diverged by mutations, deletions and insertions, if selected, eventually becomes a new different domain whose structure and/or function varies from the original one [ 12 ]. (biochemsoctrans.org)
  • indicate
  • These findings indicate that different domains of the same protein may contribute selectively to different pain states. (bl.uk)
  • PMID
  • By contrast, the occludin-binding domain of ZO-1 has been shown to lie in the GK and acidic domains [ PMID: 9792688 ]. (ebi.ac.uk)
  • nuclear
  • We show that FBP21 is present in highly purified spliceosomal complex A, is associated with U2 snRNPs, and colocalizes with splicing factors in nuclear speckle domains. (embl.de)
  • As mentioned in the text, only ZO-1 and ZO-2 localize to the nucleus, while nuclear targeting of ZO-3 has not been observed so far. (hindawi.com)
  • Dinap1 is a dinoflagellate nuclear protein that has a WW domain and is synthesized mainly in G1 and S phases of the cell cycle. (embl-heidelberg.de)
  • yeast
  • Two of these WW domains, in the proteins FBP11 and FBP21, are strikingly similar to those found in the yeast splicing factor PRP40. (embl.de)
  • We found that the worm SH3 interactome resembles the analogous yeast network because it is significantly enriched for proteins with roles in endocytosis. (harvard.edu)
  • however
  • However, this notion was quickly reevaluated, since these proteins were found to associate with the cadherin-based adherens junctions (AJs) in cells lacking TJs [ 3 ]. (hindawi.com)
  • However, changes in domain architecture happen at a higher frequency after gene duplication. (biochemsoctrans.org)
  • However, although there is evidence that, in prokaryotes, changes in protein domain composition are directed by gene fusion and fission [ 8 , 9 ], little is still known about exact mechanisms that underlie these changes in eukaryotes [ 3 , 6 ]. (biochemsoctrans.org)
  • requires
  • Pre-mRNA splicing requires the bridging of the 5' and 3' ends of the intron. (embl.de)
  • potential
  • This, together with the fact that they show evidence of strong purifying selection affecting them [ 11 ], implies that these domains were able to become promiscuous in the first place because they had a potential to be useful in various contexts. (biochemsoctrans.org)
  • different
  • Interestingly, some domains are observed in a number of different domain combinations, and are considered to be 'promiscuous', whereas others occur in only one or a few combinations [ 10 ]. (biochemsoctrans.org)
  • whereas
  • whereas a high genetic variation was found across both strains (average π value was equal to 0.3899). (biomedcentral.com)
  • The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. (nih.gov)
  • direct
  • Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. (ebi.ac.uk)
  • receptors
  • Excitatory synapses in the brain release the transmitter glutamate, which acts primarily on two subtypes of ionotropic receptors, the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N -methyl- d -aspartate (NMDA) receptors. (pnas.org)
  • analogous
  • This arrangement is analogous to a homo-tetramer formed by single-domain subunits of voltage-gated potassium channels (that also each contain 6 TM helices). (wikipedia.org)